Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0673 | 0.6622 | 0.6622 |
Brugia malayi | protein kinase C II. | 0.0322 | 0.2866 | 0.2693 |
Giardia lamblia | Kinase, AGC PKA | 0.0625 | 0.6111 | 0.5 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0322 | 0.2866 | 0.2693 |
Brugia malayi | Hr1 repeat family protein | 0.0322 | 0.2866 | 0.2693 |
Trichomonas vaginalis | AGC family protein kinase | 0.0322 | 0.2866 | 0.2866 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0673 | 0.6622 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0625 | 0.6111 | 0.9227 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0315 | 0.2792 | 0.2792 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0625 | 0.6111 | 0.8638 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0673 | 0.6622 | 1 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0322 | 0.2866 | 0.2693 |
Trichomonas vaginalis | AGC family protein kinase | 0.0322 | 0.2866 | 0.2866 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0673 | 0.6622 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.094 | 0.9488 | 0.9488 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0625 | 0.6111 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.094 | 0.9488 | 0.9476 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0673 | 0.6622 | 0.6622 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.2866 | 0.2693 |
Echinococcus multilocularis | nervana 2 | 0.0618 | 0.6036 | 0.844 |
Toxoplasma gondii | AGC kinase | 0.094 | 0.9488 | 1 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0322 | 0.2866 | 0.2693 |
Echinococcus multilocularis | nervana 2 | 0.0618 | 0.6036 | 0.844 |
Entamoeba histolytica | protein kinase, putative | 0.0322 | 0.2866 | 0.2866 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0673 | 0.6622 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0322 | 0.2866 | 0.2693 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0322 | 0.2866 | 0.2693 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.094 | 0.9488 | 0.9476 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0618 | 0.6036 | 0.844 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0322 | 0.2866 | 0.2693 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0625 | 0.6111 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0618 | 0.6036 | 0.844 |
Echinococcus granulosus | nervana 2 | 0.0618 | 0.6036 | 0.844 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0618 | 0.6036 | 0.844 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0625 | 0.6111 | 0.8638 |
Brugia malayi | Protein kinase domain containing protein | 0.0322 | 0.2866 | 0.2693 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0673 | 0.6622 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0625 | 0.6111 | 0.8638 |
Brugia malayi | Protein kinase domain containing protein | 0.0322 | 0.2866 | 0.2693 |
Echinococcus granulosus | nervana 2 | 0.0618 | 0.6036 | 0.844 |
Trichomonas vaginalis | AGC family protein kinase | 0.037 | 0.3378 | 0.3378 |
Trypanosoma cruzi | Protein kinase B | 0.0673 | 0.6622 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0618 | 0.6036 | 0.844 |
Entamoeba histolytica | protein kinase 2, putative | 0.0625 | 0.6111 | 0.6111 |
Trichomonas vaginalis | AGC family protein kinase | 0.0322 | 0.2866 | 0.2866 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.