Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lipoprotein lipase | Starlite/ChEMBL | References |
Homo sapiens | lipase, endothelial | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | musashi | 0.0031 | 0.1193 | 0.2594 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.1193 | 0.2594 |
Echinococcus granulosus | RUN | 0.0048 | 0.2548 | 0.5711 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.2982 | 0.6709 |
Schistosoma mansoni | polycystin 1-related | 0.0048 | 0.2548 | 0.5711 |
Loa Loa (eye worm) | doublecortin family protein | 0.0048 | 0.2548 | 0.2548 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.9821 | 0.9821 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4413 | 1 |
Brugia malayi | Doublecortin family protein | 0.0048 | 0.2548 | 0.2548 |
Schistosoma mansoni | loxhd1 | 0.0048 | 0.2548 | 0.5711 |
Echinococcus granulosus | tar DNA binding protein | 0.007 | 0.4413 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.2982 | 0.6709 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.2982 | 0.6709 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.1193 | 0.2594 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1738 | 0.1738 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2548 | 0.2548 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.1193 | 0.2594 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0065 | 0.0065 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.1193 | 0.1193 |
Loa Loa (eye worm) | TAR-binding protein | 0.007 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | hypothetical protein | 0.0136 | 0.9821 | 0.9821 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.1193 | 0.1193 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0048 | 0.2548 | 0.5711 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.318 | 0.318 |
Brugia malayi | RNA binding protein | 0.007 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.007 | 0.4413 | 0.4413 |
Loa Loa (eye worm) | RNA binding protein | 0.007 | 0.4413 | 0.4413 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.9821 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1738 | 0.1738 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.2548 | 0.5711 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0048 | 0.2548 | 0.5711 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1146 | 0.1146 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0048 | 0.2548 | 0.5711 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4413 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0048 | 0.2548 | 0.5711 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.2982 | 0.2982 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.2982 | 0.2982 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0053 | 0.2982 | 0.6709 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4413 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.318 | 0.318 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0065 | 0.0065 |
Brugia malayi | TAR-binding protein | 0.007 | 0.4413 | 0.4413 |
Echinococcus multilocularis | tar DNA binding protein | 0.007 | 0.4413 | 1 |
Brugia malayi | hypothetical protein | 0.0048 | 0.2548 | 0.2548 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0048 | 0.2548 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.1193 | 0.1193 |
Brugia malayi | RNA recognition motif domain containing protein | 0.007 | 0.4413 | 0.4413 |
Schistosoma mansoni | lamin | 0.0031 | 0.1193 | 0.2594 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.2982 | 0.6709 |
Onchocerca volvulus | 0.0048 | 0.2548 | 0.157 | |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0065 | 0.0065 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.318 | 0.318 |
Onchocerca volvulus | Huntingtin homolog | 0.0136 | 0.9821 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.2548 | 0.2548 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1738 | 0.3848 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.318 | 0.318 |
Schistosoma mansoni | rab6-interacting | 0.0048 | 0.2548 | 0.5711 |
Echinococcus multilocularis | RUN | 0.0048 | 0.2548 | 0.5711 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0048 | 0.2548 | 0.5711 |
Brugia malayi | hypothetical protein | 0.0048 | 0.2548 | 0.2548 |
Onchocerca volvulus | 0.0048 | 0.2548 | 0.157 | |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4413 | 1 |
Brugia malayi | hypothetical protein | 0.0136 | 0.9821 | 0.9821 |
Schistosoma mansoni | rab6-interacting | 0.0048 | 0.2548 | 0.5711 |
Echinococcus granulosus | lamin | 0.0031 | 0.1193 | 0.2594 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.1193 | 0.1193 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0048 | 0.2548 | 0.5711 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0065 | 0.0065 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0048 | 0.2548 | 0.5711 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.1193 | 0.2594 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0053 | 0.2982 | 0.6709 |
Echinococcus multilocularis | lamin | 0.0031 | 0.1193 | 0.2594 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.1193 | 0.1193 |
Schistosoma mansoni | lamin | 0.0031 | 0.1193 | 0.2594 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0053 | 0.2982 | 0.6709 |
Schistosoma mansoni | tar DNA-binding protein | 0.007 | 0.4413 | 1 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0048 | 0.2548 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.4 uM | Inhibition of human endothelial lipase overexpressed in HUVEC cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate addition by micelle assay | ChEMBL. | 22225633 |
IC50 (binding) | = 4.5 uM | Inhibition of human endothelial lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay | ChEMBL. | 22225633 |
IC50 (binding) | = 15 uM | Inhibition of human lipoprotein lipase expressed in HEK293 cells using bis-BD-PC and mono-BD-TG as substrate incubated for 10 mins prior to substrate addition by micelle assay | ChEMBL. | 22225633 |
IC50 (binding) | > 50 uM | Inhibition of human lipoprotein lipase expressed using recombinant adenovirus using glycerol-tri[9,10(n)-3H]oleate after 1 hr by vesicle assay | ChEMBL. | 22225633 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.