Detailed information for compound 1619947

Basic information

Technical information
  • TDR Targets ID: 1619947
  • Name: (NE)-N-[1-(4-chlorophenyl)-2-methoxy-2-phenyl ethylidene]hydroxylamine
  • MW: 275.73 | Formula: C15H14ClNO2
  • H donors: 1 H acceptors: 1 LogP: 4.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(/C(=N/O)/c1ccc(cc1)Cl)c1ccccc1
  • InChi: 1S/C15H14ClNO2/c1-19-15(12-5-3-2-4-6-12)14(17-18)11-7-9-13(16)10-8-11/h2-10,15,18H,1H3/b17-14+
  • InChiKey: GWIGKMUIRGDAEF-SAPNQHFASA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-(4-chlorophenyl)-2-methoxy-2-phenylethylidene]hydroxylamine
  • 1-(4-chlorophenyl)-2-methoxy-2-phenyl-ethanone oxime
  • 1-(4-chlorophenyl)-2-methoxy-2-phenylethanone oxime
  • (NE)-N-[1-(4-chlorophenyl)-2-methoxy-2-phenyl-ethylidene]hydroxylamine
  • N-[1-(4-chlorophenyl)-2-methoxy-2-phenyl-ethylidene]hydroxylamine
  • MS-1131

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens synuclein, alpha (non A4 component of amyloid precursor) Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus survival motor neuron protein 1 0.0237 0.0885 0.0844
Mycobacterium tuberculosis Conserved protein 0.0108 0.0355 0.0833
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0086 0.0261 0.0243
Leishmania major pyruvate kinase 0.0067 0.0184 0.0137
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0171 0.0611 0.0594
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0104 0.0227
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0331 0.1274 0.3302
Toxoplasma gondii pyruvate carboxylase 0.0932 0.3748 0.374
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0216 0.0276
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0355 0.0504
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0216 0.0276
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0417 0.1627 1
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0031
Onchocerca volvulus 0.0108 0.0355 0.649
Onchocerca volvulus 0.0108 0.0355 0.649
Schistosoma mansoni pyruvate kinase 0.0034 0.005 0.0004
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0331 0.1274 0.3651
Brugia malayi Probable ClpP-like protease 0.0078 0.0231 0.0191
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0102 0.009
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0054 0.0008
Echinococcus granulosus Biotin lipoyl attachment 0.0086 0.0261 0.0216
Mycobacterium ulcerans pyruvate kinase 0.0067 0.0184 0.035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0104 0.0059
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0086 0.0261 0.035
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0932 0.3748 0.3752
Trypanosoma brucei acetyl-CoA carboxylase 0.2446 0.999 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0223
Echinococcus granulosus tumor protein p63 0.0408 0.159 0.1552
Trypanosoma cruzi acetyl-CoA carboxylase 0.1514 0.615 1
Mycobacterium ulcerans lipase LipD 0.0108 0.0355 0.0813
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0932 0.3748 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0277 0.0233
Schistosoma mansoni survival motor neuron protein 0.0048 0.0107 0.0062
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0277 0.0233
Brugia malayi Ets-domain containing protein 0.0076 0.0222 0.0182
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0477
Brugia malayi beta-lactamase 0.0108 0.0355 0.0321
Echinococcus granulosus pyruvate kinase 0.0034 0.005 0.0004
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0104 0.0134
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0294
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0086 0.0261 0.0261
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0331 0.1274 0.1235
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0031
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0104 0.0358
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0211 0.0776 0.0734
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0086 0.0261 0.0215
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0184 0.0142
Loa Loa (eye worm) hypothetical protein 0.0048 0.0104 0.0059
Loa Loa (eye worm) beta-lactamase 0.0108 0.0355 0.0321
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0104 0.0057
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0086 0.0261 0.035
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.0611 0.0568
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0156 0.0113
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0086 0.0261 0.0337
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0932 0.3748 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Schistosoma mansoni hypothetical protein 0.0515 0.2033 0.1998
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0086 0.0261 0.0337
Brugia malayi hypothetical protein 0.0048 0.0107 0.0062
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0104 0.0134
Echinococcus granulosus pyruvate kinase 0.0067 0.0184 0.0139
Loa Loa (eye worm) hypothetical protein 0.0141 0.0491 0.0462
Leishmania major phosphoglycerate kinase C, glycosomal 0.0171 0.0611 0.0567
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0102 0.0057
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0119 0.0269
