Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Glutamate receptor ionotropic, AMPA | Starlite/ChEMBL | References |
Rattus norvegicus | Glutamate NMDA receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0295 | 1 | 1 |
Chlamydia trachomatis | glutamine binding protein | 0.0052 | 0.0078 | 0.5 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.0295 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0052 | 0.0078 | 0.5 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0295 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0052 | 0.0078 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0295 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0295 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0295 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0072 | 0.0902 | 0.0902 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0052 | 0.0078 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0072 | 0.0902 | 0.0902 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0072 | 0.0902 | 0.0902 |
Echinococcus granulosus | carboxylesterase 5A | 0.0295 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.005 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 1 | 1 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0052 | 0.0078 | 0.5 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0052 | 0.0078 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0295 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 130 nM | In vitro binding affinity towards glycine modulatory site on the NMDA receptors using [3H]-DCKA as radioligand in rat cortical membrane preparations | ChEMBL. | 10571148 |
IC50 (binding) | = 130 nM | In vitro binding affinity towards glycine modulatory site on the NMDA receptors using [3H]-DCKA as radioligand in rat cortical membrane preparations | ChEMBL. | 10571148 |
IC50 (binding) | = 7100 nM | In vitro binding affinity towards ionotropic glutamate receptor AMPA using [3H]-AMPA as radioligand in rat cortical membrane preparations | ChEMBL. | 10571148 |
IC50 (binding) | = 7100 nM | In vitro binding affinity towards ionotropic glutamate receptor AMPA using [3H]-AMPA as radioligand in rat cortical membrane preparations | ChEMBL. | 10571148 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.