Detailed information for compound 161802

Basic information

Technical information
  • TDR Targets ID: 161802
  • Name: tert-butyl N-[N-cyclohexyl-N'-[4-(1H-imidazol -5-yl)butyl]carbamimidoyl]carbamate
  • MW: 363.498 | Formula: C19H33N5O2
  • H donors: 3 H acceptors: 2 LogP: 3.83 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(OC(C)(C)C)N/C(=N/C1CCCCC1)/NCCCCc1nc[nH]c1
  • InChi: 1S/C19H33N5O2/c1-19(2,3)26-18(25)24-17(23-15-9-5-4-6-10-15)21-12-8-7-11-16-13-20-14-22-16/h13-15H,4-12H2,1-3H3,(H,20,22)(H2,21,23,24,25)
  • InChiKey: YDOXMYJHEPXGAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[(cyclohexylamino)-[4-(1H-imidazol-5-yl)butylimino]methyl]carbamic acid tert-butyl ester
  • N-[N-cyclohexyl-N'-[4-(1H-imidazol-5-yl)butyl]amidino]carbamic acid tert-butyl ester
  • tert-butyl N-[N-cyclohexyl-N'-[4-(3H-imidazol-4-yl)butyl]carbamimidoyl]carbamate
  • N-[(cyclohexylamino)-[4-(3H-imidazol-4-yl)butylimino]methyl]carbamic acid tert-butyl ester
  • N-[N-cyclohexyl-N'-[4-(3H-imidazol-4-yl)butyl]carbamimidoyl]carbamic acid tert-butyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cavia porcellus Histamine H3 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis neuropeptides capa receptor Histamine H3 receptor   445 aa 441 aa 20.4 %
Echinococcus granulosus biogenic amine 5HT receptor Histamine H3 receptor   445 aa 412 aa 23.8 %
Loa Loa (eye worm) hypothetical protein Histamine H3 receptor   445 aa 386 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.0055 0.0055
Schistosoma mansoni furin-1 (S08 family) 0.0855 0.4473 0.4473
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus neuropeptide FF receptor 2 0.0082 0.0055 0.0055
Onchocerca volvulus Prolyl endopeptidase homolog 0.0132 0.0344 1
Brugia malayi prolyl oligopeptidase family protein 0.0132 0.0344 0.0344
Echinococcus multilocularis neuropeptide receptor 0.0082 0.0055 0.007
Plasmodium vivax subtilisin-like protease 2, putative 0.0084 0.0067 0.5
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0488 0.2379 0.2379
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0084 0.0067 0.0067
Schistosoma mansoni neuropeptide F-like receptor 0.0082 0.0055 0.0055
Echinococcus granulosus g protein coupled receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus epidermal growth factor receptor 0.0128 0.0319 0.0319
Loa Loa (eye worm) subtilase 0.0084 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Schistosoma mansoni site-1 peptidase (S08 family) 0.0084 0.0067 0.0067
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0132 0.0344 0.0344
Loa Loa (eye worm) endoprotease bli-4 0.1822 1 1
Onchocerca volvulus 0.0084 0.0067 0.0429
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0082 0.0055 0.0055
Echinococcus multilocularis sex peptide receptor 0.0082 0.0055 0.007
Schistosoma mansoni opsin-like receptor 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Echinococcus granulosus hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus neuropeptide s receptor 0.0082 0.0055 0.0055
Echinococcus multilocularis serotonin receptor 0.0082 0.0055 0.007
Echinococcus multilocularis fmrfamide receptor 0.0082 0.0055 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0055 0.0055
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.0055 0.007
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.1051 0.5594 0.5594
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0082 0.0055 0.0055
Brugia malayi neuroendocrine convertase 1 precursor 0.1414 0.7667 0.7667
Schistosoma mansoni amine GPCR 0.0082 0.0055 0.0055
Brugia malayi Tachykinin-like peptides receptor 99D 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1051 0.5594 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0404 0.1899 0.3395
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0055 0.0055
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0119 0.0265 1
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0084 0.0067 0.0067
Loa Loa (eye worm) TK/EGFR protein kinase 0.0128 0.0319 0.0319
Schistosoma mansoni neuropeptide receptor 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0082 0.0055 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0055 0.007
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0067 0.012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.0055 0.0055
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.0055 0.007
Schistosoma mansoni myosin xvIII 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0055 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Brugia malayi Furin-like cysteine rich region family protein 0.0128 0.0319 0.0319
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.0055 0.0055
Schistosoma mansoni adenoreceptor 0.0082 0.0055 0.0055
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.0055 0.0055
Schistosoma mansoni biogenic amine receptor 0.0082 0.0055 0.0055
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1822 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0055 0.007
