Detailed information for compound 1614806

Basic information

Technical information
  • TDR Targets ID: 1614806
  • Name: (2Z)-2-indolo[1,2-b]indazol-11-ylideneacetami de
  • MW: 261.278 | Formula: C16H11N3O
  • H donors: 1 H acceptors: 2 LogP: 1.9 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)/C=c/1\c2c3ccccc3nn2c2c1cccc2
  • InChi: 1S/C16H11N3O/c17-15(20)9-12-10-5-2-4-8-14(10)19-16(12)11-6-1-3-7-13(11)18-19/h1-9H,(H2,17,20)/b12-9-
  • InChiKey: RIALFJJNUAQMNT-XFXZXTDPSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2Z)-2-(11-indolo[1,2-b]indazolylidene)acetamide
  • (2Z)-2-indolo[1,2-b]indazol-11-ylideneethanamide
  • 11-Aminocarbonylmethylen-11H-indolo[1,2-a]indazole
  • NSC719691

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hexokinase type II 0.0253 0.309 0.309
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0219 0.2658 0.2658
Loa Loa (eye worm) hypothetical protein 0.0036 0.0332 0.0332
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0039 0.0363 0.0062
Loa Loa (eye worm) AGC/AKT protein kinase 0.0674 0.844 0.844
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0425 0.5279 0.5131
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Schistosoma mansoni serine/threonine kinase 0.0219 0.2658 0.2658
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0024 0.0024
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0039 0.0363 0.0062
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0425 0.5279 0.5279
Echinococcus granulosus Pleckstrin y 0.0034 0.0302 0.0302
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0363 0.0062
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0034 0.0302 0.0302
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0039 0.0363 0.0062
Trichomonas vaginalis AGC family protein kinase 0.0219 0.2658 0.2895
Trichomonas vaginalis AGC family protein kinase 0.0674 0.844 1
Loa Loa (eye worm) uncoordinated protein 104 0.0034 0.0302 0.0302
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0039 0.0363 0.0363
Toxoplasma gondii hypothetical protein 0.0034 0.0302 0.0302
Echinococcus multilocularis actin binding protein anillin 0.0034 0.0302 0.0302
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0302 0.0302
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0034 0.0302 0.0302
Echinococcus granulosus pdz domain containing protein 0.0034 0.0302 0.0302
Echinococcus granulosus Pleckstrin y 0.0034 0.0302 0.0302
Plasmodium falciparum oxysterol-binding protein, putative 0.0034 0.0302 0.0302
Leishmania major serine/threonine-protein kinase a, putative 0.0039 0.0363 0.0363
Echinococcus granulosus oxysterol binding protein 1 0.0034 0.0302 0.0302
Entamoeba histolytica PH domain containing protein kinase, putative 0.0459 0.5712 0.5578
Loa Loa (eye worm) hypothetical protein 0.0219 0.2658 0.2658
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0024 0.0024
Echinococcus granulosus nervana 2 0.042 0.5219 0.5219
Loa Loa (eye worm) hypothetical protein 0.0253 0.309 0.309
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2658 0.2658
Entamoeba histolytica protein kinase, putative 0.0039 0.0363 0.0062
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Entamoeba histolytica protein kinase, putative 0.0039 0.0363 0.0062
Echinococcus granulosus nervana 2 0.042 0.5219 0.5219
Echinococcus multilocularis pleckstrin y domain containing family A 0.0034 0.0302 0.0302
Schistosoma mansoni hypothetical protein 0.0034 0.0302 0.0302
Echinococcus multilocularis DCC interacting protein 13 beta 0.0034 0.0302 0.0302
Echinococcus multilocularis myotubularin protein 13 0.0034 0.0302 0.0302
Echinococcus multilocularis cytohesin 1 0.0034 0.0302 0.0302
Loa Loa (eye worm) AGC/PKN protein kinase 0.0219 0.2658 0.2658
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0039 0.0363 0.0062
Entamoeba histolytica p21-activated kinase 0.0039 0.0363 0.0062
Entamoeba histolytica protein kinase, putative 0.0039 0.0363 0.0062
Brugia malayi protein kinase C II. 0.0219 0.2658 0.2658
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0034 0.0302 0.0302
Brugia malayi Dynamin 0.0034 0.0302 0.0302
Entamoeba histolytica PH domain containing protein kinase, putative 0.0459 0.5712 0.5578
Brugia malayi probable spectrin beta chain 0.0034 0.0302 0.0302
Echinococcus multilocularis rac serine:threonine kinase 0.0459 0.5712 0.5712
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0219 0.2658 0.2658
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Echinococcus multilocularis nervana 2 0.042 0.5219 0.5219
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Brugia malayi Hexokinase family protein 0.0246 0.3004 0.3004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0039 0.0363 0.0062
Onchocerca volvulus 0.0499 0.6225 0.6107
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0039 0.0363 0.0062
Echinococcus granulosus Protein kinase C brain isozyme 0.0219 0.2658 0.2658
Entamoeba histolytica hypothetical protein 0.0039 0.0363 0.0062
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0034 0.0302 0.0302
Brugia malayi PH domain containing protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0024
Trichomonas vaginalis AGC family protein kinase 0.0674 0.844 1
