Detailed information for compound 1618321

Basic information

Technical information
  • TDR Targets ID: 1618321
  • Name: 3-[1,3-bis(4-chlorophenyl)-3-oxopropyl]sulfan yl-N-(4-chlorophenyl)propanamide
  • MW: 492.845 | Formula: C24H20Cl3NO2S
  • H donors: 1 H acceptors: 2 LogP: 6.41 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(CC(=O)c1ccc(cc1)Cl)SCCC(=O)Nc1ccc(cc1)Cl
  • InChi: 1S/C24H20Cl3NO2S/c25-18-5-1-16(2-6-18)22(29)15-23(17-3-7-19(26)8-4-17)31-14-13-24(30)28-21-11-9-20(27)10-12-21/h1-12,23H,13-15H2,(H,28,30)
  • InChiKey: ZBCUECKEOGVDSP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[1,3-bis(4-chlorophenyl)-3-oxo-propyl]sulfanyl-N-(4-chlorophenyl)propanamide
  • 3-[[1,3-bis(4-chlorophenyl)-3-oxopropyl]thio]-N-(4-chlorophenyl)propanamide
  • 3-[[1,3-bis(4-chlorophenyl)-3-keto-propyl]thio]-N-(4-chlorophenyl)propionamide
  • NCI60_040608
  • NSC717769

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) SRC-1 0.1353 0.9994 1
Echinococcus multilocularis fch and double sh3 domains protein 2 0.0165 0.0689 0.067
Brugia malayi Variant SH3 domain containing protein 0.0178 0.0786 0.0786
Brugia malayi tRNA modification GTPase TrmE family protein 0.0169 0.0722 0.0722
Entamoeba histolytica hypothetical protein, conserved 0.0165 0.0689 0.0901
Echinococcus multilocularis transfer RNA-Ala 0.0165 0.0689 0.067
Echinococcus granulosus laminin 0.0084 0.005 0.0029
Loa Loa (eye worm) hypothetical protein 0.0165 0.0689 0.067
Loa Loa (eye worm) protein-tyrosine kinase 0.0165 0.0689 0.067
Echinococcus granulosus expressed protein 0.0165 0.0689 0.0669
Onchocerca volvulus 0.0165 0.0689 0.1142
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Entamoeba histolytica hypothetical protein 0.0165 0.0689 0.0901
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0178 0.0786 0.0767
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Entamoeba histolytica BAR/SH3 domain containing protein 0.0165 0.0689 0.0901
Echinococcus multilocularis tyrosine protein kinase Abl 0.0804 0.5689 0.5684
Loa Loa (eye worm) TK/ROR protein kinase 0.0099 0.0171 0.0151
Schistosoma mansoni tyrosine kinase 0.0237 0.1249 0.1231
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0929 0.667 0.6667
Echinococcus granulosus Spectrin alpha actinin 0.0165 0.0689 0.0669
Onchocerca volvulus 0.0169 0.0722 0.1199
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0169 0.0722 0.0703
Echinococcus granulosus intersectin 2 0.0165 0.0689 0.0669
Echinococcus granulosus tensin 0.0169 0.0722 0.0702
Echinococcus multilocularis raf serine:threonine protein kinase 0.03 0.1742 0.1726
Loa Loa (eye worm) hypothetical protein 0.0126 0.0379 0.0359
Trichomonas vaginalis neutrophil cytosolic factor 2, neutrophil NADPH oxidase factor, putative 0.0165 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Loa Loa (eye worm) hypothetical protein 0.0165 0.0689 0.067
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0402 0.2543 0.2528
Schistosoma mansoni cell adhesion molecule 0.0157 0.0626 0.0606
Schistosoma mansoni hypothetical protein 0.0165 0.0689 0.067
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0165 0.0689 0.067
Echinococcus granulosus tyrosine protein kinase Src42A 0.1353 0.9994 0.9993
Schistosoma mansoni tyrosine kinase 0.1118 0.8152 0.8154
Echinococcus multilocularis tyrosine protein kinase Blk 0.1188 0.87 0.8703
Loa Loa (eye worm) hypothetical protein 0.0165 0.0689 0.067
Onchocerca volvulus 0.0169 0.0722 0.1199
Echinococcus multilocularis Immunoglobulin 0.0109 0.0249 0.0228
Plasmodium falciparum cysteine repeat modular protein 2 0.0081 0.0027 0.5
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.1353 0.9994 0.9993
Brugia malayi SH2 domain containing protein 0.0271 0.1516 0.1517
Echinococcus multilocularis signal transduction protein lnk realted 0.0169 0.0722 0.0703
