Detailed information for compound 161838

Basic information

Technical information
  • TDR Targets ID: 161838
  • Name: 2-[(1S,3S,5R)-3-[[(2S)-1-benzyl-5-oxopyrrolid in-2-yl]methyl]-5-(1H-imidazol-5-ylmethyl)cyc lohexyl]acetamide
  • MW: 408.536 | Formula: C24H32N4O2
  • H donors: 2 H acceptors: 3 LogP: 2.85 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=O)C[C@H]1C[C@H](C[C@H](C1)Cc1c[nH]cn1)C[C@@H]1CCC(=O)N1Cc1ccccc1
  • InChi: 1S/C24H32N4O2/c25-23(29)13-20-9-18(11-21-14-26-16-27-21)8-19(10-20)12-22-6-7-24(30)28(22)15-17-4-2-1-3-5-17/h1-5,14,16,18-20,22H,6-13,15H2,(H2,25,29)(H,26,27)/t18-,19+,20-,22+/m1/s1
  • InChiKey: RPIAWARBUUTSDJ-DYQZNNLLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(1S,3S,5R)-3-[[(2S)-1-benzyl-5-oxo-pyrrolidin-2-yl]methyl]-5-(1H-imidazol-5-ylmethyl)cyclohexyl]acetamide
  • 2-[(1S,3S,5R)-3-[[(2S)-1-benzyl-5-oxo-2-pyrrolidinyl]methyl]-5-(1H-imidazol-5-ylmethyl)cyclohexyl]acetamide
  • 2-[(1S,3R,5S)-3-(1H-imidazol-5-ylmethyl)-5-[[(2S)-5-oxo-1-(phenylmethyl)pyrrolidin-2-yl]methyl]cyclohexyl]ethanamide
  • 2-[(1S,3S,5R)-3-[[(2S)-1-benzyl-5-keto-pyrrolidin-2-yl]methyl]-5-(1H-imidazol-5-ylmethyl)cyclohexyl]acetamide
  • 2-[(1S,3R,5S)-3-(3H-imidazol-4-ylmethyl)-5-[[(2S)-5-oxo-1-(phenylmethyl)pyrrolidin-2-yl]methyl]cyclohexyl]acetamide
  • 2-[(1S,3R,5S)-3-(3H-imidazol-4-ylmethyl)-5-[[(2S)-5-oxo-1-(phenylmethyl)-2-pyrrolidinyl]methyl]cyclohexyl]acetamide
  • 2-[(1S,3S,5R)-3-[[(2S)-1-(benzyl)-5-keto-pyrrolidin-2-yl]methyl]-5-(3H-imidazol-4-ylmethyl)cyclohexyl]acetamide
  • 2-[(1S,3R,5S)-3-(3H-imidazol-4-ylmethyl)-5-[[(2S)-5-oxo-1-(phenylmethyl)pyrrolidin-2-yl]methyl]cyclohexyl]ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0349 0.0349
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0246 0.0246
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.01 0.01
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1243 0.7318 0.7318
Loa Loa (eye worm) jmjC domain-containing protein 0.0134 0.0684 0.0678
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.0041 0.0045
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0104 0.0392
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0245 0.0245
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.0041 0.0045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0017 0.0012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0027 0.0041 0.0086
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Brugia malayi PHD-finger family protein 0.006 0.0236 0.0312
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.166 0.5863
Brugia malayi follicle stimulating hormone receptor 0.0027 0.0041 0.0045
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni phd/f-box containing protein 0.0035 0.0091 0.0091
Loa Loa (eye worm) TATA binding protein associated factor 0.009 0.0418 0.0411
Schistosoma mansoni biogenic amine receptor 0.0027 0.0041 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0017 0.0017
Echinococcus multilocularis jumonji domain containing protein 0.0083 0.0376 0.0376
Loa Loa (eye worm) hypothetical protein 0.0037 0.0101 0.0094
Brugia malayi beta-lactamase family protein 0.0037 0.0101 0.0127
Echinococcus granulosus g protein coupled receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0017 0.0011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0231 0.0231
Brugia malayi larval opioid receptor 0.0027 0.0041 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0041 0.0041
Echinococcus granulosus puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.006 0.0236 0.0236
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0101 0.0101
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0831 0.4853 0.4853
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0204 0.0197
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0277 0.1539 0.1534
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0104 0.0027
Echinococcus multilocularis lysine specific demethylase 6a 0.0035 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Echinococcus granulosus expressed protein 0.0388 0.2199 0.2199
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0231 0.2005
Toxoplasma gondii ABC1 family protein 0.0037 0.0101 0.0294
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.032 0.032
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.0041 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0017 0.0012
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.016 0.016
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0101 0.008
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.009 0.0418 1
Brugia malayi Pre-SET motif family protein 0.0425 0.2424 0.3305
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0104 0.0104
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0017 0.0011
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.0041 0.0041
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0017 0.0017
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0204 0.0267
Brugia malayi jmjC domain containing protein 0.0035 0.0091 0.0114
Echinococcus granulosus lysine specific demethylase 6a 0.0035 0.0091 0.0091
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1243 0.7318 1
Schistosoma mansoni jumonji domain containing protein 0.0035 0.0091 0.0091
Loa Loa (eye worm) PHD-finger family protein 0.006 0.0236 0.023
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0349 0.0349
Brugia malayi Dopamine receptor 0.0027 0.0041 0.0045
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.0041 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.166 0.5863
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.009 0.0418 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0041 0.0041
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Schistosoma mansoni amine GPCR 0.0027 0.0041 0.0041
