Detailed information for compound 1617440

Basic information

Technical information
  • TDR Targets ID: 1617440
  • Name: 3-(1-cyclopropylethylideneamino)oxypropanoic acid
  • MW: 171.194 | Formula: C8H13NO3
  • H donors: 1 H acceptors: 2 LogP: 0.48 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: C/C(=N/OCCC(=O)O)/C1CC1
  • InChi: 1S/C8H13NO3/c1-6(7-2-3-7)9-12-5-4-8(10)11/h7H,2-5H2,1H3,(H,10,11)/b9-6-
  • InChiKey: TVKWPRUURFJJGD-TWGQIWQCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(1-cyclopropylethylideneamino)oxypropionic acid
  • 3-(((1-Cyclopropylethylidene)amino)oxy)propanoic acid
  • AIDS-140159
  • AIDS140159
  • NSC651220

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.292 0.3787 1
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0453 0.0558 0.0561
Schistosoma mansoni neuropeptide F-like receptor 0.0453 0.0558 0.0558
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.066 0.0829 0.0529
Echinococcus multilocularis rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Schistosoma mansoni neuropeptide receptor 0.0453 0.0558 0.0558
Echinococcus granulosus roundabout 2 0.0064 0.0048 0.0045
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0453 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1039 0.1325 0.172
Echinococcus granulosus glycine receptor subunit alpha 1 0.0061 0.0044 0.0041
Brugia malayi neuropeptide F receptor 0.0453 0.0558 0.0561
Loa Loa (eye worm) hypothetical protein 0.0055 0.0036 0.002
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0453 0.0558 0.0558
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.1039 0.1325 0.2905
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0061 0.0044 0.0041
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0453 0.0558 0.0561
Chlamydia trachomatis biotin carboxylase 0.2651 0.3436 1
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0061 0.0044 0.0044
Echinococcus granulosus dro:myosuppressin receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0453 0.0558 0.0561
Echinococcus multilocularis fmrfamide receptor 0.0453 0.0558 0.0555
Echinococcus granulosus hypothetical protein 0.0453 0.0558 0.0555
Loa Loa (eye worm) neuropeptide F receptor 0.0453 0.0558 0.0561
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.292 0.3787 0.3584
Schistosoma mansoni alpha-1 adrenergic receptor 0.0453 0.0558 0.0558
Echinococcus granulosus Immunoglobulin 0.004 0.0017 0.0015
Schistosoma mansoni vesicular amine transporter 0.004 0.0017 0.0017
Echinococcus multilocularis neuropeptide receptor 0.0453 0.0558 0.0555
Brugia malayi RE15519p 0.0453 0.0558 0.0561
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis neuropeptide Y receptor 0.0453 0.0558 0.0555
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.1039 0.1325 0.1325
Schistosoma mansoni amine GPCR 0.0453 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0064 0.0048 0.0032
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.292 0.3787 0.5922
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.292 0.3787 1
Schistosoma mansoni carbamoyl-phosphate synthetase 0.066 0.0829 0.0829
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi sulfakinin receptor protein 0.0453 0.0558 0.0561
Schistosoma mansoni hypothetical protein 0.0453 0.0558 0.0558
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0453 0.0558 0.0555
Echinococcus multilocularis neuropeptide Y receptor 0.0453 0.0558 0.0555
Echinococcus granulosus ankyrin repeat protein 0.0161 0.0175 0.0172
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0453 0.0558 0.0555
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.1039 0.1325 0.1041
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0453 0.0558 0.0561
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis Immunoglobulin 0.004 0.0017 0.0015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Brugia malayi Dopamine receptor 0.0453 0.0558 0.0561
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.1039 0.1325 0.2905
Loa Loa (eye worm) neuropeptide F receptor 0.0453 0.0558 0.0561
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.066 0.0829 0.1476
Echinococcus multilocularis geminin 0.0193 0.0217 0.0214
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0453 0.0558 0.0561
Loa Loa (eye worm) TYRA-2 protein 0.0453 0.0558 0.0561
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis g protein coupled receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.1039 0.1325 0.3233
Treponema pallidum pyruvate carboxylase subunit B 0.0268 0.0316 0.5
Echinococcus granulosus neuropeptide receptor 0.0453 0.0558 0.0555
