Detailed information for compound 1616743

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 253.22 | Formula: C13H10F3NO
  • H donors: 0 H acceptors: 1 LogP: 2.32 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1ccc(cn1Cc1ccccc1)C(F)(F)F
  • InChi: 1S/C13H10F3NO/c14-13(15,16)11-6-7-12(18)17(9-11)8-10-4-2-1-3-5-10/h1-7,9H,8H2
  • InChiKey: VROJCTCWSMQLSE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0169 0.2198 0.2167
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0507 0.0923
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0359 0.5108 0.5089
Loa Loa (eye worm) hypothetical protein 0.0034 0.0121 0.016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0297 0.7608
Schistosoma mansoni coup transcription factor 0.0359 0.5108 0.5089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.0011
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0361 0.0323
Brugia malayi nuclear receptor NHR-67 0.0169 0.2198 0.4259
Trichomonas vaginalis set domain proteins, putative 0.0232 0.317 0.5
Loa Loa (eye worm) hypothetical protein 0.0359 0.5108 1
Plasmodium vivax SET domain protein, putative 0.0029 0.005 0.0659
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0743 0.0707
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0132 0.0093
Schistosoma mansoni hypothetical protein 0.0031 0.0072 0.0033
Echinococcus granulosus FTZ F1 alpha 0.0359 0.5108 0.5092
Brugia malayi Nuclear hormone receptor E75 0.0169 0.2198 0.4259
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0169 0.2198 0.2167
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Echinococcus multilocularis ecdysone induced protein 78C 0.0359 0.5108 0.5089
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0297 0.275
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.004 0.052
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0359 0.5108 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0169 0.2198 0.4259
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0045 0.0297 0.3899
Schistosoma mansoni hypothetical protein 0.0031 0.0072 0.0033
Plasmodium falciparum phd finger protein, putative 0.0029 0.004 0.052
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0359 0.5108 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0169 0.2198 0.4259
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0045 0.0297 0.7608
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0169 0.2198 0.2167
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.005 0.0011
Brugia malayi orphan nuclear receptor NR2E1 0.0169 0.2198 0.4259
Mycobacterium ulcerans hypothetical protein 0.0045 0.0297 0.275
Brugia malayi steroid hormone receptor 0.0359 0.5108 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0045 0.0297 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0359 0.5108 0.5089
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0045 0.0297 0.275
Brugia malayi hypothetical protein 0.0169 0.2198 0.4259
Loa Loa (eye worm) steroid hormone receptor 0.0359 0.5108 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.0121 0.1584
Onchocerca volvulus 0.0232 0.317 0.6176
Loa Loa (eye worm) hypothetical protein 0.0034 0.0121 0.016
Loa Loa (eye worm) hypothetical protein 0.0359 0.5108 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0761 0.0724
Brugia malayi Steroid receptor seven-up type 2 0.0359 0.5108 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0359 0.5108 0.5092
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.2737 0.5321
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0045 0.0297 0.275
Loa Loa (eye worm) hypothetical protein 0.0076 0.0761 0.1423
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0761 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.1091 0.2075
Echinococcus granulosus Nuclear hormone receptor HR96 0.0169 0.2198 0.2172
Loa Loa (eye worm) DR-78 0.0169 0.2198 0.4259
Echinococcus granulosus thyroid hormone receptor alpha 0.0169 0.2198 0.2172
Brugia malayi Nuclear hormone receptor-like 1 0.0189 0.251 0.4874
Loa Loa (eye worm) hypothetical protein 0.0189 0.251 0.4874
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0359 0.5108 1
Brugia malayi conserved hypotetical protein 0.0169 0.2198 0.4259
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Schistosoma mansoni nuclear receptor 0.0169 0.2198 0.2167
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0359 0.5108 0.5092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0072 0.0033
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.0121 0.1057
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Schistosoma mansoni retinoic acid receptor RXR 0.0359 0.5108 0.5089
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0169 0.2198 0.2167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0359 0.5108 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0189 0.251 0.248
Echinococcus granulosus Nuclear hormone receptor HR96 0.0169 0.2198 0.2172
Loa Loa (eye worm) hypothetical protein 0.0066 0.0619 0.1144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0359 0.5108 1
Brugia malayi ecdysone receptor 0.0169 0.2198 0.4259
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0761 0.0724
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0359 0.5108 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0361 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0045 0.0297 0.5
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0361 0.0328
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0361 0.4744
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0761 0.5
Brugia malayi hypothetical protein 0.0189 0.251 0.4874
