Detailed information for compound 1620754

Basic information

Technical information
  • TDR Targets ID: 1620754
  • Name: (2-ethoxy-3,3,4-trimethyl-2-oxo-1,4-diaza-2$l ^{5}-phosphacyclopent-5-en-5-yl)cyanamide
  • MW: 230.204 | Formula: C8H15N4O2P
  • H donors: 1 H acceptors: 2 LogP: 0.13 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOP1(=O)N/C(=N/C#N)/N(C1(C)C)C
  • InChi: 1S/C8H15N4O2P/c1-5-14-15(13)8(2,3)12(4)7(11-15)10-6-9/h5H2,1-4H3,(H,10,11,13)
  • InChiKey: UNZXIRGVUSODFR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2-ethoxy-2-keto-3,3,4-trimethyl-1,4-diaza-2$l^{5}-phosphacyclopent-5-en-5-yl)cyanamide
  • NSC670100
  • AIDS161081
  • 2-Ethoxy-3,3,4-trimethyl-2-oxido-3,4-dihydro-2H-1,4,2-diazaphosphol-5-ylcyanamide
  • AIDS-161081
  • NCI60_024561

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.008 0.1001 0.901
Loa Loa (eye worm) hypothetical protein 0.0024 0.02 0.034
Entamoeba histolytica cell division protein kinase 2, putative 0.008 0.1001 0.901
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0024 0.0202 0.1819
Schistosoma mansoni kinase 0.0047 0.0529 0.0902
Echinococcus multilocularis protein kinase c eta type 0.0024 0.02 0.02
Trypanosoma cruzi polo-like protein kinase, putative 0.0087 0.1111 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0564 0.5079
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0069
Echinococcus multilocularis cyclin dependent kinase 0.008 0.1001 0.1001
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0374 0.0636
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0013 0.004 0.0068
Brugia malayi hypothetical protein 0.022 0.303 0.5128
Brugia malayi WH1 domain containing protein 0.0014 0.0045 0.0008
Onchocerca volvulus 0.0047 0.0528 0.0837
Brugia malayi p70 ribosomal S6 kinase beta 0.0054 0.063 0.1012
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0417 0.5869 1
Schistosoma mansoni protein kinase 0.0145 0.1936 0.3298
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0036 0.0374 0.0636
Echinococcus multilocularis Immunoglobulin 0.0022 0.016 0.016
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0417 0.5869 1
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.2181 0.3715
Echinococcus granulosus cyclin dependent kinase 0.008 0.1001 0.1705
Brugia malayi probable protein kinase 0.0015 0.0067 0.0046
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0417 0.5869 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Schistosoma mansoni hypothetical protein 0.0013 0.004 0.0068
Schistosoma mansoni zinc finger protein 0.0197 0.2689 0.4581
Loa Loa (eye worm) hypothetical protein 0.0034 0.0343 0.0584
Schistosoma mansoni tyrosine kinase 0.0018 0.0113 0.0192
Trypanosoma brucei protein kinase, putative 0.0047 0.0528 0.4752
Echinococcus granulosus cpg binding protein 0.0026 0.0229 0.0391
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0417 0.5869 1
Schistosoma mansoni diacylglycerol kinase theta 0.0024 0.02 0.034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0417 0.5869 1
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0096 0.1233 0.1233
Loa Loa (eye worm) hypothetical protein 0.0026 0.0228 0.0388
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0013 0.004 0.0068
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0197 0.2689 0.4544
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.0108 0.1413 0.2355
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Echinococcus granulosus neuroglian 0.0024 0.019 0.0323
Echinococcus granulosus defective proboscis extension response 0.0022 0.016 0.0272
Trichomonas vaginalis STE family protein kinase 0.0095 0.1217 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.004 0.0068
Schistosoma mansoni protein kinase C mu 0.0024 0.02 0.034
Onchocerca volvulus Protein ultraspiracle homolog 0.0417 0.5869 1
Schistosoma mansoni protein kinase 0.0038 0.0397 0.0677
Trichomonas vaginalis CMGC family protein kinase 0.008 0.1001 0.8018
Schistosoma mansoni cpg binding protein 0.0025 0.0209 0.0356
Loa Loa (eye worm) hypothetical protein 0.0024 0.02 0.034
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0564 0.5079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0417 0.5869 1
Schistosoma mansoni cell adhesion molecule 0.0024 0.0198 0.0337
Brugia malayi Nuclear hormone receptor-like 1 0.022 0.303 0.5128
Entamoeba histolytica protein kinase, putative 0.0056 0.0656 0.5903
Brugia malayi putative serine/threonine kinase SADA gamma 0.0025 0.0213 0.0297
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0528 0.09
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0564 0.0961
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0404 0.0688
Entamoeba histolytica hypothetical protein 0.0024 0.02 0.1798
Loa Loa (eye worm) nuclear receptor NHR-67 0.0197 0.2689 0.4582
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0528 0.4752
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0528 0.3299
Loa Loa (eye worm) hypothetical protein 0.0417 0.5869 1
Toxoplasma gondii AGC kinase 0.0054 0.063 0.5178
Giardia lamblia Kinase, PLK 0.0087 0.1111 0.897
Entamoeba histolytica protein kinase, putative 0.0021 0.0153 0.1378
Loa Loa (eye worm) steroid hormone receptor 0.0417 0.5869 1
Echinococcus granulosus rho-associated protein kinase 1 0.0132 0.1751 0.2983
Brugia malayi Protein kinase domain containing protein 0.0015 0.0067 0.0046
Loa Loa (eye worm) hypothetical protein 0.0025 0.0213 0.0363
