Detailed information for compound 1617752

Basic information

Technical information
  • TDR Targets ID: 1617752
  • Name: [1-amino-2-(1H-indol-3-yl)ethyl]-methoxyphosp hinic acid
  • MW: 254.222 | Formula: C11H15N2O3P
  • H donors: 3 H acceptors: 2 LogP: -2.04 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COP(=O)(C(Cc1c[nH]c2c1cccc2)N)O
  • InChi: 1S/C11H15N2O3P/c1-16-17(14,15)11(12)6-8-7-13-10-5-3-2-4-9(8)10/h2-5,7,11,13H,6,12H2,1H3,(H,14,15)
  • InChiKey: UIXPRYNNEGLCHX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [1-amino-2-(1H-indol-3-yl)ethyl]-methoxy-phosphinic acid
  • AIDS-145183
  • AIDS145183
  • Methyl hydrogen 1-amino-2-(1H-indol-3-yl)ethylphosphonate
  • NSC669635
  • Phosphonic acid, {[1-amino-2-(3-indolyl)ethyl]-,} methyl ester
  • Phosphonic acid, [1-amino-2-(3-indolyl)ethyl]-, methyl ester
  • NCI60_024298

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni adenoreceptor 0.0079 0.0093 0.0093
Schistosoma mansoni neuropeptide receptor 0.0079 0.0093 0.0093
Brugia malayi sulfakinin receptor protein 0.0079 0.0093 0.0097
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Loa Loa (eye worm) hypothetical protein 0.0055 0.0008 0.0008
Brugia malayi Melatonin receptor type 1A 0.0079 0.0093 0.0097
Echinococcus granulosus sex peptide receptor 0.0079 0.0093 0.0093
Onchocerca volvulus 0.0079 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1083 0.3691 0.3691
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0385 0.1191 0.3211
Echinococcus granulosus neuropeptide receptor A26 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0385 0.1191 0.3211
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0385 0.1191 0.172
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.01 0.0167 0.0432
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0385 0.1191 0.3211
Onchocerca volvulus 0.0079 0.0093 1
Onchocerca volvulus 0.0079 0.0093 1
Brugia malayi putative neuropeptide receptor NPR1 0.0079 0.0093 0.0097
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.031 0.0321
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0385 0.1191 0.3233
Onchocerca volvulus 0.0079 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1083 0.3691 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0245 0.0687 0.0529
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0093 0.0093
Echinococcus granulosus serotonin receptor 0.0079 0.0093 0.0093
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0385 0.1191 0.1134
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2057 0.7184 1
Echinococcus granulosus Biotin lipoyl attachment 0.01 0.0167 0.0167
Onchocerca volvulus 0.0079 0.0093 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0093 0.0093
Onchocerca volvulus 0.0079 0.0093 1
Onchocerca volvulus 0.0079 0.0093 1
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0093 0.0093
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0093 0.0093
Chlamydia trachomatis biotin carboxylase 0.0983 0.3334 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.01 0.0167 0.0103
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0941 0.3184 0.3184
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0385 0.1191 0.172
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0385 0.1191 0.3211
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Onchocerca volvulus 0.0079 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus multilocularis G protein coupled receptor 139 0.0079 0.0093 0.0093
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0079 0.0093 0.0097
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.01 0.0167 0.0432
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1083 0.3691 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.01 0.0167 0.0167
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0079 0.0093 0.0093
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0385 0.1191 0.1184
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.01 0.0167 0.0159
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0055 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.01 0.0167 0.0103
Schistosoma mansoni amine GPCR 0.0079 0.0093 0.0093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0093 0.0093
Schistosoma mansoni amine GPCR 0.0079 0.0093 0.0093
Onchocerca volvulus 0.0079 0.0093 1
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.01 0.0167 0.0159
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0385 0.1191 0.3211
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0079 0.0093 0.0093
Echinococcus granulosus neuropeptide receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0093 0.0093
Echinococcus granulosus alpha 1A adrenergic receptor 0.0079 0.0093 0.0093
Schistosoma mansoni growth hormone secretagogue receptor 0.0079 0.0093 0.0093
Echinococcus granulosus g protein coupled receptor 0.0079 0.0093 0.0093
Schistosoma mansoni neuropeptide F-like receptor 0.0079 0.0093 0.0093
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.01 0.0167 0.0167
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0385 0.1191 0.1191
Brugia malayi G-protein coupled receptor 0.0079 0.0093 0.0097
