TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 484.394 | Formula: C20H25IN2O2S
H donors: 2 H acceptors: 2 LogP: 5.68 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCNc1ccc(c2c1c(=O)c1c(s2)ccc(c1)O)C)CC.I
InChi: 1S/C20H24N2O2S.HI/c1-4-22(5-2)11-10-21-16-8-6-13(3)20-18(16)19(24)15-12-14(23)7-9-17(15)25-20;/h6-9,12,21,23H,4-5,10-11H2,1-3H3;1H
InChiKey: XNQPDXXSAUJASE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	GPCR family 2	0.0031	0.0092	0.0345
Brugia malayi	nuclear receptor RXR	0.0052	0.0912	0.2736
Trypanosoma brucei	trypanothione reductase	0.0092	0.2404	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0047	0.07	0.2101
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0233	0.7733	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0047	0.07	0.2616
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0031	0.0092	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0761	0.2283
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0224	0.0224
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0092	0.2423	0.9051
Echinococcus granulosus	FTZ F1 alpha	0.0099	0.2677	1
Brugia malayi	hypothetical protein	0.0052	0.0912	0.2736
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0233	0.7733	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0099	0.2677	0.8033
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0209	0.6849	0.8837
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0099	0.2677	0.8033
Loa Loa (eye worm)	hypothetical protein	0.0097	0.2593	0.7779
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0097	0.2593	0.7779
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0099	0.2677	1
Brugia malayi	hypothetical protein	0.0047	0.07	0.2101
Entamoeba histolytica	hypothetical protein	0.0035	0.0249	0.5
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0047	0.07	0.2616
Brugia malayi	Latrophilin receptor protein 2	0.0031	0.0092	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0099	0.2677	0.8033
Treponema pallidum	NADH oxidase	0.0032	0.0137	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0047	0.07	0.2616
Echinococcus granulosus	lysine specific demethylase 5A	0.0034	0.0224	0.0837
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0099	0.2677	0.8033
Loa Loa (eye worm)	hypothetical protein	0.0066	0.1435	0.4306
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0099	0.2677	1
Echinococcus granulosus	thyroid hormone receptor alpha	0.0047	0.07	0.2616
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0032	0.0137	0.5
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0047	0.07	0.2101
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0031	0.0092	0.0345
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0032	0.0137	0.5
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0032	0.0137	0.0512
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0032	0.0137	0.0571
Loa Loa (eye worm)	MH2 domain-containing protein	0.0116	0.3333	1
Schistosoma mansoni	jumonji domain containing protein	0.0073	0.1706	0.1706
Plasmodium falciparum	thioredoxin reductase	0.0032	0.0137	0.0571
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0032	0.0137	0.0571
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0249	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2677	0.8033
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0099	0.2677	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0099	0.2677	0.8033
Entamoeba histolytica	hypothetical protein	0.0035	0.0249	0.5
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0092	0.2404	0.898
Loa Loa (eye worm)	thioredoxin reductase	0.0092	0.2404	0.7214
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0099	0.2677	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0233	0.7733	1
Brugia malayi	nuclear receptor NHR-88	0.0047	0.07	0.2101
Schistosoma mansoni	thyroid hormone receptor	0.0099	0.2677	0.2677
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0097	0.2593	0.7779
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Brugia malayi	jmjC domain containing protein	0.0092	0.2423	0.727
Schistosoma mansoni	hypothetical protein	0.0031	0.0092	0.0092
Plasmodium falciparum	glutathione reductase	0.0032	0.0137	0.0571
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0032	0.0137	0.5
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2677	0.8033
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0047	0.07	0.2101
Schistosoma mansoni	nuclear receptor nhr-48	0.0047	0.07	0.07
Echinococcus multilocularis	GPCR, family 2	0.0031	0.0092	0.0345
Brugia malayi	nuclear receptor RXR	0.0047	0.07	0.2101
Brugia malayi	glutathione reductase	0.0092	0.2404	0.7214
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0047	0.07	0.2616
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0099	0.2677	0.2677
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0047	0.07	0.2101
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0099	0.2677	1
Brugia malayi	steroid hormone receptor	0.0099	0.2677	0.8033
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0047	0.07	0.2616
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Brugia malayi	jmjC domain containing protein	0.0034	0.0224	0.0672
Onchocerca volvulus		0.0099	0.2677	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0066	0.1435	0.4306
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0099	0.2677	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0912	0.2736