Echinococcus granulosus growth factor receptor bound protein 2 0.0335 0.2016 0.1999
Echinococcus granulosus tyrosine kinase 0.0237 0.1249 0.123
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.008 0.0025 0.0025
Schistosoma mansoni nck2/grb4 0.0335 0.2016 0.2
Schistosoma mansoni suppressor of cytokine signaling 0.0169 0.0722 0.0703
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.1353 0.9994 1
Trypanosoma cruzi paraflagellar rod protein 5, putative 0.0165 0.0689 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0134 0.0447 0.0427
Entamoeba histolytica SH2-protein kinase domain containing protein 0.017 0.0728 0.0954
Schistosoma mansoni Dab2-interacting protein-like 0.0165 0.0689 0.067
Brugia malayi Sex muscle abnormal protein 5 0.0335 0.2016 0.2017
Entamoeba histolytica hypothetical protein 0.0165 0.0689 0.0901
Echinococcus multilocularis tensin 0.0169 0.0722 0.0703
Schistosoma mansoni adapter molecule crk 0.0335 0.2016 0.2
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1121 0.8173 0.8174
Echinococcus granulosus tyrosine protein kinase ABL1 0.1287 0.9479 0.9478
Entamoeba histolytica hypothetical protein 0.0165 0.0689 0.0901
Brugia malayi Calcium binding EGF domain containing protein 0.0084 0.005 0.005
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0099 0.0171 0.0151
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0169 0.0722 0.0702
Brugia malayi Myosin tail family protein 0.0165 0.0689 0.069
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0085 0.0059 0.0055
Echinococcus granulosus expressed conserved protein 0.0169 0.0722 0.0702
Schistosoma mansoni tyrosine kinase 0.0402 0.2543 0.2528
Schistosoma mansoni tyrosine kinase 0.0131 0.0418 0.0398
Schistosoma mansoni slit-robo rho gtpase activating protein 0.0165 0.0689 0.067
Brugia malayi Variant SH3 domain containing protein 0.0165 0.0689 0.069
Brugia malayi Tyrosine-protein kinase abl-1 0.0649 0.4479 0.4481
Echinococcus multilocularis tyrosine protein kinase csk 0.0101 0.0189 0.0169
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0169 0.0722 0.0703
Schistosoma mansoni shc transforming protein 0.0169 0.0722 0.0703
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0152 0.0589 0.057
Echinococcus granulosus neuroglian 0.0141 0.0498 0.0478
Loa Loa (eye worm) SH2 domain-containing protein 0.0204 0.0989 0.0971
Onchocerca volvulus 0.0271 0.1516 0.2571
Echinococcus granulosus epidermal growth factor receptor kinase 0.0165 0.0689 0.0669
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.1188 0.87 0.8697
Echinococcus granulosus hypothetical protein 0.0169 0.0722 0.0702
Echinococcus multilocularis hematopoietic lineage cell specific protein 0.0165 0.0689 0.067
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0306 0.1794 0.1778
Schistosoma mansoni growth factor receptor-bound protein 0.0335 0.2016 0.2
Brugia malayi Protein kinase domain containing protein 0.0237 0.1249 0.125
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0165 0.0689 0.067
Onchocerca volvulus 0.0089 0.0094 0.0114
Echinococcus multilocularis 0.0169 0.0722 0.0703
Schistosoma mansoni sh3-containing grb2-like protein 1 (endophilin II) 0.0165 0.0689 0.067
Entamoeba histolytica SH2 domain containing protein 0.0169 0.0722 0.0946
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0335 0.2016 0.2
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0099 0.0171 0.015
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0109 0.0249 0.0228
Loa Loa (eye worm) hypothetical protein 0.0081 0.0027 0.0006
Onchocerca volvulus 0.0237 0.1249 0.2109
Echinococcus multilocularis expressed protein 0.0165 0.0689 0.067
Echinococcus granulosus c src tyrosine kinase 0.0436 0.281 0.2795
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0178 0.0786 0.0767
Schistosoma mansoni run and tbc1 domain containing 0.0165 0.0689 0.067