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0072 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0359 0.5108 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0142 0.0103
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0189 0.251 0.2485
Giardia lamblia PHD finger protein 15 0.0029 0.004 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0359 0.5108 0.5089
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0359 0.5108 0.5092
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0169 0.2198 0.4259
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.005 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0359 0.5108 0.5092
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0169 0.2198 0.2167
Brugia malayi photoreceptor-specific nuclear receptor 0.0359 0.5108 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.005 0.0011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0761 1
Schistosoma mansoni hypothetical protein 0.0066 0.0619 0.0582
Onchocerca volvulus Bile acid receptor homolog 0.0359 0.5108 1
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0361 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0189 0.251 0.4874
Brugia malayi hypothetical protein 0.0169 0.2198 0.4259
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0189 0.251 0.248
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Brugia malayi jmjC domain containing protein 0.0094 0.1039 0.1972
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.004 0.052
Entamoeba histolytica acyl-CoA synthetase, putative 0.0045 0.0297 1
Loa Loa (eye worm) hypothetical protein 0.0359 0.5108 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0169 0.2198 0.4259
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.004 0.0006
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.0121 0.1584
Loa Loa (eye worm) hypothetical protein 0.0359 0.5108 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0169 0.2198 0.2167
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0212 0.0173
Brugia malayi Probable ClpP-like protease 0.0076 0.0761 0.1423
Loa Loa (eye worm) hypothetical protein 0.0097 0.1091 0.2075
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0359 0.5108 1
Brugia malayi ecdysteroid receptor 0.0359 0.5108 1
Schistosoma mansoni nuclear hormone receptor 0.0359 0.5108 0.5089
Loa Loa (eye worm) hypothetical protein 0.0359 0.5108 1
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.0132 0.0099
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0761 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0169 0.2198 0.2172
Schistosoma mansoni hypothetical protein 0.0031 0.0072 0.0033
Schistosoma mansoni nuclear hormone receptor 0.0169 0.2198 0.2167
Brugia malayi nuclear hormone receptor family member nhr-6 0.0169 0.2198 0.4259
Loa Loa (eye worm) hypothetical protein 0.0045 0.0297 0.0507
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0359 0.5108 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0169 0.2198 0.2172
Schistosoma mansoni hypothetical protein 0.0035 0.0142 0.0103
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0359 0.5108 0.5089
Echinococcus granulosus jumonji domain containing protein 0.004 0.0212 0.0179
Onchocerca volvulus Protein ultraspiracle homolog 0.0359 0.5108 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0169 0.2198 0.2167
Loa Loa (eye worm) hypothetical protein 0.0029 0.005 0.0021
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0761 0.073
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0359 0.5108 0.5089
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0142 0.0109
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0359 0.5108 0.5089
Loa Loa (eye worm) hypothetical protein 0.0359 0.5108 1
Brugia malayi Pre-SET motif family protein 0.0204 0.2737 0.5321
Leishmania major 4-coumarate:coa ligase-like protein 0.0045 0.0297 0.5
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.005 0.0017
Brugia malayi hypothetical protein 0.0189 0.251 0.4874
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0761 1
Loa Loa (eye worm) hypothetical protein 0.0189 0.251 0.4874
Echinococcus multilocularis FTZ F1 alpha 0.0359 0.5108 0.5089
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0072 0.0064
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0169 0.2198 0.4259
Echinococcus granulosus peregrin 0.0029 0.004 0.0006
Schistosoma mansoni nuclear hormone receptor 0.0169 0.2198 0.2167
Brugia malayi nuclear receptor RXR 0.0169 0.2198 0.4259
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0359 0.5108 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0132 0.0182
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0072 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.1091 0.2075
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0297 0.0507
Schistosoma mansoni thyroid hormone receptor 0.0359 0.5108 0.5089
Loa Loa (eye worm) hypothetical protein 0.0049 0.0353 0.0619
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0761 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0121 0.016
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0169 0.2198 0.4259
Schistosoma mansoni RAR-like nuclear receptor 0.0359 0.5108 0.5089
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0072 0.0039
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Schistosoma mansoni hypothetical protein 0.0031 0.0072 0.0033
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0359 0.5108 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.1091 0.2075
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0359 0.5108 0.5089
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0132 0.0093
Brugia malayi Pre-SET motif family protein 0.0029 0.005 0.0021
