Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0014 | 0.0108 | 0.0082 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0026 | 0.0552 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2891 | 0.2872 |
Loa Loa (eye worm) | hexokinase | 0.0087 | 0.2802 | 0.2783 |
Brugia malayi | Hexokinase family protein | 0.0087 | 0.2802 | 0.2724 |
Brugia malayi | hexokinase type II | 0.0089 | 0.2891 | 0.2813 |
Brugia malayi | Cytochrome P450 family protein | 0.0066 | 0.2014 | 0.1927 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0552 | 0.0449 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0026 | 0.0552 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0015 | 0.0146 | 0.012 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0026 | 0.0552 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0026 | 0.0552 | 0.0552 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0026 | 0.0552 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.0552 | 0.0527 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0026 | 0.0552 | 0.5 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0256 | 0.0231 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0552 | 0.0552 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0026 | 0.0552 | 0.5 |
Schistosoma mansoni | cell adhesion molecule | 0.0012 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.6686 | 0.6678 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0026 | 0.0552 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0256 | 0.0231 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0026 | 0.0552 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.2891 | 0.2872 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0256 | 0.0112 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0026 | 0.0552 | 0.5 |
Brugia malayi | Hexokinase family protein | 0.0176 | 0.6116 | 0.6074 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0026 | 0.0552 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0256 | 0.0231 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0026 | 0.0552 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0066 | 0.2014 | 0.1993 |
Loa Loa (eye worm) | hexokinase | 0.0176 | 0.6116 | 0.6106 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0026 | 0.0552 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0552 | 0.0449 |
Echinococcus multilocularis | 0.0026 | 0.0552 | 0.0412 | |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0026 | 0.0552 | 0.0527 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0026 | 0.0552 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0552 | 0.0527 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0026 | 0.0552 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.0552 | 0.0449 |
Echinococcus granulosus | twitchin | 0.0015 | 0.0146 | 0.012 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0026 | 0.0552 | 0.5 |
Schistosoma mansoni | nephrin | 0.0015 | 0.0146 | 0.0146 |
Mycobacterium leprae | putative cytochrome p450 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0026 | 0.0552 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0026 | 0.0552 | 0.0527 |
Brugia malayi | cytochrome P450 | 0.0026 | 0.0552 | 0.0449 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.0552 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0026 | 0.0552 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.0552 | 0.0527 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0026 | 0.0552 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.686 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.51 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.506 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.496 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.347 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.