Echinococcus granulosus SH2 domain containing protein 7 0.0169 0.0722 0.0702
Loa Loa (eye worm) hypothetical protein 0.0165 0.0689 0.067
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0152 0.0589 0.0589
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.1353 0.9994 0.9993
Loa Loa (eye worm) hypothetical protein 0.0081 0.0027 0.0006
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0237 0.1249 0.1231
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0021 0.0021
Echinococcus multilocularis SH2 motif 0.0169 0.0722 0.0703
Schistosoma mansoni eps8-related protein 0.0165 0.0689 0.067
Schistosoma mansoni protein kinase 0.008 0.0025 0.0003
Echinococcus multilocularis Spectrin alpha actinin 0.0165 0.0689 0.067
Loa Loa (eye worm) hypothetical protein 0.0165 0.0689 0.067
Schistosoma mansoni tyrosine kinase 0.1353 0.9994 1
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0689 1
Echinococcus multilocularis roundabout 2 0.0189 0.0875 0.0856
Brugia malayi Variant SH3 domain containing protein 0.0165 0.0689 0.069
Plasmodium falciparum cysteine repeat modular protein 4 0.0081 0.0027 0.5
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0169 0.0722 0.0702
Schistosoma mansoni formin binding protein and related proteins 0.0165 0.0689 0.067
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0402 0.2543 0.2528
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0081 0.0028 0.0007
Entamoeba histolytica BAR/SH3 domain containing protein 0.0165 0.0689 0.0901
Brugia malayi Variant SH3 domain containing protein 0.0165 0.0689 0.069
Echinococcus granulosus fch and double sh3 domains protein 2 0.0165 0.0689 0.0669
Echinococcus multilocularis tyrosine protein kinase HCK 0.1018 0.7373 0.7372
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Loa Loa (eye worm) calcium binding EGF domain-containing protein 0.03 0.1743 0.1727
Loa Loa (eye worm) hypothetical protein 0.014 0.0495 0.0475
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0169 0.0722 0.0703
Schistosoma mansoni tensin 0.0169 0.0722 0.0703
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.008 0.0025 0.0003
Onchocerca volvulus 0.0166 0.0696 0.1154
Echinococcus granulosus src region 0.0165 0.0689 0.0669
Schistosoma mansoni vav2 0.0178 0.0786 0.0767
Loa Loa (eye worm) TK/EGFR protein kinase 0.0227 0.1174 0.1156
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0169 0.0722 0.0703
Schistosoma mansoni hypothetical protein 0.0165 0.0689 0.067
Brugia malayi Tensin 0.0169 0.0722 0.0722
Schistosoma mansoni hypothetical protein 0.0081 0.0027 0.0006
Loa Loa (eye worm) hypothetical protein 0.0165 0.0689 0.067
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1353 0.9994 1
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0084 0.005 0.0029
Entamoeba histolytica hypothetical protein 0.0165 0.0689 0.0901
Schistosoma mansoni tensin-related 0.0169 0.0722 0.0703
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0402 0.2543 0.2527
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Echinococcus granulosus suppressor of cytokine signaling 7 0.0169 0.0722 0.0702
Entamoeba histolytica hypothetical protein 0.0165 0.0689 0.0901
Brugia malayi Guanylate kinase family protein 0.0165 0.0689 0.069
Echinococcus multilocularis fibrillin 1 0.0084 0.005 0.0029
Brugia malayi SH2 domain containing protein 0.0169 0.0722 0.0722
Echinococcus granulosus breast cancer anti estrogen resistance protein 0.0165 0.0689 0.0669
Brugia malayi SH2 domain containing protein 0.0237 0.1249 0.125
Loa Loa (eye worm) hypothetical protein 0.0172 0.0745 0.0726
Brugia malayi Tyrosine-protein kinase abl-1 0.0804 0.5689 0.5693
Schistosoma mansoni SH2A 0.0169 0.0722 0.0703
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0109 0.0249 0.0228
Brugia malayi Spectrin alpha chain 0.0165 0.0689 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0689 1