Schistosoma mansoni opsin-like receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0041 0.0034
Onchocerca volvulus 0.0027 0.0041 0.0086
Onchocerca volvulus 0.0027 0.0041 0.0086
Loa Loa (eye worm) hypothetical protein 0.009 0.0418 0.0411
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0041 0.0041
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0018 0.0018
Plasmodium vivax SET domain protein, putative 0.0061 0.0245 0.4708
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0204 0.0676
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0017 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0104 0.0092
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.032 0.1406
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0104 0.0022
Brugia malayi PHD-finger family protein 0.0026 0.0033 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0017 0.0012
Brugia malayi hypothetical protein 0.009 0.0418 0.056
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0231 0.0231
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.0041 0.0041
Echinococcus granulosus PHD finger protein rhinoceros 0.006 0.0236 0.0236
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0204 0.0267
Onchocerca volvulus 0.0027 0.0041 0.0086
Onchocerca volvulus Chorion peroxidase homolog 0.0054 0.0204 0.0676
Schistosoma mansoni neuropeptide receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.1243 0.7318 0.7316
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.0041 0.0041
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0231 0.4279
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0011
Onchocerca volvulus Alhambra homolog 0.006 0.0236 0.0794
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0041 0.0041
Echinococcus multilocularis JmjC domain containing protein 4 0.0035 0.0091 0.0091
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.01 0.01
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0022 0.001 0.001
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0245 0.0245
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0041 0.0041
Brugia malayi hypothetical protein 0.0037 0.0101 0.0126
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0041 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0017 0.0017
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0061 0.0245 0.0825
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0101 0.0101
Echinococcus granulosus puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0425 0.2424 0.2419
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0041 0.0041
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0104 0.0131
Echinococcus granulosus neuropeptide receptor 0.0027 0.0041 0.0041
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.0041 0.0041
Brugia malayi Inositol-1 0.0074 0.032 0.0427
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0236 0.4447
Brugia malayi ecdysteroid receptor 0.0023 0.0017 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0017 0.0012
Treponema pallidum fructose-bisphosphate aldolase 0.0298 0.166 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0104 0.0392
Echinococcus multilocularis neuropeptide s receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Brugia malayi jmjC domain containing protein 0.0134 0.0684 0.0924
Loa Loa (eye worm) hypothetical protein 0.0037 0.0101 0.0094
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.016 0.0154
Schistosoma mansoni opsin-like receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0041 0.0034
Brugia malayi Peptidase family M1 containing protein 0.009 0.0418 0.056
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.0041 0.0045
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0245 0.4708
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1372 0.4796
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0859 0.2893
Schistosoma mansoni hypothetical protein 0.0337 0.1898 0.1898
Brugia malayi Dopamine receptor protein 2 0.0027 0.0041 0.0045
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0204 0.0197
Onchocerca volvulus 0.0027 0.0041 0.0086
Echinococcus multilocularis neuropeptide receptor A26 0.0027 0.0041 0.0041
Toxoplasma gondii aminopeptidase n, putative 0.009 0.0418 1
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0113 0.0113
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0041 0.0041
Schistosoma mansoni hypothetical protein 0.0027 0.0041 0.0041
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1692 1 1
Brugia malayi Bromodomain containing protein 0.0062 0.0251 0.0332
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.0041 0.0041
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.032 0.0893
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0101 0.0094
Brugia malayi Pre-SET motif family protein 0.0061 0.0245 0.0324
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.0041 0.0041
Echinococcus multilocularis serotonin receptor 0.0277 0.1539 0.1539
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0041 0.0041
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0246 0.0246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.016 0.016
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0035 0.0091 0.0091
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0044 0.0142 0.0135
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0037 0.0103 0.0103
Brugia malayi Melatonin receptor type 1A 0.0027 0.0041 0.0045
Schistosoma mansoni amine GPCR 0.0027 0.0041 0.0041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0041 0.0041
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.166 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0027 0.0041 0.0086
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.0041 0.0045
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.0041 0.0045
