TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 764.796 | Formula: C41H36N2O11S
H donors: 2 H acceptors: 4 LogP: 5.88 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(cc(c1OC)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)NC(=O)c1ccc(cc1)NS(=O)(=O)c1ccc(cc1)Oc1ccccc1
InChi: 1S/C41H36N2O11S/c1-48-34-17-24(18-35(49-2)39(34)50-3)36-29-19-32-33(53-22-52-32)20-30(29)38(31-21-51-41(45)37(31)36)42-40(44)23-9-11-25(12-10-23)43-55(46,47)28-15-13-27(14-16-28)54-26-7-5-4-6-8-26/h4-20,31,36-38,43H,21-22H2,1-3H3,(H,42,44)/t31-,36+,37-,38+/m0/s1
InChiKey: ANVLVZUFYOODDX-AUUUEPFHSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0323	0.0845
Leishmania major	hypothetical protein, conserved	0.0096	0.336	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0028	0.0751	0.6357
Brugia malayi	hypothetical protein	0.0009	0.0036	0.0018
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0364	0.3077
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Brugia malayi	hypothetical protein	0.001	0.0077	0.0059
Schistosoma mansoni	transcription factor LCR-F1	0.0103	0.3629	0.3617
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0131	0.4696	0.4687
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0009	0.0036	0.0018
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0323	0.0306
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0046	0.1438	0.1422
Echinococcus multilocularis	cysteine protease	0.0016	0.0323	0.0306
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0009	0.0036	0.0018
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0096	0.336	0.3348
Mycobacterium ulcerans	thioesterase TesA	0.0022	0.0523	0.443
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.001	0.0077	0.0059
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0049	0.158	0.1565
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.1883	0.558
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.042	0.0402
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0032	0.0902	0.0869
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0144	0.5205	0.5187
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.001	0.0073	0.0055
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0028	0.0751	0.6357
Mycobacterium ulcerans	thioesterase	0.0022	0.0523	0.443
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0103	0.3629	0.3617
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0323	0.0306
Brugia malayi	nuclear receptor NHR-67	0.0009	0.0036	0.0018
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0198	0.018
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0046	0.1438	0.1422
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Loa Loa (eye worm)	hypothetical protein	0.0144	0.5205	0.5187
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0009	0.0033	0.5
Onchocerca volvulus	Fatty acid synthase homolog	0.0047	0.1488	0.1457
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0019	0.042	0.0402
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0019	0.042	0.0402
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0026	0.0689	0.5834
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0019	0.042	0.0385
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0026	0.0689	0.5834
Loa Loa (eye worm)	hypothetical protein	0.0019	0.042	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0019	0.042	0.0385
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0019	0.042	0.0385
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0115	0.0097
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0025	0.0642	0.5433
Loa Loa (eye worm)	hypothetical protein	0.0098	0.3461	0.3437
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0131	0.4696	0.4687
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.042	0.0402
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0115	0.0097
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0036	0.0018
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0642	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0019	0.042	0.0385
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0028	0.0751	0.6357
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0046	0.1438	0.1422
Loa Loa (eye worm)	hypothetical protein	0.001	0.0077	0.0041
Leishmania major	hypothetical protein, conserved	0.0096	0.336	1
Loa Loa (eye worm)	steroid hormone receptor	0.0019	0.042	0.0385
Onchocerca volvulus	Bile acid receptor homolog	0.0019	0.042	0.0385
Brugia malayi	hypothetical protein	0.0103	0.3629	0.3617
Plasmodium vivax	vivapain-2	0.0016	0.0323	0.0306
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0115	0.0097
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0323	0.0845
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0131	0.4696	0.4677
Mycobacterium tuberculosis	Polyketide synthetase MbtC (polyketide synthase)	0.0009	0.0036	0.0306
Brugia malayi	tailless protein	0.0009	0.0036	0.0018
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0019	0.042	0.0385
Plasmodium falciparum	acyl-CoA synthetase	0.0019	0.0402	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0402	0.0367