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Brugia malayi Glycosyl hydrolases family 31 protein 0.0152 0.0536 0.051
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0331 0.1274 0.3366
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0086 0.0261 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0003
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0063 0.0166 0.0195
Schistosoma mansoni gabp alpha 0.0076 0.0222 0.0177
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0108 0.0355 0.0833
Echinococcus multilocularis geminin 0.0515 0.2033 0.1996
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0315 0.027
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0086 0.0261 0.0261
Trypanosoma brucei phosphoglycerate kinase 0.0063 0.0166 0.0166
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0331 0.1274 0.3302
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0086 0.0261 0.035
Schistosoma mansoni alpha glucosidase 0.0034 0.0047 0.0001
Mycobacterium tuberculosis Probable esterase LipL 0.0108 0.0355 0.0833
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0102 0.0057
Mycobacterium ulcerans hypothetical protein 0.0108 0.0355 0.0813
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0086 0.0261 0.0216
Entamoeba histolytica hypothetical protein 0.0035 0.0054 0.0044
Echinococcus granulosus lysosomal alpha glucosidase 0.0152 0.0536 0.0493
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0086 0.0261 0.058
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0104 0.0059
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0223
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0102 0.0103
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0166 0.0195
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0119 0.0197
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0104 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0034 0.0357
Echinococcus granulosus pyruvate kinase 0.0067 0.0184 0.0139
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0184 0.0223
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.0611 1
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0086 0.0261 0.0087
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.088 0.0868
Schistosoma mansoni pyruvate kinase 0.0067 0.0184 0.0139
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0211 0.0776 0.0777
Mycobacterium ulcerans hypothetical protein 0.0048 0.0104 0.0134
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0184 0.0223
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0063 0.0025
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0184 0.2063
Brugia malayi hypothetical protein 0.0237 0.0885 0.0874
Loa Loa (eye worm) hypothetical protein 0.006 0.0156 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0038 0.0427
Echinococcus granulosus geminin 0.0515 0.2033 0.1998
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0932 0.3748 1
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0086 0.0261 0.035
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Leishmania major hypothetical protein, conserved 0.0108 0.0355 0.0309
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0171 0.0611 0.1082
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0932 0.3748 0.372
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.005 0.0042
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0184 0.2856
Onchocerca volvulus 0.0141 0.0491 1
Echinococcus multilocularis pyruvate kinase 0.0067 0.0184 0.0138
Treponema pallidum pyruvate carboxylase subunit B 0.0086 0.0261 0.4088
Schistosoma mansoni hypothetical protein 0.0041 0.0078 0.0032
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0231 0.0186
Brugia malayi hypothetical protein 0.0075 0.0216 0.0175
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0063 0.0063
Onchocerca volvulus 0.0108 0.0355 0.649
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0086 0.0261 0.0216
Loa Loa (eye worm) hypothetical protein 0.0052 0.0122 0.0078
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0932 0.3748 0.3723
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0083 0.1166
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0107 0.0063
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0086 0.0261 0.035
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0104 0.0134
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0102 0.0057
Loa Loa (eye worm) hypothetical protein 0.0048 0.0104 0.0059
Toxoplasma gondii carbamoylphosphate synthetase 0.0211 0.0776 0.0759
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0067 0.0184 0.0371
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0104 0.0358
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0932 0.3748 0.3723
Echinococcus multilocularis Biotin lipoyl attachment 0.0086 0.0261 0.0216
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0277 0.024
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0086 0.0261 0.0243
Trypanosoma brucei hypothetical protein, conserved 0.0108 0.0355 0.0355
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0063 0.0015
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0331 0.1274 0.3366
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0102 0.0348