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0041 0.0041
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Brugia malayi beta-lactamase 0.0037 0.0101 0.0127
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.009 0.0418 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.0041 0.0041
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.1243 0.7318 0.7316
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.009 0.0418 1
Echinococcus multilocularis aminopeptidase N 0.009 0.0418 0.0418
Brugia malayi Peptidase family M1 containing protein 0.009 0.0418 0.056
Echinococcus multilocularis peregrin 0.0062 0.0251 0.0251
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.0041 0.0041
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0104 0.0104
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0091 0.0085
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0017 0.0017
Echinococcus granulosus neuropeptide s receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1692 1 1
Entamoeba histolytica aminopeptidase, putative 0.009 0.0418 0.2033
Schistosoma mansoni hypothetical protein 0.0037 0.0101 0.0101
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0017 0.0017
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0017 0.0011
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.075 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0101 0.008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.0041 0.0041
Echinococcus multilocularis phd:f box containing protein 0.0035 0.0091 0.0091
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0041 0.0041
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.032 0.7008
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0231 0.2005
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0017 0.0017
Trypanosoma brucei aminopeptidase, putative 0.009 0.0418 1
Schistosoma mansoni phosphatidylserine receptor 0.0035 0.0091 0.0091
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Schistosoma mansoni ap endonuclease 0.0037 0.0104 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0101 0.008
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.0041 0.0041
Schistosoma mansoni biogenic amine receptor 0.0027 0.0041 0.0041
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.009 0.0418 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0011
Schistosoma mansoni amine GPCR 0.0027 0.0041 0.0041
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0274 0.1454
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0041 0.0034
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Echinococcus multilocularis sex peptide receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0093 0.0087
Giardia lamblia PHD finger protein 15 0.006 0.0236 0.0851
Loa Loa (eye worm) hypothetical protein 0.0031 0.0065 0.0059
Trypanosoma cruzi aminopeptidase, putative 0.009 0.0418 1
Echinococcus multilocularis expressed protein 0.0388 0.2199 0.2199
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0298 0.166 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0027 0.0041 0.0041
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0101 0.0127
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.166 0.5863
Brugia malayi Bromodomain containing protein 0.0039 0.0115 0.0146
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0011
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0027 0.0041 0.0086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni myosin xvIII 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0115 0.0109
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.009 0.0418 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0859 0.2893
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni bromodomain containing protein 0.0065 0.0268 0.0268
Brugia malayi GnHR receptor homolog 0.0027 0.0041 0.0045
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0017 0.0012
Schistosoma mansoni aminopeptidase A (M01 family) 0.009 0.0418 0.0418
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.016 0.016
Onchocerca volvulus Peroxidasin homolog 0.0054 0.0204 0.0676
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0017 0.0017
Trypanosoma brucei Aminopeptidase M1, putative 0.009 0.0418 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.0041 0.0041
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0093 0.0093
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0041 0.0034
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0091 0.0085
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0041 0.0034
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.009 0.0418 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0255 0.1408 0.1408
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0041 0.0041
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.009 0.0418 0.1255
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0017 0.0017
Loa Loa (eye worm) inositol-1 0.0074 0.032 0.0314
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0859 0.2893
Echinococcus granulosus fmrfamide receptor 0.0027 0.0041 0.0041
Echinococcus granulosus hypothetical protein 0.0027 0.0041 0.0041
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Brugia malayi jmjC domain containing protein 0.0035 0.0091 0.0114
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Trichomonas vaginalis set domain proteins, putative 0.0484 0.2775 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.032 0.7008
Brugia malayi neuropeptide F receptor 0.0027 0.0041 0.0045
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0101 0.0294
Onchocerca volvulus 0.009 0.0418 0.1452
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0104 0.0392
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Onchocerca volvulus 0.0027 0.0041 0.0086
