Detailed information for compound 161663

Basic information

Technical information
  • TDR Targets ID: 161663
  • Name: 5-[[2-(4-chlorophenyl)-4-methylidene-5-oxooxo lan-2-yl]methoxy]-2-methylpyrazole-3-carboxyl ic acid
  • MW: 362.764 | Formula: C17H15ClN2O5
  • H donors: 1 H acceptors: 4 LogP: 2.9 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1(COc2nn(c(c2)C(=O)O)C)CC(=C)C(=O)O1
  • InChi: 1S/C17H15ClN2O5/c1-10-8-17(25-16(10)23,11-3-5-12(18)6-4-11)9-24-14-7-13(15(21)22)20(2)19-14/h3-7H,1,8-9H2,2H3,(H,21,22)
  • InChiKey: JEQFDSHWZJRCOG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[[2-(4-chlorophenyl)-4-methylene-5-oxo-tetrahydrofuran-2-yl]methoxy]-2-methyl-pyrazole-3-carboxylic acid
  • 5-[[2-(4-chlorophenyl)-4-methylene-5-oxo-2-tetrahydrofuranyl]methoxy]-2-methyl-3-pyrazolecarboxylic acid
  • 5-[[2-(4-chlorophenyl)-4-methylidene-5-oxo-oxolan-2-yl]methoxy]-2-methyl-pyrazole-3-carboxylic acid
  • 5-[[2-(4-chlorophenyl)-5-keto-4-methylene-tetrahydrofuran-2-yl]methoxy]-2-methyl-pyrazole-3-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) acetyltransferase 0.0149 0.0567 0.0556
Schistosoma mansoni RAR-like nuclear receptor 0.028 0.1094 0.144
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0011 0.0016 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.028 0.1094 0.1083
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0012 0.0018
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.028 0.1094 0.1454
Brugia malayi Nuclear hormone receptor family member nhr-25 0.028 0.1094 0.1083
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0132 1
Schistosoma mansoni nuclear hormone receptor 0.028 0.1094 0.144
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0011 0.0016 1
Brugia malayi nuclear receptor RXR 0.0132 0.0501 0.0489
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0012 0.0839
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0132 0.0501 0.0723
Brugia malayi Nuclear hormone receptor-like 1 0.028 0.1094 0.1083
Brugia malayi hypothetical protein 0.0148 0.0564 0.0553
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0012 0.0018
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0012 0.0839
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.028 0.1094 0.1454
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0147 1
Trichomonas vaginalis abcb9, putative 0.001 0.0012 0.0839
Brugia malayi Nuclear hormone receptor family member nhr-41 0.028 0.1094 0.1083
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0012 0.0839
Brugia malayi Nuclear hormone receptor family member nhr-40 0.028 0.1094 0.1083
Schistosoma mansoni thyroid hormone receptor 0.028 0.1094 0.144
Trichomonas vaginalis abcb9, putative 0.001 0.0012 0.0839
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0089 1
Brugia malayi Nuclear hormone receptor-like 1 0.0148 0.0564 0.0553
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0148 0.0564 0.0735
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.028 0.1094 0.1083
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0012 0.0018
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0089 1
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0012 0.0016
Brugia malayi nuclear receptor NHR-67 0.0132 0.0501 0.0489
Loa Loa (eye worm) hypothetical protein 0.028 0.1094 0.1083
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0132 0.0501 0.0489
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0011 0.0016 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0011 0.0016 1
Brugia malayi conserved hypotetical protein 0.0132 0.0501 0.0489
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0012 0.0839
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0012 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.028 0.1094 0.1454
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.028 0.1094 0.1578
Brugia malayi nuclear hormone receptor family member odr-7 0.0132 0.0501 0.0489
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0089 0.0078
Loa Loa (eye worm) hypothetical protein 0.028 0.1094 0.1083
Brugia malayi Nuclear hormone receptor-like 1 0.0148 0.0564 0.0553
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0012 0.0018
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0147 1
Echinococcus multilocularis multidrug resistance protein 1 0.001 0.0012 0.0018
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0012 0.0839
Brugia malayi photoreceptor-specific nuclear receptor 0.028 0.1094 0.1083
Onchocerca volvulus Bile acid receptor homolog 0.2504 1 1
Brugia malayi steroid hormone receptor 0.028 0.1094 0.1083
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.028 0.1094 0.144
Brugia malayi Nuclear hormone receptor family member nhr-31 0.028 0.1094 0.1083
