TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 450.61 | Formula: C29H38O4
H donors: 1 H acceptors: 2 LogP: 5.51 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccccc1/C=C/C(=O)[C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2C[C@H]2[C@@]3([C@]1(C)CC[C@@H](C3)O)O2
InChi: 1S/C29H38O4/c1-27-14-13-22-20(16-26-29(33-26)17-19(30)12-15-28(22,29)2)21(27)9-10-23(27)24(31)11-8-18-6-4-5-7-25(18)32-3/h4-8,11,19-23,26,30H,9-10,12-17H2,1-3H3/b11-8+/t19-,20-,21-,22-,23+,26-,27-,28+,29-/m0/s1
InChiKey: BIUYJJBYUNYLRS-OMNMEUQSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	tyrosine protein kinase csk	0.0162	0.3651	0.3651
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0162	0.3651	1
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0252	0.5903	0.5903
Brugia malayi	Furin-like cysteine rich region family protein	0.0162	0.3651	0.3651
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0252	0.5903	0.5903
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0162	0.3651	0.3651
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Entamoeba histolytica	hypothetical protein, conserved	0.0162	0.3651	0.3036
Echinococcus multilocularis	tyrosine protein kinase csk	0.0162	0.3651	0.3651
Echinococcus granulosus	SH2 motif	0.0252	0.5903	0.5903
Echinococcus multilocularis	lamin dm0	0.0032	0.0352	0.0352
Leishmania major	hypothetical protein, conserved	0.0162	0.3651	1
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0053	0.0883	0.242
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0162	0.3651	0.342
Onchocerca volvulus		0.0162	0.3651	0.342
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0352	0.0352
Schistosoma mansoni	growth factor receptor-bound protein	0.0252	0.5903	0.5903
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0272	0.0745
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0025	0.0183	0.0501
Schistosoma mansoni	SH2A	0.0252	0.5903	0.5903
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Onchocerca volvulus	Tyrosine kinase homolog	0.0162	0.3651	0.342
Trichomonas vaginalis	protein kinase atn1, putative	0.0162	0.3651	1
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Brugia malayi	ephrin receptor 1 precursor	0.0162	0.3651	0.3651
Schistosoma mansoni	tensin-related	0.0252	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Brugia malayi	intermediate filament protein	0.0032	0.0352	0.0352
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Echinococcus granulosus	tyrosine protein kinase	0.0162	0.3651	0.3651
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0162	0.3651	1
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Schistosoma mansoni	serine/threonine RGC	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TK/ACK protein kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	tyrosin kinase, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.0883	0.242
Echinococcus multilocularis	SH2 motif	0.0252	0.5903	0.5903
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0162	0.3651	1
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	tyrosin kinase, putative	0.0162	0.3651	0.3036
Echinococcus granulosus	natriuretic peptide receptor 1	0.0162	0.3651	0.3651
Trichomonas vaginalis	CAMK family protein kinase	0.0162	0.3651	1
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0053	0.0883	0.0883
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0252	0.5903	0.5903
Echinococcus granulosus	activin receptor type	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0352	0.0352
Loa Loa (eye worm)	TK/ALK protein kinase	0.0162	0.3651	0.3651
Onchocerca volvulus		0.0162	0.3651	0.342
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0053	0.0883	0.242
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Toxoplasma gondii	protein kinase	0.0162	0.3651	1
Trypanosoma cruzi	target of rapamycin kinase 3	0.0042	0.0613	0.1678
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Onchocerca volvulus		0.0252	0.5903	0.5754
Entamoeba histolytica	serine/threonine kinase, putative	0.0162	0.3651	0.3036
Entamoeba histolytica	cysteine surface protein, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	cellular tumor antigen P53	0.0058	0.1017	0.1017
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0252	0.5903	0.5903
Schistosoma mansoni	hypothetical protein	0.0018	0.0021	0.0021
Echinococcus multilocularis	protein tyrosine kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0341	0.0933
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus granulosus	tyrosine kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0162	0.3651	0.3651
Onchocerca volvulus		0.0162	0.3651	0.342
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Brugia malayi	RhoGAP domain containing protein	0.0252	0.5903	0.5903
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TK/RYK protein kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Schistosoma mansoni	GTPase activating protein	0.0252	0.5903	0.5903
Brugia malayi	SH2 domain containing protein	0.0252	0.5903	0.5903
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.0883	0.242