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.1039 0.1325 0.2905
Echinococcus granulosus alpha 1A adrenergic receptor 0.0453 0.0558 0.0555
Schistosoma mansoni hypothetical protein 0.0193 0.0217 0.0217
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0053 0.0034 0.0032
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0268 0.0316 0.0316
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.004 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi putative neuropeptide receptor NPR1 0.0453 0.0558 0.0561
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.5547 0.7227 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0453 0.0558 0.0558
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0654 0.082 0.0834
Leishmania major propionyl-coa carboxylase beta chain, putative 0.1039 0.1325 0.1041
Echinococcus multilocularis basement membrane specific heparan sulfate 0.004 0.0017 0.0015
Echinococcus granulosus g protein coupled receptor 0.0453 0.0558 0.0555
Echinococcus multilocularis neuropeptide receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0453 0.0558 0.0555
Echinococcus multilocularis fmrfamide receptor 0.0453 0.0558 0.0555
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.5547 0.7227 1
Echinococcus multilocularis transient receptor potential cation channel 0.0161 0.0175 0.0173
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis neuroglian 0.005 0.0031 0.0028
Onchocerca volvulus 0.0597 0.0746 0.9115
Echinococcus multilocularis neuropeptides capa receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis g-protein coupled receptor 0.0453 0.0558 0.0555
Brugia malayi follicle stimulating hormone receptor 0.0453 0.0558 0.0561
Echinococcus multilocularis sex peptide receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0453 0.0558 0.0555
Echinococcus granulosus g protein coupled receptor 0.0453 0.0558 0.0555
Entamoeba histolytica acetyl-coA carboxylase, putative 0.1307 0.1676 0.5
Echinococcus granulosus glycine receptor subunit beta 0.0061 0.0044 0.0041
Echinococcus multilocularis orexin receptor type 2 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi G-protein coupled receptor 0.0453 0.0558 0.0561
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.066 0.0829 0.0874
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus orexin receptor type 2 0.0453 0.0558 0.0555
Echinococcus granulosus glycine receptor subunit alpha 1 0.0061 0.0044 0.0041
Echinococcus granulosus biogenic amine 5HT receptor 0.0453 0.0558 0.0555
Echinococcus multilocularis roundabout 2 0.0064 0.0048 0.0045
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0453 0.0558 0.0558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0453 0.0558 0.0558
Echinococcus granulosus allatostatin A receptor 0.0453 0.0558 0.0555
Echinococcus granulosus biogenic amine 5HT receptor 0.0453 0.0558 0.0555
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.1039 0.1325 0.2905
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.1039 0.1325 0.2905
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis somatostatin receptor 0.0453 0.0558 0.0555
Echinococcus granulosus g-protein coupled receptor 0.0453 0.0558 0.0555
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0268 0.0316 0.031
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.0558 0.0555
Brugia malayi neuropeptide F receptor 0.0453 0.0558 0.0561
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.1039 0.1325 0.1322
Echinococcus multilocularis g protein coupled receptor 0.0453 0.0558 0.0555
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0453 0.0558 0.0558
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.292 0.3787 0.5922
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Schistosoma mansoni growth hormone secretagogue receptor 0.0453 0.0558 0.0558
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0268 0.0316 0.031
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0453 0.0558 0.0561
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.292 0.3787 1
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0268 0.0316 0.0314
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.292 0.3787 0.3787
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.1307 0.1676 0.5
Schistosoma mansoni neuropeptide receptor 0.0453 0.0558 0.0558
Echinococcus multilocularis neuropeptide FF receptor 2 0.0453 0.0558 0.0555
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0453 0.0558 0.0555
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.292 0.3787 0.3786
Echinococcus multilocularis serotonin receptor 0.0453 0.0558 0.0555
Schistosoma mansoni opsin-like receptor 0.0453 0.0558 0.0558