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0025 0.0213 0.1919
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.005 0.0576 0.5183
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0022 0.016 0.0272
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0069
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0417 0.5869 1
Giardia lamblia Kinase, STE STE20 0.0038 0.0397 0.203
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0417 0.5869 1
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0047 0.0528 0.4752
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Brugia malayi nuclear receptor RXR 0.022 0.303 0.5128
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0417 0.5869 1
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0041 0.0442 0.0752
Loa Loa (eye worm) hypothetical protein 0.0032 0.0315 0.0536
Echinococcus granulosus twitchin 0.0029 0.0273 0.0464
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0025 0.0215 0.193
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0514 0.3546
Brugia malayi RhoGAP domain containing protein 0.0024 0.02 0.0274
Echinococcus multilocularis nervana 2 0.0018 0.0106 0.0106
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0024 0.02 0.034
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0374 0.2259
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1233 0.2101
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.022 0.303 0.5162
Plasmodium falciparum serine/threonine protein kinase KIN 0.0025 0.0213 0.1752
Loa Loa (eye worm) hypothetical protein 0.0417 0.5869 1
Schistosoma mansoni protein kinase C mu 0.01 0.1299 0.2212
Brugia malayi nuclear receptor NHR-88 0.0417 0.5869 1
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Brugia malayi RhoGEF domain containing protein 0.0024 0.02 0.0274
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0656 0.485
Entamoeba histolytica protein kinase, putative 0.0036 0.0374 0.3362
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0417 0.5869 0.5869
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0047 0.0528 0.4339
Toxoplasma gondii diacylglycerol kinase, putative 0.0024 0.02 0.1641
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0036 0.0374 0.0373
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0024 0.02 0.034
Entamoeba histolytica protein kinase 2, putative 0.0024 0.0189 0.1699
Brugia malayi hypothetical protein 0.0019 0.0131 0.0155
Entamoeba histolytica protein kinase, putative 0.0054 0.063 0.5672
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0036 0.0374 0.0636
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.1111 0.9028
Echinococcus granulosus serine threonine protein kinase nrc 0.0024 0.0189 0.0321
Echinococcus granulosus glycoprotein Antigen 5 0.0013 0.004 0.0068
Echinococcus multilocularis serine:threonine protein kinase N2 0.0036 0.0374 0.0373
Onchocerca volvulus 0.0097 0.1242 0.2061
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0213 0.0238
Echinococcus granulosus Mastin 0.0013 0.004 0.0068
Loa Loa (eye worm) hypothetical protein 0.012 0.1577 0.2687
Brugia malayi Protein kinase c protein 2 0.0065 0.0792 0.129
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Echinococcus multilocularis roundabout 2 0.0026 0.0228 0.0228
Loa Loa (eye worm) hypothetical protein 0.0059 0.0693 0.1181
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0038 0.0397 0.0677
Schistosoma mansoni diacylglycerol kinase theta 0.0024 0.02 0.034
Echinococcus multilocularis ecdysone induced protein 78C 0.0417 0.5869 0.5869
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0514 0.3546
Schistosoma mansoni nephrin 0.0024 0.019 0.0323
Brugia malayi nuclear hormone receptor 0.0417 0.5869 1
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0374 0.0636
Brugia malayi Nuclear hormone receptor E75 0.0197 0.2689 0.4544
Echinococcus granulosus Diacylglycerol kinase theta 0.0024 0.02 0.034
Loa Loa (eye worm) hypothetical protein 0.0024 0.02 0.034
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.074 0.126
Schistosoma mansoni retinoid-x-receptor (RXR) 0.022 0.303 0.5162
Echinococcus granulosus roundabout 2 0.0026 0.0228 0.0388
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.004 0.0068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0417 0.5869 1
Brugia malayi Protein kinase domain containing protein 0.0144 0.1922 0.3227
Loa Loa (eye worm) hypothetical protein 0.0022 0.016 0.0273
Brugia malayi serine/threonine-protein kinase plk-2 0.0087 0.1111 0.1837
Echinococcus granulosus nuclear receptor nhr 48 0.0197 0.2689 0.4581
Schistosoma mansoni protein kinase 0.0015 0.0067 0.0114
Giardia lamblia Kinase, NEK 0.0095 0.1217 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0024 0.02 0.1798
Loa Loa (eye worm) nuclear hormone receptor 0.0197 0.2689 0.4582
Loa Loa (eye worm) hypothetical protein 0.007 0.0865 0.1475
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.003 0.0283 0.0482
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.022 0.303 0.303
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Echinococcus granulosus raf serine:threonine protein kinase 0.0029 0.0268 0.0456
Brugia malayi hypothetical protein 0.0197 0.2689 0.4544
Echinococcus granulosus transmembrane protease serine 3 0.0013 0.004 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0151 0.2021 0.3443
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0069
Brugia malayi Protein kinase domain containing protein 0.0151 0.2021 0.3398
