Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Vasoactive intestinal polypeptide receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Vasoactive intestinal polypeptide receptor 1 | 459 aa | 411 aa | 26.8 % |
Onchocerca volvulus | Pseudouridine-5 prime-monophosphatase homolog | Vasoactive intestinal polypeptide receptor 1 | 459 aa | 395 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | Vasoactive intestinal polypeptide receptor 1 | 459 aa | 387 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.074 | 0.3414 | 0.3378 |
Leishmania major | protein kinase, putative,serine/threonine protein kinase, putative | 0.0071 | 0.0054 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0684 | 0.3131 | 0.3131 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0684 | 0.3131 | 0.3131 |
Brugia malayi | Hr1 repeat family protein | 0.0684 | 0.3131 | 0.3131 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0684 | 0.3131 | 0.3131 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1382 | 0.664 | 1 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0684 | 0.3131 | 0.3131 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.1382 | 0.664 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1326 | 0.6358 | 0.9571 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.1326 | 0.6358 | 0.9195 |
Echinococcus granulosus | nervana 2 | 0.1311 | 0.6284 | 0.8984 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.1311 | 0.6284 | 0.8984 |
Toxoplasma gondii | AGC kinase | 0.1995 | 0.9717 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0684 | 0.3131 | 0.3094 |
Entamoeba histolytica | protein kinase, putative | 0.1995 | 0.9717 | 0.9716 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1382 | 0.664 | 0.6622 |
Trichomonas vaginalis | AGC family protein kinase | 0.0684 | 0.3131 | 0.3094 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.1326 | 0.6358 | 0.9195 |
Brugia malayi | protein kinase C II. | 0.0684 | 0.3131 | 0.3131 |
Echinococcus multilocularis | nervana 2 | 0.1311 | 0.6284 | 0.8984 |
Leishmania major | folate/biopterin transporter, putative | 0.0071 | 0.0054 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0684 | 0.3131 | 0.3131 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0684 | 0.3131 | 0.3131 |
Giardia lamblia | Kinase, AGC PKA | 0.1326 | 0.6358 | 0.5 |
Entamoeba histolytica | protein kinase 2, putative | 0.1326 | 0.6358 | 0.6338 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.1995 | 0.9717 | 0.9717 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.1326 | 0.6358 | 0.9195 |
Leishmania major | protein kinase, putative | 0.0071 | 0.0054 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0684 | 0.3131 | 0.3131 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.1995 | 0.9717 | 0.9717 |
Trichomonas vaginalis | serine/threonine-protein kinase sgk, putative | 0.0669 | 0.3057 | 0.3019 |
Leishmania major | serine/threonine-protein kinase a, putative | 0.0071 | 0.0054 | 0.5 |
Echinococcus granulosus | serine/threonine protein kinase | 0.1382 | 0.664 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.1382 | 0.664 | 0.6622 |
Trichomonas vaginalis | AGC family protein kinase | 0.0684 | 0.3131 | 0.3094 |
Echinococcus granulosus | nervana 2 | 0.1311 | 0.6284 | 0.8984 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.1311 | 0.6284 | 0.8984 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.1311 | 0.6284 | 0.8984 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.1382 | 0.664 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0684 | 0.3131 | 0.3094 |
Echinococcus multilocularis | nervana 2 | 0.1311 | 0.6284 | 0.8984 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.1382 | 0.664 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.1311 | 0.6284 | 0.8984 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.1326 | 0.6358 | 1 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0684 | 0.3131 | 0.3131 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0684 | 0.3131 | 0.3131 |
Trypanosoma cruzi | Protein kinase B | 0.1382 | 0.664 | 1 |
Leishmania major | rac serine-threonine kinase, putative,protein kinase, putative | 0.0071 | 0.0054 | 0.5 |
Leishmania major | protein kinase, putative | 0.0071 | 0.0054 | 0.5 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.1326 | 0.6358 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Displacement of [125I]VIP from vasoactive intestinal peptide receptor 1 in rat RKE cell membrane after 3 hrs by TopCount assay | ChEMBL. | 22365758 | |
IC50 (functional) | = 17 uM | Antagonist activity at vasoactive intestinal peptide receptor 1 in rat RKE cells assessed as inhibition of VIP-induced intracellular cAMP accumulation incubated for 10 mins prior to VIP-stimulation measured after 30 mins by HTRF assay | ChEMBL. | 22365758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.