Detailed information for compound 1614807

Basic information

Technical information
  • TDR Targets ID: 1614807
  • Name: 4-(4-chlorophenyl)-2-oxo-1,5-dihydrothiochrom eno[3,4-e]pyridine-3-carbonitrile
  • MW: 350.821 | Formula: C19H11ClN2OS
  • H donors: 1 H acceptors: 2 LogP: 3.21 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(=O)[nH]c2c(c1c1ccc(cc1)Cl)CSc1c2cccc1
  • InChi: 1S/C19H11ClN2OS/c20-12-7-5-11(6-8-12)17-14(9-21)19(23)22-18-13-3-1-2-4-16(13)24-10-15(17)18/h1-8H,10H2,(H,22,23)
  • InChiKey: NJDZQHHWGFAOPP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-chlorophenyl)-2-keto-1,5-dihydrothiochromeno[3,4-e]pyridine-3-carbonitrile
  • ZINC01035699
  • NSC719473
  • NCI60_041021

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0266 0.1699 0.1699
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0248 0.0121
Echinococcus granulosus serine:threonine protein kinase N2 0.0266 0.1699 0.1699
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0054 0.0286 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Trichomonas vaginalis centaurin beta, putative 0.0048 0.0248 0.0121
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0048 0.0248 0.0248
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0054 0.0286 0.0039
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0517 0.3365 0.3197
Trichomonas vaginalis centaurin alpha, putative 0.0048 0.0248 0.0121
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.0286 0.0039
Brugia malayi PH domain containing protein 0.0048 0.0248 0.0248
Trypanosoma cruzi Protein kinase B 0.0565 0.3687 0.3527
Brugia malayi Uncoordinated protein 104 0.0048 0.0248 0.0248
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0048 0.0248 0.0248
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0048 0.0248 0.0248
Schistosoma mansoni goodpasture antigen-binding protein 0.0048 0.0248 0.0248
Trichomonas vaginalis centaurin gamma, putative 0.0048 0.0248 0.0121
Brugia malayi Cytohesin 3 0.0048 0.0248 0.0248
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0048 0.0248 0.0248
Toxoplasma gondii AGC kinase 0.0777 0.51 0.51
Echinococcus granulosus Pleckstrin y 0.0048 0.0248 0.0248
Brugia malayi PH domain containing protein 0.0048 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.1032 0.6797 0.6797
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0054 0.0286 0.0039
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0048 0.0248 0.0248
Brugia malayi PH domain containing protein 0.0048 0.0248 0.0248
Echinococcus granulosus cytohesin 1 0.0048 0.0248 0.0248
Plasmodium falciparum calcium-dependent protein kinase 7 0.0054 0.0286 0.0286
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Echinococcus granulosus Rho GTPase activating protein 24 0.0048 0.0248 0.0248
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.0286 0.0039
Trichomonas vaginalis protein transport protein sec7, putative 0.0048 0.0248 0.0121
Brugia malayi hypothetical protein 0.0048 0.0248 0.0248
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0048 0.0248 0.0248
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0203 0.0203
Echinococcus granulosus dynamin 1 0.0048 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0777 0.51 0.51
Echinococcus multilocularis pdz domain containing protein 0.0048 0.0248 0.0248
Trichomonas vaginalis centaurin/arf, putative 0.0048 0.0248 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0517 0.3365 0.3365
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0054 0.0286 0.0039
Leishmania major protein kinase, putative 0.0054 0.0286 0.0286
Loa Loa (eye worm) cytohesin 3 0.0048 0.0248 0.0248
Toxoplasma gondii hypothetical protein 0.0048 0.0248 0.0248
Schistosoma mansoni vav2 0.0048 0.0248 0.0248
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0048 0.0248 0.0248
Entamoeba histolytica protein kinase, putative 0.0054 0.0286 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.1699 0.1699
Trypanosoma cruzi NIMA-related kinase, putative 0.0054 0.0286 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0315 0.2021 0.3506
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0825 0.5423 1
Echinococcus multilocularis serine:threonine protein kinase 38 0.0266 0.1699 0.1699
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Trichomonas vaginalis hypothetical protein 0.0048 0.0248 0.0121
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0054 0.0286 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Echinococcus multilocularis Ras associated and pleckstrin y 0.0048 0.0248 0.0248