Schistosoma mansoni hypothetical protein 0.0355 0.4969 0.8467
Loa Loa (eye worm) hypothetical protein 0.0417 0.5869 1
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Loa Loa (eye worm) hypothetical protein 0.0417 0.5869 1
Loa Loa (eye worm) hypothetical protein 0.0156 0.2101 0.358
Schistosoma mansoni unc-13 (munc13) 0.0025 0.0216 0.0367
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Schistosoma mansoni steroid hormone receptor ad4bp 0.0417 0.5869 1
Brugia malayi Protein kinase domain containing protein 0.0398 0.559 0.9521
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.0108 0.1413 0.1413
Echinococcus granulosus ecdysone induced protein 78C 0.0417 0.5869 1
Brugia malayi ecdysteroid receptor 0.0417 0.5869 1
Onchocerca volvulus 0.012 0.1577 0.2636
Echinococcus multilocularis protein kinase c iota type 0.0061 0.0724 0.0724
Brugia malayi Protein kinase domain containing protein 0.0133 0.1763 0.2956
Echinococcus multilocularis neuroglian 0.0024 0.019 0.019
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0374 0.2259
Onchocerca volvulus 0.0025 0.0209 0.0289
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0144 0.1922 0.3227
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.005 0.0576 0.5183
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0144 0.1922 0.3274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0417 0.5869 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0015 0.0067 0.0067
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0036 0.0374 0.0373
Echinococcus multilocularis serine:threonine protein kinase 3 0.0199 0.2719 0.2719
Echinococcus multilocularis nervana 2 0.0018 0.0106 0.0106
Echinococcus granulosus N chimaerin 0.0024 0.02 0.034
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.1111 0.9028
Brugia malayi Hr1 repeat family protein 0.0036 0.0374 0.0572
Echinococcus multilocularis nuclear receptor nhr 48 0.0197 0.2689 0.2689
Brugia malayi Protein kinase domain containing protein 0.008 0.1001 0.1648
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0417 0.5869 1
Brugia malayi Nuclear hormone receptor-like 1 0.022 0.303 0.5128
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.022 0.303 0.5162
Schistosoma mansoni vav2 0.0026 0.0226 0.0384
Schistosoma mansoni nuclear hormone receptor 0.0197 0.2689 0.4581
Schistosoma mansoni protein kinase 0.0019 0.0128 0.0217
Trichomonas vaginalis AGC family protein kinase 0.0038 0.0399 0.2494
Brugia malayi Protein kinase domain 0.0038 0.0397 0.0613
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0398 0.559 0.9524
Brugia malayi nuclear hormone receptor 0.0197 0.2689 0.4544
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.0132 0.1751 0.2983
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Brugia malayi CXXC zinc finger family protein 0.0025 0.0209 0.0289
Echinococcus multilocularis cyclin dependent kinase 1 0.008 0.1001 0.1001
Brugia malayi steroid hormone receptor 0.0417 0.5869 1
Entamoeba histolytica protein kinase, putative 0.0038 0.0404 0.3635
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.1111 0.1892
Trypanosoma cruzi cdc2-related kinase 1 0.008 0.1001 0.901
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0417 0.5869 1
Echinococcus granulosus serine/threonine protein kinase 0.0025 0.0215 0.0365
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0144 0.1922 0.3274
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0013 0.004 0.004
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0024 0.0202 0.0686
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0197 0.2689 0.4581
Brugia malayi Nuclear hormone receptor E75 0.0197 0.2689 0.4544
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0656 0.485
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.008 0.1001 0.1705
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0564 0.401
Onchocerca volvulus 0.012 0.1577 0.2636
Echinococcus granulosus protein kinase c iota type 0.0061 0.0724 0.1233
Loa Loa (eye worm) hypothetical protein 0.0022 0.016 0.0273
Echinococcus granulosus cyclin dependent kinase 5 0.008 0.1001 0.1705
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0564 0.0961
Echinococcus granulosus cyclin dependent kinase 1 0.008 0.1001 0.1705
Trichomonas vaginalis STE family protein kinase 0.005 0.0576 0.4116
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0202 0.0344
Loa Loa (eye worm) hypothetical protein 0.0097 0.1242 0.2115
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Schistosoma mansoni thyroid hormone receptor 0.0417 0.5869 1
Trichomonas vaginalis AGC family protein kinase 0.0036 0.0374 0.2259
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0656 0.485
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0013 0.004 0.0068
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Entamoeba histolytica hypothetical protein 0.0014 0.0045 0.0401
Echinococcus granulosus thyroid hormone receptor alpha 0.0197 0.2689 0.4581
Brugia malayi Nuclear hormone receptor-like 1 0.0417 0.5869 1
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0213 0.0363
Echinococcus multilocularis cpg binding protein 0.0026 0.0229 0.0229
Brugia malayi intracellular kinase 0.0047 0.0528 0.0837
Echinococcus multilocularis PAK box P21 Rho binding 0.0014 0.0045 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.1021 0.1739
Schistosoma mansoni RAR-like nuclear receptor 0.0417 0.5869 1
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0025 0.0216 0.0215
