Detailed information for compound 1616026

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 545.522 | Formula: C23H23N5O9S
  • H donors: 5 H acceptors: 9 LogP: 4.09 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-][N+](=O)c1cc(ccc1N/N=C/c1ccc(c(c1)O)O)S(=O)(=O)Nc1ccccc1C(=O)O.O=CN(C)C
  • InChi: 1S/C20H16N4O8S.C3H7NO/c25-18-8-5-12(9-19(18)26)11-21-22-16-7-6-13(10-17(16)24(29)30)33(31,32)23-15-4-2-1-3-14(15)20(27)28;1-4(2)3-5/h1-11,22-23,25-26H,(H,27,28);3H,1-2H3/b21-11+;
  • InChiKey: KAMLCBILIKVWEO-YUZSSDIYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references
Trypanosoma brucei phosphoglycerate kinase Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens Wolf-Hirschhorn syndrome candidate 1 Starlite/ChEMBL No references
Homo sapiens Rap guanine nucleotide exchange factor (GEF) 3 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi N-terminal motif family protein Get druggable targets OG5_131726 All targets in OG5_131726
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum hypothetical protein Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum Histone-lysine N-methyltransferase NSD3, putative Get druggable targets OG5_130029 All targets in OG5_130029
Babesia bovis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium parvum protein with 4 PHD domains plus a SET domain and associated cysteine cluster at the C-terminus Get druggable targets OG5_130029 All targets in OG5_130029
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii phosphoglycerate kinase PGKI Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog Get druggable targets OG5_131726 All targets in OG5_131726
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Cryptosporidium hominis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Chlamydia trachomatis phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium knowlesi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum ko:K00927 phosphoglycerate kinase [EC2.7.2.3], putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative Get druggable targets OG5_130029 All targets in OG5_130029
Schistosoma mansoni phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania major phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei gambiense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium parvum phosphoglycerate kinase 1 Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium vivax phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis PGKC, phosphoglycerate kinase C Get druggable targets OG5_126776 All targets in OG5_126776
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_130029 All targets in OG5_130029
Trypanosoma cruzi phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni SET domain protein Get druggable targets OG5_130029 All targets in OG5_130029
Trypanosoma congolense phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Entamoeba histolytica phosphoglycerate kinase, putative Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans 3-phosphoglycerate kinase similar to S. cerevisiae PGK1 (YCR012W) Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Neospora caninum Phosphoglycerate kinase (EC 2.7.2.3), related Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii phosphoglycerate kinase PGKII Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana phosphoglycerate kinase B, cytosolic Get druggable targets OG5_126776 All targets in OG5_126776
Schistosoma japonicum expressed protein Get druggable targets OG5_130029 All targets in OG5_130029
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium leprae Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum phosphoglycerate kinase C, glycosomal Get druggable targets OG5_126776 All targets in OG5_126776
Echinococcus multilocularis histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131726 All targets in OG5_131726
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk Get druggable targets OG5_126776 All targets in OG5_126776
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Phosphoglycerate kinase Get druggable targets OG5_126776 All targets in OG5_126776
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei unspecified product 0.0044 0.1725 0.3583
Trypanosoma brucei phosphoglycerate kinase 0.0038 0.1417 0.2874
Loa Loa (eye worm) RecQ helicase 0.0029 0.1001 0.0921
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Brugia malayi regulator of G-protein signaling egl-10 0.0011 0.0132 0.0044
Echinococcus multilocularis phosphoglycerate kinase 1 0.0103 0.4513 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0014 0.0276 0.019
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0014 0.0276 0.0199
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0013 0.0231 0.0322
Schistosoma mansoni hypothetical protein 0.0011 0.0168 0.018
Loa Loa (eye worm) helicase 0.0014 0.0276 0.019
Trypanosoma brucei unspecified product 0.0044 0.1725 0.3583
Schistosoma mansoni dep domain containing protein 0.0011 0.0132 0.0098