Entamoeba histolytica protein kinase, putative 0.0825 0.5423 0.5306
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Schistosoma mansoni serine/threonine-protein kinase 0.0565 0.3687 0.3687
Trichomonas vaginalis AGC family protein kinase 0.0825 0.5423 1
Loa Loa (eye worm) syntrophin-1 0.0048 0.0248 0.0248
Echinococcus multilocularis calcium dependent secretion activator 1 0.0048 0.0248 0.0248
Echinococcus multilocularis protein kinase c iota type 0.0266 0.1699 0.1699
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Entamoeba histolytica PH domain containing protein kinase, putative 0.0565 0.3687 0.3527
Echinococcus multilocularis Pleckstrin y 0.0048 0.0248 0.0248
Echinococcus granulosus Pleckstrin y 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Onchocerca volvulus Hexokinase homolog 0.0949 0.6246 0.615
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0048 0.0248 0.0121
Brugia malayi Hr1 repeat family protein 0.0266 0.1699 0.1699
Echinococcus multilocularis Pleckstrin y 0.0048 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Brugia malayi Protein kinase domain containing protein 0.0266 0.1699 0.1699
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0048 0.0248 0.0248
Echinococcus multilocularis Pleckstrin y 0.0048 0.0248 0.0248
Toxoplasma gondii Oxysterol-binding protein 0.0048 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0203 0.0203
Trichomonas vaginalis protein transport protein sec7, putative 0.0048 0.0248 0.0121
Schistosoma mansoni serine/threonine-protein kinase 0.0565 0.3687 0.3687
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0266 0.1699 0.1699
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0048 0.0248 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.1699 0.1699
Echinococcus multilocularis serine threonine protein kinase 0.0266 0.1699 0.1699
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Schistosoma mansoni zinc finger protein 0.0048 0.0248 0.0248
Schistosoma mansoni dynamin 0.0048 0.0248 0.0248
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0012 0.0005 0.0005
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0266 0.1699 0.2891
Trypanosoma cruzi NIMA-related kinase, putative 0.0054 0.0286 0.0039
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0048 0.0248 0.0248
Brugia malayi PH domain containing protein 0.0048 0.0248 0.0248
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0517 0.3365 0.3365
Entamoeba histolytica protein kinase 2, putative 0.0517 0.3365 0.3197
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Brugia malayi Pleckstrin Homology Domain 0.0048 0.0248 0.0248
Brugia malayi Hexokinase family protein 0.0468 0.3043 0.3043
Brugia malayi PH domain containing protein 0.0048 0.0248 0.0248
Schistosoma mansoni syntrophin 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Echinococcus granulosus serine threonine protein kinase nrc 0.0517 0.3365 0.3365
Brugia malayi MAX-1A 0.0048 0.0248 0.0248
Echinococcus multilocularis Oxysterol binding protein 11 0.0048 0.0248 0.0248
Brugia malayi Dynamin 0.0048 0.0248 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.1699 0.1699
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Brugia malayi Hexokinase family protein 0.0949 0.6246 0.6246
Echinococcus granulosus Glutaredoxin protein 5 0.0511 0.3327 0.3327
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0266 0.1699 0.1699
Entamoeba histolytica hypothetical protein 0.0054 0.0286 0.0039
Schistosoma mansoni hypothetical protein 0.0048 0.0248 0.0248
Echinococcus granulosus Oxysterol binding protein 11 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0266 0.1699 0.2891
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Echinococcus granulosus DCC interacting protein 13 beta 0.0048 0.0248 0.0248
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0048 0.0248 0.0248
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0266 0.1699 0.1699
Entamoeba histolytica p21-activated kinase 0.0054 0.0286 0.0039
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0054 0.0286 0.0286
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0517 0.3365 0.3365
Echinococcus multilocularis GRB2 associated binding protein 3 0.0048 0.0248 0.0248
Brugia malayi PH domain containing protein 0.0048 0.0248 0.0248
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0261 0.166 0.2818
Echinococcus multilocularis nervana 2 0.0511 0.3327 0.3327
Brugia malayi Oxysterol-binding protein 0.0048 0.0248 0.0248
