TDR Targets

Basic information

Technical information

TDR Targets ID: 1616736
Name: 5-[3-(4-methoxyphenyl)prop-2-enylidene]-2-sul fanylidene-1,3-thiazolidin-4-one
MW: 277.362 | Formula: C13H11NO2S2
H donors: 1 H acceptors: 1 LogP: 3.41 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)/C=C/C=C/1\SC(=S)NC1=O
InChi: 1S/C13H11NO2S2/c1-16-10-7-5-9(6-8-10)3-2-4-11-12(15)14-13(17)18-11/h2-8H,1H3,(H,14,15,17)/b3-2+,11-4-
InChiKey: DZJNBSVRWKLBRF-ICKRUQPGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(5Z)-5-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
5-[3-(4-methoxyphenyl)prop-2-enylidene]-2-thioxo-thiazolidin-4-one
(5Z)-5-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]-2-thioxo-thiazolidin-4-one
5-[3-(4-methoxyphenyl)prop-2-enylidene]-2-thioxo-4-thiazolidinone
(5Z)-5-[(E)-3-(4-methoxyphenyl)prop-2-enylidene]-2-thioxo-4-thiazolidinone
ZINC01210137

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	ABC1 family protein	0.0032	0.0058	1
Onchocerca volvulus		0.0032	0.0058	0.0173
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2741	0.9558
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0044	0.0255	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0195	0.2741	0.279
Onchocerca volvulus		0.0092	0.1039	0.3121
Plasmodium vivax	acyl-CoA synthetase, putative	0.0033	0.0069	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0195	0.2741	0.279
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0092	0.1039	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0195	0.2741	0.2741
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0195	0.2741	0.9558
Brugia malayi	Nuclear hormone receptor E75	0.0092	0.1039	0.3624
Mycobacterium tuberculosis	Conserved protein	0.0032	0.0058	0.0062
Echinococcus multilocularis	microtubule associated protein 2	0.0622	0.9824	0.9824
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0092	0.1039	0.1039
Brugia malayi	ecdysone receptor	0.0092	0.1039	0.3624
Echinococcus granulosus	nuclear receptor nhr 48	0.0092	0.1039	0.1039
Schistosoma mansoni	nuclear receptor	0.0092	0.1039	0.1058
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0092	0.1039	0.3624
Loa Loa (eye worm)	nuclear hormone receptor	0.0092	0.1039	0.3624
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2741	0.9558
Plasmodium falciparum	acyl-CoA synthetase	0.0033	0.0069	0.5
Schistosoma mansoni	coup transcription factor	0.0195	0.2741	0.279
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0044	0.0255	0.0741
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0092	0.1039	0.3121
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0033	0.0069	0.0103
Schistosoma mansoni	retinoic acid receptor RXR	0.0195	0.2741	0.279
Brugia malayi	orphan nuclear receptor NR2E1	0.0092	0.1039	0.3624
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0242
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0195	0.2741	0.9558
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0058	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1221	0.426
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0195	0.2741	0.8231
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0195	0.2741	0.9558
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0058	0.0201
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0195	0.2741	0.9558
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0092	0.1039	0.1039
Brugia malayi	hypothetical protein	0.0092	0.1039	0.3624
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0092	0.1039	0.3121
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0255	0.089
Schistosoma mansoni	nuclear receptor nhr-48	0.0092	0.1039	0.1058
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0058	0.0201
Brugia malayi	nuclear receptor RXR	0.0092	0.1039	0.3624
Brugia malayi	nuclear receptor NHR-67	0.0092	0.1039	0.3624
Schistosoma mansoni	nuclear receptor	0.0092	0.1039	0.1058
Echinococcus multilocularis	nuclear receptor nhr 48	0.0092	0.1039	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Schistosoma mansoni	thyroid hormone receptor	0.0195	0.2741	0.279
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1221	0.426
Onchocerca volvulus	Protein ultraspiracle homolog	0.0195	0.2741	0.8231
Brugia malayi	Nuclear hormone receptor-like 1	0.0103	0.1221	0.426
Brugia malayi	nuclear receptor NHR-88	0.0092	0.1039	0.3624
Echinococcus multilocularis	FTZ F1 alpha	0.0195	0.2741	0.2741
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0058	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1221	0.426
Brugia malayi	nuclear hormone receptor	0.0092	0.1039	0.3624
Echinococcus granulosus	beta LACTamase domain containing family member	0.0032	0.0058	0.0058
Brugia malayi	beta-lactamase family protein	0.0032	0.0058	0.0201
Trichomonas vaginalis	set domain proteins, putative	0.023	0.333	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2741	0.9558
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0195	0.2741	0.279
Mycobacterium tuberculosis	Conserved protein	0.0032	0.0058	0.0062
Echinococcus granulosus	FTZ F1 alpha	0.0195	0.2741	0.2741
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0044	0.0255	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0092	0.1039	0.3624