Brugia malayi protein-tyrosine kinase 0.1188 0.87 0.8705
Loa Loa (eye worm) hypothetical protein 0.0165 0.0689 0.067
Brugia malayi Immunoglobulin I-set domain containing protein 0.0338 0.2044 0.2045
Brugia malayi Fibulin-1 precursor 0.0084 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0086 0.0066 0.0045
Schistosoma mansoni hypothetical protein 0.0169 0.0722 0.0703
Schistosoma mansoni serine/threonine protein kinase 0.03 0.1742 0.1726
Brugia malayi GCC2 and GCC3 family protein 0.0081 0.0027 0.0028
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0178 0.0786 0.0767
Echinococcus multilocularis rho guanine nucleotide exchange factor 7 0.0165 0.0689 0.067
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0689 1
Loa Loa (eye worm) hypothetical protein 0.0237 0.1249 0.1231
Plasmodium falciparum cysteine repeat modular protein 3 0.0081 0.0027 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.1287 0.9479 0.9484
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Schistosoma mansoni tensin-related 0.0169 0.0722 0.0703
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Brugia malayi Variant SH3 domain containing protein 0.0335 0.2016 0.2017
Onchocerca volvulus 0.0169 0.0722 0.1199
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1353 0.9994 1
Loa Loa (eye worm) TK/INSR protein kinase 0.0118 0.0317 0.0297
Entamoeba histolytica unconventional myosin IB 0.0165 0.0689 0.0901
Loa Loa (eye worm) hypothetical protein 0.0201 0.0968 0.095
Echinococcus granulosus hematopoietic lineage cell specific protein 0.0165 0.0689 0.0669
Schistosoma mansoni suppressor of cytokine signaling 0.0169 0.0722 0.0703
Loa Loa (eye worm) thyroid receptor interactor 0.0165 0.0689 0.067
Schistosoma mansoni tyrosine kinase 0.0306 0.1794 0.1778
Loa Loa (eye worm) hypothetical protein 0.0161 0.0655 0.0636
Schistosoma mansoni tyrosine kinase 0.0085 0.0065 0.0044
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0306 0.1794 0.1778
Echinococcus granulosus tyrosine protein kinase Src42A 0.1121 0.8173 0.8169
Echinococcus granulosus epidermal growth factor receptor 0.0153 0.0591 0.0571
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Schistosoma mansoni tyrosine kinase 0.0153 0.0591 0.0572
Loa Loa (eye worm) hypothetical protein 0.0335 0.2016 0.2
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0335 0.2016 0.2
Echinococcus granulosus ephrin type A receptor 4 A 0.0487 0.3208 0.3194
Echinococcus multilocularis endonuclease reverse transcriptase 0.0081 0.0027 0.0006
Loa Loa (eye worm) protein kinase C and casein kinase substrate in neurons protein 2 0.0165 0.0689 0.067
Onchocerca volvulus 0.0165 0.0689 0.1142
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0689 1
Brugia malayi Peripheral plasma membrane protein CASK 0.0165 0.0689 0.069
Entamoeba histolytica hypothetical protein 0.0165 0.0689 0.0901
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0169 0.0722 0.0703
Schistosoma mansoni cell polarity protein 0.0165 0.0689 0.067
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0021 0.0021
Schistosoma mansoni signal transduction protein lnk-related 0.0169 0.0722 0.0703
Loa Loa (eye worm) hypothetical protein 0.0126 0.0379 0.0359
Loa Loa (eye worm) p53BP2 0.0165 0.0689 0.067
Entamoeba histolytica hypothetical protein, conserved 0.0165 0.0689 0.0901
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1353 0.9994 1
Schistosoma mansoni tyrosine kinase 0.0436 0.281 0.2797
Brugia malayi Protein kinase domain containing protein 0.0237 0.1249 0.125
Echinococcus granulosus SHC transforming protein 3 0.0169 0.0722 0.0702
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.0379 0.0379
Schistosoma mansoni tyrosine kinase 0.0153 0.0591 0.0572
Schistosoma mansoni sorting nexin 0.0165 0.0689 0.067
Echinococcus granulosus rho guanine nucleotide exchange factor 7 0.0165 0.0689 0.0669