Mycobacterium leprae	Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase)	0.001	0.0073	0.0563
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Loa Loa (eye worm)	hypothetical protein	0.001	0.0077	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.042	0.0402
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0077	0.0059
Mycobacterium ulcerans	hypothetical protein	0.0025	0.0642	0.5433
Echinococcus granulosus	Zinc finger RanBP2 type	0.0096	0.336	0.3348
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0025	0.0642	0.5433
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0323	0.0306
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0016	0.0323	0.0306
Schistosoma mansoni	ferritin light chain	0.0009	0.0033	0.0015
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0198	0.0538
Mycobacterium leprae	Polyketide synthase Pks13	0.0039	0.1181	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0009	0.0036	0.0018
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0046	0.1438	0.1422
Brugia malayi	nuclear hormone receptor	0.0019	0.042	0.0402
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0077	0.0059
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0198	0.0538
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0642	0.1404
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0323	0.0306
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE	0.0017	0.0352	0.2941
Schistosoma mansoni	zinc finger protein	0.0009	0.0036	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0019	0.042	0.0385
Onchocerca volvulus		0.0016	0.0323	0.0288
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.001	0.0073	0.0616
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0019	0.042	0.0385
Treponema pallidum	bacterioferrin (TpF1)	0.0009	0.0033	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.0019	0.042	0.0402
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.1578	0.4667
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0025	0.0642	0.5433
Echinococcus granulosus	thyroid hormone receptor alpha	0.0009	0.0036	0.0018
Trypanosoma cruzi	WLM domain containing protein, putative	0.0096	0.336	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0642	0.1404
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0039	0.1181	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0019	0.042	0.0402
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.0021	0.0495	0.4155
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0131	0.4696	0.4687
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0096	0.336	0.3348
Brugia malayi	Nuclear hormone receptor E75	0.0009	0.0036	0.0018
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0323	0.0288
Brugia malayi	orphan nuclear receptor NR2E1	0.0009	0.0036	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0019	0.042	0.0402
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0323	0.0306
Leishmania major	cathepsin L-like protease	0.0063	0.2091	0.5986
Echinococcus multilocularis	cysteine protease	0.0016	0.0323	0.0306
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0019	0.042	0.0402
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0027	0.0742	0.2006
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.001	0.0073	0.0616
Echinococcus multilocularis	GPCR, family 2	0.0046	0.1438	0.1422
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Brugia malayi	Latrophilin receptor protein 2	0.0046	0.1438	0.1422
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0019	0.042	0.0385
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0019	0.0409	0.3461
Echinococcus granulosus	expressed protein	0.0009	0.0033	0.0015
Onchocerca volvulus		0.0019	0.042	0.0385
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0096	0.336	0.3348
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.042	0.0402
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0025	0.0659	0.5576
Echinococcus multilocularis	FTZ F1 alpha	0.0019	0.042	0.0402
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0019	0.042	0.0402
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0323	0.0306
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtE	0.001	0.0073	0.0616
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.2091	0.6202
Schistosoma mansoni	RNA binding protein	0.0096	0.336	0.3348
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0028	0.0751	0.6337
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0096	0.336	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0096	0.336	0.3348
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0096	0.336	0.3336
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0642	0.0625
Toxoplasma gondii	type I fatty acid synthase, putative	0.0029	0.079	0.0567
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0096	0.336	0.3348
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0019	0.042	0.0402
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0019	0.0402	0.3405
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0026	0.0689	0.581
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1438	0.1406