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0331 0.1274 0.1276
Mycobacterium ulcerans hypothetical protein 0.0086 0.0261 0.056
Brugia malayi Phosphoglycerate kinase 0.0171 0.0611 0.0588
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0086 0.0261 0.0243
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0331 0.1274 0.3302
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.2446 0.999 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0104 0.0057
Loa Loa (eye worm) hypothetical protein 0.0041 0.0078 0.0032
Echinococcus multilocularis pyruvate kinase 0.0034 0.005 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0104 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.017
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0331 0.1274 0.3302
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0054 0.0008
Brugia malayi beta-lactamase family protein 0.0108 0.0355 0.0321
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0331 0.1274 0.3317
Schistosoma mansoni aspartate carbamoyltransferase 0.0211 0.0776 0.0734
Brugia malayi Pyruvate kinase, M2 isozyme 0.0067 0.0184 0.0142
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0034 0.0047 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Schistosoma mansoni alpha-glucosidase 0.0131 0.0449 0.0405
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0211 0.0776 0.1551
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0104 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0216 0.0273
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0231 0.0212
Brugia malayi hypothetical protein 0.0035 0.0054 0.0007
Plasmodium falciparum phosphoglycerate kinase 0.0171 0.0611 0.0824
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0166 0.0195
Giardia lamblia Phosphoglycerate kinase 0.0171 0.0611 0.356
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0086 0.0261 0.0223
Mycobacterium tuberculosis Conserved protein 0.0108 0.0355 0.0833
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0086 0.0261 0.0216
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0102 0.0103
Mycobacterium ulcerans phosphoglycerate kinase 0.0171 0.0611 0.1507
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0489 0.0446
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0355 0.5715
Echinococcus multilocularis pyruvate kinase 0.0067 0.0184 0.0138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0277 0.0233
Trypanosoma brucei pyruvate kinase 1, putative 0.0067 0.0184 0.0184
Brugia malayi Pyruvate kinase, muscle isozyme 0.0067 0.0184 0.0142
Echinococcus granulosus expressed conserved protein 0.0093 0.029 0.0246
Entamoeba histolytica hypothetical protein 0.0035 0.0054 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0166 0.0119
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0023 0.017
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0086 0.0261 0.0243
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0355 0.5715
Loa Loa (eye worm) hypothetical protein 0.006 0.0154 0.0111
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0171 0.0611 0.1588
Brugia malayi Carboxyl transferase domain containing protein 0.2361 0.9637 1
Echinococcus multilocularis protein dispatched 1 0.0048 0.0107 0.0062
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.177 0.7204 1
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0331 0.1274 0.201
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0216 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Echinococcus granulosus GA binding protein alpha chain 0.0076 0.0222 0.0177
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0086 0.0261 0.035
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.01 0.0055
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0086 0.0261 0.0215
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0086 0.0261 0.0619
Loa Loa (eye worm) hypothetical protein 0.0237 0.0885 0.0874
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0331 0.1274 0.2967
Schistosoma mansoni hypothetical protein 0.0048 0.0107 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0104 0.0155
Entamoeba histolytica phosphoglycerate kinase, putative 0.0171 0.0611 0.3569
Loa Loa (eye worm) fli-1 protein 0.0232 0.0862 0.085
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0154 0.0109
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0108 0.0355 0.0321
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.2446 0.999 1
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0355 0.0467
Echinococcus multilocularis survival motor neuron protein 1 0.0237 0.0885 0.0843
Loa Loa (eye worm) hypothetical protein 0.0099 0.0315 0.0279
Echinococcus multilocularis beta LACTamase domain containing family member 0.0108 0.0355 0.031
Giardia lamblia GTOR 0.0047 0.0102 0.0335
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0171 0.0611 1
Echinococcus granulosus pyruvate kinase 0.0034 0.005 0.0004
Echinococcus multilocularis neutral alpha glucosidase AB 0.0034 0.0047 0.0001
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0031
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0315 0.1693
Brugia malayi CHE-14 protein 0.0042 0.0083 0.0037
Schistosoma mansoni pyruvate kinase 0.0067 0.0184 0.0139
