Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0205 | 0.0163 | 1 |
Echinococcus granulosus | Oxysterol binding protein 11 | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | Pleckstrin y | 0.0162 | 0.0089 | 0.0134 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Echinococcus multilocularis | arf GAP with SH3 domain, ANK repeat and PH | 0.0162 | 0.0089 | 0.0134 |
Plasmodium vivax | calcium-dependent protein kinase 7, putative | 0.0205 | 0.0163 | 0.0116 |
Trichomonas vaginalis | AGC family protein kinase | 0.1984 | 0.3208 | 0.3147 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Echinococcus granulosus | NDR protein kinase | 0.1984 | 0.3208 | 0.4805 |
Echinococcus multilocularis | Arf GAP and Pleckstrin domain containing protein | 0.0162 | 0.0089 | 0.0134 |
Brugia malayi | Hr1 repeat family protein | 0.1984 | 0.3208 | 0.3147 |
Echinococcus multilocularis | arf GAP with coiled coil, ANK repeat and PH | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.1984 | 0.3208 | 0.4805 |
Echinococcus granulosus | Rho GTPase activating protein 24 | 0.0162 | 0.0089 | 0.0134 |
Onchocerca volvulus | Putative zinc finger protein | 0.0162 | 0.0089 | 0.5 |
Echinococcus granulosus | arf GAP with SH3 domain ANK repeat and PH | 0.0162 | 0.0089 | 0.0134 |
Echinococcus granulosus | oxysterol binding protein 1 | 0.0162 | 0.0089 | 0.0134 |
Echinococcus granulosus | DCC interacting protein 13 beta | 0.0162 | 0.0089 | 0.0134 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0205 | 0.0163 | 0.0111 |
Echinococcus granulosus | serine/threonine protein kinase | 0.4009 | 0.6677 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0205 | 0.0163 | 0.0074 |
Echinococcus granulosus | Pleckstrin domain containing protein family B | 0.0162 | 0.0089 | 0.0134 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.1984 | 0.3208 | 0.3147 |
Echinococcus multilocularis | Pleckstrin y | 0.0162 | 0.0089 | 0.0134 |
Leishmania major | protein kinase, putative | 0.0205 | 0.0163 | 1 |
Onchocerca volvulus | 0.0162 | 0.0089 | 0.5 | |
Echinococcus granulosus | GRB2 associated binding protein 3 | 0.0162 | 0.0089 | 0.0134 |
Trichomonas vaginalis | 3-phosphoinositide dependent protein kinase-1, putative | 0.0205 | 0.0163 | 0.0074 |
Toxoplasma gondii | calcium dependent protein kinase CDPK7 | 0.0205 | 0.0163 | 0.0076 |
Toxoplasma gondii | protein kinase domain-containing protein | 0.0205 | 0.0163 | 0.0076 |
Plasmodium falciparum | calcium-dependent protein kinase 7 | 0.0205 | 0.0163 | 0.0116 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Trichomonas vaginalis | ribosomal protein S6 kinase, 90kD, polypeptide, putative | 0.0205 | 0.0163 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1984 | 0.3208 | 0.4734 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.3848 | 0.64 | 0.9585 |
Echinococcus multilocularis | Rho GTPase activating protein 24 | 0.0162 | 0.0089 | 0.0134 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.1984 | 0.3208 | 0.3147 |
Entamoeba histolytica | protein kinase 2, putative | 0.3848 | 0.64 | 0.6367 |
Echinococcus granulosus | ras specific guanine nucleotide releasing factor | 0.0162 | 0.0089 | 0.0134 |
Leishmania major | protein kinase, putative | 0.0205 | 0.0163 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Echinococcus multilocularis | cytohesin 1 | 0.0162 | 0.0089 | 0.0134 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.5788 | 0.9723 | 0.972 |
Echinococcus granulosus | protein kinase c epsilon type | 0.1984 | 0.3208 | 0.4805 |
Trypanosoma brucei | serine/threonine-protein kinase NrkA | 0.0205 | 0.0163 | 0.0074 |
Onchocerca volvulus | 0.0162 | 0.0089 | 0.5 | |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.1984 | 0.3208 | 0.4805 |
Echinococcus granulosus | Arf GAP and Pleckstrin domain containing protein | 0.0162 | 0.0089 | 0.0134 |
Entamoeba histolytica | hypothetical protein | 0.0205 | 0.0163 | 0.0074 |
Echinococcus multilocularis | collagen type iv alpha 3 binding protein | 0.0162 | 0.0089 | 0.0134 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.3805 | 0.6326 | 0.9475 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Echinococcus multilocularis | serine threonine protein kinase | 0.1984 | 0.3208 | 0.4805 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.1984 | 0.3208 | 0.4805 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0205 | 0.0163 | 0.0111 |
Echinococcus multilocularis | Ras associated and pleckstrin y | 0.0162 | 0.0089 | 0.0134 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1984 | 0.3208 | 0.4734 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0205 | 0.0163 | 0.0111 |
Echinococcus granulosus | collagen type iv alpha 3 binding protein | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | Pleckstrin domain containing protein, family B | 0.0162 | 0.0089 | 0.0134 |