Echinococcus granulosus bloom syndrome protein 0.0029 0.1001 0.2062
Trypanosoma brucei chrX additional, unordered contigs 0.002 0.0568 0.092
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.019 0.0103
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0132 0.0044
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0014 0.0276 0.0199
Loa Loa (eye worm) hypothetical protein 0.0146 0.6568 0.6537
Schistosoma mansoni DNA helicase recq5 0.0012 0.019 0.0231
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.1417 0.2874
Schistosoma mansoni SET domain protein 0.0013 0.0231 0.0322
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0103 0.4513 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.019 0.0103
Onchocerca volvulus 0.0011 0.0168 0.0037
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0276 0.00000000055447
Loa Loa (eye worm) hypothetical protein 0.0014 0.0276 0.019
Loa Loa (eye worm) hypothetical protein 0.0014 0.0276 0.019
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0132 0.0098
Treponema pallidum phosphoglycerate kinase 0.0103 0.4513 0.5
Schistosoma mansoni SET domain protein 0.004 0.1505 0.3201
Brugia malayi SET domain containing protein 0.0015 0.0339 0.0253
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Loa Loa (eye worm) hypothetical protein 0.0041 0.158 0.1505
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.019 0.0134
Toxoplasma gondii hypothetical protein 0.0011 0.0168 0.0083
Onchocerca volvulus 0.0015 0.0339 0.0211
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0028 0.0947 0.1861
Schistosoma mansoni chromobox protein 0.0084 0.3626 0.7996
Brugia malayi hypothetical protein 0.0011 0.0168 0.008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0072 0.3051 0.6761
Onchocerca volvulus 0.0037 0.1381 0.1266
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0276 0.00000000055447
Schistosoma mansoni hypothetical protein 0.0041 0.158 0.3371
Entamoeba histolytica hypothetical protein 0.0014 0.0276 0.025
Entamoeba histolytica deoxycytidyl transferase, putative 0.0064 0.2672 0.5763
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0132 0.0098
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.121 0.2205
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0011 0.0132 0.0098
Schistosoma mansoni terminal deoxycytidyl transferase 0.0064 0.2672 0.5839
Echinococcus multilocularis hepatoma derived growth factor protein 0.0011 0.0168 0.018
Schistosoma mansoni chromobox protein 0.0084 0.3626 0.7996
Mycobacterium tuberculosis Conserved hypothetical protein 0.0064 0.2672 0.592
Echinococcus granulosus PWWP domain containing protein 2A 0.0011 0.0168 0.018
Mycobacterium ulcerans phosphoglycerate kinase 0.0103 0.4513 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0038 0.1417 0.2874
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.1001 0.171
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0276 0.0425
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0276 0.00000000055447
Schistosoma mansoni hypothetical protein 0.0011 0.0168 0.018
Schistosoma mansoni hypothetical protein 0.0019 0.0528 0.0993
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.0276 0.033
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.2104 0.4456
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0358 0.0438
Echinococcus multilocularis chromobox protein 1 0.0084 0.3626 0.7996
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0358 0.0438
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.6485 0.6453
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0358 0.0438
Echinococcus multilocularis bloom syndrome protein 0.0029 0.1001 0.2062
Trypanosoma brucei phosphoglycerate kinase 0.0103 0.4513 1
Schistosoma mansoni hypothetical protein 0.0019 0.0528 0.0993
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0276 0.00000000055447
Leishmania major DNA polymerase kappa, putative 0.0072 0.3051 0.6636
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0014 0.0276 0.033
Schistosoma mansoni hypothetical protein 0.0019 0.0528 0.0993
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0103 0.4513 1
Brugia malayi Phosphoglycerate kinase 0.0103 0.4513 0.4464
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0103 0.4513 1
Schistosoma mansoni chromobox protein 0.0014 0.0276 0.0425
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0568 0.092
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0014 0.0276 0.0425
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0103 0.4513 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0072 0.3051 0.6636
Entamoeba histolytica hypothetical protein 0.0014 0.0276 0.025
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0014 0.0276 0.019
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.4201 0.9281
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.2097 0.4438
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.158 0.1505