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0315 0.0279
Trichomonas vaginalis penicillin-binding protein, putative 0.0108 0.0355 0.5715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0277 0.0233
Mycobacterium ulcerans beta-lactamase 0.0108 0.0355 0.0813
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0489 0.0446
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0104 0.0134
Plasmodium vivax pyruvate kinase, putative 0.0067 0.0184 0.0229
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0932 0.3748 1
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0331 0.1274 0.3317
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0211 0.0776 0.1953
Echinococcus multilocularis GA binding protein alpha chain 0.0076 0.0222 0.0177
Leishmania major carbamoyl-phosphate synthase, putative 0.0211 0.0776 0.0733
Trypanosoma cruzi hypothetical protein, conserved 0.0108 0.0355 0.0504
Leishmania major hypothetical protein, conserved 0.0075 0.0216 0.0169
Loa Loa (eye worm) hypothetical protein 0.0075 0.0216 0.0175
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0104 0.0134
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0211 0.0776 0.1194
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0119 0.0074
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0171 0.0611 0.1526
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0086 0.0261 0.058
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0086 0.0261 0.058
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0054 0.0049
Schistosoma mansoni hypothetical protein 0.0515 0.2033 0.1998
Schistosoma mansoni alpha-glucosidase 0.0131 0.0449 0.0405
Chlamydia trachomatis biotin carboxylase 0.0846 0.3395 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0034 0.0047 0.0578
Trichomonas vaginalis esterase, putative 0.0108 0.0355 0.5715
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0108 0.0355 0.0833
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0231 0.0567
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0054 0.0008
Toxoplasma gondii pyruvate kinase PyK1 0.0067 0.0184 0.0165
Echinococcus multilocularis pyruvate kinase 0.0034 0.005 0.0004
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0053 0.0034
Brugia malayi Phosphoglycerate kinase 0.0063 0.0166 0.0124
Schistosoma mansoni phosphoglycerate kinase 0.0171 0.0611 0.0568
Echinococcus granulosus phosphoglycerate kinase 1 0.0171 0.0611 0.0568
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.0611 0.0924
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0331 0.1274 0.3366
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0086 0.0261 0.0337
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.2446 0.999 1
Brugia malayi MH2 domain containing protein 0.0236 0.088 0.0868
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0086 0.0261 0.0216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0355 0.0311
Onchocerca volvulus 0.0088 0.0271 0.4328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0277 0.0233
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0083 0.0037
Loa Loa (eye worm) hypothetical protein 0.0065 0.0177 0.0135
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0063 0.0166 0.0195
Mycobacterium ulcerans pyruvate carboxylase 0.0932 0.3748 1
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0932 0.3748 1
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.177 0.7204 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0034 0.0047 0.0001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0108 0.0355 0.0833
Schistosoma mansoni ets-related 0.0232 0.0862 0.0821
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0086 0.0261 0.056
Schistosoma mansoni patched 1 0.0042 0.0083 0.0037
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0086 0.0261 0.0619
Mycobacterium tuberculosis Conserved protein 0.0108 0.0355 0.0833
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0932 0.3748 0.3722
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0086 0.0261 0.0243
Trypanosoma brucei phosphoglycerate kinase, putative 0.0063 0.0166 0.0166
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0932 0.3748 0.3723
Schistosoma mansoni hypothetical protein 0.0041 0.0076 0.0031
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0102 0.0057
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0086 0.0261 0.0087
Onchocerca volvulus 0.006 0.0154 0.13
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0231 0.0294
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0152 0.0536 0.051
Schistosoma mansoni acetyl-CoA carboxylase 0.2446 0.999 1
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0086 0.0261 0.0337
Mycobacterium leprae Probable pyruvate kinase PykA 0.0067 0.0184 0.0441
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0086 0.0261 0.0223
Plasmodium falciparum pyruvate kinase 2 0.0034 0.005 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0108 0.0355 0.0833
Toxoplasma gondii ABC1 family protein 0.0108 0.0355 0.0337
Leishmania major pyruvate kinase 0.0067 0.0184 0.0137
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0034 0.0047 0.0028
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.0611 0.0612