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0041 0.0041
Brugia malayi Blistered cuticle protein 3 0.0054 0.0204 0.0267
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0054 0.0204 0.0676
Giardia lamblia Fructose-bisphosphate aldolase 0.0298 0.166 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0104 0.0392
Onchocerca volvulus 0.0037 0.0101 0.0303
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Mycobacterium ulcerans aminopeptidase N PepN 0.009 0.0418 0.4884
Schistosoma mansoni neuropeptide receptor 0.0027 0.0041 0.0041
Schistosoma mansoni peroxidasin 0.0054 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0231 0.0231
Plasmodium vivax hypothetical protein, conserved 0.006 0.0236 0.4447
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0017 0.0017
Schistosoma mansoni peroxidasin 0.0054 0.0204 0.0204
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.009 0.0418 1
Schistosoma mansoni hypothetical protein 0.0337 0.1898 0.1898
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0104 0.0098
Schistosoma mansoni hypothetical protein 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0037 0.0101 0.0303
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.0041 0.0041
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0231 0.0231
Schistosoma mansoni hypothetical protein 0.0021 0.0006 0.0006
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Onchocerca volvulus 0.0037 0.0101 0.0303
Loa Loa (eye worm) peptidase family M1 containing protein 0.009 0.0418 0.0411
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0017 0.0017
Brugia malayi Dopamine receptor protein 1 0.0027 0.0041 0.0045
Echinococcus granulosus neuropeptide receptor 0.0027 0.0041 0.0041
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.016 0.0208
Schistosoma mansoni jumonji/arid domain-containing protein 0.0134 0.0684 0.0684
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1372 0.4796
Echinococcus granulosus neuropeptide receptor A26 0.0027 0.0041 0.0041
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.0041 0.0041
Brugia malayi Serotonin receptor 0.0027 0.0041 0.0045
Schistosoma mansoni histamine h1 receptor 0.0027 0.0041 0.0041
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0204 0.0267
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0054 0.0204 0.0676
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0085
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Brugia malayi hypothetical protein 0.009 0.0418 0.056
Echinococcus granulosus orexin receptor type 2 0.0027 0.0041 0.0041
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.0041 0.0045
Brugia malayi nuclear hormone receptor 0.0023 0.0017 0.0012
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.009 0.0418 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0017 0.0012
Loa Loa (eye worm) hypothetical protein 0.0296 0.1649 0.1643
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0113 0.0113
Loa Loa (eye worm) jmjC domain-containing protein 0.0123 0.0616 0.061
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0041 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.009 0.0418 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Brugia malayi hypothetical protein 0.0027 0.0041 0.0045
Echinococcus granulosus JmjC domain containing protein 4 0.0035 0.0091 0.0091
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0018 0.0018
Echinococcus granulosus geminin 0.0337 0.1898 0.1898
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1692 1 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Brugia malayi G-protein coupled receptor 0.0027 0.0041 0.0045
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0017 0.0017
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0041 0.0041
Leishmania major hypothetical protein, conserved 0.0037 0.0101 0.0294
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.1372 0.1367
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Echinococcus granulosus peregrin 0.0062 0.0251 0.0251
Brugia malayi beta-lactamase family protein 0.0037 0.0101 0.0127
Echinococcus granulosus lysine specific demethylase 5A 0.0134 0.0684 0.0684
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Echinococcus multilocularis jumonji domain containing 1A 0.0035 0.0091 0.0091
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0017 0.0017
Echinococcus multilocularis lysine specific demethylase 5A 0.0132 0.0672 0.0672
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0041 0.0041
Toxoplasma gondii exonuclease III APE 0.0037 0.0104 0.0392
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0118 0.0587 0.0587
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Loa Loa (eye worm) beta-lactamase 0.0037 0.0101 0.0094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni retinoic acid receptor RXR 0.0118 0.0587 0.0587
Schistosoma mansoni protein phosphatase 2C 0.0035 0.0091 0.0091
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.032 0.7008
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.0041 0.0086
Brugia malayi jmjC domain containing protein 0.0035 0.0091 0.0114
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0093 0.0116
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0017 0.0017
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0018 0.0018
Onchocerca volvulus 0.0027 0.0041 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.016 0.016
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0204 0.0267
Schistosoma mansoni amine GPCR 0.0027 0.0041 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0101 0.0294
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.0041 0.0041
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.032 0.0893
Brugia malayi ORL1-like opioid receptor 0.0027 0.0041 0.0045
Brugia malayi nuclear receptor NHR-88 0.0023 0.0017 0.0012
