Detailed information for compound 161639

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 362.461 | Formula: C24H26O3
  • H donors: 1 H acceptors: 3 LogP: 6.34 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)/C=C\c1ccc(cc1)C(=O)c1ccc2c(c1)C(C)(C)CCC2(C)C
  • InChi: 1S/C24H26O3/c1-23(2)13-14-24(3,4)20-15-18(10-11-19(20)23)22(27)17-8-5-16(6-9-17)7-12-21(25)26/h5-12,15H,13-14H2,1-4H3,(H,25,26)/b12-7-
  • InChiKey: PKXWKCWUBFDHSQ-GHXNOFRVSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0081 0.0275 0.0353
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Loa Loa (eye worm) aminopeptidase N 0.0092 0.0337 0.0337
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0512 0.0512
Brugia malayi hypothetical protein 0.0792 0.4487 0.6486
Echinococcus multilocularis c src tyrosine kinase 0.0061 0.0153 0.0153
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Brugia malayi hypothetical protein 0.0037 0.0013 0.0018
Onchocerca volvulus 0.0046 0.0066 0.0077
Brugia malayi Cathepsin L-like precursor 0.004 0.0032 0.0046
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Loa Loa (eye worm) DOMON domain-containing protein 0.0046 0.0066 0.0066
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0512 0.0512
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0183 0.0265
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0037 0.0013 0.0013
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.038 0.2047 0.2926
Echinococcus multilocularis Mastin 0.0082 0.0278 0.0278
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0048 0.008 0.008
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Schistosoma mansoni coup transcription factor 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0037 0.0013 0.0013
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Plasmodium falciparum cysteine proteinase falcipain 3 0.0121 0.0512 0.0515
Brugia malayi TATA binding protein associated factor 0.0092 0.0337 0.0487
Echinococcus granulosus epidermal growth factor receptor 0.0526 0.2912 0.2912
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0249 0.1273 0.1273
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.0183 0.0183
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Echinococcus multilocularis tyrosine protein kinase Blk 0.0226 0.1132 0.1132
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Plasmodium falciparum cysteine repeat modular protein 1 0.0139 0.062 0.0675
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0061 0.0153 0.0153
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Brugia malayi Tyrosine-protein kinase abl-1 0.0061 0.0153 0.0222
Brugia malayi Trypsin family protein 0.0082 0.0278 0.0402
Schistosoma mansoni tyrosine kinase 0.0973 0.5561 0.5561
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0092 0.0337 0.0443
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0316 0.1665 0.1665
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Schistosoma mansoni tyrosine kinase 0.0316 0.1665 0.1665
Loa Loa (eye worm) thymidylate synthase 0.1202 0.6918 0.6918
Echinococcus granulosus tissue type plasminogen activator 0.0139 0.062 0.062
Schistosoma mansoni hypothetical protein 0.0082 0.0278 0.0278
Onchocerca volvulus 0.0121 0.0512 0.0723
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Brugia malayi Protein kinase domain containing protein 0.0316 0.1665 0.2407
Onchocerca volvulus 0.0121 0.0512 0.0723
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0183 0.0265
Brugia malayi nuclear hormone receptor 0.0065 0.0183 0.0265
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0183 0.0183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.0275
Echinococcus granulosus thymidylate synthase 0.1202 0.6918 0.6918
Echinococcus granulosus enteropeptidase 0.0082 0.0278 0.0278
Echinococcus multilocularis enteropeptidase 0.0082 0.0278 0.0278
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0164 0.0164
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.038 0.2047 0.2926
Echinococcus multilocularis thymidylate synthase 0.1202 0.6918 0.6918
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Trypanosoma cruzi aminopeptidase, putative 0.0092 0.0337 0.0443
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0085 0.0301 0.0301
Echinococcus multilocularis tyrosine protein kinase Srms 0.0226 0.1132 0.1132
Onchocerca volvulus 0.0256 0.1314 0.1885
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0092 0.0337 0.0573
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0061 0.0153 0.0153
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.0183 0.0183
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0572 0.3184 0.4577
Echinococcus granulosus tyrosine protein kinase shark 0.0037 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0213 0.1059 0.1059
Brugia malayi cathepsin F-like cysteine proteinase 0.004 0.0032 0.0046
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Loa Loa (eye worm) TK/INSR protein kinase 0.0316 0.1665 0.1665
Brugia malayi steroid hormone receptor 0.0065 0.0183 0.0265
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0164 0.1556
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.0183 0.0183
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0512 0.0723