Loa Loa (eye worm) hypothetical protein 0.0543 0.6779 0.6779
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0219 0.2658 0.2658
Echinococcus multilocularis Pleckstrin y 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Trypanosoma cruzi NIMA-related kinase, putative 0.0039 0.0363 0.0062
Leishmania major protein kinase, putative 0.0039 0.0363 0.0363
Loa Loa (eye worm) cytohesin 3 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0034 0.0302 0.0302
Echinococcus granulosus Rho GTPase activating protein 24 0.0034 0.0302 0.0302
Trypanosoma brucei protein kinase, putative 0.0039 0.0363 0.0062
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0039 0.0363 0.0363
Schistosoma mansoni atypical protein kinase C 0.0219 0.2658 0.2658
Schistosoma mansoni myotubularin-related protein 0.0034 0.0302 0.0302
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0451 0.0451
Entamoeba histolytica protein kinase 2, putative 0.0425 0.5279 0.5131
Toxoplasma gondii protein kinase domain-containing protein 0.0039 0.0363 0.0363
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0302 0.0302
Leishmania major hypothetical protein, conserved 0.0034 0.0302 0.0302
Loa Loa (eye worm) PH domain-containing protein 0.0034 0.0302 0.0302
Echinococcus multilocularis beta 1 syntrophin 0.0034 0.0302 0.0302
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0034 0.0302 0.0302
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0039 0.0363 0.0062
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0034 0.0302 0.0302
Schistosoma mansoni goodpasture antigen-binding protein 0.0034 0.0302 0.0302
Toxoplasma gondii AtPH1 family protein 0.0034 0.0302 0.0302
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0034 0.0302 0.0302
Echinococcus multilocularis serine:threonine protein kinase N2 0.0219 0.2658 0.2658
Toxoplasma gondii hypothetical protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) syntrophin-1 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0253 0.3091 0.3427
Echinococcus multilocularis oxysterol binding protein 1 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0674 0.844 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Brugia malayi Protein kinase domain containing protein 0.0219 0.2658 0.2658
Schistosoma mansoni hypothetical protein 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0219 0.2658 0.2658
Brugia malayi MAX-1A 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0674 0.844 1
Entamoeba histolytica protein kinase, putative 0.0639 0.8007 0.7945
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2658 0.2658
Leishmania major protein kinase, putative 0.0039 0.0363 0.0363
Brugia malayi Protein kinase domain containing protein 0.0674 0.844 0.844
Entamoeba histolytica protein kinase, putative 0.0039 0.0363 0.0062
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0219 0.2658 0.2895
Schistosoma mansoni voltage-gated potassium channel 0.0046 0.0451 0.0451
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0034 0.0302 0.0302
Echinococcus multilocularis Ras associated and pleckstrin y 0.0034 0.0302 0.0302
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0039 0.0363 0.0074
Entamoeba histolytica hypothetical protein 0.0039 0.0363 0.0062
Echinococcus multilocularis oxysterol binding protein 9 0.0034 0.0302 0.0302
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0034 0.0302 0.0302
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0402 0.0402
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0363 0.0062
Echinococcus multilocularis serine threonine protein kinase 0.0219 0.2658 0.2658
Entamoeba histolytica protein kinase, putative 0.0674 0.844 0.8391
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0034 0.0302 0.0302
Schistosoma mansoni serine/threonine-protein kinase 0.0459 0.5712 0.5712
Brugia malayi PH domain containing protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0674 0.844 1
Schistosoma mansoni serine/threonine-protein kinase 0.0459 0.5712 0.5712
Trypanosoma cruzi NIMA-related kinase, putative 0.0039 0.0363 0.0062
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0034 0.0302 0.0302
Echinococcus multilocularis Rho GTPase activating protein 24 0.0034 0.0302 0.0302
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0034 0.0302 0.0302
Schistosoma mansoni zinc finger protein 0.0034 0.0302 0.0302
Echinococcus granulosus Oxysterol binding protein 11 0.0034 0.0302 0.0302
Echinococcus granulosus Glutaredoxin protein 5 0.042 0.5219 0.5219
Schistosoma mansoni syntrophin 0.0034 0.0302 0.0302
Echinococcus granulosus GRB2 associated binding protein 3 0.0034 0.0302 0.0302
Echinococcus multilocularis Pleckstrin y 0.0034 0.0302 0.0302
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0402 0.0402
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2658 0.2658
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Plasmodium falciparum PH domain-containing protein, putative 0.0034 0.0302 0.0302
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0219 0.2658 0.2658
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0024 0.0024
Echinococcus granulosus serine/threonine protein kinase 0.0459 0.5712 0.5712