Trichomonas vaginalis chromobox protein, putative 0.0051 0.2037 0.4155
Schistosoma mansoni phd finger protein 0.0011 0.0168 0.018
Brugia malayi hypothetical protein 0.0011 0.0132 0.0044
Schistosoma mansoni DNA polymerase IV / kappa 0.002 0.0568 0.1083
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0528 0.0443
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0358 0.0438
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0568 0.092
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0064 0.2672 0.5839
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0528 0.0993
Schistosoma mansoni regulator of G protein signaling 0.0011 0.0132 0.0098
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0011 0.0132 0.0044
Brugia malayi Heterochromatin protein 1 0.0084 0.3626 0.357
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0358 0.0193
Schistosoma mansoni DNA helicase recq1 0.0012 0.019 0.0231
Giardia lamblia DNA damage repair protein 0.002 0.0568 0.0873
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Brugia malayi hypothetical protein 0.0011 0.0168 0.008
Brugia malayi polk-prov protein 0.0052 0.2097 0.2026
Echinococcus granulosus Chromo domain 0.0014 0.0276 0.0425
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.4201 0.9208
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0568 0.092
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.1866 0.1758
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.2487 0.242
Loa Loa (eye worm) hypothetical protein 0.0012 0.019 0.0103
Brugia malayi Valyl-tRNA synthetase 0.0014 0.0276 0.019
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0064 0.2672 0.2607
Brugia malayi PWWP domain containing protein 0.0011 0.0168 0.008
Echinococcus multilocularis PWWP domain containing protein 2A 0.0011 0.0168 0.018
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.2032 0.4291
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.3626 0.357
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.6485 0.6453
Onchocerca volvulus 0.0014 0.0276 0.0147
Loa Loa (eye worm) hypothetical protein 0.0052 0.2097 0.2026
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0276 0.00000000055447
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0103 0.4513 0.5
Loa Loa (eye worm) hypothetical protein 0.0037 0.1381 0.1304
Schistosoma mansoni z-protein (S1r protein) 0.0011 0.0132 0.0098
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Echinococcus granulosus PWWP domain containing protein 2A 0.0011 0.0168 0.018
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0528 0.0443
Echinococcus granulosus regulator of G protein signaling 7 0.0011 0.0132 0.0098
Giardia lamblia Phosphoglycerate kinase 0.0103 0.4513 1
Echinococcus granulosus Chromobox protein 3 0.0014 0.0276 0.0425
Echinococcus granulosus dna polymerase eta 0.0095 0.4137 0.9149
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Trypanosoma brucei phosphoglycerate kinase, putative 0.0038 0.1417 0.2874
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0011 0.0132 0.0098
Brugia malayi Associated with TFs and helicases family protein 0.0014 0.0276 0.019
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.2672 0.2607
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.019 0.0231
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0528 0.0443
Trypanosoma brucei unspecified product 0.0088 0.3822 0.8408
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0276 0.00000000055447
Loa Loa (eye worm) hypothetical protein 0.0014 0.0276 0.019
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0103 0.4513 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0072 0.3051 0.6636
Echinococcus multilocularis PWWP domain containing protein 2A 0.0011 0.0168 0.018
Trypanosoma brucei DNA polymerase eta, putative 0.0095 0.4137 0.9133
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0103 0.4513 1
Plasmodium vivax phosphoglycerate kinase, putative 0.0103 0.4513 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0276 0.019
Toxoplasma gondii ImpB/MucB/SamB family protein 0.002 0.0568 0.0995
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Schistosoma mansoni dishevelled 0.0011 0.0132 0.0098
Echinococcus multilocularis GPCR, family 2 0.0019 0.0528 0.0993
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0568 0.092
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0013 0.0231 0.0322
Leishmania major DNA polymerase eta, putative 0.0051 0.2032 0.4291
Schistosoma mansoni phosphoglycerate kinase 0.0103 0.4513 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0276 0.019
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0568 0.092
Brugia malayi Protein cec-1. 0.0014 0.0276 0.019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0528 0.0993
Schistosoma mansoni hepatoma derived growth factor 0.0011 0.0168 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.2097 0.4438
Echinococcus granulosus chromobox protein 2 0.0014 0.0276 0.0425