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1202 0.6918 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Echinococcus multilocularis tyrosine protein kinase HCK 0.0201 0.0987 0.0987
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.0183 0.0183
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 0.6918
Echinococcus multilocularis cysteine protease 0.0121 0.0512 0.0512
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Echinococcus multilocularis 0.0299 0.1567 0.1567
Loa Loa (eye worm) hypothetical protein 0.0121 0.0512 0.0512
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.0183 0.0265
Echinococcus granulosus cathepsin L cysteine protease 0.0062 0.0164 0.0164
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Schistosoma mansoni cathepsin s 0.004 0.0032 0.0032
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0082 0.0278 0.0402
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1202 0.6918 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0164 0.1556
Toxoplasma gondii cathepsin CPL 0.0121 0.0512 0.0265
Echinococcus granulosus transmembrane protease serine 3 0.0082 0.0278 0.0278
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1722 1 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Brugia malayi SH2 domain containing protein 0.0037 0.0013 0.0018
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.0183 0.0183
Onchocerca volvulus 0.0082 0.0278 0.0385
Schistosoma mansoni tyrosine kinase 0.0514 0.2839 0.2839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0275 0.0366
Onchocerca volvulus 0.0082 0.0278 0.0385
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0139 0.062 0.062
Echinococcus granulosus tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Brugia malayi ecdysteroid receptor 0.0065 0.0183 0.0265
Schistosoma mansoni hypothetical protein 0.0046 0.0066 0.0066
Onchocerca volvulus 0.1202 0.6918 1
Schistosoma mansoni tyrosine kinase 0.0037 0.0013 0.0013
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0092 0.0337 0.0337
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0121 0.0512 0.0512
Loa Loa (eye worm) fibroinase 0.0121 0.0512 0.0512
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.004 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Onchocerca volvulus Cathepsin F homolog 0.0121 0.0512 0.0723
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0249 0.1273 0.1273
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0048 0.008 0.008
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0173 0.0821 0.0821
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.0183 0.0265
Brugia malayi Peptidase family M1 containing protein 0.0092 0.0337 0.0487
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0512 0.0512
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Brugia malayi protein-tyrosine kinase 0.0226 0.1132 0.1636
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0249 0.1273 0.1273
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0164 0.1556
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Echinococcus granulosus tyrosine protein kinase Srms 0.0037 0.0013 0.0013
Onchocerca volvulus 0.0121 0.0512 0.0723
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0092 0.0337 0.0256
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Onchocerca volvulus 0.0081 0.0275 0.038
Brugia malayi Cathepsin L-like cysteine proteinase 0.0081 0.0275 0.0397
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.0183 0.0265
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.0183 0.0183
Echinococcus granulosus NCK adaptor protein 0.0048 0.008 0.008
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0009 0.0009
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0249 0.1273 0.1273
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0183 0.0183
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.0183 0.0247
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0082 0.0278 0.0278
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0048 0.008 0.008
Echinococcus multilocularis tyrosine kinase 0.0037 0.0013 0.0013
Onchocerca volvulus 0.0121 0.0512 0.0723
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0092 0.0337 0.0256
Echinococcus granulosus cathepsin L cysteine proteinase 0.0121 0.0512 0.0512
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Onchocerca volvulus 0.0046 0.0066 0.0077
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Brugia malayi hypothetical protein 0.0092 0.0337 0.0487
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Mycobacterium ulcerans aminopeptidase N PepN 0.0092 0.0337 0.0089
Schistosoma mansoni cathepsin F (C01 family) 0.0081 0.0275 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0183 0.0265
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.038 0.2047 0.2926
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0092 0.0337 0.0443
Brugia malayi Peptidase family M1 containing protein 0.0092 0.0337 0.0487
Brugia malayi hypothetical protein 0.0082 0.0278 0.0402
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0512 0.0697
Echinococcus multilocularis NCK adaptor protein 0.0048 0.008 0.008
Brugia malayi Kringle domain containing protein 0.0139 0.062 0.0896
