Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0206 | 0.5614 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0206 | 0.5614 | 1 |
Brugia malayi | SH2 domain containing protein | 0.0206 | 0.5614 | 0.5614 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0206 | 0.5614 | 0.5614 |
Onchocerca volvulus | 0.0206 | 0.5614 | 1 | |
Onchocerca volvulus | 0.0206 | 0.5614 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Echinococcus multilocularis | tyrosine kinase | 0.0206 | 0.5614 | 0.5614 |
Brugia malayi | SH2 domain containing protein | 0.0206 | 0.5614 | 0.5614 |
Echinococcus granulosus | tyrosine kinase | 0.0206 | 0.5614 | 0.5614 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Brugia malayi | Protein kinase domain containing protein | 0.0206 | 0.5614 | 0.5614 |
Brugia malayi | Protein kinase domain containing protein | 0.0206 | 0.5614 | 0.5614 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Brugia malayi | Protein kinase domain containing protein | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK protein kinase | 0.0206 | 0.5614 | 0.5614 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0206 | 0.5614 | 0.5614 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0206 | 0.5614 | 0.5614 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Brugia malayi | hypothetical protein | 0.0206 | 0.5614 | 0.5614 |
Onchocerca volvulus | 0.0206 | 0.5614 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.02 | 0.4386 | 0.4386 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.5614 | 0.5614 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0206 | 0.5614 | 0.5614 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0206 | 0.5614 | 0.5614 |
Schistosoma mansoni | tyrosine kinase | 0.0206 | 0.5614 | 0.5614 |
Brugia malayi | Protein kinase domain containing protein | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Onchocerca volvulus | 0.0206 | 0.5614 | 1 | |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0206 | 0.5614 | 0.5614 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0206 | 0.5614 | 0.5614 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0206 | 0.5614 | 0.5614 |
Brugia malayi | protein-tyrosine kinase | 0.0206 | 0.5614 | 0.5614 |
Schistosoma mansoni | tyrosine kinase | 0.0206 | 0.5614 | 0.5614 |
Echinococcus granulosus | tyrosine kinase | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0206 | 0.5614 | 0.5614 |
Onchocerca volvulus | 0.0206 | 0.5614 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.43 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.886 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.47 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.357 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.096 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.