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.028 0.1094 0.1083
Mycobacterium leprae putative cytochrome p450 0.0011 0.0016 0.5
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0011 0.0016 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.028 0.1094 0.1083
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Loa Loa (eye worm) hypothetical protein 0.0148 0.0564 0.0553
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0147 0.0195
Loa Loa (eye worm) hypothetical protein 0.028 0.1094 0.1083
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0012 0.0016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0132 0.0501 0.0489
Brugia malayi nuclear receptor RXR 0.0148 0.0564 0.0553
Brugia malayi orphan nuclear receptor NR2E1 0.0132 0.0501 0.0489
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0132 0.0501 0.065
Loa Loa (eye worm) hypothetical protein 0.028 0.1094 0.1083
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0012 0.0839
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0148 0.0564 0.0735
Toxoplasma gondii cytochrome p450 superfamily protein 0.0011 0.0016 0.0293
Loa Loa (eye worm) hypothetical protein 0.028 0.1094 0.1083
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Brugia malayi Cytochrome P450 family protein 0.0029 0.0089 0.0077
Brugia malayi hypothetical protein 0.0148 0.0564 0.0553
Echinococcus granulosus Nuclear hormone receptor HR96 0.0132 0.0501 0.0666
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0012 0.0839
Schistosoma mansoni zinc finger protein 0.0132 0.0501 0.065
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0132 0.0501 0.0666
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0012 0.0839
Loa Loa (eye worm) DR-78 0.0132 0.0501 0.049
Leishmania major cytochrome p450-like protein 0.0011 0.0016 0.0511
Brugia malayi nuclear hormone receptor 0.0132 0.0501 0.0489
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0132 0.0501 0.065
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0011 0.0016 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0011 0.0016 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.028 0.1094 0.1578
Echinococcus multilocularis 0.0011 0.0016 0.0023
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0132 0.0501 0.0489
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0147 1
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0132 0.5
Loa Loa (eye worm) hypothetical protein 0.028 0.1094 0.1083
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.028 0.1094 0.1083
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0012 0.0016
Loa Loa (eye worm) hypothetical protein 0.0148 0.0564 0.0553
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0012 0.0839
Schistosoma mansoni retinoid-x-receptor (RXR) 0.028 0.1094 0.144
Schistosoma mansoni retinoic acid receptor RXR 0.1885 0.7523 1
Schistosoma mansoni coup transcription factor 0.028 0.1094 0.144
Schistosoma mansoni thyroid hormone receptor 0.028 0.1094 0.144
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0012 0.0839
Echinococcus multilocularis FTZ F1 alpha 0.028 0.1094 0.1578
Onchocerca volvulus 0.0132 0.0501 0.0489
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0012 0.0839
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.028 0.1094 0.144
Trichomonas vaginalis abcb9, putative 0.001 0.0012 0.0839
Brugia malayi Nuclear hormone receptor family member nhr-14 0.028 0.1094 0.1083
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0148 0.0564 0.075
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0567 0.0556
Onchocerca volvulus 0.028 0.1094 0.1083
Echinococcus granulosus retinoic acid receptor rxr beta a 0.1885 0.7523 1
Schistosoma mansoni cytochrome P450 0.0011 0.0016 0.0005
Schistosoma mansoni nuclear receptor nhr-48 0.0132 0.0501 0.065
Schistosoma mansoni hypothetical protein 0.0011 0.0016 0.0005
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0132 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.028 0.1094 0.1578
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0012 0.0839
Loa Loa (eye worm) hypothetical protein 0.0018 0.0045 0.0033
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0132 0.0501 0.049
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Brugia malayi nuclear receptor NHR-88 0.028 0.1094 0.1083
Brugia malayi Steroid receptor seven-up type 2 0.028 0.1094 0.1083
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0089 1
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0011 0.0016 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0011 0.0016 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0089 0.0078
Schistosoma mansoni Tr4/Tr2 (homologue) 0.028 0.1094 0.144
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0011 0.0016 1