Loa Loa (eye worm) hypothetical protein 0.0014 0.0276 0.019
Mycobacterium ulcerans DNA polymerase IV 0.0096 0.4201 0.9208
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0528 0.0993
Echinococcus multilocularis segment polarity protein dishevelled 0.0011 0.0132 0.0098
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0276 0.025
Echinococcus granulosus dna polymerase kappa 0.0096 0.4201 0.9294
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.1417 0.2874
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.004 0.1505 0.3201
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0038 0.1417 0.2874
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0276 0.00000000055447
Trichomonas vaginalis DNA polymerase eta, putative 0.0096 0.4201 0.9263
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.2487 0.242
Echinococcus granulosus chromobox protein 1 0.0084 0.3626 0.7996
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0276 0.00000000055447
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.2032 0.4338
Echinococcus multilocularis peregrin 0.0011 0.0168 0.018
Loa Loa (eye worm) PWWP domain-containing protein 0.0011 0.0168 0.008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0276 0.00000000055447
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0014 0.0276 0.033
Plasmodium vivax DNA repair protein REV1, putative 0.002 0.0568 0.0688
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0038 0.1417 0.2874
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.1001 0.0921
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.019 0.0134
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.071 0.1406
Loa Loa (eye worm) hypothetical protein 0.0014 0.0276 0.019
Trypanosoma brucei DNA polymerase IV, putative 0.0088 0.3822 0.8408
Echinococcus multilocularis chromobox protein 2 0.0014 0.0276 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Leishmania major phosphoglycerate kinase C, glycosomal 0.0103 0.4513 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0543 0.0939
Entamoeba histolytica phosphoglycerate kinase, putative 0.0103 0.4513 1
Chlamydia trachomatis phosphoglycerate kinase 0.0103 0.4513 0.5
Brugia malayi hypothetical protein 0.0014 0.0276 0.019
Schistosoma mansoni hepatoma derived growth factor 0.0011 0.0168 0.018
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0014 0.0276 0.0425
Brugia malayi ImpB/MucB/SamB family protein 0.0095 0.4137 0.4084
Brugia malayi DIX domain containing protein 0.0011 0.0132 0.0044
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0554 0.0655
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.1001 0.171
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Loa Loa (eye worm) hypothetical protein 0.0011 0.0168 0.008
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0011 0.0132 0.0044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0528 0.0993
Leishmania major phosphoglycerate kinase B, cytosolic 0.0103 0.4513 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.4137 0.4084
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1866 0.3752
Echinococcus granulosus peregrin 0.0011 0.0168 0.018
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.019 0.0231
Echinococcus granulosus GPCR family 2 0.0019 0.0528 0.0993
Trichomonas vaginalis chromobox protein, putative 0.0084 0.3626 0.7907
Schistosoma mansoni phosphoglycerate kinase 0.0103 0.4513 1
Echinococcus multilocularis Chromo domain 0.0014 0.0276 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.1866 0.3752
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0276 0.00000000055447
Trypanosoma brucei hypothetical protein, conserved 0.002 0.0568 0.092
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.2487 0.242
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.019 0.0231
Leishmania major DNA polymerase eta, putative 0.0095 0.4137 0.9133
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0014 0.0276 0.0425
Brugia malayi hypothetical protein 0.0011 0.0132 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.0528 0.0443
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0132 0.0098
Onchocerca volvulus 0.0011 0.0168 0.0037
Schistosoma mansoni chromobox protein 0.0014 0.0276 0.0425
Schistosoma mansoni hypothetical protein 0.0014 0.0276 0.0425
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0096 0.4201 0.9263
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0038 0.1417 0.2874
Brugia malayi chromobox protein homolog 3 0.0047 0.1866 0.1794
Brugia malayi CHD4 protein 0.0014 0.0276 0.019
Plasmodium falciparum DNA repair protein REV1, putative 0.002 0.0568 0.0873
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0276 0.00000000055447
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.2037 0.193
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.004 0.1505 0.3201
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.019 0.0231
Schistosoma mansoni hypothetical protein 0.0011 0.0168 0.018