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0268 0.0316 0.0314
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0453 0.0558 0.0558
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.292 0.3787 0.3584
Schistosoma mansoni Neurotrimin precursor (hNT) 0.004 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi Carboxyl transferase domain containing protein 0.7397 0.9648 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0453 0.0558 0.0558
Schistosoma mansoni hypothetical protein 0.0453 0.0558 0.0558
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0161 0.0175 0.0175
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0453 0.0558 0.0558
Schistosoma mansoni opsin-like receptor 0.0453 0.0558 0.0558
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0453 0.0558 0.0555
Schistosoma mansoni hypothetical protein 0.0453 0.0558 0.0558
Echinococcus multilocularis serotonin receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus somatostatin receptor 0.0453 0.0558 0.0555
Echinococcus multilocularis Biotin lipoyl attachment 0.0268 0.0316 0.0314
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0061 0.0044 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi Tachykinin-like peptides receptor 99D 0.0453 0.0558 0.0561
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.292 0.3787 0.3584
Schistosoma mansoni biogenic amine receptor 0.0453 0.0558 0.0558
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0453 0.0558 0.0558
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.1039 0.1325 0.2905
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0453 0.0558 0.0555
Echinococcus granulosus rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0453 0.0558 0.0561
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Leishmania major carbamoyl-phosphate synthase, putative 0.066 0.0829 0.0529
Echinococcus granulosus neuroglian 0.005 0.0031 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0453 0.0558 0.0558
Echinococcus multilocularis allatostatin A receptor 0.0453 0.0558 0.0555
Brugia malayi putative neuropeptide receptor 0.0453 0.0558 0.0561
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus neuropeptides capa receptor 0.0453 0.0558 0.0555
Echinococcus granulosus neuropeptide Y receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) G-protein coupled receptor 0.0453 0.0558 0.0561
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.1039 0.1325 0.2905
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus tachykinin peptides receptor 99D 0.0453 0.0558 0.0555
Trypanosoma brucei unspecified product 0.192 0.2478 0.2232
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Echinococcus granulosus rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Brugia malayi G protein-coupled receptor 0.0453 0.0558 0.0561
Echinococcus granulosus Biotin lipoyl attachment 0.0268 0.0316 0.0314
Echinococcus granulosus 7tm_1 domain containing protein 0.0453 0.0558 0.0555
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0453 0.0558 0.0555
Schistosoma mansoni hypothetical protein 0.0193 0.0217 0.0217
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.0558 0.0555
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.1039 0.1325 0.2905
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0453 0.0558 0.0555
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.292 0.3787 0.3787
Schistosoma mansoni biogenic amine receptor 0.0453 0.0558 0.0558
Echinococcus granulosus neuropeptide FF receptor 2 0.0453 0.0558 0.0555
Schistosoma mansoni amine GPCR 0.0453 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.292 0.3787 1
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0268 0.0316 0.0316
Schistosoma mansoni neuropeptide receptor 0.0453 0.0558 0.0558
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0453 0.0558 0.0558
Echinococcus granulosus transient receptor potential cation channel 0.0161 0.0175 0.0172
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0453 0.0558 0.0555
Echinococcus granulosus neuropeptide Y receptor 0.0453 0.0558 0.0555
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.292 0.3787 0.3786
Brugia malayi AKH receptor 0.0453 0.0558 0.0561
Echinococcus granulosus glycine receptor subunit alpha 1 0.0061 0.0044 0.0041
Loa Loa (eye worm) hypothetical protein 0.0061 0.0044 0.0028
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0061 0.0044 0.0041
Echinococcus granulosus sex peptide receptor 0.0453 0.0558 0.0555
Schistosoma mansoni nephrin 0.005 0.0031 0.0031
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.292 0.3787 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0453 0.0558 0.0558