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0404 0.1899 0.3395
Schistosoma mansoni biogenic amine receptor 0.0082 0.0055 0.0055
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.0055 0.007
Brugia malayi Serotonin receptor 0.0082 0.0055 0.0055
Schistosoma mansoni neuropeptide receptor 0.0082 0.0055 0.0055
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Echinococcus multilocularis prolyl endopeptidase 0.0132 0.0344 0.044
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0082 0.0055 0.0055
Echinococcus multilocularis neuropeptide Y receptor 0.0082 0.0055 0.007
Echinococcus granulosus dro:myosuppressin receptor 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0055 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0055 0.007
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Brugia malayi putative neuropeptide receptor 0.0082 0.0055 0.0055
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus neuropeptide receptor 0.0429 0.2038 0.2038
Brugia malayi G protein-coupled receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Brugia malayi proprotein convertase 2 0.1259 0.6785 0.6785
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0082 0.0055 0.0055
Echinococcus granulosus G protein coupled receptor 139 0.0082 0.0055 0.0055
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0082 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0179 0.0608 0.0608
Echinococcus granulosus furin 0.1822 1 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus multilocularis neuropeptide s receptor 0.0082 0.0055 0.007
Echinococcus multilocularis neuropeptide receptor A26 0.0082 0.0055 0.007
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Brugia malayi G protein-coupled receptor F59B2.13 0.0082 0.0055 0.0055
Echinococcus granulosus neuropeptide Y receptor 0.0082 0.0055 0.0055
Echinococcus multilocularis dro:myosuppressin receptor 0.0082 0.0055 0.007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0082 0.0055 0.0055
Brugia malayi RE15519p 0.0082 0.0055 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0055 0.0055
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0055 0.007
Echinococcus granulosus allatostatin A receptor 0.0082 0.0055 0.0055
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0084 0.0067 0.5
Schistosoma mansoni amine GPCR 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0055 0.0055
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0082 0.0055 0.0055
Echinococcus granulosus Furin 1 0.0488 0.2379 0.2379
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0067 0.012
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0082 0.0055 0.007
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0084 0.0067 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0082 0.0055 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Giardia lamblia High cysteine membrane protein Group 2 0.0587 0.2942 1
Echinococcus multilocularis neuroendocrine convertase 2 0.1259 0.6785 0.8668
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.038 0.176 0.3145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Loa Loa (eye worm) proprotein convertase 2 0.0488 0.2379 0.2379
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Schistosoma mansoni neuropeptide receptor 0.0082 0.0055 0.0055
Brugia malayi sulfakinin receptor protein 0.0082 0.0055 0.0055
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0055 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0055 0.007
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Echinococcus multilocularis fmrfamide receptor 0.0082 0.0055 0.007
Echinococcus granulosus sex peptide receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Brugia malayi Dopamine receptor 0.0082 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0082 0.0055 0.0055
Echinococcus multilocularis G-protein coupled receptor, putative 0.0082 0.0055 0.007
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0084 0.0067 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0055 0.007
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0082 0.0055 0.007
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.0055 0.0055
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.0055 0.0055
Echinococcus multilocularis g-protein coupled receptor 0.0082 0.0055 0.007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0082 0.0055 0.007
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0055 0.0055
Schistosoma mansoni biogenic amine receptor 0.0082 0.0055 0.0055
Echinococcus granulosus neuropeptide receptor A26 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0055 0.0055
Echinococcus multilocularis epidermal growth factor receptor 0.0128 0.0319 0.0407
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0488 0.2379 0.4253
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0055 0.007
Brugia malayi G-protein coupled receptor 0.0082 0.0055 0.0055
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0055 0.0055