Echinococcus granulosus | Pleckstrin y | 0.0162 | 0.0089 | 0.0134 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.5788 | 0.9723 | 0.972 |
Leishmania major | hypothetical protein, conserved | 0.0162 | 0.0089 | 0.5493 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Trypanosoma brucei | Serine/threonine-protein kinase NEK21, putative | 0.0205 | 0.0163 | 0.0074 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0205 | 0.0163 | 1 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.1984 | 0.3208 | 0.4805 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1984 | 0.3208 | 0.4734 |
Echinococcus granulosus | pleckstrin y domain containing family A | 0.0162 | 0.0089 | 0.0134 |
Loa Loa (eye worm) | hypothetical protein | 0.1984 | 0.3208 | 0.3147 |
Echinococcus multilocularis | Oxysterol binding protein 11 | 0.0162 | 0.0089 | 0.0134 |
Entamoeba histolytica | protein kinase, putative | 0.1984 | 0.3208 | 0.3147 |
Onchocerca volvulus | 0.0162 | 0.0089 | 0.5 | |
Echinococcus multilocularis | calcium dependent secretion activator 1 | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | protein kinase c iota type | 0.1984 | 0.3208 | 0.4805 |
Entamoeba histolytica | protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Echinococcus multilocularis | pdz domain containing protein | 0.0162 | 0.0089 | 0.0134 |
Onchocerca volvulus | 0.0162 | 0.0089 | 0.5 | |
Echinococcus granulosus | nervana 2 | 0.3805 | 0.6326 | 0.9475 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.1984 | 0.3208 | 0.3147 |
Brugia malayi | Protein kinase domain containing protein | 0.1984 | 0.3208 | 0.3147 |
Echinococcus granulosus | protein kinase C gamma type | 0.1984 | 0.3208 | 0.4805 |
Leishmania major | folate/biopterin transporter, putative | 0.0205 | 0.0163 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.3805 | 0.6326 | 0.9475 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.3848 | 0.64 | 1 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0162 | 0.0089 | 0.0134 |
Trypanosoma brucei | NEK family Serine/threonine-protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Echinococcus granulosus | cytohesin 1 | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | actin binding protein anillin | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | Pleckstrin y | 0.0162 | 0.0089 | 0.0134 |
Trypanosoma cruzi | serine/threonine protein kinase, putative | 0.0205 | 0.0163 | 0.0111 |
Brugia malayi | protein kinase C II. | 0.1984 | 0.3208 | 0.3147 |
Leishmania major | hypothetical protein, conserved | 0.0162 | 0.0089 | 0.5493 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Echinococcus granulosus | pdz domain containing protein | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | ras specific guanine nucleotide releasing factor | 0.0162 | 0.0089 | 0.0134 |
Trypanosoma cruzi | serine/threonine-protein kinase NRKB, putative | 0.0205 | 0.0163 | 0.0111 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.1984 | 0.3208 | 0.3147 |
Entamoeba histolytica | protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.4009 | 0.6677 | 0.6647 |
Onchocerca volvulus | 0.0162 | 0.0089 | 0.5 | |
Echinococcus multilocularis | type II inositol 3,4 bisphosphate 4 phosphatase | 0.0162 | 0.0089 | 0.0134 |
Brugia malayi | Protein kinase domain containing protein | 0.1984 | 0.3208 | 0.3147 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.1941 | 0.3135 | 0.3073 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0205 | 0.0163 | 0.0111 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.3848 | 0.64 | 0.9585 |
Trypanosoma cruzi | NIMA-related kinase, putative | 0.0205 | 0.0163 | 0.0111 |
Echinococcus granulosus | Pleckstrin y | 0.0162 | 0.0089 | 0.0134 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0205 | 0.0163 | 1 |
Echinococcus multilocularis | pleckstrin y domain containing family A | 0.0162 | 0.0089 | 0.0134 |
Echinococcus granulosus | myotubularin protein 13 | 0.0162 | 0.0089 | 0.0134 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.4009 | 0.6677 | 1 |
Trypanosoma cruzi | Protein kinase B | 0.4009 | 0.6677 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.5788 | 0.9723 | 0.972 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.4009 | 0.6677 | 1 |
Echinococcus granulosus | calcium dependent secretion activator 1 | 0.0162 | 0.0089 | 0.0134 |
Echinococcus granulosus | oxysterol binding protein 9 | 0.0162 | 0.0089 | 0.0134 |
Echinococcus granulosus | dynamin 1 | 0.0162 | 0.0089 | 0.0134 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1984 | 0.3208 | 0.4734 |
Trichomonas vaginalis | AGC family protein kinase | 0.1984 | 0.3208 | 0.3147 |
Echinococcus multilocularis | GRB2 associated binding protein 3 | 0.0162 | 0.0089 | 0.0134 |
Onchocerca volvulus | 0.0162 | 0.0089 | 0.5 | |
Echinococcus granulosus | nervana 2 | 0.3805 | 0.6326 | 0.9475 |
Echinococcus multilocularis | oxysterol binding protein 9 | 0.0162 | 0.0089 | 0.0134 |