Giardia lamblia Kinase, AGC PKA 0.0425 0.5279 0.5
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0034 0.0302 0.0302
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0219 0.2658 0.2658
Echinococcus granulosus protein kinase C gamma type 0.0219 0.2658 0.2658
Plasmodium falciparum calcium-dependent protein kinase 7 0.0039 0.0363 0.0363
Trichomonas vaginalis AGC family protein kinase 0.0674 0.844 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0639 0.8007 0.8007
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0039 0.0363 0.0062
Loa Loa (eye worm) hexokinase 0.0246 0.3004 0.3004
Brugia malayi PH domain containing protein 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Brugia malayi Cytohesin 3 0.0034 0.0302 0.0302
Echinococcus multilocularis calcium dependent secretion activator 1 0.0034 0.0302 0.0302
Echinococcus granulosus calcium dependent secretion activator 1 0.0034 0.0302 0.0302
Echinococcus granulosus beta 1 syntrophin 0.0034 0.0302 0.0302
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0034 0.0302 0.0302
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0402 0.0402
Brugia malayi Hr1 repeat family protein 0.0219 0.2658 0.2658
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0402 0.0402
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0034 0.0302 0.0302
Echinococcus granulosus protein kinase c epsilon type 0.0219 0.2658 0.2658
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0219 0.2658 0.2658
Brugia malayi Dynamin 0.0034 0.0302 0.0302
Leishmania major folate/biopterin transporter, putative 0.0039 0.0363 0.0363
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0459 0.5712 0.5578
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Echinococcus multilocularis protein kinase c iota type 0.0219 0.2658 0.2658
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Echinococcus multilocularis nervana 2 0.042 0.5219 0.5219
Echinococcus granulosus cytohesin 1 0.0034 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.042 0.5219 0.5219
Brugia malayi Syntrophin-1 0.0034 0.0302 0.0302
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0367 0.0079
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0219 0.2658 0.2658
Schistosoma mansoni dynamin 0.0034 0.0302 0.0302
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0302 0.0302
Brugia malayi PH domain containing protein 0.0034 0.0302 0.0302
Brugia malayi PH domain containing protein 0.0034 0.0302 0.0302
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0039 0.0363 0.0062
Trichomonas vaginalis AGC family protein kinase 0.0674 0.844 1
Brugia malayi TBC domain containing protein 0.0034 0.0302 0.0302
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0363 0.0062
Loa Loa (eye worm) oxysterol binding protein 0.0034 0.0302 0.0302
Brugia malayi hypothetical protein 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0219 0.2658 0.2658
Brugia malayi Uncoordinated protein 104 0.0034 0.0302 0.0302
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0425 0.5279 0.5279
Schistosoma mansoni hypothetical protein 0.0034 0.0302 0.0302
Echinococcus multilocularis serine:threonine protein kinase 38 0.0219 0.2658 0.2658
Trypanosoma brucei rac serine-threonine kinase, putative 0.0674 0.844 0.8391
Echinococcus granulosus serine threonine protein kinase nrc 0.0425 0.5279 0.5279
Toxoplasma gondii AGC kinase 0.0639 0.8007 0.8007
Brugia malayi Pleckstrin Homology Domain 0.0034 0.0302 0.0302
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0034 0.0302 0.0302
Brugia malayi PH domain containing protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) AGC/NDR protein kinase 0.0219 0.2658 0.2658
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0034 0.0302 0.0302
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0034 0.0302 0.0302
Entamoeba histolytica protein kinase, putative 0.0219 0.2658 0.2429
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0034 0.0302 0.0302
Brugia malayi Oxysterol binding protein 0.0034 0.0302 0.0302
Brugia malayi PH domain containing protein 0.0034 0.0302 0.0302
Schistosoma mansoni zinc finger protein 0.0034 0.0302 0.0302
Echinococcus granulosus serine:threonine protein kinase N2 0.0219 0.2658 0.2658
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0214 0.2598 0.2821
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0425 0.5279 0.5279
Loa Loa (eye worm) hypothetical protein 0.0253 0.309 0.309
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2658 0.2658
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2658 0.2658
Brugia malayi Plekhf2 protein 0.0034 0.0302 0.0302
Brugia malayi Protein kinase domain containing protein 0.0219 0.2658 0.2658
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Brugia malayi Hexokinase family protein 0.0499 0.6225 0.6225
Echinococcus multilocularis dynamin 1 0.0034 0.0302 0.0302
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0219 0.2658 0.2658
Loa Loa (eye worm) rho-GTPase-activating 0.0034 0.0302 0.0302
Echinococcus granulosus oxysterol binding protein 9 0.0034 0.0302 0.0302
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0034 0.0302 0.0302