Loa Loa (eye worm) hypothetical protein 0.006 0.2487 0.242
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.121 0.2205
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0044
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0064 0.2672 0.5839
Schistosoma mansoni DNA polymerase eta 0.0095 0.4137 0.9149
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0015 0.0339 0.0567
Echinococcus multilocularis dna polymerase eta 0.0095 0.4137 0.9149
Giardia lamblia DINP protein human, muc B family 0.0072 0.3051 0.6618
Trichomonas vaginalis chromobox protein, putative 0.0051 0.2037 0.4155
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0276 0.00000000055447
Trypanosoma brucei DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Echinococcus multilocularis chromobox protein 1 0.0084 0.3626 0.7996
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.019 0.0103
Entamoeba histolytica hypothetical protein 0.0014 0.0276 0.025
Echinococcus multilocularis regulator of G protein signaling 7 0.0011 0.0132 0.0098
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0044
Trypanosoma brucei DNA polymerase IV, putative 0.0096 0.4201 0.9281
Echinococcus granulosus phosphoglycerate kinase 1 0.0103 0.4513 1
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0103 0.4513 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.2104 0.4456
Trypanosoma cruzi DNA damage repair protein, putative 0.002 0.0568 0.092
Schistosoma mansoni hypothetical protein 0.0019 0.0528 0.0993
Onchocerca volvulus 0.0014 0.0276 0.0147
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0276 0.0425
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0132 0.0098
Schistosoma mansoni dishevelled 0.0011 0.0132 0.0098
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0014 0.0276 0.0425
Trypanosoma brucei DNA damage repair protein, putative 0.002 0.0568 0.092
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0014 0.0276 0.0425
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0103 0.4513 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0276 0.00000000055447
Echinococcus granulosus hepatoma derived growth factor protein 0.0011 0.0168 0.018
Echinococcus granulosus Pleckstrin G protein interacting region 0.0011 0.0132 0.0098
Leishmania major DNA damage repair protein, putative 0.002 0.0568 0.092
Brugia malayi M-phase phosphoprotein, mpp8 0.0014 0.0276 0.019
Echinococcus granulosus segment polarity protein dishevelled 0.0011 0.0132 0.0098
Brugia malayi Phosphoglycerate kinase 0.0038 0.1417 0.134
Plasmodium falciparum phosphoglycerate kinase 0.0103 0.4513 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.1866 0.1794
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0833 0.1487
Loa Loa (eye worm) hypothetical protein 0.0103 0.4513 0.4464
Echinococcus multilocularis Chromobox protein 3 0.0014 0.0276 0.0425
Echinococcus multilocularis dna polymerase kappa 0.0096 0.4201 0.9294
Echinococcus granulosus chromobox protein 1 0.0084 0.3626 0.7996
Loa Loa (eye worm) hypothetical protein 0.0011 0.0132 0.0044
Loa Loa (eye worm) DIX domain-containing protein 0.0011 0.0132 0.0044
Brugia malayi MH2 domain containing protein 0.0144 0.6485 0.6453
Trypanosoma cruzi DNA polymerase eta, putative 0.0095 0.4137 0.9133
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0276 0.025
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0014 0.0276 0.0425
Trypanosoma brucei DNA polymerase kappa, putative 0.0052 0.2104 0.4456
Trichomonas vaginalis chromobox protein, putative 0.0084 0.3626 0.7907
Trypanosoma cruzi DNA polymerase kappa, putative 0.0096 0.4201 0.9281
Leishmania major DNA polymerase kappa, putative 0.002 0.0568 0.092
Plasmodium falciparum heterochromatin protein 1 0.0014 0.0276 0.0199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0276 0.00000000055447
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0276 0.025
Trypanosoma brucei phosphoglycerate kinase 0.0103 0.4513 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0064 0.2672 0.5839

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 1.71 uM PubChem BioAssay. Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 60.7 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 94.077 uM PubChem BioAssay. Counterscreen for inhibitors of T-cell receptor (TCR)-CD3 interaction: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 2.8184 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 10.3119 uM PubChem BioAssay. qHTS for inhibitors of Phosphogylcerate Kinase: Hit Validation Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.6795 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.1313 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 47.7548 uM PubChem BioAssay. qHTS Assay for the Inhibitors of FEN1: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 58.4789 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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