Onchocerca volvulus 0.0197 0.2689 0.4544
Schistosoma mansoni hypothetical protein 0.0014 0.0045 0.0076
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Brugia malayi nuclear receptor NHR-67 0.0197 0.2689 0.4544
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Trichomonas vaginalis STE family protein kinase 0.0038 0.0397 0.2478
Loa Loa (eye worm) hypothetical protein 0.022 0.303 0.5162
Echinococcus granulosus NDR protein kinase 0.0036 0.0374 0.0636
Loa Loa (eye worm) hypothetical protein 0.0026 0.0228 0.0388
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0076 0.0948 0.1616
Giardia lamblia Kinase, NEK 0.0095 0.1217 1
Echinococcus multilocularis myotubularin protein 13 0.0026 0.0226 0.0225
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0417 0.5869 1
Trypanosoma cruzi cdc2-related kinase 3 0.008 0.1001 0.901
Echinococcus granulosus neural Wiskott Aldrich syndrome protein 0.0014 0.0045 0.0076
Schistosoma mansoni wiskott-aldrich syndrome protein 0.0014 0.0045 0.0076
Echinococcus multilocularis FTZ F1 alpha 0.0417 0.5869 0.5869
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0197 0.2689 0.2689
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0151 0.2021 0.3444
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0062 0.074 0.126
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1233 0.2101
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.004 0.0068
Loa Loa (eye worm) RasGEF domain-containing protein 0.0024 0.02 0.034
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0162 0.2181 0.2181
Brugia malayi P21-Rho-binding domain containing protein 0.0014 0.0045 0.0008
Brugia malayi hypothetical protein 0.022 0.303 0.5128
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0564 0.5079
Onchocerca volvulus Tyrosine kinase homolog 0.0127 0.1675 0.2804
Echinococcus multilocularis N chimaerin 0.0024 0.02 0.02
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0024 0.0189 0.1699
Echinococcus multilocularis dnaJ subfamily B 0.0355 0.4969 0.4969
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0038 0.0404 0.0688
Echinococcus multilocularis PAK box P21 Rho binding 0.0019 0.0128 0.0127
Loa Loa (eye worm) hypothetical protein 0.0095 0.1216 0.2072
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0417 0.5869 1
Echinococcus granulosus enteropeptidase 0.0013 0.004 0.0068
Plasmodium vivax glycogen synthase kinase 3, putative 0.0047 0.0528 0.3299
Trypanosoma brucei cdc2-related kinase 1 0.008 0.1001 0.901
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0197 0.2689 0.4581
Echinococcus multilocularis thyroid hormone receptor alpha 0.0417 0.5869 0.5869
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0095 0.1217 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0216 0.0367
Brugia malayi Fibronectin type III domain containing protein 0.0022 0.016 0.0206
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.1111 0.9028
Brugia malayi Protein kinase domain containing protein 0.0036 0.0374 0.0572
Brugia malayi MAP kinase sur-1 0.005 0.0564 0.0899
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0047 0.0528 0.0528
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0564 0.0564
Schistosoma mansoni hypothetical protein 0.0014 0.0045 0.0076
Brugia malayi tailless protein 0.0197 0.2689 0.4544
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0015 0.0067 0.0114
Brugia malayi Ras association domain family 1 isoform A 0.0024 0.02 0.0274
Echinococcus granulosus myotubularin protein 13 0.0026 0.0226 0.0384
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.008 0.1001 0.1705
Loa Loa (eye worm) hypothetical protein 0.0022 0.016 0.0273
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Plasmodium vivax protein kinase Crk2 0.008 0.1001 0.79
Trichomonas vaginalis STE family protein kinase 0.0038 0.0397 0.2478
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0417 0.5869 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0417 0.5869 0.5869
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.008 0.1001 0.1705
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.022 0.303 0.5162
Onchocerca volvulus 0.0095 0.1216 0.2017
Schistosoma mansoni hypothetical protein 0.0014 0.0045 0.0076
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0087 0.1111 0.1893
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0564 0.4637
Loa Loa (eye worm) hypothetical protein 0.022 0.303 0.5162
Echinococcus granulosus RNA directed DNA polymerase 0.0034 0.0343 0.0584
Loa Loa (eye worm) AGC/PKN protein kinase 0.0036 0.0374 0.0636
Echinococcus granulosus serine:threonine protein kinase 3 0.0199 0.2719 0.4633
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.0215 0.0365
Trypanosoma brucei rac serine-threonine kinase, putative 0.0056 0.0656 0.5903
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0036 0.0374 0.0636
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0087 0.1111 0.1892
Loa Loa (eye worm) P21-Rho-binding domain-containing protein 0.0014 0.0045 0.0076
Loa Loa (eye worm) CAMK/PKD protein kinase 0.01 0.1299 0.2213
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0197 0.2689 0.2689
Loa Loa (eye worm) hypothetical protein 0.022 0.303 0.5162
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0038 0.0404 0.0404
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0024 0.0202 0.0345
Mycobacterium ulcerans hypothetical protein 0.0013 0.004 0.5
Loa Loa (eye worm) hypothetical protein 0.022 0.303 0.5162
