Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cholinergic receptor, nicotinic, alpha 4 (neuronal) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0101 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.2546 | 0.2546 |
Brugia malayi | RNA binding protein | 0.0073 | 0.6717 | 0.6717 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.6717 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.6717 | 0.6717 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.6717 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.4741 | 0.4741 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.6717 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0101 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0101 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.6717 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0101 | 1 | 1 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0101 | 1 | 1 |
Onchocerca volvulus | Putative nachr subunit | 0.0101 | 1 | 0.5 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0101 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.6717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.2546 | 0.2546 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.6717 | 0.6717 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.6717 | 0.6717 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.6717 | 0.6717 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.4741 | 0.4741 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.4741 | 0.4741 |
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.6717 | 0.6717 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.6717 | 0.6717 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0101 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2546 | 0.3791 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.6717 | 0.6717 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.4741 | 0.4741 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.12 nM | Potency to displace [3H]-IMI binding to Nicotinic acetylcholine receptor from Drosophila head membranes | ChEMBL. | 12061885 |
Ki (binding) | = 60 nM | Potency to displace [3H]-Nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 immuno-isolated from M10 cells | ChEMBL. | 12061885 |
Ki (binding) | = 60 nM | Potency to displace [3H]-Nicotine binding to Nicotinic acetylcholine receptor alpha4-beta2 immuno-isolated from M10 cells | ChEMBL. | 12061885 |
Selectivity (binding) | = 500 | Selectivity ratio of Ki of Nicotinic acetylcholine receptor of Drosophila to Nicotinic acetylcholine receptor alpha4-beta2 | ChEMBL. | 12061885 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.