TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 398.381 | Formula: C21H17F3N4O
H donors: 3 H acceptors: 3 LogP: 5.07 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)c1[nH]c2c(c1)c(ncn2)NC(c1ccc(cc1)C(F)(F)F)C
InChi: 1S/C21H17F3N4O/c1-12(13-2-6-15(7-3-13)21(22,23)24)27-19-17-10-18(28-20(17)26-11-25-19)14-4-8-16(29)9-5-14/h2-12,29H,1H3,(H2,25,26,27,28)
InChiKey: SLTFOBNOJWROLI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0011	0.5757
Onchocerca volvulus		0.0046	0.0021	0.3651
Wolbachia endosymbiont of Brugia malayi	branched-chain alpha-keto acid dehydrogenase subunit E2	0.0435	0.0335	0.0778
Wolbachia endosymbiont of Brugia malayi	Acetyl-CoA carboxylase, carboxyltransferase component	0.1683	0.1341	0.3457
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0009	0.444
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0034	0.0011	0.5757
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0048	0.0023	0.0054
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0042	0.0018	0.0094
Chlamydia trachomatis	dihydrolipoamide succinyltransferase	0.0435	0.0335	0.0858
Onchocerca volvulus		0.0088	0.0055	1
Trypanosoma brucei	glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative	0.1069	0.0846	0.0846
Echinococcus granulosus	propionyl coenzyme A carboxylase beta chain	0.1683	0.1341	0.1332
Leishmania major	propionyl-coa carboxylase beta chain, putative	0.1683	0.1341	0.134
Echinococcus granulosus	dihydrolipoyllysine residue acetyltransferase	0.0435	0.0335	0.0324
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.4731	0.3799	0.3792
Plasmodium falciparum	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex	0.0435	0.0335	0.0457
Toxoplasma gondii	acyl-CoA carboxyltransferase beta chain, putative	0.1683	0.1341	0.1338
Toxoplasma gondii	dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase	0.0435	0.0335	0.0331
Trypanosoma brucei	glucosidase, putative	0.0034	0.0011	0.0011
Trypanosoma cruzi	acetyl-CoA carboxylase	0.7689	0.6185	1
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0031	0.0009	0.0005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0018	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E2	0.0435	0.0335	0.0331
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0002	0.0018
Leishmania major	carboxylase, putative	0.4731	0.3799	0.3798
Mycobacterium ulcerans	bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3	0.4731	0.3799	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0004	0.1138
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0034	0.0011	0.0055
Mycobacterium ulcerans	branched-chain alpha-keto acid dehydrogenase subunit E2	0.0435	0.0335	0.0877
Echinococcus multilocularis	dihydrolipoyllysine residue acetyltransferase	0.0435	0.0335	0.0324
Plasmodium falciparum	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex	0.0435	0.0335	0.0457
Mycobacterium tuberculosis	Probable branched-chain keto acid dehydrogenase E2 component BkdC	0.0435	0.0335	0.0877
Chlamydia trachomatis	acetyl-coenzyme A carboxylase carboxyl transferase subunit beta	0.1683	0.1341	0.3813
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0042	0.0018	0.0011
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0152	0.0106	0.0108
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.0034	0.0011	0.001
Schistosoma mansoni	propionyl-CoA carboxylase beta chain mitochondrial precursor	0.1683	0.1341	0.1332
Schistosoma mansoni	microtubule-associated protein tau	0.0643	0.0502	0.0492
Leishmania major	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative	0.0435	0.0335	0.0333
Loa Loa (eye worm)	hypothetical protein	0.0435	0.0335	0.0345
Treponema pallidum	pyruvate carboxylase subunit B	0.0435	0.0335	1
Mycobacterium leprae	Probable biotinylated protein homolog TB7.3	0.0435	0.0335	0.0877
Loa Loa (eye worm)	MH2 domain-containing protein	0.0111	0.0074	0.0074
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0048	0.0023	0.0054
Loa Loa (eye worm)	phosphatidylinositol 3	0.0042	0.0018	0.0017
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0034	0.0011	0.001
Mycobacterium tuberculosis	Probable pyruvate carboxylase Pca (pyruvic carboxylase)	0.4731	0.3799	1
Chlamydia trachomatis	dihydrolipoamide succinyltransferase	0.0435	0.0335	0.0858
Leishmania major	carbamoyl-phosphate synthase, putative	0.1069	0.0846	0.0845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0011	0.556
Brugia malayi	MH2 domain containing protein	0.0111	0.0074	0.0074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0004	0.1138
