Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0681 | 0.2994 | 0.4032 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1287 | 0.7426 | 1 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0571 | 0.2192 | 0.2726 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0554 | 0.2074 | 0.2793 |
Mycobacterium ulcerans | thioesterase TesA | 0.0733 | 0.3377 | 0.4548 |
Loa Loa (eye worm) | hypothetical protein | 0.145 | 0.8616 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0907 | 0.4648 | 0.6238 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0852 | 0.4249 | 0.5722 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0853 | 0.4251 | 0.5725 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0632 | 0.2639 | 0.3554 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0853 | 0.4251 | 0.5725 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0907 | 0.4648 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0554 | 0.2074 | 0.2793 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0692 | 0.3079 | 0.4146 |
Mycobacterium ulcerans | thioesterase | 0.0733 | 0.3377 | 0.4548 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0822 | 0.4026 | 0.5422 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0852 | 0.4249 | 0.4249 |
Mycobacterium ulcerans | polyketide synthase | 0.0852 | 0.4249 | 0.5722 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0852 | 0.4249 | 0.5698 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0681 | 0.2994 | 0.4032 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0733 | 0.3377 | 0.4517 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0907 | 0.4648 | 0.626 |
Loa Loa (eye worm) | hypothetical protein | 0.0466 | 0.1425 | 0.0584 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0852 | 0.4249 | 0.5698 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0852 | 0.4249 | 0.5722 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0907 | 0.4648 | 0.626 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0852 | 0.4249 | 0.5722 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0852 | 0.4249 | 0.5722 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1287 | 0.7426 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1287 | 0.7426 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0907 | 0.4648 | 0.626 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0852 | 0.4249 | 0.5722 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0681 | 0.2994 | 0.3998 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0275 | 0.0034 | 0.0046 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0276 | 0.0043 | 0.0058 |
Loa Loa (eye worm) | fatty acid synthase | 0.0868 | 0.4362 | 0.4431 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0276 | 0.0043 | 0.0058 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0852 | 0.4249 | 0.5722 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0626 | 0.2597 | 0.3927 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0822 | 0.4026 | 0.399 |
Brugia malayi | AMP-binding enzyme family protein | 0.0822 | 0.4026 | 0.4026 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.05 | 0.1677 | 0.2258 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1287 | 0.7426 | 1 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0907 | 0.4648 | 0.6238 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.1586 | 0.9603 | 1 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0907 | 0.4648 | 0.626 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0733 | 0.3377 | 0.4548 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0852 | 0.4249 | 0.5722 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0554 | 0.2074 | 0.2751 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0356 | 0.0623 | 0.0838 |
Mycobacterium ulcerans | polyketide synthase | 0.0907 | 0.4648 | 0.626 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0907 | 0.4648 | 0.626 |
Onchocerca volvulus | 0.1531 | 0.9204 | 0.9285 | |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0907 | 0.4648 | 0.6238 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.