Trypanosoma brucei protein kinase, putative 0.0054 0.0286 0.0039
Echinococcus multilocularis beta 1 syntrophin 0.0048 0.0248 0.0248
Echinococcus granulosus oxysterol binding protein 9 0.0048 0.0248 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.1699 0.1699
Echinococcus granulosus beta 1 syntrophin 0.0048 0.0248 0.0248
Leishmania major hypothetical protein, conserved 0.0048 0.0248 0.0248
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0048 0.0248 0.0248
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0266 0.1699 0.1699
Leishmania major serine/threonine-protein kinase a, putative 0.0054 0.0286 0.0286
Echinococcus multilocularis dynamin 1 0.0048 0.0248 0.0248
Brugia malayi Protein kinase domain containing protein 0.0266 0.1699 0.1699
Schistosoma mansoni rho gtpase activating protein 0.0048 0.0248 0.0248
Echinococcus multilocularis oxysterol binding protein 3 0.0048 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Entamoeba histolytica protein kinase, putative 0.0054 0.0286 0.0039
Brugia malayi Protein kinase domain containing protein 0.0825 0.5423 0.5423
Echinococcus multilocularis actin binding protein anillin 0.0048 0.0248 0.0248
Toxoplasma gondii AtPH1 family protein 0.0048 0.0248 0.0248
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0054 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0048 0.0248 0.0248
Loa Loa (eye worm) hexokinase 0.0468 0.3043 0.3043
Leishmania major protein kinase, putative 0.0054 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0048 0.0248 0.0248
Entamoeba histolytica protein kinase, putative 0.0777 0.51 0.4976
Trichomonas vaginalis AGC family protein kinase 0.0825 0.5423 1
Echinococcus granulosus protein kinase c iota type 0.0266 0.1699 0.1699
Schistosoma mansoni dynamin 0.0048 0.0248 0.0248
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0266 0.1699 0.1699
Trichomonas vaginalis AGC family protein kinase 0.0825 0.5423 1
Brugia malayi PH domain containing protein 0.0048 0.0248 0.0248
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.0248 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.1699 0.1699
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Brugia malayi Oxysterol binding protein 0.0048 0.0248 0.0248
Toxoplasma gondii hypothetical protein 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0266 0.1699 0.2891
Echinococcus multilocularis myotubularin protein 13 0.0048 0.0248 0.0248
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0048 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0481 0.3128 0.3128
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.0286 0.0039
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.1699 0.1699
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0048 0.0248 0.0248
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.0248 0.0248
Echinococcus granulosus serine/threonine protein kinase 0.0565 0.3687 0.3687
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0203 0.0203
Echinococcus granulosus protein kinase C gamma type 0.0266 0.1699 0.1699
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Echinococcus granulosus oxysterol binding protein 3 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Entamoeba histolytica protein kinase, putative 0.0054 0.0286 0.0039
Leishmania major folate/biopterin transporter, putative 0.0054 0.0286 0.0286
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0048 0.0248 0.0248
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0048 0.0248 0.0248
Trichomonas vaginalis centaurin/arf, putative 0.0048 0.0248 0.0121
Brugia malayi Plekhf2 protein 0.0048 0.0248 0.0248
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0048 0.0248 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Entamoeba histolytica protein kinase, putative 0.0054 0.0286 0.0039
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0048 0.0248 0.0248
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0048 0.0248 0.0121
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0266 0.1699 0.1699
Echinococcus multilocularis serine:threonine protein kinase N2 0.0266 0.1699 0.1699
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0228 0.0228
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0517 0.3365 0.3197
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Echinococcus granulosus voltage gated potassium channel 0.0012 0.0005 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0054 0.0286 0.0039
Brugia malayi TBC domain containing protein 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Loa Loa (eye worm) hypothetical protein 0.0481 0.3128 0.3128
