Detailed information for compound 1616745

Basic information

Technical information
  • TDR Targets ID: 1616745
  • Name: (5Z)-5-(furan-2-ylmethylidene)-2-sulfanyliden e-1,3-thiazolidin-4-one
  • MW: 211.261 | Formula: C8H5NO2S2
  • H donors: 1 H acceptors: 1 LogP: 1.9 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: S=C1NC(=O)/C(=C/c2ccco2)/S1
  • InChi: 1S/C8H5NO2S2/c10-7-6(13-8(12)9-7)4-5-2-1-3-11-5/h1-4H,(H,9,10,12)/b6-4-
  • InChiKey: ISSUVJNRFWFRIV-XQRVVYSFSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-(furan-2-ylmethylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
  • 5-(2-furylmethylene)-2-thioxo-thiazolidin-4-one
  • (5Z)-5-(2-furylmethylene)-2-thioxo-thiazolidin-4-one
  • 5-(2-furylmethylene)-2-thioxo-4-thiazolidinone
  • (5Z)-5-(2-furylmethylene)-2-thioxo-4-thiazolidinone
  • 4703-96-2
  • BAS 15425094
  • 5-(2-Furylmethylene)-2-thioxo-1,3-thiazolidin-4-one
  • AIDS-124437
  • AIDS124437
  • NCI60_002691
  • 5-[1-Furan-2-yl-meth-(Z)-ylidene]-2-thioxo-thiazolidin-4-one
  • NSC 31192
  • ZINC01083116
  • 6W-0219