Trypanosoma brucei protein kinase, putative 0.005 0.0564 0.5079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0417 0.5869 0.5869
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Loa Loa (eye worm) hypothetical protein 0.007 0.0865 0.1475
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0145 0.1936 0.3298
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0025 0.0213 0.1919
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.008 0.1001 0.901
Giardia lamblia Kinase, CMGC GSK 0.0047 0.0528 0.3299
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0018 0.0106 0.018
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0417 0.5869 1
Entamoeba histolytica hypothetical protein 0.0014 0.0045 0.0401
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.1413 0.2408
Brugia malayi Temporarily assigned gene name protein 59 0.0111 0.1455 0.2428
Schistosoma mansoni nuclear receptor 0.0197 0.2689 0.4581
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0047 0.0528 0.09
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0024 0.0202 0.0345
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0417 0.5869 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.133 0.2266
Echinococcus multilocularis raf serine:threonine protein kinase 0.0029 0.0268 0.0268
Echinococcus granulosus protein kinase shaggy 0.0047 0.0528 0.0899
Echinococcus multilocularis Rac GTPase activating protein 1 0.0024 0.02 0.02
Giardia lamblia Kinase, NEK 0.0095 0.1217 1
Loa Loa (eye worm) raf kinase 0.0024 0.02 0.034
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0417 0.5869 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0197 0.2689 0.2689
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.004 0.0068
Loa Loa (eye worm) hypothetical protein 0.0022 0.016 0.0273
Loa Loa (eye worm) hypothetical protein 0.0024 0.02 0.034
Onchocerca volvulus 0.007 0.0865 0.1416
Schistosoma mansoni serine/threonine protein kinase 0.0024 0.0202 0.0344
Echinococcus granulosus protein kinase C gamma type 0.0072 0.0883 0.1504
Echinococcus granulosus nervana 2 0.0018 0.0106 0.018
Brugia malayi hypothetical protein 0.0022 0.016 0.0206
Entamoeba histolytica protein kinase, putative 0.0056 0.0656 0.5903
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.004 0.0068
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0417 0.5869 1
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0528 0.3677
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0656 0.485
Loa Loa (eye worm) hypothetical protein 0.0024 0.02 0.034
Entamoeba histolytica protein kinase, putative 0.0038 0.0397 0.3577
Plasmodium falciparum NIMA related kinase 1 0.0095 0.1217 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0417 0.5869 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0417 0.5869 1
Echinococcus multilocularis neural Wiskott Aldrich syndrome protein 0.0014 0.0045 0.0045
Schistosoma mansoni ste20-related kinase 0.0154 0.2076 0.3536
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.01 0.1299 0.2159
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0024 0.0189 0.1551
Entamoeba histolytica protein kinase, putative 0.0019 0.0128 0.1146
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0213 0.0363
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0197 0.2689 0.2689
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1001 0.1705
Echinococcus granulosus FTZ F1 alpha 0.0417 0.5869 1
Schistosoma mansoni hypothetical protein 0.0013 0.004 0.0068
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0022 0.016 0.0272
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0564 0.401
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0047 0.0528 0.4752
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0038 0.0397 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.1111 0.9028
Brugia malayi nuclear receptor RXR 0.0197 0.2689 0.4544
Loa Loa (eye worm) hypothetical protein 0.0026 0.0226 0.0384
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0015 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.1111 0.9028
Schistosoma mansoni atypical protein kinase C 0.0061 0.0724 0.1233
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0564 0.401
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0564 0.5079
Loa Loa (eye worm) AGC/NDR protein kinase 0.0036 0.0374 0.0636
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0197 0.2689 0.4581
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0417 0.5869 0.5869
Entamoeba histolytica serine/threonine protein kinase, putative 0.0087 0.1111 1
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.0113 0.0192
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.1111 0.9028
Echinococcus granulosus Nuclear hormone receptor HR96 0.0197 0.2689 0.4581
Echinococcus granulosus Immunoglobulin 0.0022 0.016 0.0272
Schistosoma mansoni vesicular amine transporter 0.0022 0.016 0.0272
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0564 0.3653
Echinococcus granulosus nervana 2 0.0018 0.0106 0.018
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0162 0.2181 0.3715
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0024 0.02 0.034
Trypanosoma cruzi cdc2-related kinase 1 0.008 0.1001 0.901
Echinococcus multilocularis serine:threonine protein kinase N2 0.0036 0.0374 0.0373
Loa Loa (eye worm) hypothetical protein 0.012 0.1577 0.2687
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0024 0.0198 0.0337
Schistosoma mansoni serine/threonine-protein kinase 0.0025 0.0215 0.0365