Echinococcus multilocularis pleckstrin y domain containing family A 0.0048 0.0248 0.0248
Schistosoma mansoni hypothetical protein 0.0048 0.0248 0.0248
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0248 0.0121
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0048 0.0248 0.0248
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0511 0.3327 0.3327
Echinococcus multilocularis oxysterol binding protein 1 0.0048 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Giardia lamblia Kinase, AGC PKA 0.0517 0.3365 0.5
Echinococcus multilocularis DCC interacting protein 13 beta 0.0048 0.0248 0.0248
Plasmodium falciparum oxysterol-binding protein, putative 0.0048 0.0248 0.0248
Echinococcus granulosus calcium dependent secretion activator 1 0.0048 0.0248 0.0248
Schistosoma mansoni zinc finger protein 0.0048 0.0248 0.0248
Brugia malayi Cadps2 protein 0.0048 0.0248 0.0248
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0248 0.0248
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Schistosoma mansoni atypical protein kinase C 0.0266 0.1699 0.1699
Echinococcus granulosus pleckstrin y domain containing family A 0.0048 0.0248 0.0248
Loa Loa (eye worm) AGC/NDR protein kinase 0.0266 0.1699 0.1699
Brugia malayi PH domain containing protein 0.0048 0.0248 0.0248
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0012 0.0005 0.0005
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0054 0.0286 0.0039
Brugia malayi Variant SH3 domain containing protein 0.0048 0.0248 0.0248
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0054 0.0286 0.0039
Echinococcus granulosus Pleckstrin y 0.0048 0.0248 0.0248
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0048 0.0248 0.0248
Entamoeba histolytica PH domain containing protein kinase, putative 0.0565 0.3687 0.3527
Echinococcus multilocularis serine:threonine protein kinase N2 0.0266 0.1699 0.1699
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Echinococcus granulosus myotubularin protein 13 0.0048 0.0248 0.0248
Entamoeba histolytica PH domain containing protein kinase, putative 0.0054 0.0286 0.0039
Echinococcus granulosus protein kinase c epsilon type 0.0266 0.1699 0.1699
Trypanosoma brucei rac serine-threonine kinase, putative 0.0825 0.5423 0.5306
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0048 0.0248 0.0248
Schistosoma mansoni goodpasture antigen-binding protein 0.0048 0.0248 0.0248
Schistosoma mansoni hypothetical protein 0.0048 0.0248 0.0248
Echinococcus multilocularis nervana 2 0.0511 0.3327 0.3327
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0054 0.0286 0.0194
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0054 0.0286 0.0039
Schistosoma mansoni oxysterol-binding protein 1 0.0048 0.0248 0.0248
Schistosoma mansoni serine/threonine protein kinase 0.0266 0.1699 0.1699
Brugia malayi PH domain containing protein 0.0048 0.0248 0.0248
Brugia malayi probable spectrin beta chain 0.0048 0.0248 0.0248
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0005 0.0005
Echinococcus multilocularis cytohesin 1 0.0048 0.0248 0.0248
Brugia malayi p70 ribosomal S6 kinase beta 0.0777 0.51 0.51
Loa Loa (eye worm) hexokinase 0.0949 0.6246 0.6246
Loa Loa (eye worm) uncoordinated protein 104 0.0048 0.0248 0.0248
Loa Loa (eye worm) oxysterol binding protein 0.0048 0.0248 0.0248
Loa Loa (eye worm) AGC/AKT protein kinase 0.0825 0.5423 0.5423
Echinococcus granulosus nervana 2 0.0511 0.3327 0.3327
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Plasmodium falciparum PH domain-containing protein, putative 0.0048 0.0248 0.0248
Schistosoma mansoni hypothetical protein 0.0048 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Trichomonas vaginalis alpha chimerin, putative 0.0048 0.0248 0.0121
Trichomonas vaginalis kinesin light chain, putative 0.0048 0.0248 0.0121
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0048 0.0248 0.0248
Echinococcus multilocularis Rho GTPase activating protein 24 0.0048 0.0248 0.0248
Toxoplasma gondii protein kinase domain-containing protein 0.0054 0.0286 0.0286
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0054 0.0286 0.0286
Echinococcus granulosus GRB2 associated binding protein 3 0.0048 0.0248 0.0248
Schistosoma mansoni serine/threonine kinase 0.0266 0.1699 0.1699
Trichomonas vaginalis AGC family protein kinase 0.0825 0.5423 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0005 0.0005
Trichomonas vaginalis AGC family protein kinase 0.0825 0.5423 1