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0143 0.133 0.1337
Brugia malayi conserved hypotetical protein 0.0143 0.133 0.138
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Brugia malayi tailless protein 0.0143 0.133 0.138
Onchocerca volvulus 0.0143 0.133 0.4125
Loa Loa (eye worm) hypothetical protein 0.0302 0.3225 0.3241
Loa Loa (eye worm) hypothetical protein 0.0302 0.3225 0.3241
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0302 0.3225 0.3241
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0143 0.133 0.133
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0143 0.133 0.133
Loa Loa (eye worm) raf kinase 0.0869 0.9949 1
Schistosoma mansoni thyroid hormone receptor 0.0302 0.3225 0.3225
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0032 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0302 0.3225 0.3241
Schistosoma mansoni nuclear hormone receptor 0.0143 0.133 0.133
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0143 0.133 0.133
Schistosoma mansoni RAR-like nuclear receptor 0.0302 0.3225 0.3225
Loa Loa (eye worm) DR-78 0.0143 0.133 0.1337
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Echinococcus granulosus Nuclear hormone receptor HR96 0.0143 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Echinococcus granulosus protein kinase c epsilon type 0.0032 0.0023 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0143 0.133 0.133
Brugia malayi nuclear hormone receptor 0.0302 0.3225 0.3346
Echinococcus multilocularis FTZ F1 alpha 0.0302 0.3225 0.3225
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0302 0.3225 0.3346
Brugia malayi orphan nuclear receptor NR2E1 0.0143 0.133 0.138
Brugia malayi hypothetical protein 0.0143 0.133 0.138
Brugia malayi nuclear hormone receptor family member odr-7 0.0143 0.133 0.138
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0302 0.3225 0.3225
Brugia malayi protein kinase C II. 0.0032 0.0023 0.0024
Brugia malayi nuclear receptor RXR 0.016 0.1533 0.1591
Brugia malayi Nuclear hormone receptor-like 1 0.016 0.1533 0.1591
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0302 0.3225 0.3346
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0023 0.0023
Schistosoma mansoni coup transcription factor 0.0302 0.3225 0.3225
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0143 0.133 0.133
Schistosoma mansoni protein kinase C mu 0.0032 0.0023 0.0023
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0302 0.3225 0.3241
Brugia malayi Protein kinase domain containing protein 0.0032 0.0023 0.0024
Echinococcus granulosus protein kinase c iota type 0.0032 0.0023 0.0023
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0302 0.3225 0.3241
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0495 0.5513 0.5541
Schistosoma mansoni nuclear receptor 0.0143 0.133 0.133
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0023 0.0023
Brugia malayi photoreceptor-specific nuclear receptor 0.0302 0.3225 0.3346
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0023 0.0023
Onchocerca volvulus 0.0302 0.3225 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0032 0.0023 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0302 0.3225 0.3346
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.016 0.1533 0.1533
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0302 0.3225 0.3346
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Loa Loa (eye worm) hypothetical protein 0.0302 0.3225 0.3241
Echinococcus multilocularis protein kinase c iota type 0.0032 0.0023 0.0023
Trichomonas vaginalis STE family protein kinase 0.0308 0.3297 0.5
Brugia malayi hypothetical protein 0.0143 0.133 0.138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0302 0.3225 0.3241
Schistosoma mansoni retinoic acid receptor RXR 0.0302 0.3225 0.3225
Trichomonas vaginalis STE family protein kinase 0.0308 0.3297 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0302 0.3225 0.3225
Schistosoma mansoni zinc finger protein 0.0143 0.133 0.133
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0143 0.133 0.4125
Brugia malayi ecdysone receptor 0.0143 0.133 0.138
Schistosoma mansoni nuclear receptor 0.0143 0.133 0.133
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0302 0.3225 0.3225
Onchocerca volvulus Bile acid receptor homolog 0.0302 0.3225 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0302 0.3225 0.3225
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0302 0.3225 0.3225
Onchocerca volvulus Protein ultraspiracle homolog 0.0302 0.3225 1
Schistosoma mansoni nuclear receptor nhr-48 0.0143 0.133 0.133
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0023 0.0023
Brugia malayi Nuclear hormone receptor-like 1 0.016 0.1533 0.1591
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0143 0.133 0.133
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.016 0.1533 0.1541
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0302 0.3225 0.3225
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0032 0.0023 0.0023
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0143 0.133 0.133
Schistosoma mansoni protein kinase 0.0308 0.3297 0.3297
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0302 0.3225 0.3225
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0302 0.3225 0.3346
Onchocerca volvulus 0.0143 0.133 0.4125
Brugia malayi Protein kinase c protein 2 0.0032 0.0023 0.0024
Schistosoma mansoni steroid hormone receptor ad4bp 0.0302 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0302 0.3225 0.3241
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0032 0.0023 0.0023
Schistosoma mansoni nuclear hormone receptor 0.0302 0.3225 0.3225
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0302 0.3225 0.3225
Brugia malayi nuclear receptor RXR 0.0143 0.133 0.138
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0302 0.3225 0.3346
Brugia malayi steroid hormone receptor 0.0302 0.3225 0.3346
Giardia lamblia Kinase, STE STE20 0.0308 0.3297 0.5
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0308 0.3297 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0302 0.3225 0.3241