Echinococcus granulosus Protein kinase C brain isozyme 0.0096 0.1233 0.2101
Brugia malayi hypothetical protein 0.0197 0.2689 0.4544
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0054 0.063 0.1074
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0081 0.1021 0.1021
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0025 0.0213 0.0213
Entamoeba histolytica p21-activated kinase 0.004 0.0423 0.3808
Loa Loa (eye worm) hypothetical protein 0.0022 0.016 0.0273
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0087 0.1111 1
Schistosoma mansoni thyroid hormone receptor 0.0417 0.5869 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0417 0.5869 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0197 0.2689 0.4544
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0036 0.0374 0.0373
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.004 0.0068
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0025 0.0213 0.0238
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0656 0.485
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0018 0.0106 0.0106
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0022 0.016 0.016
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Entamoeba histolytica protein kinase, putative 0.0021 0.0153 0.1378
Loa Loa (eye worm) AGC/AKT protein kinase 0.0056 0.0656 0.1117
Schistosoma mansoni protein kinase C 0.0025 0.0216 0.0367
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0417 0.5869 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0069
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.005 0.0576 0.5183
Trypanosoma cruzi polo-like protein kinase, putative 0.0087 0.1111 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0417 0.5869 1
Schistosoma mansoni unc-13 (munc13) 0.0025 0.0216 0.0367
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.005 0.0576 0.5183
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0038 0.0404 0.0687
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0095 0.1217 1
Plasmodium falciparum protein kinase 5 0.008 0.1001 0.8226
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.008 0.1001 0.8226
Brugia malayi map kinase activated protein kinase protein 2 0.0162 0.2181 0.3672
Leishmania major protein kinase, putative 0.005 0.0576 0.5183
Echinococcus granulosus protein kinase c eta type 0.0024 0.02 0.034
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.005 0.0576 0.5183
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.0215 0.193
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Brugia malayi STE20-like kinase MST 0.0199 0.2719 0.4596
Entamoeba histolytica protein kinase, putative 0.0047 0.0528 0.4752
Loa Loa (eye worm) hypothetical protein 0.0417 0.5869 1
Schistosoma mansoni rac gtpase activating protein 0.0024 0.02 0.034
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.019 0.2583 0.4401
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0162 0.2181 0.3715
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0564 0.5079
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0197 0.2689 0.4544
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0053 0.0612 0.1042
Echinococcus multilocularis rho associated protein kinase 0.0132 0.1751 0.1751
Echinococcus multilocularis RNA directed DNA polymerase 0.0034 0.0343 0.0343
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.008 0.1001 0.1705
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0087 0.1111 0.1111
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Echinococcus granulosus dnaJ subfamily B 0.0355 0.4969 0.8467
Trypanosoma brucei polo-like protein kinase 0.0087 0.1111 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0417 0.5869 1
Echinococcus multilocularis protein kinase shaggy 0.0047 0.0528 0.0528
Echinococcus multilocularis transmembrane protease serine 3 0.0013 0.004 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0417 0.5869 1
Trypanosoma cruzi cdc2-related kinase 3 0.008 0.1001 0.901
Trypanosoma brucei cdc2-related kinase 3 0.008 0.1001 0.901
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0315 0.1718
Schistosoma mansoni retinoic acid receptor RXR 0.0417 0.5869 1
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0031 0.0291 0.1498
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0024 0.0189 0.0321
Toxoplasma gondii histone kinase SNF1, putative 0.0025 0.0213 0.1752
Entamoeba histolytica diacylglycerol kinase, putative 0.0024 0.02 0.1798
Brugia malayi conserved hypotetical protein 0.0197 0.2689 0.4544
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0069
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0564 0.5079
Schistosoma mansoni nuclear hormone receptor 0.0197 0.2689 0.4581
Loa Loa (eye worm) hypothetical protein 0.0024 0.0198 0.0337
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0038 0.0397 0.0677
Echinococcus granulosus Glutaredoxin protein 5 0.0018 0.0106 0.018
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0047 0.0528 0.0899
Giardia lamblia Kinase, CMGC CDK 0.008 0.1001 0.79
Brugia malayi protein kinase C3,putative 0.003 0.0283 0.0416
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0015 0.0067 0.0114
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0025 0.0216 0.0367
Brugia malayi protein kinase C II. 0.0062 0.074 0.12
Brugia malayi Pleckstrin Homology Domain 0.0026 0.0226 0.0318
Schistosoma mansoni nuclear receptor 0.0197 0.2689 0.4581
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0199 0.2719 0.4633
