Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | SH2 domain containing protein | 0.072 | 0.5 | 0.5 |
Onchocerca volvulus | 0.072 | 0.5 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.072 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.072 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.072 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.072 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.072 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.072 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.072 | 0.5 | 0.5 |
Onchocerca volvulus | 0.072 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.072 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.072 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.072 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.072 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.072 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.072 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.072 | 0.5 | 0.5 |
Onchocerca volvulus | 0.072 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase shark | 0.072 | 0.5 | 0.5 |
Onchocerca volvulus | 0.072 | 0.5 | 0.5 | |
Schistosoma mansoni | tyrosine kinase | 0.072 | 0.5 | 0.5 |
Onchocerca volvulus | 0.072 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.072 | 0.5 | 0.5 |
Onchocerca volvulus | 0.072 | 0.5 | 0.5 | |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.072 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.072 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.072 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.072 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.072 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 15.1 uM | Cytotoxicity against human KB cells after 24 hrs by MTT assay | ChEMBL. | 22365913 |
IC50 (functional) | = 25.1 uM | Cytotoxicity against human PC3 cells after 24 hrs by MTT assay | ChEMBL. | 22365913 |
IC50 (functional) | = 33.8 uM | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | ChEMBL. | 22365913 |
Inhibition (functional) | = 0.75 % | Growth inhibition of human MCF7 cells at 20 uM after 24 hrs by MTT assay | ChEMBL. | 22365913 |
Inhibition (functional) | = 2.62 % | Growth inhibition of human KB cells at 20 uM after 24 hrs by MTT assay | ChEMBL. | 22365913 |
Inhibition (functional) | = 39.58 % | Growth inhibition of human PC3 cells at 20 uM after 24 hrs by MTT assay | ChEMBL. | 22365913 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22365913 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.