Loa Loa (eye worm) hypothetical protein 0.016 0.1533 0.1541
Echinococcus multilocularis ecdysone induced protein 78C 0.0302 0.3225 0.3225
Schistosoma mansoni nuclear hormone receptor 0.0143 0.133 0.133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0302 0.3225 0.3241
Brugia malayi nuclear hormone receptor family member nhr-6 0.0143 0.133 0.138
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0032 0.0023 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0302 0.3225 0.3225
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0302 0.3225 0.3241
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Brugia malayi Steroid receptor seven-up type 2 0.0302 0.3225 0.3346
Echinococcus granulosus nuclear receptor nhr 48 0.0143 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.016 0.1533 0.1541
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0302 0.3225 0.3346
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0143 0.133 0.133
Brugia malayi nuclear receptor NHR-67 0.0143 0.133 0.138
Echinococcus multilocularis nuclear receptor nhr 48 0.0143 0.133 0.133
Loa Loa (eye worm) nuclear hormone receptor 0.0143 0.133 0.1337
Echinococcus multilocularis protein kinase c epsilon type 0.0032 0.0023 0.0023
Echinococcus granulosus Protein kinase C brain isozyme 0.0032 0.0023 0.0023
Brugia malayi hypothetical protein 0.016 0.1533 0.1591
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0302 0.3225 1
Brugia malayi C1-like domain containing protein 0.0032 0.0023 0.0024
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Loa Loa (eye worm) steroid hormone receptor 0.0302 0.3225 0.3241
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0302 0.3225 0.3225
Echinococcus granulosus thyroid hormone receptor alpha 0.0143 0.133 0.133
Loa Loa (eye worm) nuclear receptor NHR-67 0.0143 0.133 0.1337
Brugia malayi Nuclear hormone receptor E75 0.0143 0.133 0.138
Echinococcus granulosus dual specificity mitogen activated protein 0.0308 0.3297 0.3297
Loa Loa (eye worm) hypothetical protein 0.016 0.1533 0.1541
Brugia malayi Nuclear hormone receptor E75 0.0143 0.133 0.138
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0302 0.3225 0.3346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0302 0.3225 0.3241
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.016 0.1533 0.1533
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0302 0.3225 0.3225
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0302 0.3225 0.3346
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0302 0.3225 0.3225
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0302 0.3225 0.3346
Loa Loa (eye worm) hypothetical protein 0.016 0.1533 0.1541
Brugia malayi hypothetical protein 0.016 0.1533 0.1591
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0302 0.3225 0.3225
Trichomonas vaginalis STE family protein kinase 0.0308 0.3297 0.5
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0308 0.3297 0.3421
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0143 0.133 0.138
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0308 0.3297 0.5
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0143 0.133 0.4125
Brugia malayi ecdysteroid receptor 0.0302 0.3225 0.3346
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Echinococcus granulosus ecdysone induced protein 78C 0.0302 0.3225 0.3225
Echinococcus multilocularis dual specificity mitogen activated protein 0.0308 0.3297 0.3297
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0302 0.3225 0.3346
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0302 0.3225 0.3346
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0302 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0302 0.3225 0.3241
Schistosoma mansoni thyroid hormone receptor 0.0302 0.3225 0.3225
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0302 0.3225 0.3225
Schistosoma mansoni atypical protein kinase C 0.0032 0.0023 0.0023
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0302 0.3225 0.3225
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Loa Loa (eye worm) hypothetical protein 0.0302 0.3225 0.3241
Echinococcus granulosus Nuclear hormone receptor HR96 0.0143 0.133 0.133
Brugia malayi nuclear receptor NHR-88 0.0143 0.133 0.138
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0032 0.0023 0.0023
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.016 0.1533 0.1533
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0308 0.3297 0.5
Brugia malayi nuclear hormone receptor 0.0143 0.133 0.138
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0143 0.133 0.133
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0302 0.3225 0.3346
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0302 0.3225 0.3225
Brugia malayi Nuclear hormone receptor-like 1 0.0302 0.3225 0.3346
Schistosoma mansoni retinoid-x-receptor (RXR) 0.016 0.1533 0.1533
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0302 0.3225 0.3225
Brugia malayi protein kinase C3,putative 0.0032 0.0023 0.0024
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0308 0.3297 0.3314
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0302 0.3225 0.3225
Brugia malayi nuclear receptor NHR-88 0.0302 0.3225 0.3346
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0032 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0143 0.133 0.1337
Loa Loa (eye worm) hypothetical protein 0.016 0.1533 0.1541
Echinococcus granulosus FTZ F1 alpha 0.0302 0.3225 0.3225
Echinococcus multilocularis thyroid hormone receptor alpha 0.0302 0.3225 0.3225
Brugia malayi Raf kinase 0.0843 0.9639 1

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antibacterial activity against Escherichia coli K-12 ChEMBL. 22444680
Inhibition (binding) = 25 % Inhibition of bovine plasma thrombin using Boc-Val-Pro-Arg-AMC as substrate at 25 uM preincubated for 15 mins measured after 10 mins by fluorimetric assay ChEMBL. 22077389

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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