Echinococcus multilocularis G protein coupled receptor 139 0.0453 0.0558 0.0555
Schistosoma mansoni biogenic amine receptor 0.0453 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus defective proboscis extension response 0.004 0.0017 0.0015
Brugia malayi Immunoglobulin I-set domain containing protein 0.0654 0.082 0.0834
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.1039 0.1325 0.172
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi larval opioid receptor 0.0453 0.0558 0.0561
Schistosoma mansoni myosin xvIII 0.0453 0.0558 0.0558
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.7397 0.9648 1
Toxoplasma gondii carbamoylphosphate synthetase 0.066 0.0829 0.0529
Echinococcus granulosus twitchin 0.005 0.0031 0.0028
Loa Loa (eye worm) hypothetical protein 0.0053 0.0034 0.0018
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Schistosoma mansoni aspartate carbamoyltransferase 0.066 0.0829 0.0829
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.066 0.0829 0.1476
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0453 0.0558 0.0558
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0054 0.0035 0.0019
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0453 0.0558 0.0561
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0453 0.0558 0.0561
Brugia malayi Dopamine receptor protein 1 0.0453 0.0558 0.0561
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus g protein coupled receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0268 0.0316 0.031
Echinococcus multilocularis G-protein coupled receptor, putative 0.0453 0.0558 0.0555
Echinococcus granulosus tm gpcr rhodopsin 0.0453 0.0558 0.0555
Schistosoma mansoni hypothetical protein 0.0453 0.0558 0.0558
Echinococcus granulosus rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Echinococcus multilocularis rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Brugia malayi G protein-coupled receptor F59B2.13 0.0453 0.0558 0.0561
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0268 0.0316 0.0314
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0268 0.0316 0.031
Brugia malayi Dopamine receptor protein 2 0.0453 0.0558 0.0561
Echinococcus multilocularis ankyrin repeat protein 0.0161 0.0175 0.0172
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0453 0.0558 0.0555
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0453 0.0558 0.0555
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.292 0.3787 1
Echinococcus multilocularis glycine receptor subunit beta 0.0061 0.0044 0.0041
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1039 0.1325 0.1041
Mycobacterium ulcerans pyruvate carboxylase 0.292 0.3787 1
Brugia malayi ORL1-like opioid receptor 0.0453 0.0558 0.0561
Echinococcus granulosus tm gpcr rhodopsin 0.0453 0.0558 0.0555
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0453 0.0558 0.0558
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0453 0.0558 0.0558
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0054 0.0035 0.0019
Schistosoma mansoni cell adhesion molecule 0.0053 0.0034 0.0034
Schistosoma mansoni neuropeptide F-like receptor 0.0453 0.0558 0.0558
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1039 0.1325 0.172
Onchocerca volvulus Tyrosine kinase homolog 0.061 0.0764 1
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) melatonin receptor type 1A 0.0453 0.0558 0.0561
Schistosoma mansoni adenoreceptor 0.0453 0.0558 0.0558
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0453 0.0558 0.0558
Echinococcus multilocularis g protein coupled receptor 0.0453 0.0558 0.0555
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.066 0.0829 0.0742
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0054 0.0035 0.0033
Echinococcus granulosus neuropeptides capa receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus granulosus tm gpcr rhodopsin 0.0453 0.0558 0.0555
Toxoplasma gondii pyruvate carboxylase 0.292 0.3787 0.3584
Echinococcus granulosus peptide allatostatin:somatostatin 0.0453 0.0558 0.0555
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.1039 0.1325 0.2905
Echinococcus multilocularis neuropeptides capa receptor 0.0453 0.0558 0.0555
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.0558 0.0555
Plasmodium falciparum carbamoyl phosphate synthetase 0.066 0.0829 0.0742
Brugia malayi G-protein coupled receptor 0.0453 0.0558 0.0561
Schistosoma mansoni amine GPCR 0.0453 0.0558 0.0558
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0061 0.0044 0.0041
Echinococcus granulosus neuropeptide s receptor 0.0453 0.0558 0.0555