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.4731	0.3799	0.6136
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0073	0.0043	0.0108
Trypanosoma cruzi	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative	0.0435	0.0335	0.0525
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0004	0.1267
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.0034	0.0011	0.5757
Brugia malayi	dihydrolipoamide S-acetyltransferase precursor, putative	0.0435	0.0335	0.0345
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0018	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0011	0.556
Trypanosoma brucei	pyruvate dehydrogenase complex E3 binding protein, putative	0.0435	0.0335	0.0335
Trypanosoma cruzi	dihydrolipoamide acetyltransferase precursor, putative	0.0435	0.0335	0.0525
Brugia malayi	Carboxyl transferase domain containing protein	1.1985	0.9649	1
Trypanosoma cruzi	glutamine dependent carbamoyl-phosphate synthase, putative	0.1069	0.0846	0.1353
Mycobacterium ulcerans	dihydrolipoamide acetyltransferase	0.0435	0.0335	0.0877
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0073	0.0043	0.0032
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0036	0.0013	0.6827
Mycobacterium tuberculosis	Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie	0.4731	0.3799	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.0034	0.0011	0.5757
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0048	0.0023	0.0054
Leishmania major	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.1683	0.1341	0.134
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2	0.4731	0.3799	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0009	0.444
Trypanosoma cruzi	dihydrolipoamide branched chain transacylase, putative	0.0435	0.0335	0.0525
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0009	0.444
Trypanosoma cruzi	3-methylcrotonyl-CoA carboxylase, putative	0.4731	0.3799	0.6136
Giardia lamblia	Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative	0.2118	0.1692	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0073	0.0043	0.0108
Plasmodium vivax	carbamoyl phosphate synthetase, putative	0.1069	0.0846	0.1165
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0002	0.0018
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0042	0.0018	0.0007
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0009	0.444
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0025	0.0004	0.0006
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0027	0.0006	0.2387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0009	0.444
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0152	0.0106	0.0095
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0011	0.556
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0073	0.0043	0.0039
Mycobacterium ulcerans	carbamoyl phosphate synthase large subunit	0.1069	0.0846	0.2224
Trypanosoma cruzi	2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative	0.0435	0.0335	0.0525
Schistosoma mansoni	methylcrotonyl-CoA carboxylase	0.4731	0.3799	0.3792
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.1683	0.1341	0.2155
Loa Loa (eye worm)	hypothetical protein	0.0435	0.0335	0.0345
Echinococcus multilocularis	propionyl coenzyme A carboxylase alpha chain	0.4731	0.3799	0.3792
Mycobacterium ulcerans	acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1	0.4731	0.3799	1
Echinococcus multilocularis	lysosomal alpha glucosidase	0.0152	0.0106	0.0095
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0011	0.556
Loa Loa (eye worm)	hypothetical protein	0.0435	0.0335	0.0345
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0042	0.0018	0.0018
Wolbachia endosymbiont of Brugia malayi	carbamoyl phosphate synthase large subunit	0.1069	0.0846	0.2139
Echinococcus granulosus	lysosomal alpha glucosidase	0.0152	0.0106	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0043	0.0042
Toxoplasma gondii	carbamoylphosphate synthetase	0.1069	0.0846	0.0842
Toxoplasma gondii	biotin-requiring enzyme domain-containing protein	0.0435	0.0335	0.0331
Plasmodium vivax	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.8988	0.7232	1
Mycobacterium tuberculosis	Biotinylated protein TB7.3	0.0435	0.0335	0.0877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0009	0.444
Brugia malayi	Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta	0.0435	0.0335	0.0345