Trypanosoma brucei	protein kinase, putative	0.0162	0.3651	1
Trichomonas vaginalis	STE family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TK protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0611	0.1675
Brugia malayi	Raf kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0021	0.0021
Entamoeba histolytica	hypothetical protein	0.0168	0.3804	0.3203
Echinococcus granulosus	tensin	0.0252	0.5903	0.5903
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0252	0.5903	0.5903
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0352	0.0352
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Echinococcus granulosus	GPCR family 2	0.0018	0.0021	0.0021
Echinococcus multilocularis	lamin	0.0032	0.0352	0.0352
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Echinococcus granulosus	protein tyrosine kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Echinococcus granulosus	protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	lamin	0.0032	0.0352	0.0352
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0162	0.3651	0.3651
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0252	0.5903	0.5903
Loa Loa (eye worm)	TK protein kinase	0.0162	0.3651	0.3651
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0162	0.3651	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TK/FER protein kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Brugia malayi	hypothetical protein	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TK protein kinase	0.0162	0.3651	0.3651
Brugia malayi	SH2 domain containing protein	0.0252	0.5903	0.5903
Echinococcus granulosus	kinase suppressor of Ras 1	0.0162	0.3651	0.3651
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0252	0.5903	0.5903
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	vav2	0.0252	0.5903	0.5903
Entamoeba histolytica	hypothetical protein	0.0168	0.3804	0.3203
Schistosoma mansoni	ephrin receptor	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0177	0.4024	0.4024
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Schistosoma mansoni	growth factor receptor-bound protein	0.0252	0.5903	0.5903
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Echinococcus multilocularis	activin receptor type	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0337	0.0337
Echinococcus multilocularis	tensin	0.0252	0.5903	0.5903
Schistosoma mansoni	hypothetical protein	0.0018	0.0021	0.0021
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Brugia malayi	C-terminal src kinase protein 1	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1029	0.1029
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0162	0.3651	0.5
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0162	0.3651	0.3651
Leishmania major	protein kinase, putative	0.0162	0.3651	1
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0162	0.3651	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Echinococcus multilocularis	tyrosine protein kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Trypanosoma brucei	Pseudokinase, putative	0.0162	0.3651	1
Echinococcus granulosus	SHC transforming protein 3	0.0252	0.5903	0.5903
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Onchocerca volvulus		0.0252	0.5903	0.5754
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0611	0.1675
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0162	0.3651	0.3651
Schistosoma mansoni	suppressor of cytokine signaling	0.0252	0.5903	0.5903
Brugia malayi	Tyrosine-protein kinase PR2	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0162	0.3651	0.3651
Entamoeba histolytica	hypothetical protein	0.0162	0.3651	0.3036
Brugia malayi	integrin-linked kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0162	0.3651	0.3651
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0053	0.0883	0.0883
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Echinococcus granulosus	activated cdc42 kinase 1	0.0162	0.3651	0.3651
Entamoeba histolytica	tyrosin kinase, putative	0.0162	0.3651	0.3036
Echinococcus granulosus	tyrosine protein kinase HCK	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0162	0.3651	0.3651
Schistosoma mansoni	serine/threonine protein kinase	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Echinococcus granulosus	SH2 motif	0.0252	0.5903	0.5903
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TK protein kinase	0.0162	0.3651	0.3651
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0021	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0058	0.1017	0.1017
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0272	0.0745
Echinococcus granulosus	epidermal growth factor receptor	0.0162	0.3651	0.3651
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0272	0.0745
Echinococcus granulosus	receptor type guanylyl cyclase	0.0162	0.3651	0.3651
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0252	0.5903	0.5754
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Leishmania major	protein kinase, putative	0.0162	0.3651	1
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0053	0.0883	0.242