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0564 0.5079
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Brugia malayi cell division control protein 2 homolog 0.008 0.1001 0.1648
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.0108 0.1413 0.2408
Loa Loa (eye worm) hypothetical protein 0.0417 0.5869 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0222
Echinococcus granulosus 3'partial|serine:threonine protein kinase PAK 2 0.0014 0.0045 0.0076
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.1111 0.9028
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0034 0.0343 0.0343
Echinococcus multilocularis serine:threonine protein kinase 38 0.0036 0.0374 0.0373
Onchocerca volvulus Serine\/threonine kinase homolog 0.0087 0.1111 0.1837
Onchocerca volvulus 0.0197 0.2689 0.4544
Brugia malayi C1-like domain containing protein 0.01 0.1299 0.2159
Loa Loa (eye worm) hypothetical protein 0.0019 0.0131 0.0222
Giardia lamblia Kinase, STE STE20 0.005 0.0576 0.3765
Echinococcus granulosus serine:threonine protein kinase N2 0.0036 0.0374 0.0636
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0564 0.0961
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0149 0.1994 0.3396
Loa Loa (eye worm) hypothetical protein 0.0144 0.1927 0.3284
Loa Loa (eye worm) hypothetical protein 0.012 0.1577 0.2687
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0144 0.1922 0.3227
Schistosoma mansoni coup transcription factor 0.0417 0.5869 1
Schistosoma mansoni protein kinase 0.0038 0.0397 0.0677
Loa Loa (eye worm) DR-78 0.0197 0.2689 0.4582
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Schistosoma mansoni cpg binding protein 0.0026 0.0229 0.0391
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0564 0.0961
Loa Loa (eye worm) hypothetical protein 0.022 0.303 0.5162
Loa Loa (eye worm) hypothetical protein 0.0074 0.0918 0.1564
Trichomonas vaginalis CMGC family protein kinase 0.0047 0.0528 0.3677
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0417 0.5869 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0197 0.2689 0.4544
Schistosoma mansoni nuclear hormone receptor 0.0417 0.5869 1
Schistosoma mansoni nuclear receptor nhr-48 0.0197 0.2689 0.4581
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0081 0.1021 0.1739
Entamoeba histolytica protein kinase domain containing protein 0.0047 0.0528 0.4752
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0656 0.485
Brugia malayi Steroid receptor seven-up type 2 0.0417 0.5869 1
Brugia malayi nuclear hormone receptor family member odr-7 0.0197 0.2689 0.4544
Echinococcus multilocularis Immunoglobulin 0.0022 0.016 0.016
Echinococcus multilocularis Mastin 0.0013 0.004 0.004
Echinococcus granulosus Nuclear hormone receptor HR96 0.0197 0.2689 0.4581
Echinococcus multilocularis serine threonine protein kinase 0.0072 0.0883 0.0883
Giardia lamblia Kinase, CAMK CAMKL 0.0025 0.0213 0.0238
Brugia malayi RhoGAP domain containing protein 0.0024 0.02 0.0274
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0144 0.1922 0.3274
Brugia malayi Protein kinase domain containing protein 0.0056 0.0656 0.1056
Schistosoma mansoni cpg binding protein 0.0026 0.0229 0.0391
Echinococcus multilocularis cyclin dependent kinase 5 0.008 0.1001 0.1001
Trichomonas vaginalis AGC family protein kinase 0.0056 0.0656 0.485
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0417 0.5869 1
Echinococcus multilocularis enteropeptidase 0.0013 0.004 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Trypanosoma cruzi p21-activated kinase 3, putative 0.0024 0.0202 0.1819
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Onchocerca volvulus 0.0126 0.1668 0.2792
Echinococcus multilocularis rac serine:threonine kinase 0.0025 0.0215 0.0214
Echinococcus multilocularis myosin iiia 0.005 0.0576 0.0576
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Echinococcus multilocularis unc 13 (munc13) 0.0025 0.0216 0.0215
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0197 0.2689 0.4581
Brugia malayi nuclear receptor NHR-88 0.0197 0.2689 0.4544
Echinococcus granulosus unc 13 munc13 0.0025 0.0216 0.0367
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0417 0.5869 1
Schistosoma mansoni protein kinase 0.0014 0.0045 0.0076
Brugia malayi Variant SH3 domain containing protein 0.0024 0.02 0.0274
Giardia lamblia Kinase, CMGC CDK 0.008 0.1001 0.79
Trichomonas vaginalis STE family protein kinase 0.0038 0.0397 0.2478
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0374 0.0636
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0019 0.0128 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0213 0.0788
Echinococcus granulosus serine:threonine kinase SAD 1 0.0025 0.0213 0.0363
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0036 0.0374 0.0636
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0013 0.004 0.004
Echinococcus granulosus PAK box P21 Rho binding 0.0014 0.0045 0.0076
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0417 0.5869 0.5869
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.0108 0.1413 0.2408
Schistosoma mansoni hypothetical protein 0.0024 0.02 0.034
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0025 0.0213 0.1919
Brugia malayi diacylglycerol kinase 0.0024 0.02 0.0274
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0197 0.2689 0.4582
Echinococcus granulosus protein kinase c epsilon type 0.0062 0.074 0.126
Trichomonas vaginalis AGC family protein kinase 0.0095 0.1217 1