Schistosoma mansoni tyrosine kinase 0.0316 0.1665 0.1665
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0092 0.0337 0.0337
Trypanosoma cruzi cysteine proteinase, putative 0.0062 0.0164 0.0192
Trypanosoma cruzi cysteine protease, putative 0.0062 0.0164 0.0192
Echinococcus granulosus tyrosine protein kinase Src42A 0.0249 0.1273 0.1273
Echinococcus granulosus FTZ F1 alpha 0.0065 0.0183 0.0183
Onchocerca volvulus 0.0092 0.0337 0.047
Echinococcus multilocularis transmembrane protease serine 3 0.0082 0.0278 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.0183 0.0183
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.0183 0.0183
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.0183 0.0183
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Trichomonas vaginalis CMGC family protein kinase 0.038 0.2047 0.6235
Brugia malayi MAP kinase sur-1 0.038 0.2047 0.2959
Loa Loa (eye worm) hypothetical protein 0.0048 0.008 0.008
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Toxoplasma gondii kringle domain-containing protein 0.0139 0.062 0.043
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Echinococcus granulosus epidermal growth factor receptor 0.0973 0.5561 0.5561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Schistosoma mansoni tyrosine kinase 0.0526 0.2912 0.2912
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Loa Loa (eye worm) papain family cysteine protease containing protein 0.004 0.0032 0.0032
Onchocerca volvulus 0.0092 0.0337 0.047
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Echinococcus multilocularis cathepsin L cysteine protease 0.0121 0.0512 0.0512
Onchocerca volvulus 0.0139 0.062 0.088
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Loa Loa (eye worm) hypothetical protein 0.0092 0.0337 0.0337
Trypanosoma brucei protein kinase, putative 0.038 0.2047 0.2788
Echinococcus granulosus Mastin 0.0082 0.0278 0.0278
Schistosoma mansoni tyrosine kinase 0.0249 0.1273 0.1273
Echinococcus granulosus cathepsin L 0.0062 0.0164 0.0164
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1202 0.6918 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0092 0.0337 0.0443
Brugia malayi Trypsin-like protease protein 5 0.0082 0.0278 0.0402
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0092 0.0337 0.0256
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.0183 0.0183
Echinococcus granulosus cysteine protease 0.0062 0.0164 0.0164
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Echinococcus multilocularis mitogen activated protein kinase 0.038 0.2047 0.2047
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0121 0.0512 0.0512
Schistosoma mansoni tyrosine kinase 0.0514 0.2839 0.2839
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Plasmodium vivax vivapain-2 0.0121 0.0512 0.0697
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Loa Loa (eye worm) TK/EGFR protein kinase 0.0973 0.5561 0.5561
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0082 0.0278 0.0278
Onchocerca volvulus Cathepsin L homolog 0.0121 0.0512 0.0723
Brugia malayi Sex muscle abnormal protein 5 0.0048 0.008 0.0116
Schistosoma mansoni tyrosine kinase 0.0514 0.2839 0.2839
Onchocerca volvulus 0.0121 0.0512 0.0723
Onchocerca volvulus 0.0338 0.1797 0.2585
Onchocerca volvulus 0.0121 0.0512 0.0723
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Schistosoma mansoni tyrosine kinase 0.0526 0.2912 0.2912
Onchocerca volvulus 0.0046 0.0066 0.0077
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.0183 0.0183
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Plasmodium vivax vivapain-2 0.0121 0.0512 0.0697
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0249 0.1273 0.1273
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0065 0.0183 0.0183
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.038 0.2047 0.2598
Entamoeba histolytica cysteine proteinase, putative 0.0062 0.0164 0.1556
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0121 0.0512 0.0512
Echinococcus granulosus tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.0183 0.0183
Brugia malayi Peptidase family M1 containing protein 0.0092 0.0337 0.0487
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.035 0.1869 0.1869
Loa Loa (eye worm) peptidase family M1 containing protein 0.0092 0.0337 0.0337
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0249 0.1273 0.1273
Entamoeba histolytica cysteine proteinase, putative 0.0081 0.0275 0.269
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0092 0.0337 0.0443
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Echinococcus multilocularis cysteine protease 0.0121 0.0512 0.0512
Echinococcus granulosus c src tyrosine kinase 0.0061 0.0153 0.0153
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0065 0.0183 0.0183
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0092 0.0337 0.0337
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.004 0.0032 0.0046
Schistosoma mansoni tyrosine kinase 0.0037 0.0013 0.0013
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Echinococcus multilocularis epidermal growth factor receptor 0.0526 0.2912 0.2912
Echinococcus multilocularis tyrosine protein kinase Abl 0.0061 0.0153 0.0153