Entamoeba histolytica	hypothetical protein	0.0103	0.3629	1
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0039	0.1181	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0115	0.0079
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0025	0.0642	0.5433
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0019	0.042	0.0402
Brugia malayi	AMP-binding enzyme family protein	0.0025	0.0642	0.0625
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.001	0.0077	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0402	0.0367
Schistosoma mansoni	ferritin	0.0009	0.0033	0.0015
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0642	0.5433
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0323	0.0306
Schistosoma mansoni	zinc finger protein	0.0096	0.336	0.3348
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0013	0.0198	0.1676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0028	0.0751	0.6337
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0131	0.4696	0.4687
Onchocerca volvulus	Protein ultraspiracle homolog	0.0019	0.042	0.0385
Onchocerca volvulus		0.0025	0.0642	0.0608
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0096	0.336	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0323	0.0306
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0096	0.336	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0642	0.0608
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0019	0.042	0.0385
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0096	0.336	1
Brugia malayi	nuclear receptor RXR	0.001	0.0077	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0402	0.0367
Entamoeba histolytica	acyl-coA synthetase, putative	0.0025	0.0642	0.1727
Brugia malayi	nuclear receptor NHR-88	0.0019	0.042	0.0402
Plasmodium vivax	acyl-CoA synthetase, putative	0.0019	0.0402	0.0385
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0009	0.0036	0.0018
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0077	0.0059
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0144	0.5205	0.5196
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0642	0.0608
Leishmania major	hypothetical protein, conserved	0.0096	0.336	1
Brugia malayi	AMP-binding enzyme family protein	0.0009	0.0039	0.0021
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0028	0.0751	0.6337
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0016	0.0323	0.0306
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0096	0.336	0.3348
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0323	0.0306
Mycobacterium ulcerans	non-ribosomal peptide synthetase MbtF	0.001	0.0073	0.0616
Brugia malayi	ecdysone receptor	0.0009	0.0036	0.0018
Loa Loa (eye worm)	cysteine protease	0.0016	0.0323	0.0288
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.0036	0.0018
Loa Loa (eye worm)	hypothetical protein	0.001	0.0077	0.0041
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0019	0.042	0.0402
Loa Loa (eye worm)	fatty acid synthase	0.0026	0.0676	0.0642
Loa Loa (eye worm)	acyl carrier protein	0.0012	0.0152	0.0116
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.001	0.0077	0.0059
Onchocerca volvulus		0.0016	0.0323	0.0288
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0323	0.0306
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0019	0.042	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0323	0.0288
Schistosoma mansoni	nuclear receptor nhr-48	0.0009	0.0036	0.0018
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0019	0.042	0.0402
Brugia malayi	hypothetical protein	0.0009	0.0036	0.0018
Loa Loa (eye worm)	hypothetical protein	0.001	0.0077	0.0041
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.0036	0.0018
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0046	0.1438	0.1406
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0028	0.0751	0.6357
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0096	0.336	0.32
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0028	0.0751	0.6357
Leishmania major	cathepsin L-like protease	0.0063	0.2091	0.5986
Brugia malayi	YY1-associated factor 2	0.0096	0.336	0.3348
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Trypanosoma cruzi	WLM domain containing protein, putative	0.0096	0.336	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Brugia malayi	latrophilin 2 splice variant baaae	0.0098	0.3461	0.3449
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.2091	0.6202
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0642	0.5433
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0019	0.042	0.0402
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0019	0.042	0.0402
Onchocerca volvulus		0.0011	0.0115	0.0079
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0323	0.0306
Onchocerca volvulus		0.0016	0.0323	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0096	0.336	0.3336
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0252	0.0216
Mycobacterium tuberculosis	Probable bacterioferritin BfrA	0.0009	0.0033	0.0279
Entamoeba histolytica	hypothetical protein	0.0103	0.3629	1
