Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0392 | 0.3524 | 0.5834 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0392 | 0.3524 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0392 | 0.3524 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0315 | 0.253 | 0.4155 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0366 | 0.319 | 0.528 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0416 | 0.384 | 0.6357 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0416 | 0.384 | 0.6357 |
Mycobacterium ulcerans | thioesterase TesA | 0.0326 | 0.2676 | 0.443 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0585 | 0.6041 | 1 |
Mycobacterium ulcerans | thioesterase | 0.0326 | 0.2676 | 0.443 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.038 | 0.3368 | 0.5576 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0392 | 0.3524 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0259 | 0.1801 | 0.2981 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0158 | 0.0493 | 0.0817 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0416 | 0.384 | 0.6337 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0366 | 0.319 | 0.2617 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0416 | 0.384 | 0.6357 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0392 | 0.3524 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0259 | 0.1801 | 0.2981 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.032 | 0.2597 | 0.4299 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0315 | 0.253 | 0.4188 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0135 | 0.0185 | 0.0306 |
Mycobacterium ulcerans | polyketide synthase | 0.0392 | 0.3524 | 0.5834 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0416 | 0.384 | 0.6337 |
Onchocerca volvulus | 0.0682 | 0.7293 | 0.9285 | |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0326 | 0.2676 | 0.4398 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0742 | 0.8081 | 0.8081 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0326 | 0.2676 | 0.443 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0585 | 0.6041 | 1 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0392 | 0.3524 | 0.3524 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0416 | 0.384 | 0.6357 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0392 | 0.3524 | 0.5834 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0392 | 0.3524 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0315 | 0.253 | 0.4188 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0392 | 0.3524 | 0.5834 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0281 | 0.2091 | 0.3461 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0392 | 0.3524 | 0.5834 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0123 | 0.0034 | 0.0056 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0279 | 0.2058 | 0.1168 |
Loa Loa (eye worm) | hypothetical protein | 0.0658 | 0.6984 | 0.6731 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0585 | 0.6041 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0416 | 0.384 | 0.6357 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0254 | 0.1737 | 0.0811 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0123 | 0.0034 | 0.0056 |
Brugia malayi | AMP-binding enzyme family protein | 0.0366 | 0.319 | 0.319 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.1287 | 0.0554 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0706 | 0.7609 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0416 | 0.384 | 0.6337 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0416 | 0.384 | 0.315 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0223 | 0.1328 | 0.2199 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0585 | 0.6041 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0259 | 0.1801 | 0.2941 |
Loa Loa (eye worm) | fatty acid synthase | 0.0386 | 0.3456 | 0.2906 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.038 | 0.3368 | 0.5576 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0416 | 0.384 | 0.6357 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.052 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.