Echinococcus granulosus tyrosine protein kinase HCK 0.1018 0.7373 0.7367
Loa Loa (eye worm) TK protein kinase 0.0338 0.2044 0.2028
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0134 0.0447 0.0427
Echinococcus granulosus roundabout 2 0.0189 0.0875 0.0856
Echinococcus granulosus fibroblast growth factor receptor 4 0.0306 0.1794 0.1777
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Loa Loa (eye worm) hypothetical protein 0.0081 0.0027 0.0006
Onchocerca volvulus Arrow homolog 0.0152 0.0589 0.097
Echinococcus multilocularis tyrosine protein kinase csk 0.0101 0.0189 0.0169
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0169 0.0722 0.0703
Echinococcus granulosus nostrin 0.0165 0.0689 0.0669
Brugia malayi SH3 domain containing protein 0.0165 0.0689 0.069
Echinococcus granulosus defective proboscis extension response 0.0109 0.0249 0.0228
Echinococcus granulosus SH2 domain containing adapter protein F 0.0169 0.0722 0.0702
Echinococcus granulosus SH2 motif 0.0169 0.0722 0.0702
Entamoeba histolytica hypothetical protein 0.0165 0.0689 0.0901
Loa Loa (eye worm) hypothetical protein 0.0109 0.0249 0.0228
Schistosoma mansoni GTPase activating protein 0.0169 0.0722 0.0703
Brugia malayi Calcium binding EGF domain containing protein 0.03 0.1743 0.1744
Echinococcus granulosus tyrosine protein kinase shark 0.0237 0.1249 0.123
Schistosoma mansoni tyrosine kinase 0.0227 0.1174 0.1156
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0689 1
Onchocerca volvulus 0.0237 0.1249 0.2109
Brugia malayi Fibronectin type III domain containing protein 0.0126 0.0379 0.0379
Brugia malayi STAT protein, DNA binding domain containing protein 0.0169 0.0722 0.0722
Toxoplasma gondii calcium binding egf domain-containing protein 0.0084 0.005 1
Onchocerca volvulus 0.0165 0.0689 0.1142
Loa Loa (eye worm) SH2 domain-containing protein 0.0169 0.0722 0.0703
Onchocerca volvulus 0.0721 0.5043 0.866
Schistosoma mansoni tyrosine kinase 0.0237 0.1249 0.1231
Brugia malayi hypothetical protein 0.0169 0.0722 0.0722
Brugia malayi SH2 domain containing protein 0.0169 0.0722 0.0722
Echinococcus granulosus tyrosine protein kinase Src64B 0.1353 0.9994 0.9993
Echinococcus granulosus tyrosine protein kinase Srms 0.0237 0.1249 0.123
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0178 0.0786 0.0767
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0306 0.1794 0.1777
Echinococcus multilocularis tyrosine protein kinase csk 0.0101 0.0189 0.0169
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0169 0.0722 0.0703
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Echinococcus multilocularis neuroglian 0.0141 0.0498 0.0479
Echinococcus multilocularis N chimaerin 0.0178 0.0786 0.0767
Loa Loa (eye worm) guanylate kinase 0.0165 0.0689 0.067
Loa Loa (eye worm) SH2 domain-containing protein 0.0169 0.0722 0.0703
Brugia malayi Protein kinase domain containing protein 0.0237 0.1249 0.125
Echinococcus granulosus NCK adaptor protein 0.0335 0.2016 0.1999
Echinococcus granulosus tyrosine protein kinase Blk 0.1188 0.87 0.8697
Echinococcus multilocularis c src tyrosine kinase 0.0436 0.281 0.2797
Brugia malayi Immunoglobulin I-set domain containing protein 0.0929 0.667 0.6674
Brugia malayi ephrin receptor 1 precursor 0.0227 0.1173 0.1174
Echinococcus multilocularis nostrin 0.0165 0.0689 0.067
Loa Loa (eye worm) TK protein kinase 0.1188 0.87 0.8703
Loa Loa (eye worm) hypothetical protein 0.0165 0.0689 0.067
Echinococcus multilocularis tyrosine protein kinase Fgr 0.1353 0.9994 1
Brugia malayi Protein kinase domain containing protein 0.0118 0.0317 0.0317
Echinococcus multilocularis growth factor receptor bound protein 2 0.0335 0.2016 0.2
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0169 0.0722 0.0703
Echinococcus granulosus dual specificity mitogen activated protein 0.008 0.0025 0.0003
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0169 0.0722 0.0702