Trichomonas vaginalis hypothetical protein 0.038 0.176 0.3145
Loa Loa (eye worm) TYRA-2 protein 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Echinococcus multilocularis membrane bound transcription factor site 1 0.0084 0.0067 0.0086
Echinococcus granulosus peptide allatostatin:somatostatin 0.0082 0.0055 0.0055
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0082 0.0055 0.007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0055 0.007
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0082 0.0055 0.007
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0082 0.0055 0.007
Brugia malayi AKH receptor 0.0082 0.0055 0.0055
Echinococcus granulosus tm gpcr rhodopsin 0.0082 0.0055 0.0055
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0082 0.0055 0.007
Echinococcus granulosus neuropeptide receptor 0.0082 0.0055 0.0055
Schistosoma mansoni growth hormone secretagogue receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0067 0.012
Brugia malayi ORL1-like opioid receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Schistosoma mansoni amine GPCR 0.0082 0.0055 0.0055
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0082 0.0055 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0055 0.0055
Brugia malayi larval opioid receptor 0.0082 0.0055 0.0055
Plasmodium vivax subtilisin-like protease 1 0.0084 0.0067 0.5
Brugia malayi GnHR receptor homolog 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0488 0.2379 0.4253
Brugia malayi follicle stimulating hormone receptor 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0067 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Brugia malayi Subtilase family protein 0.0084 0.0067 0.0067
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Brugia malayi Serotonin receptor 0.0082 0.0055 0.0055
Echinococcus granulosus membrane bound transcription factor site 1 0.0084 0.0067 0.0067
Schistosoma mansoni alpha-1 adrenergic receptor 0.0082 0.0055 0.0055
Mycobacterium leprae Possible secreted protease 0.0084 0.0067 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0055 0.0055
Schistosoma mansoni amine GPCR 0.0082 0.0055 0.0055
Loa Loa (eye worm) neuropeptide F receptor 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Echinococcus granulosus prolyl endopeptidase 0.0132 0.0344 0.0344
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.0055 0.0055
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.1051 0.5594 0.7147
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus serotonin receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Brugia malayi Dopamine receptor protein 2 0.0082 0.0055 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0055 0.0055
Plasmodium falciparum subtilisin-like protease 1 0.0084 0.0067 0.5
Loa Loa (eye worm) hypothetical protein 0.0132 0.0344 0.0344
Brugia malayi putative neuropeptide receptor NPR1 0.0082 0.0055 0.0055
Plasmodium falciparum subtilisin-like protease 2 0.0084 0.0067 0.5
Brugia malayi neuropeptide F receptor 0.0082 0.0055 0.0055
Echinococcus multilocularis orexin receptor type 2 0.0082 0.0055 0.007
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0084 0.0067 0.5
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0082 0.0055 0.0055
Echinococcus granulosus 7tm_1 domain containing protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Trypanosoma brucei prolyl endopeptidase 0.0132 0.0344 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0084 0.0067 0.5
Schistosoma mansoni tyrosine kinase 0.0128 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus 7TM GPCR rhodopsin 0.0082 0.0055 0.0055
Echinococcus multilocularis G protein coupled receptor 139 0.0429 0.2038 0.2604
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0082 0.0055 0.0055
Echinococcus multilocularis neuropeptide FF receptor 2 0.0082 0.0055 0.007
Echinococcus multilocularis 0.1442 0.7827 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0082 0.0055 0.0055
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0084 0.0067 0.0067
Echinococcus multilocularis neuropeptides capa receptor 0.0082 0.0055 0.007
Echinococcus granulosus alpha 1A adrenergic receptor 0.0082 0.0055 0.0055
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0082 0.0055 0.0055
Echinococcus granulosus somatostatin receptor 0.0082 0.0055 0.0055
Plasmodium falciparum subtilisin-like protease 3 0.0084 0.0067 0.5
Echinococcus multilocularis neuropeptide receptor 0.0429 0.2038 0.2604
Echinococcus multilocularis somatostatin receptor 0.0082 0.0055 0.007
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1051 0.5594 1
Schistosoma mansoni amine GPCR 0.0082 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0082 0.0055 0.0055
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0082 0.0055 0.007
Echinococcus granulosus orexin receptor type 2 0.0082 0.0055 0.0055
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0108 0.0206 0.0206
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0055 0.007
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0488 0.2379 0.4253