Echinococcus granulosus tyrosine protein kinase Lyn 0.0253 0.1293 0.1293
Schistosoma mansoni aminopeptidase A (M01 family) 0.0092 0.0337 0.0337
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.004 0.0032 0.0032
Loa Loa (eye worm) TK/ABL protein kinase 0.0037 0.0013 0.0013
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0092 0.0337 0.0573
Onchocerca volvulus 0.0121 0.0512 0.0723
Echinococcus granulosus mitogen activated protein kinase 0.038 0.2047 0.2047
Entamoeba histolytica cysteine protease, putative 0.0121 0.0512 0.5121
Brugia malayi Variant SH3 domain containing protein 0.0048 0.008 0.0116
Onchocerca volvulus 0.0046 0.0066 0.0077
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0512 0.5121
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0183 0.0265
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1722 1 1
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0092 0.0337 0.0337
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0226 0.1132 0.1132
Trypanosoma cruzi cysteine proteinase, putative 0.0062 0.0164 0.0192
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0092 0.0337 0.0443
Schistosoma mansoni tyrosine kinase 0.0061 0.0153 0.0153
Trichomonas vaginalis CMGC family protein kinase 0.038 0.2047 0.6235
Echinococcus multilocularis insulin receptor 0.0316 0.1665 0.1665
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Echinococcus granulosus tyrosine kinase 0.0226 0.1132 0.1132
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.0183 0.0183
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Leishmania major cysteine peptidase A (CPA) 0.0121 0.0512 0.0265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Loa Loa (eye worm) TK protein kinase 0.0226 0.1132 0.1132
Echinococcus granulosus growth factor receptor bound protein 2 0.0048 0.008 0.008
Echinococcus granulosus insulin receptor 0.0316 0.1665 0.1665
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0512 0.1151
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.0183 0.0265
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Echinococcus multilocularis mitogen activated protein kinase 3 0.038 0.2047 0.2047
Loa Loa (eye worm) hypothetical protein 0.0046 0.0066 0.0066
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.038 0.2047 0.2926
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0512 0.0697
Trypanosoma brucei Aminopeptidase M1, putative 0.0092 0.0337 0.0256
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Echinococcus granulosus tyrosine protein kinase Src42A 0.0213 0.1059 0.1059
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1722 1 1
Brugia malayi Protein kinase domain containing protein 0.0037 0.0013 0.0018
Entamoeba histolytica protein kinase, putative 0.0201 0.0987 1
Loa Loa (eye worm) trypsin family protein 0.0082 0.0278 0.0278
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Echinococcus granulosus tyrosine protein kinase ABL1 0.0037 0.0013 0.0013
Brugia malayi Variant SH3 domain containing protein 0.0048 0.008 0.0116
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.0183 0.0265
Brugia malayi nuclear receptor NHR-88 0.0065 0.0183 0.0265
Onchocerca volvulus 0.0065 0.0183 0.0247
Giardia lamblia Kinase, CMGC MAPK 0.038 0.2047 0.5
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0512 0.0697
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0121 0.0512 0.0515
Echinococcus multilocularis tissue type plasminogen activator 0.0139 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0338 0.1797 0.1797
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0081 0.0275 0.0366
Onchocerca volvulus Bile acid receptor homolog 0.0065 0.0183 0.0247
Loa Loa (eye worm) hypothetical protein 0.0051 0.0095 0.0095
Trypanosoma brucei aminopeptidase, putative 0.0092 0.0337 0.0256
Plasmodium vivax vivapain-1 0.0062 0.0164 0.0192
Echinococcus multilocularis cathepsin L 0.0062 0.0164 0.0164
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0061 0.0153 0.0153
Echinococcus granulosus cathepsin l1 0.0081 0.0275 0.0275
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.008 0.008
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Schistosoma mansoni nck2/grb4 0.0048 0.008 0.008
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Entamoeba histolytica cysteine proteinase, putative 0.0121 0.0512 0.5121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Schistosoma mansoni adapter molecule crk 0.0048 0.008 0.008
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Loa Loa (eye worm) hypothetical protein 0.0082 0.0278 0.0278
Schistosoma mansoni tyrosine kinase 0.0249 0.1273 0.1273
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0037 0.0013 0.0013
Echinococcus multilocularis aminopeptidase N 0.0092 0.0337 0.0337
Loa Loa (eye worm) TK protein kinase 0.0201 0.0987 0.0987
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Entamoeba histolytica aminopeptidase, putative 0.0092 0.0337 0.333
Echinococcus multilocularis glycoprotein Antigen 5 0.0082 0.0278 0.0278
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0164 0.0192
Echinococcus granulosus tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Echinococcus granulosus glycoprotein Antigen 5 0.0082 0.0278 0.0278