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0169 0.0722 0.0703
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0165 0.0689 0.067
Entamoeba histolytica protein kinase, putative 0.1018 0.7373 1
Plasmodium falciparum cysteine repeat modular protein 1 0.0081 0.0027 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0101 0.0189 0.0169
Giardia lamblia Hypothetical protein 0.0081 0.0027 1
Echinococcus granulosus slit robo rho gtpase activating protein 1 0.0165 0.0689 0.0669
Loa Loa (eye worm) raf kinase 0.0232 0.1216 0.1198
Brugia malayi Furin-like cysteine rich region family protein 0.0227 0.1174 0.1175
Loa Loa (eye worm) TK protein kinase 0.1018 0.7373 0.7372
Schistosoma mansoni tensin 0.0169 0.0722 0.0703
Loa Loa (eye worm) hypothetical protein 0.0172 0.0745 0.0726
Echinococcus granulosus tyrosine protein kinase Fyn 0.1353 0.9994 0.9993
Trypanosoma brucei conserved protein 0.0165 0.0689 1
Brugia malayi RhoGAP domain containing protein 0.0178 0.0786 0.0786
Loa Loa (eye worm) TK/CSK protein kinase 0.0101 0.0189 0.0169
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0165 0.0689 0.0669
Echinococcus multilocularis NCK adaptor protein 0.0335 0.2016 0.2
Brugia malayi Src substrate cortactin 0.0165 0.0689 0.069
Schistosoma mansoni tyrosine kinase 0.0118 0.0317 0.0297
Loa Loa (eye worm) hypothetical protein 0.0469 0.3069 0.3056
Brugia malayi SH2 domain containing protein 0.0169 0.0722 0.0722
Schistosoma mansoni growth factor receptor-bound protein 0.0335 0.2016 0.2
Echinococcus multilocularis SH2 motif 0.0169 0.0722 0.0703
Echinococcus multilocularis intersectin 2 0.0165 0.0689 0.067
Onchocerca volvulus Tyrosine kinase homolog 0.082 0.5819 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0487 0.3208 0.3196
Brugia malayi Protein kinase domain containing protein 0.0237 0.1249 0.125
Echinococcus granulosus raf serine:threonine protein kinase 0.03 0.1742 0.1725
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0689 1
Echinococcus multilocularis tyrosine protein kinase shark 0.0237 0.1249 0.1231
Loa Loa (eye worm) hypothetical protein 0.0236 0.124 0.1223
Schistosoma mansoni tyrosine kinase 0.0085 0.0065 0.0044
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1188 0.87 0.8703
Schistosoma mansoni ephrin receptor 0.0406 0.2576 0.2562
Leishmania major hypothetical protein, conserved 0.0165 0.0689 1
Brugia malayi Variant SH3 domain containing protein 0.0165 0.0689 0.069
Brugia malayi hypothetical protein 0.0126 0.0379 0.0379
Brugia malayi Variant SH3 domain containing protein 0.0165 0.0689 0.069
Echinococcus multilocularis epidermal growth factor receptor 0.0153 0.0591 0.0572
Echinococcus granulosus tyrosine protein kinase csk 0.0101 0.0189 0.0169
Echinococcus granulosus N chimaerin 0.0178 0.0786 0.0766
Brugia malayi Variant SH3 domain containing protein 0.0169 0.0722 0.0722
Schistosoma mansoni signal transducing adapter molecule (stam) 0.0165 0.0689 0.067
Loa Loa (eye worm) hypothetical protein 0.0089 0.0094 0.0073
Schistosoma mansoni tyrosine kinase 0.0118 0.0317 0.0297
Brugia malayi GCC2 and GCC3 family protein 0.0089 0.0094 0.0094
Brugia malayi Fes/CIP4 homology domain containing protein 0.0165 0.0689 0.069
Echinococcus multilocularis slit robo rho gtpase activating protein 1 0.0165 0.0689 0.067
Onchocerca volvulus LIM and SH3 domain protein homolog 0.0165 0.0689 0.1142
Echinococcus multilocularis tyrosine kinase 0.0237 0.1249 0.1231
Echinococcus multilocularis insulin receptor 0.0118 0.0317 0.0297
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Loa Loa (eye worm) hypothetical protein 0.0109 0.0249 0.0228
Echinococcus multilocularis epidermal growth factor receptor 0.0227 0.1174 0.1156
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Echinococcus multilocularis SH2 domain containing protein 7 0.0169 0.0722 0.0703