Brugia malayi	nuclear hormone receptor	0.0009	0.0036	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Mycobacterium ulcerans	polyketide synthase	0.0026	0.0689	0.5834
Onchocerca volvulus		0.0016	0.0323	0.0288
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0019	0.042	0.0402
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0009	0.0036	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0019	0.042	0.0385
Mycobacterium ulcerans	polyketide synthase	0.0028	0.0751	0.6357
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0019	0.042	0.0385
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0144	0.5205	0.5196
Loa Loa (eye worm)	ctsf protein	0.0016	0.0323	0.0288
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0019	0.042	0.0402
Trichomonas vaginalis	ferritin, putative	0.0009	0.0033	0.0015
Brugia malayi	AMP-binding enzyme family protein	0.0032	0.0902	0.0886
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0019	0.042	0.0402
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0009	0.0036	0.0018
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0323	0.0306
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0323	0.0306
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0096	0.336	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0009	0.0036	0.0018
Leishmania major	cathepsin L-like protease	0.0016	0.0323	0.0396
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0026	0.0689	0.5834
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.042	0.0402
Mycobacterium ulcerans	bacterioferritin BfrB	0.0009	0.0033	0.0279
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0323	0.0288
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0026	0.0689	0.0672
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0009	0.0036	0.0018
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.2091	0.6202
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0019	0.042	0.0402
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0019	0.0402	0.3405
Echinococcus granulosus	ferritin	0.0009	0.0033	0.0015
Trypanosoma brucei	hypothetical protein, conserved	0.0096	0.336	1
Schistosoma mansoni	ferritin	0.0009	0.0033	0.0015
Mycobacterium ulcerans	acyl-CoA synthetase	0.0025	0.0642	0.5433
Brugia malayi	steroid hormone receptor	0.0019	0.042	0.0402
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0021	0.0508	0.4299
Schistosoma mansoni	hypothetical protein	0.0046	0.1438	0.1422
Echinococcus multilocularis	nuclear receptor nhr 48	0.0009	0.0036	0.0018
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0323	0.0845
Entamoeba histolytica	hypothetical protein	0.0103	0.3629	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0323	0.0306
Echinococcus granulosus	nuclear receptor nhr 48	0.0009	0.0036	0.0018
Echinococcus granulosus	zinc finger protein Ran binding	0.0096	0.336	0.3348
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0019	0.042	0.0402
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0025	0.0642	0.5433
Onchocerca volvulus		0.0014	0.0227	0.0192
Brugia malayi	ecdysteroid receptor	0.0019	0.042	0.0402
Mycobacterium ulcerans	peptide synthetase Nrp (peptide synthase)	0.001	0.0073	0.0616
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0323	0.0288
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0096	0.336	0.3348
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0323	0.0306
Schistosoma mansoni	hypothetical protein	0.0046	0.1438	0.1422
Leishmania major	cathepsin L-like protease	0.0016	0.0323	0.0396
Schistosoma mansoni	ferritin	0.0009	0.0033	0.0015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0019	0.042	0.0385
Echinococcus multilocularis	ecdysone induced protein 78C	0.0019	0.042	0.0402
Loa Loa (eye worm)	hypothetical protein	0.0096	0.336	0.3336
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0025	0.0642	0.1727
Mycobacterium ulcerans	bacterioferritin BfrA	0.0009	0.0033	0.0279
Echinococcus multilocularis	zinc finger protein Ran binding	0.0096	0.336	0.3348
Onchocerca volvulus		0.0096	0.336	0.3336
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0115	0.0269
Toxoplasma gondii	ran binding protein	0.0096	0.336	0.32
Leishmania major	hypothetical protein, conserved	0.0096	0.336	1
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0198	0.018
Onchocerca volvulus		0.0053	0.1704	0.1674
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0323	0.0396
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.042	0.0402
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsE	0.0017	0.0352	0.2981
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Onchocerca volvulus		0.0016	0.0323	0.0288
Echinococcus granulosus	ecdysone induced protein 78C	0.0019	0.042	0.0402
Entamoeba histolytica	hypothetical protein	0.0103	0.3629	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.042	0.0385
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0026	0.0689	0.5834
Mycobacterium tuberculosis	Probable fatty acid synthase Fas (fatty acid synthetase)	0.0008	0.0007	0.0056
Plasmodium vivax	vivapain-2	0.0016	0.0323	0.0306
Brugia malayi	hypothetical protein	0.001	0.0077	0.0059