Echinococcus multilocularis pdz domain containing protein 0.0034 0.0302 0.0302
Toxoplasma gondii phosphatidylinositol transfer protein 0.0034 0.0302 0.0302
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0024 0.0024
Schistosoma mansoni hypothetical protein 0.0034 0.0302 0.0302
Echinococcus granulosus NDR protein kinase 0.0219 0.2658 0.2658
Echinococcus multilocularis Oxysterol binding protein 11 0.0034 0.0302 0.0302
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0039 0.0363 0.0363
Echinococcus multilocularis serine:threonine protein kinase N2 0.0219 0.2658 0.2658
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0425 0.5279 0.5131
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0034 0.0302 0.0302
Echinococcus granulosus protein kinase c iota type 0.0219 0.2658 0.2658
Brugia malayi p70 ribosomal S6 kinase beta 0.0639 0.8007 0.8007
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0039 0.0367 0.0079
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Entamoeba histolytica protein kinase, putative 0.0039 0.0363 0.0062
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0034 0.0302 0.0302
Schistosoma mansoni oxysterol-binding protein 1 0.0034 0.0302 0.0302
Brugia malayi PH domain containing protein 0.0034 0.0302 0.0302
Brugia malayi PH domain containing protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0024 0.0024
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0039 0.0363 0.0074
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Echinococcus granulosus dynamin 1 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Schistosoma mansoni oxysterol-binding protein 1 0.0034 0.0302 0.0302
Loa Loa (eye worm) hexokinase 0.0499 0.6225 0.6225
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.042 0.5219 0.5219
Echinococcus granulosus Pleckstrin y 0.0034 0.0302 0.0302
Echinococcus granulosus pleckstrin y domain containing family A 0.0034 0.0302 0.0302
Schistosoma mansoni dynamin 0.0034 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2658 0.2658
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0039 0.0363 0.0062
Schistosoma mansoni goodpasture antigen-binding protein 0.0034 0.0302 0.0302
Schistosoma mansoni centaurin alpha 0.0034 0.0302 0.0302
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0039 0.0363 0.0062
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.2658 0.2658
Echinococcus granulosus oxysterol binding protein 3 0.0034 0.0302 0.0302
Brugia malayi Cadps2 protein 0.0034 0.0302 0.0302
Schistosoma mansoni vav2 0.0034 0.0302 0.0302
Brugia malayi Oxysterol-binding protein 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Entamoeba histolytica protein kinase, putative 0.0674 0.844 0.8391
Schistosoma mansoni hypothetical protein 0.0034 0.0302 0.0302
Onchocerca volvulus Hexokinase homolog 0.0499 0.6225 0.6107
Entamoeba histolytica PH domain containing protein kinase, putative 0.0039 0.0363 0.0062
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0024 0.0024
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0034 0.0302 0.0302
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0039 0.0363 0.0062
Schistosoma mansoni rho gtpase activating protein 0.0034 0.0302 0.0302
Loa Loa (eye worm) Plekhf2 protein 0.0034 0.0302 0.0302
Echinococcus multilocularis protein kinase c epsilon type 0.0219 0.2658 0.2658
Schistosoma mansoni growth factor receptor-bound protein 0.0034 0.0302 0.0302
Echinococcus granulosus DCC interacting protein 13 beta 0.0034 0.0302 0.0302
Trichomonas vaginalis AGC family protein kinase 0.0219 0.2658 0.2895
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Echinococcus multilocularis Pleckstrin y 0.0034 0.0302 0.0302
Echinococcus multilocularis Glutaredoxin protein 5 0.042 0.5219 0.5219
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0039 0.0363 0.0062
Trichomonas vaginalis AGC family protein kinase 0.0039 0.0363 0.0074
Echinococcus granulosus myotubularin protein 13 0.0034 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0034 0.0302 0.0302
Trypanosoma cruzi Protein kinase B 0.0459 0.5712 0.5578
Leishmania major hypothetical protein, conserved 0.0034 0.0302 0.0302
Toxoplasma gondii Oxysterol-binding protein 0.0034 0.0302 0.0302
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0219 0.2658 0.2658
Echinococcus multilocularis GRB2 associated binding protein 3 0.0034 0.0302 0.0302
Echinococcus multilocularis oxysterol binding protein 3 0.0034 0.0302 0.0302
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0024 0.0024

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.408 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.877 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.867 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.806 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.72 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.717 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.66 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.656 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.449 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.423 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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