Echinococcus granulosus g-protein coupled receptor 0.0027 0.0041 0.0041
Brugia malayi G protein-coupled receptor 0.0027 0.0041 0.0045
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0104 0.0049
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.009 0.0418 0.0411
Brugia malayi Peptidase family M1 containing protein 0.009 0.0418 0.056
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0054 0.0204 0.0676
Echinococcus granulosus puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Plasmodium falciparum M1-family alanyl aminopeptidase 0.009 0.0418 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.009 0.0418 0.0418
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0106 0.0514 0.0514
Brugia malayi Serotonin receptor 0.0027 0.0041 0.0045
Brugia malayi TATA binding protein associated factor 0.009 0.0418 0.056
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1372 0.4796
Onchocerca volvulus Dual oxidase homolog 0.0054 0.0204 0.0676
Echinococcus granulosus biogenic amine 5HT receptor 0.0277 0.1539 0.1539
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0231 0.0231
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0274 0.2667
Echinococcus multilocularis geminin 0.0337 0.1898 0.1898
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0037 0.0101 0.0094
Echinococcus granulosus aminopeptidase N 0.009 0.0418 0.0418
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0912 0.3089
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0017 0.0017
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0231 0.2005
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.032 0.7008
Echinococcus multilocularis allatostatin A receptor 0.0027 0.0041 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.166 0.5863
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.0041 0.0041
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0037 0.0103 0.0103
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0245 0.0245
Echinococcus multilocularis serotonin receptor 0.0277 0.1539 0.1539
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.075 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0231 0.4279
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0017 0.0011
Schistosoma mansoni hypothetical protein 0.0027 0.0041 0.0041
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.009 0.0418 1
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1372 0.4796
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.016 0.016
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0073 0.0314 0.0307
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.166 0.5863
Brugia malayi Animal haem peroxidase family protein 0.0054 0.0204 0.0267
Brugia malayi sulfakinin receptor protein 0.0027 0.0041 0.0045
Brugia malayi neuropeptide F receptor 0.0027 0.0041 0.0045
Brugia malayi hypothetical protein 0.0054 0.0204 0.0267
Onchocerca volvulus 0.009 0.0418 0.1452
Loa Loa (eye worm) hypothetical protein 0.006 0.0236 0.023
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0017 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.166 0.5863
Schistosoma mansoni hypothetical protein 0.006 0.0236 0.0236
Onchocerca volvulus 0.0027 0.0041 0.0086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0041 0.0041
Echinococcus granulosus puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0104 0.0392
Schistosoma mansoni coup transcription factor 0.0023 0.0017 0.0017
Brugia malayi AKH receptor 0.0027 0.0041 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Trypanosoma cruzi Aminopeptidase M1, putative 0.009 0.0418 1
Onchocerca volvulus 0.0027 0.0041 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0912 0.3089
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Echinococcus granulosus jumonji domain containing protein 0.0083 0.0376 0.0376
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.009 0.0418 0.0418
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.009 0.0418 0.0418
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0027 0.0041 0.0086
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0027 0.0041 0.0041
Schistosoma mansoni jumonji/arid domain-containing protein 0.0134 0.0684 0.0684
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0017 0.0012
Onchocerca volvulus Peroxidase homolog 0.0054 0.0204 0.0676
Mycobacterium ulcerans aminopeptidase N PepN 0.009 0.0418 0.4884
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0104 0.0092
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0011
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.009 0.0418 1
Plasmodium falciparum phd finger protein, putative 0.006 0.0236 0.4447
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.009 0.0418 0.1255
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0041 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0859 0.2893
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.1291 1
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0017 0.0012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0041 0.0041
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0118 0.0587 0.0581
Loa Loa (eye worm) hypothetical protein 0.0042 0.013 0.0123
Onchocerca volvulus 0.0027 0.0041 0.0086
Schistosoma mansoni thyroid hormone receptor 0.0023 0.0017 0.0017
Echinococcus multilocularis PHD finger protein rhinoceros 0.006 0.0236 0.0236
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0017 0.0017
Echinococcus multilocularis orexin receptor type 2 0.0027 0.0041 0.0041
Echinococcus granulosus peroxidasin 0.0054 0.0204 0.0204
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0037 0.0101 0.0094
Echinococcus granulosus puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0041 0.0041
Brugia malayi G-protein coupled receptor 0.0027 0.0041 0.0045