Trypanosoma cruzi acetyl-CoA carboxylase 0.176 0.6118 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Onchocerca volvulus 0.0079 0.0093 1
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1083 0.3691 0.3691
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0064 0.0064
Schistosoma mansoni biogenic amine receptor 0.0079 0.0093 0.0093
Onchocerca volvulus 0.0079 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.01 0.0167 0.0103
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis neuropeptide Y receptor 0.0079 0.0093 0.0093
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0093 0.0093
Schistosoma mansoni pyruvate carboxylase 0.1083 0.3691 0.3691
Loa Loa (eye worm) TYRA-2 protein 0.0079 0.0093 0.0097
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0079 0.0093 1
Onchocerca volvulus 0.0079 0.0093 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0079 0.0093 0.0093
Onchocerca volvulus Neuropeptide F receptor homolog 0.0079 0.0093 1
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0245 0.0687 0.0687
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0079 0.0093 0.0093
Echinococcus granulosus neuropeptide FF receptor 2 0.0079 0.0093 0.0093
Brugia malayi Dopamine receptor protein 1 0.0079 0.0093 0.0097
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0079 0.0093 0.0097
Echinococcus granulosus g protein coupled receptor 0.0079 0.0093 0.0093
Schistosoma mansoni alpha-1 adrenergic receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus multilocularis somatostatin receptor 0.0079 0.0093 0.0093
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.01 0.0167 0.0432
Echinococcus granulosus g protein coupled receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.2743 0.9643 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.01 0.0167 0.0432
Brugia malayi ORL1-like opioid receptor 0.0079 0.0093 0.0097
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1083 0.3691 0.3584
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1083 0.3691 0.3691
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0079 0.0093 0.0097
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0064 0.0056
Leishmania major carboxylase, putative 0.1083 0.3691 0.3686
Loa Loa (eye worm) hypothetical protein 0.0058 0.0017 0.0018
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus multilocularis neuropeptide receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis fmrfamide receptor 0.0079 0.0093 0.0093
Plasmodium falciparum carbamoyl phosphate synthetase 0.0245 0.0687 0.0742
Echinococcus granulosus orexin receptor type 2 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni histamine h1 receptor 0.0079 0.0093 0.0093
Toxoplasma gondii pyruvate carboxylase 0.1083 0.3691 0.3651
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1083 0.3691 0.5922
Schistosoma mansoni hypothetical protein 0.0079 0.0093 0.0093
Brugia malayi neuropeptide F receptor 0.0079 0.0093 0.0097
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.01 0.0167 0.0103
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0245 0.0687 0.0874
Schistosoma mansoni opsin-like receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.01 0.0167 0.0159
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0093 0.0097
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.2057 0.7184 1
Loa Loa (eye worm) hypothetical protein 0.01 0.0167 0.0173
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0008 0.0008
Echinococcus multilocularis sex peptide receptor 0.0079 0.0093 0.0093
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0064 0.0064
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1083 0.3691 1
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0093 0.0097
Brugia malayi RE15519p 0.0079 0.0093 0.0097
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0385 0.1191 0.1191
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus granulosus dro:myosuppressin receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis allatostatin A receptor 0.0079 0.0093 0.0093
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Brugia malayi follicle stimulating hormone receptor 0.0079 0.0093 0.0097
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.01 0.0167 0.0173
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0079 0.0093 0.0093
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0079 0.0093 0.0093
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.01 0.0167 0.0173
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0245 0.0687 0.1476
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0064 0.0153
Schistosoma mansoni hypothetical protein 0.0079 0.0093 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0064 0.0153
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Brugia malayi Dopamine receptor 0.0079 0.0093 0.0097
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.01 0.0167 0.0432
Trypanosoma brucei unspecified product 0.0712 0.2361 0.2232
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.01 0.0167 0.0167
Echinococcus multilocularis orexin receptor type 2 0.0079 0.0093 0.0093
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.031 0.0321