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0184 0.2063
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0277 0.0233
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0184 0.2063
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0104 0.0134
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0086 0.0261 0.0223
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0086 0.0261 0.0261
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0932 0.3748 1
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0086 0.0261 0.0216
Loa Loa (eye worm) hypothetical protein 0.0042 0.0083 0.0037
Trypanosoma brucei glucosidase, putative 0.0034 0.0047 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.019
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0184 0.0142
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0932 0.3748 0.6065
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0108 0.0355 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0003
Entamoeba histolytica hypothetical protein 0.0035 0.0054 0.0044
Echinococcus multilocularis lysosomal alpha glucosidase 0.0152 0.0536 0.0492
Trypanosoma brucei phosphoglycerate kinase 0.0171 0.0611 0.0612
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0083 0.0037
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.088 0.0868
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0184 0.0142
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0331 0.1274 0.1235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.1496
Echinococcus granulosus beta LACTamase domain containing family member 0.0108 0.0355 0.0311
Mycobacterium leprae Probable lipase LipE 0.0108 0.0355 0.09
Chlamydia trachomatis pyruvate kinase 0.0067 0.0184 0.0387
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Echinococcus multilocularis pyruvate kinase 0.0034 0.005 0.0004
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0185
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0171 0.0611 0.0924
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.019
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0693 0.2763 0.7337
Brugia malayi beta-lactamase family protein 0.0108 0.0355 0.0321
Leishmania major phosphoglycerate kinase B, cytosolic 0.0171 0.0611 0.0567
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0932 0.3748 0.3752
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0277 0.0233
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0102 0.009
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0527
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0315 0.027
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0086 0.0261 0.0619
Brugia malayi Ets-domain containing protein 0.0076 0.0222 0.0182
Giardia lamblia Pyruvate kinase 0.0067 0.0184 0.085
Brugia malayi Fli-1 protein 0.0232 0.0862 0.085
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.2361 0.9637 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0277 0.024
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0086 0.0261 0.0649
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0331 0.1274 0.201
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0083 0.0037
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0355 0.5715
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0078 0.0032
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0119 0.0197
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0086 0.0261 0.0215
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0211 0.0776 0.0734
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0086 0.0261 0.0261
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0034 0.0047 0.0578
Loa Loa (eye worm) hypothetical protein 0.0078 0.0231 0.0191
Onchocerca volvulus 0.0048 0.0107 0.0087
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0331 0.1274 0.1259
Echinococcus multilocularis lysosomal alpha glucosidase 0.0152 0.0536 0.0492
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0104 0.0358
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0331 0.1274 0.1234
Loa Loa (eye worm) hypothetical protein 0.0086 0.0261 0.0223
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0932 0.3748 0.6065
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0216 0.0216
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0104 0.0059
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0108 0.0355 0.0321
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0104 0.0134
Loa Loa (eye worm) hypothetical protein 0.0171 0.0611 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Echinococcus granulosus pyruvate kinase 0.0034 0.005 0.0004
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0216 0.0273
Echinococcus multilocularis protein patched 0.0042 0.0083 0.0037
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0086 0.0261 0.0649
Mycobacterium tuberculosis Probable lipase LipD 0.0108 0.0355 0.0833
Echinococcus multilocularis expressed conserved protein 0.0093 0.029 0.0245
Trichomonas vaginalis alpha-glucosidase, putative 0.0034 0.0047 0.0578
Leishmania major carboxylase, putative 0.0932 0.3748 0.3722
Plasmodium vivax phosphoglycerate kinase, putative 0.0171 0.0611 0.0824
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0086 0.0261 0.0215
