Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Estrogen receptor beta | Starlite/ChEMBL | References |
Rattus norvegicus | Estrogen receptor alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | Estrogen receptor beta | 530 aa | 451 aa | 25.5 % |
Onchocerca volvulus | Estrogen receptor beta | 530 aa | 430 aa | 24.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0016 | 0.5 | 0.5 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0016 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0016 | 0.5 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 0.5 | 0.5 |
Brugia malayi | steroid hormone receptor | 0.0016 | 0.5 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0016 | 0.5 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.5 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0016 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0016 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0016 | 0.5 | 0.5 | |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 0.5 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0016 | 0.5 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 0.5 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0016 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.5 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0016 | 0.5 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0016 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0016 | 0.5 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 0.5 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0016 | 0.5 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0016 | 0.5 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.5 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0016 | 0.5 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0016 | 0.5 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.5 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0016 | 0.5 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0016 | 0.5 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0016 | 0.5 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0016 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0016 | 0.5 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2700 nM | Binding to Estrogen receptor- beta (ER beta) receptor | ChEMBL. | 12270167 |
IC50 (binding) | = 2700 nM | Binding to Estrogen receptor- beta (ER beta) receptor | ChEMBL. | 12270167 |
IC50 (binding) | = 2800 nM | Binding to Estrogen receptor- alpha (ER alpha) receptor | ChEMBL. | 12270167 |
IC50 (binding) | = 2800 nM | Binding to Estrogen receptor- alpha (ER alpha) receptor | ChEMBL. | 12270167 |
Selectivity (binding) | = 0.97 | Selectivity as ratio of IC50 against ER beta receptor to IC50 against ER alpha receptor | ChEMBL. | 12270167 |
Selectivity (binding) | = 0.97 | Selectivity as ratio of IC50 against ER beta receptor to IC50 against ER alpha receptor | ChEMBL. | 12270167 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.