Schistosoma mansoni site-1 peptidase (S08 family) 0.0084 0.0067 0.0067
Echinococcus granulosus g protein coupled receptor 0.0082 0.0055 0.0055
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0084 0.0067 0.0067
Echinococcus multilocularis serotonin receptor 0.0082 0.0055 0.007
Echinococcus multilocularis Furin 1 0.0488 0.2379 0.304
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus tachykinin peptides receptor 99D 0.0082 0.0055 0.0055
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0132 0.0344 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0067 0.0067
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0488 0.2379 0.4253
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0082 0.0055 0.0055
Schistosoma mansoni opsin-like receptor 0.0082 0.0055 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0055 0.0055
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0082 0.0055 0.007
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0055 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0055 0.0055
Echinococcus granulosus g protein coupled receptor 0.0082 0.0055 0.0055
Brugia malayi Dopamine receptor protein 1 0.0082 0.0055 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0055 0.0055
Brugia malayi Melatonin receptor type 1A 0.0082 0.0055 0.0055
Brugia malayi celfurPC protein 0.1442 0.7827 0.7827
Schistosoma mansoni neuropeptide f receptor 76f 0.0082 0.0055 0.0055
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0082 0.0055 0.007
Loa Loa (eye worm) hypothetical protein 0.1822 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0082 0.0055 0.007
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus rhodopsin orphan GPCR 0.0082 0.0055 0.0055
Loa Loa (eye worm) G-protein coupled receptor 0.0082 0.0055 0.0055
Echinococcus granulosus neuroendocrine convertase 2 0.1259 0.6785 0.6785
Toxoplasma gondii prolyl endopeptidase 0.0132 0.0344 1
Plasmodium vivax subtilisin-like serine protease, putative 0.0084 0.0067 0.5
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0082 0.0055 0.0055
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Schistosoma mansoni hypothetical protein 0.038 0.176 0.176
Trichomonas vaginalis conserved hypothetical protein 0.038 0.176 0.3145
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0082 0.0055 0.0055
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Schistosoma mansoni neuropeptide receptor 0.0429 0.2038 0.2038
Trypanosoma cruzi prolyl endopeptidase 0.0132 0.0344 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus fmrfamide receptor 0.0082 0.0055 0.0055
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0132 0.0344 0.0344
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0082 0.0055 0.0055
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.0067 0.012
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus multilocularis allatostatin A receptor 0.0082 0.0055 0.007
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0082 0.0055 0.0055
Toxoplasma gondii subtilisin SUB12 0.0098 0.0149 0.2971
Brugia malayi G-protein coupled receptor 0.0082 0.0055 0.0055
Brugia malayi neuropeptide F receptor 0.0082 0.0055 0.0055
Schistosoma mansoni histamine h1 receptor 0.0082 0.0055 0.0055
Echinococcus multilocularis g protein coupled receptor 0.0082 0.0055 0.007
Echinococcus granulosus neuropeptides capa receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Echinococcus granulosus biogenic amine 5HT receptor 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0795 0.4132 0.4132
Loa Loa (eye worm) melatonin receptor type 1A 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0084 0.0067 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0108 0.0206 0.0369
Brugia malayi hypothetical protein 0.0082 0.0055 0.0055
Loa Loa (eye worm) hypothetical protein 0.0082 0.0055 0.0055
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0084 0.0067 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0488 0.2379 0.4253
Schistosoma mansoni opsin-like receptor 0.0082 0.0055 0.0055
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0082 0.0055 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0082 0.0055 0.0055
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0488 0.2379 0.4253
Echinococcus granulosus g-protein coupled receptor 0.0082 0.0055 0.0055

Activities

Activity type Activity value Assay description Source Reference
-Log Ki (functional) = 8.2 Antagonistic activity for Histamine H3 receptor on electrically evoked guinea-pig ileum contraction ChEMBL. No reference
Ki (functional) = 8.2 Antagonistic activity for Histamine H3 receptor on electrically evoked guinea-pig ileum contraction ChEMBL. No reference
Ki (binding) = 0.000000007 M Antagonistic activity for Histamine H3 receptor binding in guinea pig ChEMBL. No reference
Ki (binding) = 0.000000007 M Antagonistic activity for Histamine H3 receptor binding in guinea pig ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.