Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 1 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0174 | 0.4244 | 0.383 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 1 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0053 | 0.0671 | 0.0671 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | hypothetical protein | 0.0194 | 0.486 | 0.486 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0165 | 0.3995 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.7951 | 0.723 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.7951 | 0.723 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0165 | 0.3995 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | DR-78 | 0.0174 | 0.4244 | 0.4244 |
Schistosoma mansoni | nuclear hormone receptor | 0.0174 | 0.4244 | 0.383 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0174 | 0.4244 | 0.383 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0174 | 0.4244 | 0.383 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.7951 | 0.723 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0174 | 0.4244 | 0.383 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.486 | 0.486 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0194 | 0.486 | 0.4491 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0194 | 0.486 | 0.4491 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0299 | 0.7951 | 0.7951 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0338 | 0.9116 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0174 | 0.4244 | 0.4244 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0174 | 0.4244 | 0.383 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0207 | 0.5221 | 0.0743 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0194 | 0.486 | 0.486 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0165 | 0.3995 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0174 | 0.4244 | 0.4244 |
Schistosoma mansoni | nuclear receptor | 0.0174 | 0.4244 | 0.383 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.486 | 0.486 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0207 | 0.5221 | 0.0743 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.486 | 0.486 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0338 | 0.9116 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0174 | 0.4244 | 0.383 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0174 | 0.4244 | 0.383 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.7951 | 0.723 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 1 |
Schistosoma mansoni | nuclear receptor | 0.0174 | 0.4244 | 0.383 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0196 | 0.4908 | 0.1155 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0194 | 0.486 | 0.486 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0174 | 0.4244 | 0.383 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0174 | 0.4244 | 0.383 |
Brugia malayi | nuclear receptor RXR | 0.0194 | 0.486 | 0.486 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0174 | 0.4244 | 0.383 |
Brugia malayi | ecdysone receptor | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Schistosoma mansoni | zinc finger protein | 0.0174 | 0.4244 | 0.383 |
Schistosoma mansoni | nuclear hormone receptor | 0.0174 | 0.4244 | 0.383 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0053 | 0.0671 | 0.0671 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0194 | 0.486 | 0.486 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0194 | 0.486 | 0.4491 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.7951 | 0.723 |
Brugia malayi | nuclear receptor NHR-67 | 0.0174 | 0.4244 | 0.4244 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0174 | 0.4244 | 0.383 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0174 | 0.4244 | 0.383 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0174 | 0.4244 | 0.383 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 0.5 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.486 | 0.486 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0174 | 0.4244 | 0.383 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0338 | 0.9116 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | nuclear receptor NHR-88 | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0174 | 0.4244 | 0.383 |
Brugia malayi | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0174 | 0.4244 | 0.4244 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.486 | 0.486 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0299 | 0.7951 | 0.7951 |
Brugia malayi | tailless protein | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | conserved hypotetical protein | 0.0174 | 0.4244 | 0.4244 |
Brugia malayi | hypothetical protein | 0.0194 | 0.486 | 0.486 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.4244 | 0.4244 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0299 | 0.7951 | 0.723 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0194 | 0.486 | 0.4491 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.889 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.855 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.851 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.685 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.675 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.634 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.581 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.