Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | expressed conserved protein | 0.0106 | 0.0716 | 0.0654 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0324 | 0.2701 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0272 | 0.0272 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0324 | 0.2701 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0324 | 0.2701 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0324 | 0.2701 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0324 | 0.2701 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0324 | 0.2701 | 1 |
Schistosoma mansoni | bcl-2 homologous antagonist/killer (bak) | 0.0079 | 0.0467 | 0.1383 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0324 | 0.2701 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0324 | 0.2701 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0324 | 0.2701 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0324 | 0.2701 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0113 | 0.0778 | 0.0731 |
Echinococcus multilocularis | protein dispatched 1 | 0.0055 | 0.0255 | 0.0078 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0324 | 0.2701 | 0.815 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0113 | 0.0778 | 0.1901 |
Brugia malayi | Apoptosis regulator proteins, Bcl-2 family protein | 0.0079 | 0.0467 | 0.0467 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0324 | 0.2701 | 0.2701 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.104 | 0.104 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0268 | 0.0268 |
Brugia malayi | cytochrome P450 | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0324 | 0.2701 | 1 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0324 | 0.2701 | 0.2701 |
Brugia malayi | Muscleblind-like protein | 0.0142 | 0.104 | 0.104 |
Echinococcus multilocularis | Bcl 2 ous antagonist:killer | 0.0079 | 0.0467 | 0.0342 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0324 | 0.2701 | 0.2701 |
Echinococcus multilocularis | 0.0324 | 0.2701 | 0.3135 | |
Schistosoma mansoni | apoptosis regulator bax | 0.0079 | 0.0467 | 0.1383 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0324 | 0.2701 | 0.2701 |
Schistosoma mansoni | hypothetical protein | 0.0324 | 0.2701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0193 | 0.0193 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0324 | 0.2701 | 0.2701 |
Echinococcus multilocularis | EGFP:Bcl2 fusion protein | 0.0079 | 0.0467 | 0.0342 |
Echinococcus granulosus | tumor protein p63 | 0.0387 | 0.3271 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.0467 | 0.0467 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0324 | 0.2701 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0324 | 0.2701 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0161 | 0.1218 | 0.333 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0177 | 0.0267 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0324 | 0.2701 | 1 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0324 | 0.2701 | 0.2701 |
Echinococcus granulosus | Bcl 2 ous antagonist:killer | 0.0079 | 0.0467 | 0.0889 |
Echinococcus granulosus | muscleblind protein | 0.0142 | 0.104 | 0.2752 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0324 | 0.2701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0108 | 0.0108 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0324 | 0.2701 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0324 | 0.2701 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0324 | 0.2701 | 0.2701 |
Loa Loa (eye worm) | hypothetical protein | 0.0803 | 0.7052 | 0.7052 |
Brugia malayi | CHE-14 protein | 0.0048 | 0.0193 | 0.0193 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0324 | 0.2701 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0177 | 0.0267 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0161 | 0.1218 | 0.1281 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0324 | 0.2701 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0177 | 0.0267 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0115 | 0.0794 | 0.2645 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0324 | 0.2701 | 0.2701 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0048 | 0.0193 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0467 | 0.1383 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0177 | 0.0267 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0272 | 0.0272 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0292 | 0.0292 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0272 | 0.0272 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0142 | 0.104 | 0.1058 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0324 | 0.2701 | 0.2701 |
Loa Loa (eye worm) | cytochrome P450 | 0.0324 | 0.2701 | 0.2701 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0778 | 0.0778 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0324 | 0.2701 | 0.2701 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.104 | 0.104 |
Echinococcus granulosus | expressed conserved protein | 0.0106 | 0.0716 | 0.1699 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0467 | 0.1383 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0929 | 0.8195 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0324 | 0.2701 | 1 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0324 | 0.2701 | 0.2701 |
Leishmania major | cytochrome p450-like protein | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0324 | 0.2701 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0108 | 0.0108 |
Onchocerca volvulus | 0.0057 | 0.0268 | 1 | |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0324 | 0.2701 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.0268 | 0.0617 |
Loa Loa (eye worm) | apoptosis regulator protein | 0.0079 | 0.0467 | 0.0467 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0048 | 0.0193 | 0.0193 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.0467 | 0.1383 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0113 | 0.0778 | 0.0778 |
Echinococcus granulosus | EGFP:Bcl2 fusion protein | 0.0079 | 0.0467 | 0.0889 |
Schistosoma mansoni | patched 1 | 0.0048 | 0.0193 | 0.0328 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0324 | 0.2701 | 0.2701 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0324 | 0.2701 | 0.2701 |
Echinococcus multilocularis | muscleblind protein | 0.0142 | 0.104 | 0.1058 |
Brugia malayi | Cytochrome P450 family protein | 0.0324 | 0.2701 | 0.2701 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0272 | 0.0272 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0113 | 0.0778 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0324 | 0.2701 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0324 | 0.2701 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0324 | 0.2701 | 0.2701 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0324 | 0.2701 | 0.2701 |
Echinococcus multilocularis | tumor protein p63 | 0.0387 | 0.3271 | 0.3846 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0324 | 0.2701 | 0.2701 |
Brugia malayi | Cytochrome P450 family protein | 0.0324 | 0.2701 | 0.2701 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.354 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.585 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.475 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.115 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.