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.0017 0.0018
Echinococcus granulosus peptide allatostatin:somatostatin 0.0079 0.0093 0.0093
Brugia malayi AKH receptor 0.0079 0.0093 0.0097
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0385 0.1191 0.172
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis Biotin lipoyl attachment 0.01 0.0167 0.0167
Onchocerca volvulus 0.0079 0.0093 1
Brugia malayi GnHR receptor homolog 0.0079 0.0093 0.0097
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0245 0.0687 0.0742
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0079 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.01 0.0167 0.0167
Echinococcus granulosus neuropeptide s receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis neuropeptide FF receptor 2 0.0079 0.0093 0.0093
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.01 0.0167 0.0173
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0079 0.0093 0.0093
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0385 0.1191 0.1184
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0079 0.0093 0.0093
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1083 0.3691 0.3584
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.01 0.0167 0.0103
Onchocerca volvulus 0.0079 0.0093 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.0017 0.0018
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0079 0.0093 0.0093
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1083 0.3691 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Leishmania major carbamoyl-phosphate synthase, putative 0.0245 0.0687 0.068
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0079 0.0093 0.0097
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0485 0.1547 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0079 0.0093 0.0093
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.01 0.0167 0.0167
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1083 0.3691 0.3691
Schistosoma mansoni neuropeptide f receptor 76f 0.0079 0.0093 0.0093
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1083 0.3691 1
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0385 0.1191 0.1041
Schistosoma mansoni amine GPCR 0.0079 0.0093 0.0093
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0093 0.0093
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0093 0.0093
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.01 0.0167 0.0173
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0245 0.0687 0.1844
Echinococcus granulosus neuropeptide receptor 0.0079 0.0093 0.0093
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0079 0.0093 0.0097
Echinococcus multilocularis g-protein coupled receptor 0.0079 0.0093 0.0093
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0079 0.0093 0.0093
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus granulosus tachykinin peptides receptor 99D 0.0079 0.0093 0.0093
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0385 0.1191 0.3211
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.01 0.0167 0.0167
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0385 0.1191 0.3211
Brugia malayi neuropeptide F receptor 0.0079 0.0093 0.0097
Schistosoma mansoni biogenic amine receptor 0.0079 0.0093 0.0093
Brugia malayi Dopamine receptor protein 2 0.0079 0.0093 0.0097
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0079 0.0093 0.0097
Schistosoma mansoni biogenic amine receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis G-protein coupled receptor, putative 0.0079 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0079 0.0093 0.0093
Mycobacterium ulcerans pyruvate carboxylase 0.1083 0.3691 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni neuropeptide receptor 0.0079 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0093 0.0093
Brugia malayi G protein-coupled receptor F59B2.13 0.0079 0.0093 0.0097
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0064 0.0153
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0093 0.0093
Echinococcus granulosus G protein coupled receptor 139 0.0079 0.0093 0.0093
Schistosoma mansoni opsin-like receptor 0.0079 0.0093 0.0093
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0093 0.0093
Echinococcus granulosus fmrfamide receptor 0.0079 0.0093 0.0093
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0385 0.1191 0.2905
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0245 0.0687 0.0687
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.0017 0.0018
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.01 0.0167 0.0167
Echinococcus multilocularis g protein coupled receptor 0.0079 0.0093 0.0093
Schistosoma mansoni amine GPCR 0.0079 0.0093 0.0093
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1083 0.3691 0.5922
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0385 0.1191 0.3211
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni amine GPCR 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Brugia malayi AMP-binding enzyme family protein 0.0055 0.0008 0.0008
Echinococcus granulosus 7tm_1 domain containing protein 0.0079 0.0093 0.0093
Schistosoma mansoni myosin xvIII 0.0079 0.0093 0.0093