Entamoeba histolytica | p21-activated kinase | 0.0205 | 0.0163 | 0.0074 |
Trypanosoma brucei | serine/threonine-protein kinase NRKB, putative | 0.0205 | 0.0163 | 0.0074 |
Onchocerca volvulus | Protein melted homolog | 0.0162 | 0.0089 | 0.5 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.3805 | 0.6326 | 0.9475 |
Onchocerca volvulus | Abnormal cell migration protein 10 homolog | 0.0162 | 0.0089 | 0.5 |
Echinococcus multilocularis | FERM and pleckstrin domain containing protein | 0.0162 | 0.0089 | 0.0134 |
Trypanosoma brucei | protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.1984 | 0.3208 | 0.4805 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.1984 | 0.3208 | 0.4805 |
Entamoeba histolytica | protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.3805 | 0.6326 | 0.9475 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1984 | 0.3208 | 0.4734 |
Entamoeba histolytica | protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.3848 | 0.64 | 0.9585 |
Onchocerca volvulus | 0.0162 | 0.0089 | 0.5 | |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.4009 | 0.6677 | 0.6647 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0205 | 0.0163 | 0.0111 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.3848 | 0.64 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.4009 | 0.6677 | 1 |
Echinococcus multilocularis | nervana 2 | 0.3805 | 0.6326 | 0.9475 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Onchocerca volvulus | Putative neuronal RhoA GEF protein | 0.0162 | 0.0089 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.5788 | 0.9723 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1984 | 0.3208 | 0.4734 |
Echinococcus granulosus | protein kinase c iota type | 0.1984 | 0.3208 | 0.4805 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.4009 | 0.6677 | 1 |
Schistosoma mansoni | serine/threonine kinase | 0.1984 | 0.3208 | 0.4734 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK21, putative | 0.0205 | 0.0163 | 0.0111 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.1984 | 0.3208 | 0.4805 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.1984 | 0.3208 | 0.4805 |
Trichomonas vaginalis | AGC family protein kinase | 0.1984 | 0.3208 | 0.3147 |
Echinococcus multilocularis | oxysterol binding protein 1 | 0.0162 | 0.0089 | 0.0134 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1984 | 0.3208 | 0.4734 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Echinococcus granulosus | arf GAP with coiled coil ANK repeat and PH | 0.0162 | 0.0089 | 0.0134 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Onchocerca volvulus | outspread protein homolog | 0.0162 | 0.0089 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.1984 | 0.3208 | 0.4805 |
Echinococcus multilocularis | dynamin 1 | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | beta 1 syntrophin | 0.0162 | 0.0089 | 0.0134 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.3848 | 0.64 | 0.9579 |
Echinococcus multilocularis | oxysterol binding protein 3 | 0.0162 | 0.0089 | 0.0134 |
Echinococcus granulosus | FERM and pleckstrin domain containing protein | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.1984 | 0.3208 | 0.4805 |
Trichomonas vaginalis | AGC family protein kinase | 0.2146 | 0.3486 | 0.3427 |
Echinococcus granulosus | Pleckstrin y | 0.0162 | 0.0089 | 0.0134 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.1984 | 0.3208 | 0.3147 |
Giardia lamblia | Kinase, AGC PKA | 0.3848 | 0.64 | 0.5 |
Trypanosoma cruzi | Serine/threonine-protein kinase NEK17, putative | 0.0205 | 0.0163 | 0.0111 |
Entamoeba histolytica | protein kinase, putative | 0.0205 | 0.0163 | 0.0074 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.1984 | 0.3208 | 0.4805 |
Schistosoma mansoni | atypical protein kinase C | 0.1984 | 0.3208 | 0.4734 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.1984 | 0.3208 | 0.3147 |
Echinococcus granulosus | oxysterol binding protein 3 | 0.0162 | 0.0089 | 0.0134 |
Trichomonas vaginalis | AGC family protein kinase | 0.0205 | 0.0163 | 0.0074 |
Echinococcus multilocularis | DCC interacting protein 13 beta | 0.0162 | 0.0089 | 0.0134 |
Echinococcus granulosus | type II inositol 34 bisphosphate 4 phosphatase | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.1984 | 0.3208 | 0.4805 |
Echinococcus granulosus | beta 1 syntrophin | 0.0162 | 0.0089 | 0.0134 |
Echinococcus multilocularis | nervana 2 | 0.3805 | 0.6326 | 0.9475 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.1984 | 0.3208 | 0.4805 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 3 % | Cardiogenic activity in human H9 cells after 14 days by MYH6-mCherry reporter gene assay relative to 4-[(1R,2S,6R,7S)-3,5-dioxo-4-azatricyclo[5.2.1.0~2,6~]dec-8-en-4-yl]-N-quinolin-8-ylbenzamide | ChEMBL. | 22191557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.