Brugia malayi	Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor	0.0435	0.0335	0.0345
Loa Loa (eye worm)	carboxyl transferase domain-containing protein	1.1985	0.9649	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0042	0.0018	0.0016
Wolbachia endosymbiont of Brugia malayi	Acetyl/propionyl-CoA carboxylase, alpha subunit	0.4731	0.3799	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0073	0.0043	0.1165
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 5 AccD5	0.1683	0.1341	0.3527
Mycobacterium leprae	Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB	0.0435	0.0335	0.0877
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0073	0.0043	0.0032
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0033	0.0011	0.0009
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0011	0.5757
Toxoplasma gondii	pyruvate carboxylase	0.4731	0.3799	0.3797
Plasmodium falciparum	dihydrolipoamide acyltransferase component E2	0.0435	0.0335	0.0457
Trypanosoma cruzi	glutamine-dependent carbamoyl-phosphate synthetase, putative	0.1069	0.0846	0.1353
Trypanosoma brucei	dihydrolipoamide branched chain transacylase, putative	0.0435	0.0335	0.0335
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0011	0.5757
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.1069	0.0846	0.0836
Loa Loa (eye worm)	transcription factor SMAD2	0.0111	0.0074	0.0074
Mycobacterium ulcerans	acetyl-/propionyl-CoA carboxylase subunit beta	0.1683	0.1341	0.3527
Echinococcus multilocularis	propionyl coenzyme A carboxylase beta chain	0.1683	0.1341	0.1332
Toxoplasma gondii	dihydrolipoamide acyltransferase, putative	0.0435	0.0335	0.0331
Echinococcus granulosus	Biotin lipoyl attachment	0.0435	0.0335	0.0324
Echinococcus granulosus	dihydrolipoyllysine residue succinyltransferase	0.0435	0.0335	0.0324
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0048	0.0023	0.0011
Echinococcus multilocularis	microtubule associated protein 2	0.0643	0.0502	0.0492
Echinococcus granulosus	tumor protein p63	0.0315	0.0238	0.0227
Entamoeba histolytica	acetyl-coA carboxylase, putative	0.2118	0.1692	1
Trypanosoma cruzi	dihydrolipoamide branched chain transacylase, putative	0.0435	0.0335	0.0525
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide acyltransferase E2 component	0.0435	0.0335	0.0778
Trypanosoma brucei	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.1683	0.1341	0.1341
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4_2	0.1683	0.1341	0.3527
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0042	0.0018	0.0011
Mycobacterium ulcerans	hypothetical protein	0.0435	0.0335	0.0877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0031	0.0009	0.444
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0033	0.0011	0.0011
Mycobacterium ulcerans	pyruvate carboxylase	0.4731	0.3799	1
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0073	0.0043	0.0108
Mycobacterium leprae	Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase)	0.1683	0.1341	0.3527
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0042	0.0018	0.0007
Schistosoma mansoni	alpha-glucosidase	0.0131	0.0089	0.0078
Leishmania major	dihydrolipoamide branched chain transacylase, putative	0.0435	0.0335	0.0333
Schistosoma mansoni	carbamoyl-phosphate synthetase	0.1069	0.0846	0.0836
Echinococcus granulosus	microtubule associated protein 2	0.0643	0.0502	0.0492
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0073	0.0043	0.0053
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0011	0.5757
Schistosoma mansoni	dihydrolipoamide S-acetyltransferase	0.0435	0.0335	0.0324
Mycobacterium tuberculosis	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase)	0.1683	0.1341	0.3527
Echinococcus multilocularis	tumor protein p63	0.0315	0.0238	0.0227
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.4731	0.3799	0.3799
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0042	0.0018	0.0016
Mycobacterium leprae	Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE)	0.1683	0.1341	0.3527
Schistosoma mansoni	dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase	0.0435	0.0335	0.0324
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0042	0.0018	0.0018
Echinococcus multilocularis	dihydrolipoyllysine residue succinyltransferase	0.0435	0.0335	0.0324
Echinococcus multilocularis	Biotin lipoyl attachment	0.0435	0.0335	0.0324
Plasmodium falciparum	biotin carboxylase subunit of acetyl CoA carboxylase, putative	0.8988	0.7232	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0021	0.002