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0453 0.0558 0.0558
Schistosoma mansoni pyruvate carboxylase 0.292 0.3787 0.3787
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0453 0.0558 0.0558
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.1039 0.1325 0.1041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Leishmania major carboxylase, putative 0.292 0.3787 0.3584
Trypanosoma cruzi acetyl-CoA carboxylase 0.4746 0.6177 1
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.1039 0.1325 0.1322
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0453 0.0558 0.0558
Schistosoma mansoni biogenic amine (5HT) receptor 0.0453 0.0558 0.0558
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0055 0.0036 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0453 0.0558 0.0555
Echinococcus granulosus fmrfamide receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Brugia malayi Cation transporter family protein 0.0061 0.0044 0.0028
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Schistosoma mansoni carbamoyl-phosphate synthetase 0.066 0.0829 0.0829
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0453 0.0558 0.0558
Brugia malayi GnHR receptor homolog 0.0453 0.0558 0.0561
Loa Loa (eye worm) G-protein coupled receptor 0.0453 0.0558 0.0561
Schistosoma mansoni hypothetical protein 0.0059 0.0042 0.0042
Echinococcus granulosus 7TM GPCR rhodopsin 0.0453 0.0558 0.0555
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0453 0.0558 0.0555
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0061 0.0044 0.0044
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0061 0.0044 0.0041
Echinococcus granulosus geminin 0.0193 0.0217 0.0214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0453 0.0558 0.0558
Echinococcus granulosus neuropeptide receptor 0.0453 0.0558 0.0555
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.292 0.3787 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0453 0.0558 0.0558
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.1039 0.1325 0.2905
Echinococcus granulosus glycine receptor subunit beta 0.0061 0.0044 0.0041
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0054 0.0035 0.0033
Brugia malayi Serotonin receptor 0.0453 0.0558 0.0561
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0268 0.0316 0.0316
Echinococcus granulosus G protein coupled receptor 139 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Loa Loa (eye worm) hypothetical protein 0.0064 0.0048 0.0032
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Schistosoma mansoni amine GPCR 0.0453 0.0558 0.0558
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.1039 0.1325 0.2905
Echinococcus granulosus serotonin receptor 0.0453 0.0558 0.0555
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0268 0.0316 0.0316
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.1039 0.1325 0.2905
Echinococcus multilocularis rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0268 0.0316 0.031
Brugia malayi hypothetical protein 0.0453 0.0558 0.0561
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.066 0.0829 0.0874
Schistosoma mansoni opsin-like receptor 0.0453 0.0558 0.0558
Echinococcus multilocularis Immunoglobulin 0.004 0.0017 0.0015
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0453 0.0558 0.0555
Schistosoma mansoni amine GPCR 0.0453 0.0558 0.0558
Echinococcus multilocularis rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Echinococcus multilocularis dro:myosuppressin receptor 0.0453 0.0558 0.0555
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0453 0.0558 0.0561
Schistosoma mansoni neuropeptide receptor 0.0453 0.0558 0.0558
Brugia malayi Serotonin receptor 0.0453 0.0558 0.0561
Loa Loa (eye worm) GABA receptor subunit 0.0055 0.0036 0.002
Loa Loa (eye worm) hypothetical protein 0.0268 0.0316 0.031
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0061 0.0044 0.0028
Echinococcus multilocularis glycine receptor subunit beta 0.0061 0.0044 0.0041
Schistosoma mansoni biogenic amine (5HT) receptor 0.0453 0.0558 0.0558
Schistosoma mansoni histamine h1 receptor 0.0453 0.0558 0.0558
Brugia malayi Melatonin receptor type 1A 0.0453 0.0558 0.0561
Echinococcus granulosus rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Loa Loa (eye worm) hypothetical protein 0.0453 0.0558 0.0561
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0268 0.0316 0.0314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0453 0.0558 0.0555
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0061 0.0044 0.0044

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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