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0162	0.3651	0.3651
Entamoeba histolytica	hypothetical protein	0.0162	0.3651	0.3036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0271	0.0742
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0162	0.3651	0.3651
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0252	0.5903	0.5903
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0053	0.0883	0.242
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0543	0.1487
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0162	0.3651	1
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Onchocerca volvulus		0.0177	0.4024	0.3806
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.1029	0.1029
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Giardia lamblia	Protein 21.1	0.0162	0.3651	1
Schistosoma mansoni	tensin	0.0252	0.5903	0.5903
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Onchocerca volvulus		0.0162	0.3651	0.342
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0021	0.0021
Trypanosoma cruzi	protein kinase, putative	0.0162	0.3651	1
Onchocerca volvulus		0.0252	0.5903	0.5754
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0272	0.0745
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TK protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0252	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Echinococcus multilocularis	tyrosine kinase	0.0162	0.3651	0.3651
Echinococcus granulosus	lamin	0.0032	0.0352	0.0352
Loa Loa (eye worm)	TK protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus multilocularis	musashi	0.0032	0.0352	0.0352
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0053	0.0883	0.0883
Trichomonas vaginalis	TK family protein kinase	0.0162	0.3651	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0252	0.5903	0.5903
Brugia malayi	Variant SH3 domain containing protein	0.0252	0.5903	0.5903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0543	0.1487
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0252	0.5903	0.5903
Echinococcus multilocularis	tyrosine protein kinase csk	0.0162	0.3651	0.3651
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0252	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Onchocerca volvulus		0.0162	0.3651	0.342
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Schistosoma mansoni	serine/threonine protein kinase	0.0162	0.3651	0.3651
Echinococcus granulosus	growth factor receptor bound protein 2	0.0252	0.5903	0.5903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0045	0.0689	0.1887
Schistosoma mansoni	tyrosine protein kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0162	0.3651	0.3651
Echinococcus granulosus	signal transduction protein lnk realted	0.0252	0.5903	0.5903
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Echinococcus granulosus	activated cdc42 kinase 1	0.0162	0.3651	0.3651
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Toxoplasma gondii	STE kinase	0.0162	0.3651	1
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TK/FER protein kinase	0.0162	0.3651	0.3651
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0162	0.3651	0.3651
Echinococcus granulosus	ephrin type A receptor 4 A	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0252	0.5903	0.5903
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0252	0.5903	0.5903
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0252	0.5903	0.5903
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0053	0.0883	0.242
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0042	0.0613	0.1678
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0611	0.1675
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Loa Loa (eye worm)	TK protein kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0162	0.3651	0.3651
Schistosoma mansoni	hypothetical protein	0.0018	0.0021	0.0021
Plasmodium vivax	protein kinase, putative	0.0162	0.3651	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0162	0.3651	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0162	0.3651	0.3651
Onchocerca volvulus		0.0252	0.5903	0.5754
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Schistosoma mansoni	hypothetical protein	0.004	0.0562	0.0562
Loa Loa (eye worm)	TK/FAK protein kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3651	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Trypanosoma cruzi	protein kinase, putative	0.0162	0.3651	1
Trichomonas vaginalis	AGC family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0543	0.1487
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Brugia malayi	Sex muscle abnormal protein 5	0.0252	0.5903	0.5903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0611	0.1675
Brugia malayi	SH2 domain containing protein	0.0252	0.5903	0.5903
Schistosoma mansoni	signal transduction protein lnk-related	0.0252	0.5903	0.5903
Loa Loa (eye worm)	SH2 domain-containing protein	0.0252	0.5903	0.5903
Entamoeba histolytica	hypothetical protein	0.0162	0.3651	0.3036
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	ankyrin repeat protein	0.0162	0.3651	0.3036