Schistosoma mansoni	nuclear hormone receptor	0.0099	0.2677	0.2677
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0052	0.0912	0.2736
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0099	0.2677	0.8033
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0092	0.2404	0.2985
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0099	0.2677	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0099	0.2677	1
Brugia malayi	hypothetical protein	0.0047	0.07	0.2101
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0249	0.0931
Brugia malayi	hypothetical protein	0.0052	0.0912	0.2736
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0209	0.6849	0.8837
Toxoplasma gondii	NADPH-glutathione reductase	0.0032	0.0137	0.0571
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0032	0.0137	0.0512
Brugia malayi	hypothetical protein	0.0035	0.0249	0.0748
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0032	0.0137	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0099	0.2677	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0099	0.2677	0.2677
Brugia malayi	nuclear receptor NHR-67	0.0047	0.07	0.2101
Mycobacterium tuberculosis	Probable dehydrogenase	0.0209	0.6849	0.8837
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0031	0.0092	0.0277
Brugia malayi	ecdysone receptor	0.0047	0.07	0.2101
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0912	0.2736
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0032	0.0137	0.0412
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0031	0.0092	0.0345
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0099	0.2677	1
Onchocerca volvulus	Bile acid receptor homolog	0.0099	0.2677	1
Schistosoma mansoni	hypothetical protein	0.0031	0.0092	0.0092
Loa Loa (eye worm)	transcription factor SMAD2	0.0116	0.3333	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0912	0.2736
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2677	0.8033
Schistosoma mansoni	hypothetical protein	0.0031	0.0092	0.0092
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0912	0.2736
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0047	0.07	0.2616
Brugia malayi	nuclear hormone receptor	0.0047	0.07	0.2101
Brugia malayi	ecdysteroid receptor	0.0099	0.2677	0.8033
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2677	0.8033
Schistosoma mansoni	nuclear hormone receptor	0.0047	0.07	0.07
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0099	0.2677	0.8033
Onchocerca volvulus		0.0047	0.07	0.2616
Brugia malayi	tailless protein	0.0047	0.07	0.2101
Plasmodium vivax	glutathione reductase, putative	0.0092	0.2404	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0099	0.2677	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0047	0.07	0.2101
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0034	0.0224	0.0224
Schistosoma mansoni	hypothetical protein	0.0031	0.0092	0.0092
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0032	0.0137	0.0571
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0209	0.6849	0.8837
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0047	0.07	0.2616
Trichomonas vaginalis	glutathione reductase, putative	0.0032	0.0137	0.5
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0032	0.0137	0.0571
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0047	0.07	0.2616
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0097	0.2593	0.7779
Brugia malayi	Thioredoxin reductase	0.0092	0.2404	0.7214
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0099	0.2677	0.8033
Loa Loa (eye worm)	jmjC domain-containing protein	0.0058	0.1134	0.3403
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Schistosoma mansoni	hypothetical protein	0.0066	0.1435	0.1435
Brugia malayi	Nuclear hormone receptor E75	0.0047	0.07	0.2101
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2677	0.8033
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0099	0.2677	0.8033
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0052	0.0912	0.0912
Schistosoma mansoni	nuclear hormone receptor	0.0047	0.07	0.07
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0032	0.0137	0.5
Plasmodium vivax	thioredoxin reductase, putative	0.0092	0.2404	1
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0032	0.0137	0.5
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0032	0.0137	0.5
Toxoplasma gondii	thioredoxin reductase	0.0092	0.2404	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0099	0.2677	0.2677
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0031	0.0092	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0099	0.2677	1
Onchocerca volvulus		0.0047	0.07	0.2616
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0099	0.2677	0.8033
Schistosoma mansoni	nuclear receptor	0.0047	0.07	0.07
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0099	0.2677	1
Schistosoma mansoni	hypothetical protein	0.0035	0.0249	0.0249
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2677	0.8033
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0052	0.0912	0.3406
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Schistosoma mansoni	retinoic acid receptor RXR	0.0099	0.2677	0.2677
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0047	0.07	0.07
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0099	0.2677	0.2677
Echinococcus multilocularis	ecdysone induced protein 78C	0.0099	0.2677	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0099	0.2677	0.8033
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0052	0.0912	0.0912