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0195	0.2741	0.279
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0195	0.2741	0.9558
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0195	0.2741	0.9558
Entamoeba histolytica	acyl-coA synthetase, putative	0.0044	0.0255	0.5
Echinococcus granulosus	microtubule associated protein 2	0.0622	0.9824	0.9824
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Onchocerca volvulus		0.0044	0.0255	0.0766
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2741	0.9558
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0255	0.089
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0255	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0103	0.1221	0.1243
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0195	0.2741	0.2741
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0195	0.2741	0.9558
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0255	0.089
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0044	0.0255	0.0741
Brugia malayi	AMP-binding enzyme family protein	0.0044	0.0255	0.089
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0044	0.0255	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0195	0.2741	0.2741
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0242
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0195	0.2741	0.9558
Trypanosoma brucei	hypothetical protein, conserved	0.0032	0.0058	0.5
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0032	0.0058	0.0062
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0195	0.2741	0.2741
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1221	0.426
Brugia malayi	nuclear receptor NHR-88	0.0195	0.2741	0.9558
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0207	0.2955	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0092	0.1039	0.1058
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0032	0.0058	0.0062
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0033	0.0069	0.5
Brugia malayi	Steroid receptor seven-up type 2	0.0195	0.2741	0.9558
Schistosoma mansoni	nuclear hormone receptor	0.0092	0.1039	0.1058
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0195	0.2741	0.279
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0195	0.2741	0.2741
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0255	1
Brugia malayi	nuclear hormone receptor	0.0195	0.2741	0.9558
Onchocerca volvulus		0.0032	0.0058	0.0173
Onchocerca volvulus		0.0032	0.0058	0.0173
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0195	0.2741	0.9558
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0195	0.2741	0.9558
Leishmania major	4-coumarate:coa ligase-like protein	0.0044	0.0255	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0195	0.2741	0.279
Mycobacterium tuberculosis	Probable lipase LipE	0.0032	0.0058	0.0062
Schistosoma mansoni	nuclear hormone receptor	0.0092	0.1039	0.1058
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0044	0.0255	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0032	0.0058	0.0062
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0044	0.0255	1
Onchocerca volvulus		0.0093	0.1054	0.3165
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Brugia malayi	nuclear receptor RXR	0.0103	0.1221	0.426
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0103	0.1221	0.1221
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0255	0.089
Onchocerca volvulus	Bile acid receptor homolog	0.0195	0.2741	0.8231
Mycobacterium ulcerans	hypothetical protein	0.0044	0.0255	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0195	0.2741	0.9558
Onchocerca volvulus		0.0092	0.1039	0.3121
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0058	0.5
Brugia malayi	tailless protein	0.0092	0.1039	0.3624
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0092	0.1039	0.1058
Brugia malayi	beta-lactamase	0.0032	0.0058	0.0201
Brugia malayi	Nuclear hormone receptor E75	0.0092	0.1039	0.3624
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0044	0.0255	0.5
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0092	0.1039	0.1039
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0195	0.2741	0.2741
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0044	0.0255	0.5
Mycobacterium tuberculosis	Probable esterase LipL	0.0032	0.0058	0.0062
Echinococcus multilocularis	ecdysone induced protein 78C	0.0195	0.2741	0.2741
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0092	0.1039	0.3624
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0103	0.1221	0.1221
Schistosoma mansoni	zinc finger protein	0.0092	0.1039	0.1058
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0195	0.2741	0.279
Loa Loa (eye worm)	beta-lactamase	0.0032	0.0058	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0093	0.1054	0.3675
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0195	0.2741	0.9558
Schistosoma mansoni	nuclear hormone receptor	0.0195	0.2741	0.279
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0092	0.1039	0.1039
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0103	0.1221	0.1243
Mycobacterium tuberculosis	Conserved protein	0.0032	0.0058	0.0062
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0195	0.2741	0.2741
