Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycogen synthase kinase 3 beta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0104 | 0.2837 | 0.2837 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0104 | 0.2837 | 0.2837 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Schistosoma mansoni | nuclear receptor | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Schistosoma mansoni | zinc finger protein | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | nuclear receptor RXR | 0.0117 | 0.3604 | 0.3604 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | nuclear receptor NHR-88 | 0.0104 | 0.2837 | 0.2837 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3604 | 0.3604 |
Brugia malayi | nuclear hormone receptor | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Schistosoma mansoni | nuclear hormone receptor | 0.0104 | 0.2837 | 0.2837 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0117 | 0.3604 | 0.3604 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3604 | 0.3604 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0117 | 0.3604 | 0.3604 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3604 | 0.3604 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0117 | 0.3604 | 0.3604 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0117 | 0.3604 | 0.3604 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | tailless protein | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | conserved hypotetical protein | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | nuclear receptor RXR | 0.0104 | 0.2837 | 0.2837 |
Onchocerca volvulus | 0.0104 | 0.2837 | 0.2837 | |
Schistosoma mansoni | nuclear receptor | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0104 | 0.2837 | 0.2837 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | DR-78 | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0104 | 0.2837 | 0.2837 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0104 | 0.2837 | 0.2837 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0104 | 0.2837 | 0.2837 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3604 | 0.3604 |
Brugia malayi | hypothetical protein | 0.0117 | 0.3604 | 0.3604 |
Onchocerca volvulus | 0.0104 | 0.2837 | 0.2837 | |
Brugia malayi | hypothetical protein | 0.0117 | 0.3604 | 0.3604 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Schistosoma mansoni | nuclear hormone receptor | 0.0104 | 0.2837 | 0.2837 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0104 | 0.2837 | 0.2837 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0117 | 0.3604 | 0.3604 |
Onchocerca volvulus | Nuclear receptor subfamily 6 group A member 1 homolog | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0117 | 0.3604 | 0.3604 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | ecdysone receptor | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.3604 | 0.3604 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0104 | 0.2837 | 0.2837 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0104 | 0.2837 | 0.2837 |
Brugia malayi | nuclear receptor NHR-67 | 0.0104 | 0.2837 | 0.2837 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0117 | 0.3604 | 0.3604 |
Brugia malayi | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.2837 | 0.2837 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = -1.7 % | Inhibition of GSK3-beta assessed as residual activity at 5 uM | ChEMBL. | 22325951 |
Activity (binding) | = 38.6 % | Inhibition of CDK4 assessed as residual activity at 5 uM | ChEMBL. | 22325951 |
Activity (binding) | = 53.9 % | Inhibition of ERK1 assessed as residual activity at 5 uM | ChEMBL. | 22325951 |
Activity (binding) | = 65.2 % | Inhibition of CDK1 assessed as residual activity at 5 uM | ChEMBL. | 22325951 |
Activity (binding) | = 70.6 % | Inhibition of ERK2 assessed as residual activity at 5 uM | ChEMBL. | 22325951 |
Activity (binding) | = 74.7 % | Inhibition of IKK-beta assessed as residual activity at 5 uM | ChEMBL. | 22325951 |
Activity (binding) | = 83.6 % | Inhibition of KDR assessed as residual activity at 5 uM | ChEMBL. | 22325951 |
CCIC50 (ADMET) | = 70 uM | Cytotoxicity against human RD cells by MTS assay | ChEMBL. | 22325951 |
EC50 (binding) | = 0.04 uM | Inhibition of GSK3-beta in human RD cells assessed as glycogen synthase activation measured after 24 hrs under serum starving condition | ChEMBL. | 22325951 |
EC50 (binding) | = 0.05 uM | Inhibition of GSK3-beta in human RD cells | ChEMBL. | 22325951 |
IC50 (binding) | = 0.01 uM | Inhibition of GSK3-beta | ChEMBL. | 22325951 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.