Schistosoma mansoni	lamin	0.0032	0.0352	0.0352
Loa Loa (eye worm)	hypothetical protein	0.004	0.0562	0.0562
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3651	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0162	0.3651	0.3651
Echinococcus multilocularis	insulin receptor	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0543	0.1487
Brugia malayi	hypothetical protein	0.0252	0.5903	0.5903
Echinococcus multilocularis	SHC transforming protein 3	0.0252	0.5903	0.5903
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0252	0.5903	0.5903
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0271	0.0742
Giardia lamblia	Kinase	0.0162	0.3651	1
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0252	0.5903	0.5754
Brugia malayi	hypothetical protein	0.0162	0.3651	0.3651
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0162	0.3651	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0053	0.0883	0.0883
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0162	0.3651	0.3036
Plasmodium falciparum	protein kinase, putative	0.0162	0.3651	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Echinococcus granulosus	intermediate filament protein	0.0032	0.0352	0.0352
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	hypothetical protein	0.0252	0.5903	0.5903
Schistosoma mansoni	shc transforming protein	0.0252	0.5903	0.5903
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Echinococcus multilocularis	protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0446	0.1221
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.0883	0.242
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	serine/threonine protein kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	SH2 domain containing protein 7	0.0252	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Schistosoma mansoni	hypothetical protein	0.0018	0.0021	0.0021
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0252	0.5903	0.5903
Plasmodium falciparum	tyrosine kinase-like protein	0.0162	0.3651	0.5
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0021	0.0021
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0162	0.3651	0.3651
Brugia malayi	Variant SH3 domain containing protein	0.0252	0.5903	0.5903
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3651	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0252	0.5903	0.5903
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase, putative	0.0168	0.3804	0.3203
Echinococcus granulosus	tyrosine protein kinase pr2	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0162	0.3651	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TK/FER protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	ephrin receptor	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0611	0.1675
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0252	0.5903	0.5506
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	receptor protein kinase, putative	0.0162	0.3651	0.3036
Echinococcus multilocularis	FL cytokine receptor	0.0162	0.3651	0.3651
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0252	0.5903	0.5903
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0252	0.5903	0.5903
Schistosoma mansoni	tensin	0.0252	0.5903	0.5903
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TK/CSK protein kinase	0.0162	0.3651	0.3651
Brugia malayi	Variant SH3 domain containing protein	0.0252	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	serine/threonine kinase, putative	0.0162	0.3651	0.3036
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0162	0.3651	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0348	0.0954
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Echinococcus multilocularis	epidermal growth factor receptor	0.0162	0.3651	0.3651
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0252	0.5903	0.5903
Entamoeba histolytica	SH2 domain containing protein	0.0252	0.5903	0.5506
Plasmodium falciparum	protein kinase, putative	0.0162	0.3651	0.5
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0271	0.0742
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0162	0.3651	0.3651
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0162	0.3651	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.1029	0.1029
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0021	0.0021
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0162	0.3651	0.3036
Echinococcus granulosus	insulin receptor	0.0162	0.3651	0.3651
Entamoeba histolytica	hypothetical protein	0.0162	0.3651	0.3036
Giardia lamblia	Kinase, NEK	0.0162	0.3651	1
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TK/FER protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	suppressor of cytokine signaling	0.0252	0.5903	0.5903
Loa Loa (eye worm)	SH2 domain-containing protein	0.0252	0.5903	0.5903
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0162	0.3651	0.3036
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0162	0.3651	0.3651
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0252	0.5903	0.5903
Entamoeba histolytica	hypothetical protein	0.0162	0.3651	0.3036