Trichomonas vaginalis	mercuric reductase, putative	0.0032	0.0137	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0047	0.07	0.07
Loa Loa (eye worm)	glutathione reductase	0.0092	0.2404	0.7214
Mycobacterium tuberculosis	Probable reductase	0.0209	0.6849	0.8837
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0099	0.2677	0.8033
Loa Loa (eye worm)	DR-78	0.0047	0.07	0.2101
Schistosoma mansoni	coup transcription factor	0.0099	0.2677	0.2677
Brugia malayi	Steroid receptor seven-up type 2	0.0099	0.2677	0.8033
Plasmodium falciparum	thioredoxin reductase	0.0092	0.2404	1
Brugia malayi	nuclear receptor NHR-88	0.0099	0.2677	0.8033
Mycobacterium tuberculosis	Probable oxidoreductase	0.0233	0.7733	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0047	0.07	0.2616
Echinococcus granulosus	ecdysone induced protein 78C	0.0099	0.2677	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0099	0.2677	0.8033
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0047	0.07	0.2616
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0209	0.6849	0.8837
Entamoeba histolytica	hypothetical protein	0.0035	0.0249	0.5
Brugia malayi	orphan nuclear receptor NR2E1	0.0047	0.07	0.2101
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0249	0.0931
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0031	0.0092	0.0345
Loa Loa (eye worm)	nuclear hormone receptor	0.0047	0.07	0.2101
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0099	0.2677	1
Echinococcus multilocularis	jumonji domain containing protein	0.0039	0.0417	0.1558
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0099	0.2677	0.8033
Brugia malayi	Nuclear hormone receptor E75	0.0047	0.07	0.2101
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0099	0.2677	0.2677
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0099	0.2677	0.8033
Brugia malayi	Nuclear hormone receptor-like 1	0.0052	0.0912	0.2736
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0099	0.2677	0.2677
Schistosoma mansoni	nuclear receptor	0.0047	0.07	0.07
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0047	0.07	0.2616
Leishmania major	trypanothione reductase	0.0092	0.2404	1
Brugia malayi	MH2 domain containing protein	0.0116	0.3333	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Entamoeba histolytica	hypothetical protein	0.0035	0.0249	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0099	0.2677	0.8033
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0092	0.0277
Echinococcus multilocularis	FTZ F1 alpha	0.0099	0.2677	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0099	0.2677	1
Schistosoma mansoni	thyroid hormone receptor	0.0099	0.2677	0.2677
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0099	0.2677	0.8033
Schistosoma mansoni	zinc finger protein	0.0047	0.07	0.07
Echinococcus multilocularis	lysine specific demethylase 5A	0.0034	0.0224	0.0837
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2677	0.8033
Loa Loa (eye worm)	steroid hormone receptor	0.0099	0.2677	0.8033
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0099	0.2677	0.8033
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0032	0.0137	0.0137
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0099	0.2677	0.2677
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0052	0.0912	0.3406
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Echinococcus granulosus	thioredoxin glutathione reductase	0.0092	0.2404	0.898
Loa Loa (eye worm)	hypothetical protein	0.0047	0.07	0.2101
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0099	0.2677	0.8033
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0099	0.2677	0.8033
Loa Loa (eye worm)	hypothetical protein	0.0099	0.2677	0.8033
Plasmodium falciparum	glutathione reductase	0.0092	0.2404	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0052	0.0912	0.2736
Trypanosoma cruzi	trypanothione reductase, putative	0.0092	0.2404	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0099	0.2677	0.8033
Echinococcus granulosus	jumonji domain containing protein	0.0039	0.0417	0.1558
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0092	0.2423	0.9051
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0099	0.2677	1
Brugia malayi	conserved hypotetical protein	0.0047	0.07	0.2101
Brugia malayi	nuclear hormone receptor	0.0099	0.2677	0.8033
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0099	0.2677	0.2677
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0912	0.2736
Echinococcus multilocularis	nuclear receptor nhr 48	0.0047	0.07	0.2616
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0032	0.0137	0.0571
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0047	0.07	0.2616
Loa Loa (eye worm)	jmjC domain-containing protein	0.0034	0.0224	0.0672
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0099	0.2677	0.8033

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-6.976	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.696	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.226	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-6.07	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.944	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.941	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.938	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.92	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.728	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1973979

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1614251