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.0183 0.0183
Schistosoma mansoni cathepsin F (C01 family) 0.0121 0.0512 0.0512
Echinococcus granulosus tyrosine protein kinase Blk 0.0226 0.1132 0.1132
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Trypanosoma cruzi cysteine peptidase, putative 0.0121 0.0512 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0164 0.0164
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0092 0.0337 0.0443
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0092 0.0337 0.0337
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.038 0.2047 0.2788
Schistosoma mansoni growth factor receptor-bound protein 0.0048 0.008 0.008
Brugia malayi Trypsin family protein 0.0082 0.0278 0.0402
Echinococcus granulosus tyrosine kinase 0.0037 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0183 0.0265
Echinococcus multilocularis growth factor receptor bound protein 2 0.0048 0.008 0.008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.0183 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.0183 0.0183
Trypanosoma cruzi aminopeptidase, putative 0.0092 0.0337 0.0443
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0139 0.062 0.0854
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.0183 0.0183
Brugia malayi photoreceptor-specific nuclear receptor 0.0065 0.0183 0.0265
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0092 0.0337 0.0443
Mycobacterium ulcerans aminopeptidase N PepN 0.0092 0.0337 0.0089
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.038 0.2047 0.2047
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.0275
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.0183 0.0183
Echinococcus granulosus tyrosine protein kinase HCK 0.0201 0.0987 0.0987
Echinococcus granulosus tyrosine protein kinase Src64B 0.0249 0.1273 0.1273
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0183 0.0265
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Echinococcus granulosus cathepsin l cysteine peptidase 0.0121 0.0512 0.0512
Onchocerca volvulus 0.0092 0.0337 0.047
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0062 0.0164 0.0192
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0249 0.1273 0.1273
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0164 0.0237
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0249 0.1273 0.1273
Plasmodium vivax unspecified product 0.0062 0.0164 0.0192
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Brugia malayi Steroid receptor seven-up type 2 0.0065 0.0183 0.0265
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Loa Loa (eye worm) TK/ROR protein kinase 0.0152 0.0693 0.0693
Brugia malayi SEA domain containing protein 0.0046 0.0066 0.0095
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.0183 0.0183
Echinococcus granulosus mitogen activated protein kinase 3 0.038 0.2047 0.2047
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.0183 0.0183
Echinococcus multilocularis tyrosine protein kinase shark 0.0037 0.0013 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0572 0.3184 1
Brugia malayi Furin-like cysteine rich region family protein 0.0973 0.5561 0.8039
Onchocerca volvulus 0.0082 0.0278 0.0385
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0183 0.0183
Schistosoma mansoni cercarial elastase (S01 family) 0.0082 0.0278 0.0278
Trypanosoma brucei Aminopeptidase M1, putative 0.0092 0.0337 0.0256
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.0183 0.0265
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0526 0.2912 0.2912
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0183 0.0265
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1202 0.6918 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Brugia malayi Papain family cysteine protease containing protein 0.0121 0.0512 0.074
Brugia malayi Cathepsin L-like precursor 0.0081 0.0275 0.0397
Schistosoma mansoni hypothetical protein 0.0139 0.062 0.062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.0183 0.0183
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Brugia malayi Protein kinase domain containing protein 0.0152 0.0693 0.1002
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.0183 0.0183
Echinococcus granulosus aminopeptidase N 0.0092 0.0337 0.0337
Brugia malayi cathepsin L-like precursor 0.0081 0.0275 0.0397
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0183 0.0183
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0183 0.0183
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.038 0.2047 0.2598
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0062 0.0164 0.0164
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.038 0.2047 0.2598
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0249 0.1273 0.1273
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.0183 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Loa Loa (eye worm) hypothetical protein 0.004 0.0032 0.0032
Brugia malayi thymidylate synthase 0.1202 0.6918 1
Brugia malayi Trypsin family protein 0.0082 0.0278 0.0402
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0226 0.1132 0.1132
Schistosoma mansoni hypothetical protein 0.0082 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0065 0.0183 0.0183