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0041 0.0041
Schistosoma mansoni neuropeptide receptor 0.0027 0.0041 0.0041
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0017 0.0017
Onchocerca volvulus Peroxidase homolog 0.0054 0.0204 0.0676
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0204 0.0197
Toxoplasma gondii aminopeptidase N, putative 0.009 0.0418 1
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0041 0.0034
Echinococcus granulosus somatostatin receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0054 0.0204 0.0197
Brugia malayi Peroxidasin 0.0054 0.0204 0.0267
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0101 0.0094
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.009 0.0418 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0017 0.0017
Schistosoma mansoni amine GPCR 0.0027 0.0041 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1372 0.4796
Echinococcus granulosus phd:f box containing protein 0.0035 0.0091 0.0091
Schistosoma mansoni opsin-like receptor 0.0027 0.0041 0.0041
Schistosoma mansoni jumonji domain containing protein 0.0215 0.1168 0.1168
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0017 0.0017
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.032 0.3378
Loa Loa (eye worm) hypothetical protein 0.0037 0.0101 0.0094
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.0041 0.0041
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.009 0.0418 0.1255
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0041 0.0041
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0101 0.0294
Brugia malayi steroid hormone receptor 0.0023 0.0017 0.0012
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.0236 0.4447
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0101 0.008
Brugia malayi Bromodomain containing protein 0.0077 0.034 0.0454
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0349 0.0349
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.0041 0.0041
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0041 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0859 0.2893
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.0041 0.0086
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0859 0.2893
Echinococcus multilocularis thyroid hormone receptor alpha 0.0023 0.0017 0.0017
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0022 0.0018
Echinococcus granulosus jumonji domain containing 1A 0.0035 0.0091 0.0091
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0041 0.0034
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0041 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0017 0.0012
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0041 0.0034
Schistosoma mansoni inositol monophosphatase 0.0074 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Trypanosoma cruzi aminopeptidase, putative 0.009 0.0418 1
Brugia malayi jmjC domain containing protein 0.0035 0.0091 0.0114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0349 0.0349
Onchocerca volvulus 0.0484 0.2775 1
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0041 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0017 0.0012
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0041 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.166 0.5863
Schistosoma mansoni ap endonuclease 0.0037 0.0104 0.0104
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Onchocerca volvulus 0.0027 0.0041 0.0086
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0017 0.0012
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0255 0.1408 0.1408
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0101 0.0101
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0041 0.0034
Brugia malayi putative neuropeptide receptor 0.0027 0.0041 0.0045
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0041 0.0034
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Loa Loa (eye worm) aminopeptidase N 0.009 0.0418 0.0411
Schistosoma mansoni adenoreceptor 0.0027 0.0041 0.0041
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0101 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0017 0.0012
Trichomonas vaginalis esterase, putative 0.0037 0.0101 0.008
Echinococcus multilocularis somatostatin receptor 0.0027 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0017 0.0012
Echinococcus granulosus allatostatin A receptor 0.0027 0.0041 0.0041
Onchocerca volvulus 0.0027 0.0041 0.0086
Toxoplasma gondii aminopeptidase N protein 0.009 0.0418 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0041 0.0041
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.032 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0041 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1372 0.4796
Echinococcus granulosus g protein coupled receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0017 0.0011
Echinococcus granulosus puromycin sensitive aminopeptidase 0.009 0.0418 0.0418
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0017 0.0017
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.0078 0.0349 0.0343
Loa Loa (eye worm) animal heme peroxidase 0.0054 0.0204 0.0197
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0231 0.1093
Loa Loa (eye worm) hypothetical protein 0.0277 0.1539 0.1534
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0859 0.2893
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0101 0.008
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.032 0.0893
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.032 0.7008
Brugia malayi jmjC domain containing protein 0.0255 0.1408 0.1915
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.075 0.5452
Onchocerca volvulus 0.009 0.0418 0.1452
Loa Loa (eye worm) blistered cuticle protein 3 0.0054 0.0204 0.0197
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0104 0.0392