Onchocerca volvulus 0.0132 0.1751 0.2935
Echinococcus multilocularis Glutaredoxin protein 5 0.0018 0.0106 0.0106
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0015 0.0067 0.0114
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0197 0.2689 0.2689
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0038 0.0397 0.0677
Schistosoma mansoni serine/threonine protein kinase 0.0081 0.1021 0.1739
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0024 0.02 0.034
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0024 0.0189 0.0189
Brugia malayi Immunoglobulin I-set domain containing protein 0.0022 0.016 0.0206
Schistosoma mansoni serine/threonine protein kinase 0.0036 0.0374 0.0636
Schistosoma mansoni protein kinase 0.0145 0.1936 0.3298
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0417 0.5869 1
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0025 0.0213 0.0363
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0038 0.0397 0.0397
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0024 0.02 0.034
Trypanosoma brucei SNF1-related protein kinases, putative 0.0025 0.0213 0.1919
Onchocerca volvulus 0.0417 0.5869 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0024 0.02 0.034
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0025 0.0213 0.1919
Loa Loa (eye worm) hypothetical protein 0.0024 0.02 0.034
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0564 0.401
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0036 0.0374 0.0636
Onchocerca volvulus 0.0025 0.0216 0.0301
Trichomonas vaginalis CMGC family protein kinase 0.008 0.1001 0.8018
Brugia malayi photoreceptor-specific nuclear receptor 0.0417 0.5869 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0417 0.5869 1
Brugia malayi Protein kinase domain containing protein 0.0036 0.0374 0.0572
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1001 0.1705
Toxoplasma gondii histone lysine methyltransferase SET1 0.0047 0.0531 0.4359
Loa Loa (eye worm) trypsin family protein 0.0013 0.004 0.0069
Brugia malayi diacylglycerol kinase 0.0024 0.02 0.0274
Brugia malayi p21/Cdc42/Rac1-activated kinase 0.0024 0.0202 0.0278
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0145 0.1936 0.1936
Loa Loa (eye worm) hypothetical protein 0.0022 0.016 0.0273
Plasmodium falciparum glycogen synthase kinase 3 0.0047 0.0528 0.4339
Onchocerca volvulus Bile acid receptor homolog 0.0417 0.5869 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0047 0.0528 0.0899
Brugia malayi serine/threonine-protein kinase PAK 7 0.0019 0.0128 0.015
Echinococcus multilocularis protein kinase c epsilon type 0.0062 0.074 0.0739
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0209 0.0356
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0417 0.5869 0.5869
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0038 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0417 0.5869 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0024 0.02 0.02
Echinococcus multilocularis glycoprotein Antigen 5 0.0013 0.004 0.004
Brugia malayi P21-Rho-binding domain containing protein 0.0014 0.0045 0.0008
Echinococcus multilocularis Diacylglycerol kinase theta 0.0024 0.02 0.02
Echinococcus granulosus serine:threonine protein kinase PAK 1 0.0019 0.0119 0.0203
Loa Loa (eye worm) hypothetical protein 0.0417 0.5869 1
Echinococcus granulosus Rac GTPase activating protein 1 0.0024 0.02 0.034
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0038 0.0404 0.0404
Schistosoma mansoni protein kinase 0.0015 0.0067 0.0114
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0417 0.5869 1
Trichomonas vaginalis CMGC family protein kinase 0.008 0.1001 0.8018
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0417 0.5869 1
Brugia malayi ecdysone receptor 0.0197 0.2689 0.4544
Trichomonas vaginalis STE family protein kinase 0.0038 0.0397 0.2478
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0268 0.0456
Entamoeba histolytica cell division protein kinase 2, putative 0.008 0.1001 0.901
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0025 0.0213 0.1919
Schistosoma mansoni serine/threonine kinase 0.0036 0.0374 0.0636
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0564 0.0564
Loa Loa (eye worm) hypothetical protein 0.0197 0.2689 0.4582
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0213 0.0363
Loa Loa (eye worm) hypothetical protein 0.0013 0.004 0.0069
Brugia malayi orphan nuclear receptor NR2E1 0.0197 0.2689 0.4544
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0013 0.004 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0025 0.0213 0.0363
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0144 0.1922 0.1921
Entamoeba histolytica PH domain containing protein kinase, putative 0.0025 0.0215 0.193
Trypanosoma cruzi Protein kinase B 0.0025 0.0215 0.193
Schistosoma mansoni serine/threonine protein kinase 0.0144 0.1922 0.3274
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Entamoeba histolytica serine/threonine protein kinase, putative 0.0025 0.0213 0.1919
Schistosoma mansoni cercarial elastase (S01 family) 0.0013 0.004 0.0068
Entamoeba histolytica protein kinase, putative 0.0038 0.0404 0.3635
Brugia malayi Immunoglobulin I-set domain containing protein 0.0149 0.1994 0.3351
Echinococcus multilocularis cyclin dependent kinase 1 0.008 0.1001 0.1001

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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