Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0368 | 0.2796 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0183 | 0.0183 |
Onchocerca volvulus | 0.0041 | 0.0183 | 1 | |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0368 | 0.2796 | 1 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0368 | 0.2796 | 0.2661 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0368 | 0.2796 | 0.2661 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0308 | 0.0308 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0368 | 0.2796 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0183 | 0.0183 |
Echinococcus multilocularis | 0.0368 | 0.2796 | 1 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.0183 | 0.0183 |
Schistosoma mansoni | lamin | 0.0031 | 0.0101 | 0.0362 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0368 | 0.2796 | 0.2661 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0144 | 0.0516 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0144 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0368 | 0.2796 | 1 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0368 | 0.2796 | 0.2661 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0183 | 0.0183 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0101 | 0.0362 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0368 | 0.2796 | 0.2661 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.0183 | 0.0654 |
Onchocerca volvulus | 0.0041 | 0.0183 | 1 | |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0101 | 0.0362 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0368 | 0.2796 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0183 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0368 | 0.2796 | 0.2661 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.0183 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0183 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0368 | 0.2796 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0368 | 0.2796 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0183 | 0.5 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0368 | 0.2796 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0144 | 0.0144 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0368 | 0.2796 | 0.2661 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.0183 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0368 | 0.2796 | 0.2661 |
Leishmania major | cytochrome p450-like protein | 0.0368 | 0.2796 | 0.2661 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0368 | 0.2796 | 0.2661 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0101 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0308 | 0.0308 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0144 | 0.0516 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0101 | 0.0362 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0368 | 0.2796 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0368 | 0.2796 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0368 | 0.2796 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.0183 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0368 | 0.2796 | 1 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0368 | 0.2796 | 0.2661 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0144 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.0183 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0183 | 0.0183 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0368 | 0.2796 | 0.2661 |
Schistosoma mansoni | lamin | 0.0031 | 0.0101 | 0.0362 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.0183 | 0.0183 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0101 | 0.0362 |
Schistosoma mansoni | hypothetical protein | 0.0368 | 0.2796 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0368 | 0.2796 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0368 | 0.2796 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0183 | 0.0654 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0101 | 0.0101 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0165 | 0.0165 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0368 | 0.2796 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0368 | 0.2796 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0368 | 0.2796 | 0.2796 |
Echinococcus granulosus | lamin | 0.0031 | 0.0101 | 0.0362 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0183 | 0.0183 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0308 | 0.0308 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0368 | 0.2796 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0183 | 0.0183 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0368 | 0.2796 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0165 | 0.0165 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium leprae | putative cytochrome p450 | 0.0368 | 0.2796 | 1 |
Brugia malayi | cytochrome P450 | 0.0368 | 0.2796 | 0.2796 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0183 | 0.0183 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0368 | 0.2796 | 0.2661 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0165 | 0.0592 |
Loa Loa (eye worm) | hypothetical protein | 0.0903 | 0.7062 | 0.7062 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0144 | 0.0516 |
Brugia malayi | Cytochrome P450 family protein | 0.0368 | 0.2796 | 0.2796 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0097 | 0.0097 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0101 | 0.0101 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0144 | 0.0516 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0308 | 0.0308 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0368 | 0.2796 | 0.2661 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0144 | 0.5 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.0183 | 0.0654 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0368 | 0.2796 | 1 |
Brugia malayi | beta-lactamase | 0.0041 | 0.0183 | 0.0183 |
Leishmania major | cytochrome p450-like protein | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0368 | 0.2796 | 0.2661 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.0183 | 0.0183 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.026 | 0.1936 | 0.671 |
Onchocerca volvulus | 0.0041 | 0.0183 | 1 | |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0368 | 0.2796 | 0.2796 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0368 | 0.2796 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0101 | 0.0362 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0368 | 0.2796 | 0.2661 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0368 | 0.2796 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0368 | 0.2796 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0101 | 0.0101 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.0183 | 0.0183 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0368 | 0.2796 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.0183 | 0.0654 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0144 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 | 0.0368 | 0.2796 | 0.2796 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0368 | 0.2796 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.