Loa Loa (eye worm) TATA binding protein associated factor 0.0092 0.0337 0.0337
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.0183 0.0183
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0121 0.0512 0.0515
Plasmodium vivax vivapain-3 0.0062 0.0164 0.0192
Loa Loa (eye worm) cysteine protease 0.0121 0.0512 0.0512
Leishmania major cathepsin L-like protease 0.0121 0.0512 0.0265
Brugia malayi SRC-1 0.0249 0.1273 0.184
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0082 0.0278 0.0278
Schistosoma mansoni tyrosine kinase 0.0061 0.0153 0.0153
Brugia malayi Muscle positioning protein 4 0.0051 0.0095 0.0138
Loa Loa (eye worm) hypothetical protein 0.0092 0.0337 0.0337
Brugia malayi Papain family cysteine protease containing protein 0.0062 0.0164 0.0237
Echinococcus multilocularis epidermal growth factor receptor 0.0973 0.5561 0.5561
Loa Loa (eye worm) ctsf protein 0.0121 0.0512 0.0512
Onchocerca volvulus 0.0082 0.0278 0.0385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Trichomonas vaginalis CMGC family protein kinase 0.038 0.2047 0.6235
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0121 0.0512 0.1151
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0316 0.1665 0.1665
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0121 0.0512 0.1151
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Brugia malayi Cathepsin L-like precursor 0.0121 0.0512 0.074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0121 0.0512 0.0515
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0338 0.1797 0.1797
Brugia malayi Trypsin family protein 0.0338 0.1797 0.2598
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0092 0.0337 0.0443
Schistosoma mansoni serine/threonine protein kinase 0.038 0.2047 0.2047
Echinococcus granulosus cathepsin l1 0.0121 0.0512 0.0512
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.0183 0.0183
Leishmania major hypothetical protein, conserved 0.0139 0.062 0.043
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0183 0.0183
Trichomonas vaginalis CMGC family protein kinase 0.038 0.2047 0.6235
Loa Loa (eye worm) SRC-1 0.0249 0.1273 0.1273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0121 0.0512 0.1151
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0082 0.0278 0.0278
Brugia malayi hypothetical protein 0.0572 0.3184 0.4602
Entamoeba histolytica cysteine protease, putative 0.0062 0.0164 0.1556
Brugia malayi hypothetical protein 0.0092 0.0337 0.0487
Brugia malayi SH2 domain containing protein 0.0037 0.0013 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.0183 0.0265
Trypanosoma cruzi cruzipain precursor, putative 0.0121 0.0512 0.0697
Mycobacterium ulcerans thymidylate synthase 0.1202 0.6918 1
Loa Loa (eye worm) TK/FER protein kinase 0.0037 0.0013 0.0013
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0092 0.0337 0.0573
Onchocerca volvulus 0.0082 0.0278 0.0385
Entamoeba histolytica cysteine proteinase 1, putative 0.0062 0.0164 0.1556
Brugia malayi Cathepsin L-like precursor 0.0081 0.0275 0.0397
Loa Loa (eye worm) hypothetical protein 0.0338 0.1797 0.1797
Onchocerca volvulus 0.0051 0.0095 0.012
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0037 0.0013 0.0013
Entamoeba histolytica cysteine proteinase 2 0.0062 0.0164 0.1556
Trypanosoma cruzi hypothetical protein, conserved 0.0139 0.062 0.0854

Activities

Activity type Activity value Assay description Source Reference
EC50 ratio (binding) Transcriptional activation of retinoic acid RAR-alpha receptor; Not active ChEMBL. No reference
EC50 ratio (binding) = 20 Transcriptional activation of retinoic acid RAR-gamma receptor ChEMBL. No reference
EC50 ratio (binding) = 100 Transcriptional activation of retinoic acid RAR-beta receptor ChEMBL. No reference
EC50 ratio (binding) 0 Transcriptional activation of retinoic acid RAR-alpha receptor; Not active ChEMBL. No reference
EC50 ratio (binding) = 20 Transcriptional activation of retinoic acid RAR-gamma receptor ChEMBL. No reference
EC50 ratio (binding) = 100 Transcriptional activation of retinoic acid RAR-beta receptor ChEMBL. No reference
ED30 (functional) mM Concentration of the compound that induces 30% utriculi reduction in rhino mouse.; Not determined ChEMBL. No reference
ED30 (functional) 0 mM Concentration of the compound that induces 30% utriculi reduction in rhino mouse.; Not determined ChEMBL. No reference
Max (functional) = 0 % Maximal transcriptional activation of RAR-alpha relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 0 % Maximal transcriptional activation of RAR-alpha relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 41 % Maximal trascriptional activation of RAR-beta relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 41 % Maximal trascriptional activation of RAR-beta relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 46 % Maximal trascriptional activation of RAR-gamma relative to retinoic acid at 10e-6 M ChEMBL. No reference
Max (functional) = 46 % Maximal trascriptional activation of RAR-gamma relative to retinoic acid at 10e-6 M ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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