Plasmodium falciparum	tyrosine kinase-like protein	0.0162	0.3651	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0252	0.5903	0.5903
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0252	0.5903	0.5903
Echinococcus multilocularis	N chimaerin	0.0252	0.5903	0.5903
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0162	0.3651	1
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Brugia malayi	Tensin	0.0252	0.5903	0.5903
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus multilocularis	tensin	0.0252	0.5903	0.5903
Brugia malayi	SH2 domain containing protein	0.0252	0.5903	0.5903
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0252	0.5903	0.5903
Onchocerca volvulus		0.0162	0.3651	0.342
Entamoeba histolytica	protein kinase, putative	0.0252	0.5903	0.5506
Loa Loa (eye worm)	TK protein kinase	0.0162	0.3651	0.3651
Brugia malayi	Variant SH3 domain containing protein	0.0252	0.5903	0.5903
Schistosoma mansoni	protein kinase	0.0162	0.3651	0.3651
Echinococcus granulosus	SH2 domain containing protein 7	0.0252	0.5903	0.5903
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Onchocerca volvulus		0.0162	0.3651	0.342
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0543	0.1487
Onchocerca volvulus		0.0058	0.1017	0.0689
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0252	0.5903	0.5903
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0352	0.0352
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0168	0.3804	0.3203
Loa Loa (eye worm)	TK/EPH protein kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	NCK adaptor protein	0.0252	0.5903	0.5903
Echinococcus multilocularis	transfer RNA-Thr	0.0162	0.3651	0.3651
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0341	0.0933
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0162	0.3651	0.3651
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TK/INSR protein kinase	0.0162	0.3651	0.3651
Giardia lamblia	Kinase, NEK	0.0162	0.3651	1
Entamoeba histolytica	tyrosin kinase, putative	0.0162	0.3651	0.3036
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0162	0.3651	0.3651
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0162	0.3651	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3651	1
Echinococcus granulosus	expressed conserved protein	0.0252	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Entamoeba histolytica	hypothetical protein	0.0162	0.3651	0.3036
Brugia malayi	SH2 domain containing protein	0.0252	0.5903	0.5903
Toxoplasma gondii	protein kinase domain-containing protein	0.0162	0.3651	1
Schistosoma mansoni	serine/threonine protein kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus multilocularis	SH2 motif	0.0252	0.5903	0.5903
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0252	0.5903	0.5903
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	hypothetical protein	0.0252	0.5903	0.5903
Loa Loa (eye worm)	TK/FER protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3651	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0162	0.3651	0.3651
Entamoeba histolytica	ankyrin repeat protein	0.0162	0.3651	0.3036
Brugia malayi	hypothetical protein	0.0177	0.4024	0.4024
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0162	0.3651	0.3651
Echinococcus granulosus	N chimaerin	0.0252	0.5903	0.5903
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0252	0.5903	0.5903
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0252	0.5903	0.5903
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0252	0.5903	0.5903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0348	0.0954
Onchocerca volvulus		0.0252	0.5903	0.5754
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0162	0.3651	0.3651
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Schistosoma mansoni	serine/threonine protein kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Brugia malayi	SH2 domain containing protein	0.0252	0.5903	0.5903
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.1029	0.1029
Echinococcus multilocularis	protein kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0162	0.3651	0.3651
Loa Loa (eye worm)	STAT protein	0.0252	0.5903	0.5903
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0562	0.0562
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	tensin	0.0252	0.5903	0.5903
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0021	0.0021
Schistosoma mansoni	hypothetical protein	0.0162	0.3651	0.3651
Entamoeba histolytica	serine/threonine kinase, putative	0.0162	0.3651	0.3036
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0252	0.5903	0.5903
Brugia malayi	Guanylyl cyclase protein 23	0.0162	0.3651	0.3651
Echinococcus granulosus	tumor protein p63	0.0396	0.9549	0.9549
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TK/DDR protein kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	SH2 motif	0.0252	0.5903	0.5903
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0352	0.0352
Echinococcus granulosus	lamin dm0	0.0032	0.0352	0.0352
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0162	0.3651	0.342