Leishmania major	alpha glucosidase II subunit, putative	0.0034	0.0011	0.0009
Echinococcus granulosus	peptidase Clp S14 family	0.0048	0.0023	0.0011
Toxoplasma gondii	glycosyl hydrolase, family 31 protein	0.0034	0.0011	0.0007
Trypanosoma brucei	3-methylcrotonyl-CoA carboxylase alpha subunit, putative	0.4731	0.3799	0.3799
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.0034	0.0011	0.0055
Chlamydia trachomatis	biotin carboxylase	0.4296	0.3448	1
Trypanosoma cruzi	dihydrolipoamide acetyltransferase, putative	0.0435	0.0335	0.0525
Plasmodium falciparum	carbamoyl phosphate synthetase	0.1069	0.0846	0.1165
Trypanosoma brucei	unspecified product	0.311	0.2492	0.2492
Mycobacterium tuberculosis	DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase	0.0435	0.0335	0.0877
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0004	0.1267
Plasmodium vivax	lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative	0.0435	0.0335	0.0457
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0042	0.0018	0.0017
Trypanosoma cruzi	3-methylcrotonoyl-CoA carboxylase beta subunit, putative	0.1683	0.1341	0.2155
Schistosoma mansoni	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase	0.0435	0.0335	0.0324
Echinococcus granulosus	propionyl coenzyme A carboxylase alpha chain	0.4731	0.3799	0.3792
Brugia malayi	Glycosyl hydrolases family 31 protein	0.0152	0.0106	0.0108
Trypanosoma cruzi	acetyl-CoA carboxylase, putative	0.1683	0.1341	0.2155
Mycobacterium ulcerans	acetyl/propionyl CoA carboxylase subunit beta	0.1683	0.1341	0.3527
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0011	0.556
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0073	0.0043	0.0039
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0042	0.0018	0.0094
Mycobacterium leprae	ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6	0.1683	0.1341	0.3527
Mycobacterium leprae	Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP)	0.4731	0.3799	1
Toxoplasma gondii	2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein	0.0435	0.0335	0.0331
Leishmania major	dihydrolipoamide acetyltransferase precursorlike protein	0.0435	0.0335	0.0333
Schistosoma mansoni	pyruvate carboxylase	0.4731	0.3799	0.3792
Chlamydia trachomatis	acetyl-CoA carboxylase biotin carboxyl carrier protein	0.0435	0.0335	0.0858
Schistosoma mansoni	aspartate carbamoyltransferase	0.1069	0.0846	0.0836
Trichomonas vaginalis	sucrase-isomaltase, putative	0.0034	0.0011	0.5757
Chlamydia trachomatis	dihydrolipoamide acetyltransferase	0.0435	0.0335	0.0858
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0042	0.0018	0.0007
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0073	0.0043	0.0053
Mycobacterium ulcerans	acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3	0.1683	0.1341	0.3527
Plasmodium vivax	dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative	0.0435	0.0335	0.0457
Mycobacterium tuberculosis	Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6	0.1683	0.1341	0.3527
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0042	0.0018	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.0034	0.0011	0.5757
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0002	0.0018
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0023	0.0002	0.0018
Trypanosoma brucei	2-oxoglutarate dehydrogenase E2 component, putative	0.0435	0.0335	0.0335
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0007	0.2856
Mycobacterium ulcerans	propionyl-CoA carboxylase beta chain 4 AccD4	0.1683	0.1341	0.3527
Trypanosoma cruzi	dihydrolipoamide acetyltransferase precursor, putative	0.0435	0.0335	0.0525
Schistosoma mansoni	peptidase Clp (S14 family)	0.0073	0.0043	0.0032
Trypanosoma brucei	dihydrolipoamide acetyltransferase E2 subunit, putative	0.0435	0.0335	0.0335
Leishmania major	dihydrolipoamide acetyltransferase precursor, putative	0.0435	0.0335	0.0333
Schistosoma mansoni	alpha-glucosidase	0.0131	0.0089	0.0078
Schistosoma mansoni	dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase	0.0435	0.0335	0.0324
Schistosoma mansoni	cellular tumor antigen P53	0.0046	0.0021	0.001
Leishmania major	methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein	0.4731	0.3799	0.3798
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0004	0.1267
Brugia malayi	Probable ClpP-like protease	0.0073	0.0043	0.0042

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1963197

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1617421