Schistosoma mansoni biogenic amine receptor 0.0027 0.0041 0.0041
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0859 0.3053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0041 0.0041
Brugia malayi RE15519p 0.0027 0.0041 0.0045
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.0041 0.0041
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0298 0.166 0.5863
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.0041 0.0041
Echinococcus granulosus serotonin receptor 0.0027 0.0041 0.0041
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.009 0.0418 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0017 0.0012
Onchocerca volvulus 0.0027 0.0041 0.0086
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0101 0.0101
Schistosoma mansoni inositol monophosphatase 0.0074 0.032 0.032
Trypanosoma brucei Aminopeptidase M1, putative 0.009 0.0418 1
Schistosoma mansoni hypothetical protein 0.0027 0.0041 0.0041
Brugia malayi hypothetical protein 0.0778 0.4533 0.619
Loa Loa (eye worm) hypothetical protein 0.0035 0.0091 0.0085
Schistosoma mansoni biogenic amine (5HT) receptor 0.0277 0.1539 0.1539
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.0041 0.0041
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.1372 0.1866
Echinococcus granulosus g protein coupled receptor 0.0027 0.0041 0.0041
Loa Loa (eye worm) hypothetical protein 0.009 0.0418 0.0411
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.0041 0.0041
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.0041 0.0041
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.0091 0.0085
Onchocerca volvulus 0.0027 0.0041 0.0086
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0041 0.0041
Echinococcus granulosus sex peptide receptor 0.0027 0.0041 0.0041
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.032 0.032
Schistosoma mansoni neuropeptide receptor 0.0027 0.0041 0.0041
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0101 0.0294
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.0041 0.0041
Echinococcus multilocularis peroxidasin 0.0054 0.0204 0.0204
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0041 0.0041

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 Compound (oral) was tested for TRH reduced mean latencies mimetics in mice using the Morris water maze test; in active ChEMBL. 8230089
Concentration (functional) = 0.003 mg kg-1 Concentration required toTRH reduced mean latencies mimetics in mice after i.p. administration using the Morris water maze test; 0.003-3 ChEMBL. 8230089
Concentration (functional) = 0.003 mg kg-1 Concentration required toTRH reduced mean latencies mimetics in mice after p.o. administration using the Morris water maze test; 0.003-3 ChEMBL. 8230089
Concentration (functional) = 0.003 mg kg-1 Concentration required toTRH reduced mean latencies mimetics in mice after i.p. administration using the Morris water maze test; 0.003-3 ChEMBL. 8230089
Concentration (functional) = 0.003 mg kg-1 Concentration required toTRH reduced mean latencies mimetics in mice after p.o. administration using the Morris water maze test; 0.003-3 ChEMBL. 8230089
Mean latency (functional) = 15.65 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.03 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 15.65 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.03 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 17.62 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.3 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 17.62 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.3 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 21.1 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.03 mg/Kg p.o. dosage. ChEMBL. 7636847
Mean latency (functional) = 21.1 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.03 mg/Kg p.o. dosage. ChEMBL. 7636847
Mean latency (functional) = 22.24 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.003 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 22.24 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.003 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 30.9 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.0003 mg/Kg p.o. dosage. ChEMBL. 7636847
Mean latency (functional) = 30.9 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.0003 mg/Kg p.o. dosage. ChEMBL. 7636847
Mean latency (functional) = 31.62 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 3 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 31.62 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 3 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 33.29 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.0003 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 33.29 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.0003 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 35.23 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.003 mg/Kg p.o. dosage. ChEMBL. 7636847
Mean latency (functional) = 35.23 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.003 mg/Kg p.o. dosage. ChEMBL. 7636847
Mean latency (functional) = 46.67 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.00003 mg/Kg p.o. dosage. ChEMBL. 7636847
Mean latency (functional) = 46.67 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.00003 mg/Kg p.o. dosage. ChEMBL. 7636847
Mean latency (functional) = 62.15 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.00003 mg/Kg i.p. dosage. ChEMBL. 7636847
Mean latency (functional) = 62.15 s Activity of the compound was evaluated in C57BL/10 mice by Morris water Maze test and mean latency for TRH was reported at 0.00003 mg/Kg i.p. dosage. ChEMBL. 7636847

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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