Echinococcus multilocularis Glutaredoxin protein 5 0.0511 0.3327 0.3327
Schistosoma mansoni myotubularin-related protein 0.0048 0.0248 0.0248
Schistosoma mansoni oxysterol-binding protein 1 0.0048 0.0248 0.0248
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0048 0.0248 0.0248
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0266 0.1699 0.1699
Loa Loa (eye worm) PH domain-containing protein 0.0048 0.0248 0.0248
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0511 0.3327 0.3327
Entamoeba histolytica hypothetical protein 0.0054 0.0286 0.0039
Loa Loa (eye worm) hypothetical protein 0.0266 0.1699 0.1699
Echinococcus granulosus Protein kinase C brain isozyme 0.0266 0.1699 0.1699
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0048 0.0248 0.0121
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0266 0.1699 0.1699
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0266 0.1699 0.1699
Schistosoma mansoni hypothetical protein 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Loa Loa (eye worm) AGC/PKN protein kinase 0.0266 0.1699 0.1699
Schistosoma mansoni centaurin alpha 0.0048 0.0248 0.0248
Echinococcus granulosus pdz domain containing protein 0.0048 0.0248 0.0248
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0054 0.0286 0.0039
Brugia malayi Syntrophin-1 0.0048 0.0248 0.0248
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0054 0.0286 0.0039
Loa Loa (eye worm) rho-GTPase-activating 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Leishmania major hypothetical protein, conserved 0.0048 0.0248 0.0248
Entamoeba histolytica protein kinase, putative 0.0054 0.0286 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Schistosoma mansoni voltage-gated potassium channel 0.0012 0.0005 0.0005
Entamoeba histolytica protein kinase, putative 0.0266 0.1699 0.1488
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Trichomonas vaginalis AGC family protein kinase 0.0825 0.5423 1
Toxoplasma gondii phosphatidylinositol transfer protein 0.0048 0.0248 0.0248
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0048 0.0248 0.0248
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0054 0.0286 0.0039
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Brugia malayi hexokinase type II 0.0481 0.3128 0.3128
Echinococcus granulosus NDR protein kinase 0.0266 0.1699 0.1699
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Brugia malayi protein kinase C II. 0.0266 0.1699 0.1699
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0266 0.1699 0.1699
Onchocerca volvulus 0.0949 0.6246 0.615
Loa Loa (eye worm) Plekhf2 protein 0.0048 0.0248 0.0248
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Echinococcus multilocularis protein kinase c epsilon type 0.0266 0.1699 0.1699
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0048 0.0248 0.0248
Echinococcus granulosus nervana 2 0.0511 0.3327 0.3327
Entamoeba histolytica protein kinase, putative 0.0825 0.5423 0.5306
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0054 0.0286 0.0039
Echinococcus multilocularis rac serine:threonine kinase 0.0565 0.3687 0.3687
Trichomonas vaginalis AGC family protein kinase 0.0054 0.0286 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0248 0.0121
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0048 0.0248 0.0248
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0054 0.0286 0.0039
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0048 0.0248 0.0248
Echinococcus granulosus oxysterol binding protein 1 0.0048 0.0248 0.0248
Brugia malayi Dynamin 0.0048 0.0248 0.0248
Echinococcus multilocularis oxysterol binding protein 9 0.0048 0.0248 0.0248
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0565 0.3687 0.3527
Echinococcus multilocularis voltage gated potassium channel 0.0012 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0048 0.0248 0.0248
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0228 0.0228

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.753 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.677 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.592 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.48 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.265 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.245 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.11 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.03 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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