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus granulosus	NCK adaptor protein	0.0252	0.5903	0.5903
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0162	0.3651	0.3651
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3651	1
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0018	0.0021	0.0021
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0162	0.3651	0.3651
Echinococcus multilocularis	epidermal growth factor receptor	0.0162	0.3651	0.3651
Echinococcus multilocularis	integrin linked protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0162	0.3651	0.3651
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0162	0.3651	0.3651
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0162	0.3651	0.3651
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0162	0.3651	0.3651
Trichomonas vaginalis	conserved hypothetical protein	0.0162	0.3651	1
Onchocerca volvulus		0.0162	0.3651	0.342
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Entamoeba histolytica	protein kinase, putative	0.0162	0.3651	0.3036
Entamoeba histolytica	hypothetical protein	0.0162	0.3651	0.3036
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0021	0.0021
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.3651	0.3036
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0053	0.0883	0.0883
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0053	0.0883	0.242
Echinococcus granulosus	tyrosine protein kinase csk	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0034	0.0417	0.1142
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0162	0.3651	0.3036
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0543	0.1487
Echinococcus granulosus	epidermal growth factor receptor	0.0162	0.3651	0.3651
Loa Loa (eye worm)	SH2 domain-containing protein	0.0252	0.5903	0.5903
Loa Loa (eye worm)	TK/FER protein kinase	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Echinococcus multilocularis	signal transduction protein lnk realted	0.0252	0.5903	0.5903
Onchocerca volvulus		0.0252	0.5903	0.5754
Echinococcus granulosus	hypothetical protein	0.0252	0.5903	0.5903
Entamoeba histolytica	hypothetical protein	0.0168	0.3804	0.3203
Entamoeba histolytica	hypothetical protein	0.0162	0.3651	0.3036
Loa Loa (eye worm)	TK protein kinase	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Loa Loa (eye worm)	hypothetical protein	0.0162	0.3651	0.3651
Schistosoma mansoni	adapter molecule crk	0.0252	0.5903	0.5903
Entamoeba histolytica	receptor protein kinase, putative	0.0162	0.3651	0.3036
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Trichomonas vaginalis	TKL family protein kinase	0.0162	0.3651	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0021	0.0021
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0022	0.0106	0.0291
Plasmodium falciparum	protein kinase, putative	0.0162	0.3651	0.5
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0162	0.3651	0.3651
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Echinococcus multilocularis		0.0252	0.5903	0.5903
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0039	0.0543	0.1487
Echinococcus multilocularis	tumor protein p63	0.0396	0.9549	0.9549
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0348	0.0954
Schistosoma mansoni	nck2/grb4	0.0252	0.5903	0.5903
Schistosoma mansoni	protein tyrosine kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	tyrosine protein kinase csk	0.0162	0.3651	0.3651
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0162	0.3651	0.3651
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0162	0.3651	0.3651
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0042	0.0613	0.1678
Loa Loa (eye worm)	TK/ROR protein kinase	0.0162	0.3651	0.3651
Schistosoma mansoni	tyrosine kinase	0.0162	0.3651	0.3651
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0162	0.3651	0.3651
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0252	0.5903	0.5903
Loa Loa (eye worm)	hypothetical protein	0.0252	0.5903	0.5903
Echinococcus granulosus	integrin linked protein kinase	0.0162	0.3651	0.3651
Brugia malayi	Protein kinase domain containing protein	0.0162	0.3651	0.3651
Schistosoma mansoni	tensin-related	0.0252	0.5903	0.5903
Entamoeba histolytica	tyrosine kinase, putative	0.0162	0.3651	0.3036
Echinococcus multilocularis	heat shock protein 70	0.0162	0.3651	0.3651
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0252	0.5903	0.5903
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0252	0.5903	0.5903
Brugia malayi	SH2 domain containing protein	0.0252	0.5903	0.5903
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0162	0.3651	0.5
Onchocerca volvulus		0.0162	0.3651	0.342

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 98.7 %	Neuroprotective activity against oxygen-glucose deprivation-induced human SH-SY5Y cells assessed as cell viability at 10 uM preincubated for 2 hrs prior oxygen-glucose deprivation challenge for 1 hr measured after 24 hrs incubation under normal condition by MTT assay	ChEMBL.	22357341

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1957689

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1616714