Onchocerca volvulus 0.0237 0.1249 0.2109
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.1353 0.9994 1
Echinococcus multilocularis tyrosine protein kinase Src64B 0.1353 0.9994 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.1353 0.9994 0.9993
Echinococcus granulosus tyrosine protein kinase csk 0.0101 0.0189 0.0169
Echinococcus multilocularis endophilin A3 0.0165 0.0689 0.067
Trichomonas vaginalis p67phox protein, putative 0.0165 0.0689 1
Brugia malayi Raf kinase 0.0291 0.1678 0.168
Plasmodium falciparum conserved protein, unknown function 0.0081 0.0027 0.5
Brugia malayi Variant SH3 domain containing protein 0.0335 0.2016 0.2017
Trypanosoma cruzi hypothetical protein, conserved 0.0165 0.0689 1
Echinococcus multilocularis dual specificity mitogen activated protein 0.008 0.0025 0.0003
Echinococcus granulosus epidermal growth factor receptor 0.0227 0.1174 0.1155
Schistosoma mansoni C-fyn 0.0165 0.0689 0.067
Loa Loa (eye worm) hypothetical protein 0.0339 0.2049 0.2034
Schistosoma mansoni ephrin receptor 0.0084 0.0052 0.0031
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Trypanosoma cruzi hypothetical protein, conserved 0.0165 0.0689 1
Echinococcus multilocularis basement membrane specific heparan sulfate 0.013 0.0417 0.0397
Loa Loa (eye worm) hypothetical protein 0.0176 0.0776 0.0757
Brugia malayi SH2 domain containing protein 0.0169 0.0722 0.0722
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0169 0.0722 0.0722
Onchocerca volvulus 0.0169 0.0722 0.1199
Echinococcus granulosus twitchin 0.0142 0.0505 0.0485
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.1353 0.9994 1
Onchocerca volvulus 0.0169 0.0722 0.1199
Toxoplasma gondii calcium binding egf domain-containing protein 0.0084 0.005 1
Echinococcus multilocularis tyrosine protein kinase Srms 0.1188 0.87 0.8703
Giardia lamblia CEGP1 protein 0.0081 0.0027 1
Schistosoma mansoni nephrin 0.0157 0.0629 0.0609
Echinococcus granulosus tyrosine protein kinase Fyn 0.1353 0.9994 0.9993
Onchocerca volvulus 0.0237 0.1249 0.2109
Brugia malayi hypothetical protein 0.0237 0.1249 0.125
Echinococcus multilocularis tyrosine protein kinase ABL1 0.1287 0.9479 0.9484
Loa Loa (eye worm) hypothetical protein 0.0165 0.0689 0.067
Echinococcus granulosus suppressor of cytokine signaling 6 0.0169 0.0722 0.0702
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0178 0.0786 0.0766
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0169 0.0722 0.0703
Brugia malayi SH2 domain containing protein 0.0169 0.0722 0.0722
Brugia malayi SH2 domain containing protein 0.0169 0.0722 0.0722
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0199 0.095 0.0932
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Onchocerca volvulus 0.0339 0.2049 0.3491
Echinococcus granulosus signal transduction protein lnk realted 0.0169 0.0722 0.0702
Schistosoma mansoni apoptosis stimulating of P53 0.0165 0.0689 0.067
Entamoeba histolytica protein kinase, putative 0.017 0.0728 0.0954
Brugia malayi Variant SH3 domain containing protein 0.0165 0.0689 0.069
Trichomonas vaginalis conserved hypothetical protein 0.0165 0.0689 1
Schistosoma mansoni vesicular amine transporter 0.0109 0.0249 0.0228
Loa Loa (eye worm) hypothetical protein 0.0105 0.0219 0.0198
Echinococcus multilocularis SH2 motif 0.0169 0.0722 0.0703
Loa Loa (eye worm) hypothetical protein 0.0109 0.0249 0.0228
Echinococcus granulosus endonuclease reverse transcriptase 0.0081 0.0027 0.0006
Loa Loa (eye worm) TK/FER protein kinase 0.0237 0.1249 0.1231
Echinococcus multilocularis tyrosine protein kinase csk 0.0101 0.0189 0.0169
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0153 0.0591 0.0571
Brugia malayi Protein kinase domain containing protein 0.0237 0.1249 0.125
Onchocerca volvulus 0.0237 0.1249 0.2109
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.1216 0.1198