Onchocerca volvulus		0.023	0.333	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0195	0.2741	0.9558
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0195	0.2741	0.2741
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0195	0.2741	0.9558
Schistosoma mansoni	cellular tumor antigen P53	0.0093	0.1054	0.1073
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0195	0.2741	0.279
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0195	0.2741	0.9558
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0092	0.1039	0.3624
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0103	0.1221	0.426
Brugia malayi	photoreceptor-specific nuclear receptor	0.0195	0.2741	0.9558
Echinococcus granulosus	thyroid hormone receptor alpha	0.0092	0.1039	0.1039
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0032	0.0058	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0242
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0195	0.2741	0.2741
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0032	0.0058	0.0062
Loa Loa (eye worm)	DR-78	0.0092	0.1039	0.3624
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0255	0.089
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Schistosoma mansoni	thyroid hormone receptor	0.0195	0.2741	0.279
Brugia malayi	Nuclear hormone receptor-like 1	0.0103	0.1221	0.426
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.2867	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0058	0.0201
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0032	0.0058	0.0201
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0195	0.2741	0.9558
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0092	0.1039	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Brugia malayi	ecdysteroid receptor	0.0195	0.2741	0.9558
Trypanosoma cruzi	hypothetical protein, conserved	0.0032	0.0058	0.5
Brugia malayi	Nuclear hormone receptor-like 1	0.0195	0.2741	0.9558
Echinococcus granulosus	ecdysone induced protein 78C	0.0195	0.2741	0.2741
Mycobacterium ulcerans	acyl-CoA synthetase	0.0044	0.0255	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2741	0.9558
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2741	0.9558
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0242
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0195	0.2741	0.9558
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0058	0.0201
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0195	0.2741	0.2741
Onchocerca volvulus		0.0195	0.2741	0.8231
Leishmania major	4-coumarate:coa ligase-like protein	0.0044	0.0255	1
Mycobacterium tuberculosis	Probable hydrolase	0.0032	0.0058	0.0062
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0195	0.2741	0.2741
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Brugia malayi	conserved hypotetical protein	0.0092	0.1039	0.3624
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2741	0.9558
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0092	0.1039	0.1039
Loa Loa (eye worm)	hypothetical protein	0.0103	0.1221	0.426
Leishmania major	4-coumarate:coa ligase-like protein	0.0044	0.0255	1
Loa Loa (eye worm)	hypothetical protein	0.0195	0.2741	0.9558
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0058	0.0201
Brugia malayi	hypothetical protein	0.0103	0.1221	0.426
Brugia malayi	hypothetical protein	0.0092	0.1039	0.3624
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0032	0.0058	0.0201
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0195	0.2741	0.2741
Schistosoma mansoni	microtubule-associated protein tau	0.0622	0.9824	1
Plasmodium vivax	hypothetical protein, conserved	0.0032	0.0058	0.8295
Brugia malayi	steroid hormone receptor	0.0195	0.2741	0.9558
Brugia malayi	Pre-SET motif family protein	0.0202	0.2867	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0195	0.2741	0.2741
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0195	0.2741	0.9558
Brugia malayi	hypothetical protein	0.0103	0.1221	0.426
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0044	0.0255	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0032	0.0058	0.0059
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0195	0.2741	0.9558
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0092	0.1039	0.1039
Loa Loa (eye worm)	steroid hormone receptor	0.0195	0.2741	0.9558
Loa Loa (eye worm)	hypothetical protein	0.0092	0.1039	0.3624
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0069	0.0242
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0033	0.0069	0.0598
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0092	0.1039	0.1039
Brugia malayi	beta-lactamase family protein	0.0032	0.0058	0.0201
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0195	0.2741	0.9558
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0195	0.2741	0.2741
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0092	0.1039	0.3624

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 20 %	Inhibition of bovine plasma thrombin using Boc-Val-Pro-Arg-AMC as substrate at 25 uM preincubated for 15 mins measured after 10 mins by fluorimetric assay	ChEMBL.	22077389

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1958107

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1616736