Schistosoma mansoni nuclear receptor 0.0132 0.0501 0.065
Brugia malayi nuclear hormone receptor family member nhr-6 0.0132 0.0501 0.0489
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0132 0.0501 0.0666
Schistosoma mansoni nuclear receptor 0.0132 0.0501 0.065
Echinococcus granulosus FTZ F1 alpha 0.028 0.1094 0.1454
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.028 0.1094 0.1083
Loa Loa (eye worm) hypothetical protein 0.0148 0.0564 0.0553
Loa Loa (eye worm) hypothetical protein 0.0148 0.0564 0.0553
Brugia malayi nuclear hormone receptor 0.028 0.1094 0.1083
Brugia malayi hypothetical protein 0.0132 0.0501 0.0489
Trichomonas vaginalis ABC transporter, half transporter, putative 0.001 0.0012 0.0839
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0148 0.0564 0.0814
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0012 0.0839
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.001 0.0012 0.0018
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0012 0.0016
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.028 0.1094 0.1083
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1737 0.693 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.028 0.1094 0.1083
Schistosoma mansoni steroid hormone receptor ad4bp 0.028 0.1094 0.144
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.028 0.1094 0.1454
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0089 0.0078
Echinococcus granulosus Nuclear hormone receptor HR96 0.0132 0.0501 0.0666
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.028 0.1094 0.144
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0011 0.0016 1
Echinococcus granulosus ecdysone induced protein 78C 0.028 0.1094 0.1454
Echinococcus granulosus cytochrome P450 2K1 0.0011 0.0016 0.0022
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0147 1
Brugia malayi Cytochrome P450 family protein 0.0029 0.0089 0.0077
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0011 0.0016 1
Leishmania major cytochrome p450-like protein 0.0029 0.0089 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0551 0.0732
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Echinococcus multilocularis ecdysone induced protein 78C 0.028 0.1094 0.1578
Trichomonas vaginalis ABC transporter, putative 0.001 0.0012 0.0839
Brugia malayi Nuclear hormone receptor family member nhr-19 0.028 0.1094 0.1083
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0011 0.0016 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.0564 0.0553
Trichomonas vaginalis taga, putative 0.001 0.0012 0.0839
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0567 0.0739
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0012 0.0839
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.3109 0.4487
Brugia malayi Cytochrome P450 family protein 0.0011 0.0016 0.0004
Schistosoma mansoni nuclear hormone receptor 0.0132 0.0501 0.065
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0011 0.0016 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0147 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.028 0.1094 0.1083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.028 0.1094 0.1083
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.028 0.1094 0.144
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.001 0.0012 0.0016
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0089 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0567 0.0819
Brugia malayi cytochrome P450 0.0011 0.0016 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.028 0.1094 0.1083
Leishmania major cytochrome p450-like protein 0.0011 0.0016 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-19 0.028 0.1094 0.1083
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0098 0.0087
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0012 0.0839
Echinococcus granulosus nuclear receptor 2DBD gamma 0.028 0.1094 0.1454
Trichomonas vaginalis ABC transporter, putative 0.001 0.0012 0.0839
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0012 0.0839
Brugia malayi Nuclear hormone receptor family member nhr-1 0.028 0.1094 0.1083
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.001 0.0012 0.0839
Brugia malayi Nuclear hormone receptor E75 0.0132 0.0501 0.0489
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0132 0.0501 0.0723
Loa Loa (eye worm) hypothetical protein 0.2504 1 1
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0011 0.0016 1
Onchocerca volvulus 0.0132 0.0501 0.0489
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0012 0.0839
Brugia malayi ecdysone receptor 0.0132 0.0501 0.0489
Schistosoma mansoni nuclear hormone receptor 0.0132 0.0501 0.065