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0102 0.0348
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.1496
Mycobacterium ulcerans esterase/lipase LipP 0.0108 0.0355 0.0813
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0184 0.2856
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0331 0.1274 0.1234
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0086 0.0261 0.056
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0119 0.0074
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0102 0.1496
Schistosoma mansoni pyruvate carboxylase 0.0932 0.3748 0.3723
Leishmania major acetyl-CoA carboxylase, putative 0.2446 0.999 1
Schistosoma mansoni hypothetical protein 0.0035 0.0054 0.0008
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0331 0.1274 0.3302
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0003
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0076 0.0222 0.0182
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0086 0.0261 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0053 0.0664
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0231 0.0212
Echinococcus multilocularis pyruvate kinase 0.0053 0.0126 0.008
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0171 0.0611 0.0594
Plasmodium falciparum carbamoyl phosphate synthetase 0.0211 0.0776 0.1053
Loa Loa (eye worm) hypothetical protein 0.0108 0.0355 0.0321
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0054 0.0049
Trypanosoma brucei unspecified product 0.0613 0.2433 0.2435
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0063 0.0832
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0086 0.0261 0.0216
Plasmodium falciparum pyruvate kinase 0.0067 0.0184 0.0229
Echinococcus multilocularis phosphoglycerate kinase 1 0.0171 0.0611 0.0568
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.01 0.0335
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0086 0.0261 0.0216
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0108 0.0355 0.0311
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0417 0.1627 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0024 0.019
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.005 0.003
Mycobacterium leprae conserved hypothetical protein 0.0108 0.0355 0.09
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0156 0.0113
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0331 0.1274 0.3302
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.357
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0102 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0013 0.0003
Mycobacterium tuberculosis Probable lipase LipE 0.0108 0.0355 0.0833
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0216 0.0197
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0211 0.0776 0.1194
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0102 0.0055
Trichomonas vaginalis D-aminoacylase, putative 0.0108 0.0355 0.5715
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0321 0.0277
Entamoeba histolytica hypothetical protein 0.0035 0.0054 0.0044
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0527
Trichomonas vaginalis sucrase-isomaltase, putative 0.0034 0.0047 0.0578
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0331 0.1274 0.201
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0063 0.0166 0.0195
Trypanosoma brucei pyruvate kinase 1 0.0067 0.0184 0.0184
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0074 0.1022
Brugia malayi hypothetical protein 0.0141 0.0491 0.0462
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0083 0.0037
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0932 0.3748 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0104 0.0155
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0156 0.0113
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0086 0.0261 0.0337
Chlamydia trachomatis phosphoglycerate kinase 0.0171 0.0611 0.1667
Loa Loa (eye worm) hypothetical protein 0.0047 0.01 0.0055
Loa Loa (eye worm) hypothetical protein 0.0067 0.0184 0.0142
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0086 0.0261 0.035
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.2446 0.999 0.999
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0054 0.0022
Loa Loa (eye worm) hypothetical protein 0.0036 0.0054 0.0007
Echinococcus multilocularis tumor protein p63 0.0408 0.159 0.1551
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0102 0.0057
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0331 0.1274 0.1234
Treponema pallidum phosphoglycerate kinase 0.0171 0.0611 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0477
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0231 0.0186
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0211 0.0776 0.1053

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.3323 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 4.4668 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.1995 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 20.5962 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 30.1313 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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