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0093 0.0093
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0093 0.0093
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0055 0.0008 0.0008
Brugia malayi Serotonin receptor 0.0079 0.0093 0.0097
Echinococcus granulosus hypothetical protein 0.0079 0.0093 0.0093
Schistosoma mansoni hypothetical protein 0.0079 0.0093 0.0093
Brugia malayi G-protein coupled receptor 0.0079 0.0093 0.0097
Echinococcus granulosus allatostatin A receptor 0.0079 0.0093 0.0093
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0385 0.1191 0.1191
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0064 0.0064
Treponema pallidum pyruvate carboxylase subunit B 0.01 0.0167 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.01 0.0167 0.0432
Brugia malayi MH2 domain containing protein 0.0139 0.031 0.0321
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0385 0.1191 0.3211
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.01 0.0167 0.0167
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0079 0.0093 0.0097
Echinococcus granulosus 7TM GPCR rhodopsin 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.01 0.0167 0.0173
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.01 0.0167 0.0159
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1083 0.3691 1
Echinococcus multilocularis serotonin receptor 0.0079 0.0093 0.0093
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Brugia malayi larval opioid receptor 0.0079 0.0093 0.0097
Onchocerca volvulus 0.0079 0.0093 1
Echinococcus granulosus neuropeptide Y receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1083 0.3691 0.3686
Brugia malayi putative neuropeptide receptor 0.0079 0.0093 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Echinococcus multilocularis neuropeptides capa receptor 0.0079 0.0093 0.0093
Schistosoma mansoni neuropeptide receptor 0.0079 0.0093 0.0093
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0245 0.0687 0.0874
Echinococcus multilocularis dro:myosuppressin receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Mycobacterium ulcerans hypothetical protein 0.01 0.0167 0.0432
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0079 0.0093 0.0097
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0385 0.1191 0.3211
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0079 0.0093 0.0093
Brugia malayi hypothetical protein 0.0079 0.0093 0.0097
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0093 0.0093
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0485 0.1547 1
Echinococcus multilocularis neuropeptide receptor A26 0.0079 0.0093 0.0093
Echinococcus multilocularis serotonin receptor 0.0079 0.0093 0.0093
Schistosoma mansoni aspartate carbamoyltransferase 0.0245 0.0687 0.0687
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0079 0.0093 0.0093
Echinococcus granulosus g-protein coupled receptor 0.0079 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Echinococcus granulosus somatostatin receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) neuropeptide F receptor 0.0079 0.0093 0.0097
Schistosoma mansoni biogenic amine (5HT) receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) melatonin receptor type 1A 0.0079 0.0093 0.0097
Onchocerca volvulus 0.0079 0.0093 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0079 0.0093 0.0097
Echinococcus multilocularis rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Echinococcus granulosus rhodopsin orphan GPCR 0.0079 0.0093 0.0093
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1083 0.3691 1
Schistosoma mansoni opsin-like receptor 0.0079 0.0093 0.0093
Brugia malayi G protein-coupled receptor 0.0079 0.0093 0.0097
Brugia malayi Tachykinin-like peptides receptor 99D 0.0079 0.0093 0.0097
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0385 0.1191 0.3211
Echinococcus multilocularis neuropeptide s receptor 0.0079 0.0093 0.0093
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.01 0.0167 0.0432
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0064 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0093 0.0093
Onchocerca volvulus 0.0079 0.0093 1
Echinococcus granulosus neuropeptides capa receptor 0.0079 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0079 0.0093 0.0097
Echinococcus granulosus biogenic amine 5HT receptor 0.0079 0.0093 0.0093
Schistosoma mansoni neuropeptide receptor 0.0079 0.0093 0.0093
Echinococcus granulosus tm gpcr rhodopsin 0.0079 0.0093 0.0093
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0079 0.0093 0.0093
Toxoplasma gondii carbamoylphosphate synthetase 0.0245 0.0687 0.0627
Loa Loa (eye worm) G-protein coupled receptor 0.0079 0.0093 0.0097
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0079 0.0093 0.0093
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0079 0.0093 0.0093
Brugia malayi Serotonin receptor 0.0079 0.0093 0.0097
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0079 0.0093 0.0097
Brugia malayi Carboxyl transferase domain containing protein 0.2743 0.9643 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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