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Onchocerca volvulus Protein ultraspiracle homolog 0.028 0.1094 0.1083
Loa Loa (eye worm) nuclear hormone receptor 0.0132 0.0501 0.049
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0011 0.0016 1
Trichomonas vaginalis ABC transporter, putative 0.001 0.0012 0.0839
Trichomonas vaginalis ABC transporter, putative 0.001 0.0012 0.0839
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.001 0.0012 0.0839
Loa Loa (eye worm) hypothetical protein 0.028 0.1094 0.1083
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0011 0.0016 1
Brugia malayi Cytochrome P450 family protein 0.0032 0.0098 0.0086
Brugia malayi hypothetical protein 0.0132 0.0501 0.0489
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.028 0.1094 0.1454
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0011 0.0016 1
Loa Loa (eye worm) steroid hormone receptor 0.028 0.1094 0.1083
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0012 0.0839
Loa Loa (eye worm) nuclear receptor NHR-67 0.0132 0.0501 0.049
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0132 0.0501 0.0723
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.028 0.1094 0.1578
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.028 0.1094 0.1578
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0012 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.028 0.1094 0.1578
Brugia malayi nuclear receptor NHR-88 0.0132 0.0501 0.0489
Brugia malayi tailless protein 0.0132 0.0501 0.0489
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.001 0.0012 0.0839
Echinococcus granulosus nuclear receptor nhr 48 0.0132 0.0501 0.0666
Loa Loa (eye worm) hypothetical protein 0.0132 0.0501 0.049
Loa Loa (eye worm) cytochrome P450 0.0011 0.0016 0.0004
Brugia malayi Nuclear hormone receptor E75 0.0132 0.0501 0.0489
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0011 0.0016 0.0511
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.001 0.0012 0.5
Echinococcus multilocularis nuclear receptor nhr 48 0.0132 0.0501 0.0723
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.028 0.1094 0.1083
Mycobacterium leprae Conserved hypothetical protein 0.0011 0.0016 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0132 0.0501 0.0723
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0011 0.0016 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.028 0.1094 0.1083
Echinococcus granulosus thyroid hormone receptor alpha 0.0132 0.0501 0.0666
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0011 0.0016 1
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0012 0.0016
Echinococcus granulosus multidrug resistance protein 1 0.001 0.0012 0.0016
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.028 0.1094 0.1578
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0148 0.0564 0.0553

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 10 uM In vitro antiproliferative activity against murine lymphocytic L1210 leukemia cell line ChEMBL. 16302827
IC50 (functional) > 10 uM In vitro antiproliferative against human chronic myelogenous K562 cell line ChEMBL. 16302827
IC50 (functional) > 10 uM In vitro antiproliferative activity against murine lymphocytic L1210 leukemia cell line ChEMBL. 16302827
IC50 (functional) > 10 uM In vitro antiproliferative against human chronic myelogenous K562 cell line ChEMBL. 16302827
IC50 (functional) = 13 uM Inhibitory concentration of the compound required to inhibit murine leukemia L1210 cells proliferation ChEMBL. 15139766
IC50 (functional) = 13 uM Inhibitory concentration of the compound required to inhibit murine leukemia L1210 cells proliferation ChEMBL. 15139766
IC50 (functional) = 46.9 uM Inhibitory concentration of the compound required to inhibit human T-lymphoblast Molt4 cells proliferation ChEMBL. 15139766
IC50 (functional) = 46.9 uM Inhibitory concentration of the compound required to inhibit human T-lymphoblast Molt4 cells proliferation ChEMBL. 15139766
IC50 (functional) = 57.9 uM Inhibitory concentration of the compound required to inhibit human T-lymphoblast CEM cells proliferation ChEMBL. 15139766
IC50 (functional) = 57.9 uM Inhibitory concentration of the compound required to inhibit human T-lymphoblast CEM cells proliferation ChEMBL. 15139766
IC50 (functional) = 99.2 uM Inhibitory concentration of the compound required to inhibit murine mammary carcinoma FM3A cells proliferation ChEMBL. 15139766
IC50 (functional) = 99.2 uM Inhibitory concentration of the compound required to inhibit murine mammary carcinoma FM3A cells proliferation ChEMBL. 15139766

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 16302827
Mus musculus ChEMBL23 15139766

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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