Loa Loa (eye worm) hypothetical protein 0.0189 0.251 0.4874
Schistosoma mansoni thyroid hormone receptor 0.0359 0.5108 0.5089
Leishmania major 4-coumarate:coa ligase-like protein 0.0045 0.0297 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0169 0.2198 0.2167
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0072 0.0033
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0297 0.275
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0045 0.0297 0.275
Echinococcus granulosus ecdysone induced protein 78C 0.0359 0.5108 0.5092
Plasmodium vivax hypothetical protein, conserved 0.0029 0.004 0.052
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0761 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0359 0.5108 1
Brugia malayi nuclear hormone receptor 0.0169 0.2198 0.4259
Onchocerca volvulus 0.0169 0.2198 0.4259
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0297 0.0507
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0359 0.5108 0.5092
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0761 1
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0297 0.0507
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0359 0.5108 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0359 0.5108 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0359 0.5108 1
Brugia malayi hypothetical protein 0.0035 0.0142 0.0203
Brugia malayi nuclear receptor NHR-88 0.0359 0.5108 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0359 0.5108 0.5089
Onchocerca volvulus 0.0029 0.005 0.0021
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0761 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0359 0.5108 0.5092
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0761 1
Brugia malayi Nuclear hormone receptor-like 1 0.0359 0.5108 1
Loa Loa (eye worm) hypothetical protein 0.0359 0.5108 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0359 0.5108 0.5089
Brugia malayi nuclear hormone receptor 0.0359 0.5108 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0359 0.5108 0.5092
Loa Loa (eye worm) hypothetical protein 0.0034 0.0121 0.016
Loa Loa (eye worm) hypothetical protein 0.0189 0.251 0.4874
Echinococcus granulosus nuclear receptor nhr 48 0.0169 0.2198 0.2172
Echinococcus multilocularis GPCR, family 2 0.0031 0.0072 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.0011
Onchocerca volvulus 0.0045 0.0297 0.0507
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0045 0.0297 0.275
Schistosoma mansoni zinc finger protein 0.0169 0.2198 0.2167
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0761 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1039 0.1004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0359 0.5108 0.5089
Onchocerca volvulus 0.0169 0.2198 0.4259
Entamoeba histolytica acyl-CoA synthetase, putative 0.0045 0.0297 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.005 0.0659
Loa Loa (eye worm) nuclear hormone receptor 0.0169 0.2198 0.4259
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0189 0.251 0.248
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0142 0.0103
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Schistosoma mansoni nuclear receptor 0.0169 0.2198 0.2167
Brugia malayi jmjC domain containing protein 0.0035 0.0132 0.0182
Brugia malayi tailless protein 0.0169 0.2198 0.4259
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0619 0.1144
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0359 0.5108 1
Onchocerca volvulus 0.0359 0.5108 1
Brugia malayi Nuclear hormone receptor-like 1 0.0189 0.251 0.4874
Schistosoma mansoni nuclear receptor nhr-48 0.0169 0.2198 0.2167
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0359 0.5108 1
Loa Loa (eye worm) hypothetical protein 0.0359 0.5108 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0121 0.016
Loa Loa (eye worm) hypothetical protein 0.0189 0.251 0.4874
Loa Loa (eye worm) hypothetical protein 0.0045 0.0297 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0359 0.5108 1
Echinococcus granulosus GPCR family 2 0.0031 0.0072 0.0039
Brugia malayi nuclear receptor RXR 0.0189 0.251 0.4874
Loa Loa (eye worm) hypothetical protein 0.0045 0.0297 0.0507
Brugia malayi Nuclear hormone receptor E75 0.0169 0.2198 0.4259
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0297 0.275
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0359 0.5108 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0359 0.5108 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0072 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.005 0.0011
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1039 0.1009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.0132 0.0093
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0359 0.5108 0.5089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0072 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0359 0.5108 0.5089
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0359 0.5108 0.5089
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Loa Loa (eye worm) hypothetical protein 0.0169 0.2198 0.4259
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0359 0.5108 0.5089
Brugia malayi nuclear receptor NHR-88 0.0169 0.2198 0.4259
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0359 0.5108 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0045 0.0297 0.3899

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.71 mM Anti-fibrosis activity in mouse NIH/3T3 cells assessed as inhibition of proliferation after 72 hrs by MTT assay ChEMBL. 22342629

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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