Schistosoma mansoni tensin 0.0169 0.0722 0.0703
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0169 0.0722 0.0703
Schistosoma mansoni tyrosine kinase 0.1353 0.9994 1
Schistosoma mansoni sorbin 0.0165 0.0689 0.067
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.014 0.0495 0.0475
Onchocerca volvulus 0.0165 0.0689 0.1142
Brugia malayi SH2 domain containing protein 0.0169 0.0722 0.0722
Echinococcus multilocularis laminin 0.0084 0.005 0.0029
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0169 0.0722 0.0702
Brugia malayi GCC2 and GCC3 family protein 0.0081 0.0027 0.0028
Echinococcus multilocularis tensin 0.0169 0.0722 0.0703
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0335 0.2016 0.2
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0169 0.0722 0.1199
Echinococcus multilocularis Immunoglobulin 0.0109 0.0249 0.0228
Entamoeba histolytica hypothetical protein 0.0165 0.0689 0.0901
Echinococcus multilocularis tyrosine protein kinase Fyn 0.1353 0.9994 1
Brugia malayi SRC-1 0.1353 0.9994 1
Loa Loa (eye worm) STAT protein 0.0169 0.0722 0.0703
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0237 0.1249 0.1663
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Onchocerca volvulus 0.0169 0.0722 0.1199
Brugia malayi protein-tyrosine kinase 0.0165 0.0689 0.069
Echinococcus granulosus SH2 motif 0.0169 0.0722 0.0702
Trypanosoma cruzi hypothetical protein, conserved 0.0165 0.0689 1
Onchocerca volvulus 0.03 0.1743 0.2962
Echinococcus multilocularis SHC transforming protein 3 0.0169 0.0722 0.0703
Schistosoma mansoni dreadlocks/dock 0.0165 0.0689 0.067
Loa Loa (eye worm) TK/EPH protein kinase 0.0499 0.3304 0.3292
Brugia malayi Immunoglobulin I-set domain containing protein 0.008 0.0021 0.0021
Echinococcus multilocularis breast cancer anti estrogen resistance protein 0.0165 0.0689 0.067
Brugia malayi GCC2 and GCC3 family protein 0.0081 0.0027 0.0028
Schistosoma mansoni dynamin-associated protein 0.0165 0.0689 0.067
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0169 0.0722 0.0703
Brugia malayi cytokine inducible SH2-containing protein 5 0.0169 0.0722 0.0722
Echinococcus multilocularis epidermal growth factor receptor kinase 0.0165 0.0689 0.067
Schistosoma mansoni tyrosine kinase 0.0085 0.0065 0.0044
Echinococcus granulosus Immunoglobulin 0.0109 0.0249 0.0228
Schistosoma mansoni hypothetical protein 0.0169 0.0722 0.0703
Entamoeba histolytica protein kinase, putative 0.0165 0.0689 0.0901
Plasmodium vivax protein kinase, putative 0.0094 0.013 1
Echinococcus granulosus tyrosine kinase 0.1188 0.87 0.8697
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0237 0.1249 0.123
Loa Loa (eye worm) hypothetical protein 0.0169 0.0722 0.0703
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0169 0.0722 0.1199
Echinococcus granulosus endophilin A3 0.0165 0.0689 0.0669
Echinococcus granulosus insulin receptor 0.0118 0.0317 0.0297
Entamoeba histolytica protein kinase, putative 0.0082 0.0034 0.0009
Onchocerca volvulus Putative cortactin 0.0165 0.0689 0.1142

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5.391 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.387 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5.014 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.908 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.855 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.854 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.841 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.798 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.789 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.771 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.755 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.736 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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