Schistosoma mansoni	ferritin light chain	0.0009	0.0033	0.0015
Schistosoma mansoni	nuclear receptor	0.0009	0.0036	0.0018
Leishmania major	cathepsin L-like protease	0.0063	0.2091	0.5986
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0364	0.3077
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0198	0.0162
Echinococcus granulosus	ring and YY1 binding protein	0.0096	0.336	0.3348
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0323	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0096	0.336	0.3336
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0642	0.5407
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0115	0.0079
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0026	0.0689	0.5834
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0323	0.0306
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0323	0.0306
Brugia malayi	Nuclear hormone receptor-like 1	0.0019	0.042	0.0402
Loa Loa (eye worm)	hypothetical protein	0.001	0.0077	0.0041
Brugia malayi	conserved hypotetical protein	0.0009	0.0036	0.0018
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0115	0.0097
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0323	0.0288
Loa Loa (eye worm)	hypothetical protein	0.0019	0.042	0.0385
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.001	0.0077	0.0041
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0019	0.042	0.0402
Schistosoma mansoni	thyroid hormone receptor	0.0019	0.042	0.0402
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.001	0.0073	0.0616
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0323	0.0306
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0019	0.042	0.0402
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0009	0.0036	0.0018
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0323	0.0306
Echinococcus granulosus	cathepsin l1	0.0011	0.0115	0.0097
Mycobacterium ulcerans	polyketide synthase Pks13	0.0039	0.1181	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0019	0.042	0.0402
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0032	0.0902	0.7636
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0198	0.0162
Echinococcus granulosus	cathepsin l1	0.0016	0.0323	0.0306
Trypanosoma cruzi	hypothetical protein, conserved	0.0096	0.336	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0131	0.4696	0.4687
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0026	0.0689	0.581
Echinococcus multilocularis	ring and YY1 binding protein	0.0096	0.336	0.3348
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0009	0.0036	0.0018
Leishmania major	cathepsin L-like protease	0.0016	0.0323	0.0396
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.042	0.0402
Onchocerca volvulus		0.0032	0.0902	0.0869
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0096	0.336	1
Leishmania major	cathepsin L-like protease	0.0016	0.0323	0.0396
Brugia malayi	Steroid receptor seven-up type 2	0.0019	0.042	0.0402
Toxoplasma gondii	type I fatty acid synthase, putative	0.0019	0.0402	0.0171
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0323	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0402	0.0367
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0026	0.0689	0.5834
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0131	0.4696	0.4687
Mycobacterium tuberculosis	Probable polyketide synthase Pks9	0.0015	0.026	0.2199
Leishmania major	4-coumarate:coa ligase-like protein	0.0025	0.0642	0.1404
Onchocerca volvulus		0.0016	0.0323	0.0288
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0017	0.034	0.0106
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0019	0.042	0.0402
Mycobacterium tuberculosis	Bacterioferritin BfrB	0.0009	0.0033	0.0279
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.042	0.0402
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0131	0.4696	0.4687
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.2091	0.6202
Brugia malayi	nuclear receptor RXR	0.0009	0.0036	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0019	0.042	0.0402
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0096	0.336	0.3336
Mycobacterium ulcerans	phenyloxazoline synthase MbtB	0.001	0.0073	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0019	0.042	0.0385
Schistosoma mansoni	hypothetical protein	0.0046	0.1438	0.1422
Trypanosoma brucei	hypothetical protein, conserved	0.0096	0.336	1
Schistosoma mansoni	nuclear receptor	0.0009	0.0036	0.0018
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0323	0.0306
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.001	0.0073	0.0616
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0022	0.0523	0.443
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0323	0.0306
Onchocerca volvulus		0.0016	0.0323	0.0288
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0019	0.042	0.0402
Leishmania major	hypothetical protein, conserved	0.0096	0.336	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.0021	0.0495	0.4188
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0198	0.0538
Loa Loa (eye worm)	fibroinase	0.0016	0.0323	0.0288
Schistosoma mansoni	RAR-like nuclear receptor	0.0019	0.042	0.0402
Schistosoma mansoni	hypothetical protein	0.0103	0.3629	0.3617
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0096	0.336	1
Brugia malayi	Nuclear hormone receptor E75	0.0009	0.0036	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0019	0.042	0.0402
Schistosoma mansoni	hypothetical protein	0.0096	0.336	0.3348
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0009	0.0036	0.0018
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0009	0.0036	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0642	0.0608
Schistosoma mansoni	hypothetical protein	0.0046	0.1438	0.1422
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0323	0.0306
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0115	0.0097
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0323	0.0306
Brugia malayi	photoreceptor-specific nuclear receptor	0.0019	0.042	0.0402
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0016	0.0323	0.0306
Schistosoma mansoni	fusion	0.0096	0.336	0.3348
Schistosoma mansoni	ferritin	0.0009	0.0033	0.0015
Echinococcus multilocularis	expressed protein	0.0009	0.0033	0.0015
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0131	0.4696	0.4687
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0323	0.0306
Mycobacterium tuberculosis	Probable polyketide synthase Pks15	0.0011	0.0096	0.0817
Echinococcus granulosus	FTZ F1 alpha	0.0019	0.042	0.0402
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0025	0.0642	0.5433
Schistosoma mansoni	nuclear hormone receptor	0.0009	0.0036	0.0018
Onchocerca volvulus		0.0096	0.336	0.3336
Loa Loa (eye worm)	hypothetical protein	0.0096	0.336	0.3336
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0022	0.0523	0.4398
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0096	0.336	1
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0009	0.0033	0.0224
Schistosoma mansoni	hypothetical protein	0.0098	0.3461	0.3449
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0323	0.0306
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0323	0.0306
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0019	0.042	0.0402
Trypanosoma cruzi	hypothetical protein, conserved	0.0096	0.336	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0198	0.0162
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0323	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0402	0.0367
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0364	0.3077
Trypanosoma cruzi	hypothetical protein, conserved	0.0096	0.336	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.001	0.0073	0.0616
Loa Loa (eye worm)	hypothetical protein	0.0045	0.1404	0.1373
Brugia malayi	nuclear receptor NHR-88	0.0009	0.0036	0.0018
Mycobacterium ulcerans	polyketide synthase Pks9	0.0017	0.0352	0.2981
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0025	0.0642	0.5407
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0103	0.3629	0.3617
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0115	0.0079
Echinococcus multilocularis	ferritin	0.0009	0.0033	0.0015
Mycobacterium ulcerans	fatty acid synthase Fas	0.0008	0.0007	0.0056
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Leishmania major	cathepsin L-like protease	0.0016	0.0323	0.0396
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.2091	0.6202
Onchocerca volvulus		0.0096	0.336	0.3336
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0025	0.0659	0.5576
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0364	0.3077
Onchocerca volvulus		0.0096	0.336	0.3336
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0115	0.0097
Brugia malayi	cathepsin L-like precursor	0.0011	0.0115	0.0097
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0019	0.042	0.0402
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0026	0.0689	0.5834
Echinococcus granulosus	GPCR family 2	0.0046	0.1438	0.1422
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0021	0.0495	0.4188
Schistosoma mansoni	apoferritin-2	0.0009	0.0033	0.0015
Schistosoma mansoni	TRABID protein (C64 family)	0.0096	0.336	0.3348
Schistosoma mansoni	apoferritin-2	0.0009	0.0033	0.0015
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0046	0.1438	0.1422
Schistosoma mansoni	coup transcription factor	0.0019	0.042	0.0402
Toxoplasma gondii	cathepsin CPL	0.0016	0.0323	0.009
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.042	0.0402

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	= 2 uM	Growth inhibition of human HOP62 cells after 48 hrs by sulforhodamine B assay	ChEMBL.	22364746
GI50 (functional)	= 2.01 uM	Growth inhibition of human KB cells after 48 hrs by sulforhodamine B assay	ChEMBL.	22364746
GI50 (functional)	= 2.7 uM	Growth inhibition of human A549 cells after 48 hrs by sulforhodamine B assay	ChEMBL.	22364746
GI50 (functional)	= 2.9 uM	Growth inhibition of human ZR-75-1 cells after 48 hrs by sulforhodamine B assay	ChEMBL.	22364746

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1958478

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1617929