Detailed information for compound 162105

Basic information

Technical information
  • TDR Targets ID: 162105
  • Name: 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hyd roxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidi ne-5-carbonitrile
  • MW: 291.263 | Formula: C12H13N5O4
  • H donors: 4 H acceptors: 6 LogP: -1.62 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cc(c2c1ncnc2N)C#N
  • InChi: 1S/C12H13N5O4/c13-1-5-2-17(11-7(5)10(14)15-4-16-11)12-9(20)8(19)6(3-18)21-12/h2,4,6,8-9,12,18-20H,3H2,(H2,14,15,16)/t6-,8-,9-,12-/m1/s1
  • InChiKey: XOKJUSAYZUAMGJ-WOUKDFQISA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile
  • 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-5-pyrrolo[2,3-d]pyrimidinecarbonitrile
  • 4-azanyl-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile
  • 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile
  • Toyocamycin
  • 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrrolo[5,4-d]pyrimidine-5-carbonitrile
  • 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[5,4-d]pyrimidine-5-carbonitrile
  • 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-5-pyrrolo[5,4-d]pyrimidinecarbonitrile
  • 4-amino-7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methylol-tetrahydrofuran-2-yl]pyrrolo[5,4-d]pyrimidine-5-carbonitrile
  • 4-Amino-7-(3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
  • AIDS-125141
  • AIDS125141
  • {7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile,} 4-amino-7-.beta.-D-ribofuranosyl-
  • 4-26-00-01419 (Beilstein Handbook Reference)
  • 4-Amino-5-cyano-7-(D-ribofuranosyl)-7H-pyrrolo(2,3-d)pyrimidine
  • 4-Amino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)pyrimidine-5-carbonitrile
  • 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-beta-D-ribofuranosyl-
  • A-399-Y4
  • Ahygroscopin-B
  • Antibiotic A-399-Y4
  • Antibiotic E212
  • B 181008
  • BRN 0048454
  • Cyanotubericidin
  • E-212
  • E-212-1
  • NSC 63701
  • NSC 99843
  • NSC-63701
  • Naritheracin
  • Siromycin
  • Toyocamycin nucleoside
  • Unamycin-B
  • Uramycin B

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens adenosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Adenosine kinase-like Get druggable targets OG5_128398 All targets in OG5_128398
Neospora caninum GG10762, related Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus granulosus adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania infantum adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania mexicana adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Cryptosporidium parvum adenosine kinase like ribokinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania major adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma congolense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Echinococcus multilocularis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma cruzi adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma mansoni adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Babesia bovis adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania donovani adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Candida albicans putative adenosine kinase Get druggable targets OG5_128398 All targets in OG5_128398
Toxoplasma gondii kinase, pfkB family protein Get druggable targets OG5_128398 All targets in OG5_128398
Leishmania braziliensis adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Trypanosoma brucei gambiense adenosine kinase, putative Get druggable targets OG5_128398 All targets in OG5_128398
Schistosoma japonicum ko:K00856 adenosine kinase [EC2.7.1.20], putative Get druggable targets OG5_128398 All targets in OG5_128398
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128398 All targets in OG5_128398
Onchocerca volvulus Get druggable targets OG5_128398 All targets in OG5_128398
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma cruzi adenosine kinase, putative adenosine kinase 345 aa 337 aa 35.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0019 0.001
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0278 0.0269
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0002
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0063 0.0248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0259 0.3003 0.2997
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0575 0.0567
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0264
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0678 0.067
Leishmania major fatty acid transporter protein-like protein 0.022 0.2528 1
Trichomonas vaginalis esterase, putative 0.0107 0.1146 1
Plasmodium falciparum protein kinase 5 0.0053 0.0488 1
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0298 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Loa Loa (eye worm) hypothetical protein 0.0121 0.1321 0.3583
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.1021 0.1013
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0087 0.0079
Echinococcus granulosus cpg binding protein 0.0062 0.0596 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Leishmania major pyruvate kinase 0.0034 0.0254 0.1001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0087 0.0237
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.1605 0.4353
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0087 0.0079
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0805 0.2184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0063 0.0248
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0488 0.048
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0129 0.0427
Echinococcus multilocularis geminin 0.0665 0.798 0.7978
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0063 0.0248
Echinococcus granulosus acetylcholinesterase 0.0068 0.0678 0.067
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0432 0.3764
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1021 0.8909
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1021 0.8909
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.2094 0.2087
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0254 0.2195
Onchocerca volvulus 0.0021 0.0097 0.0733
Brugia malayi Adenosine kinase-like 0.0105 0.1127 0.3057
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0063 0.0248
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0063 0.0237
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1146 0.3902
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0097 0.0845
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0314 0.3687 0.3681
Echinococcus multilocularis cpg binding protein 0.0062 0.0596 0.0587
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0485 0.0476
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0097 0.0264
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0202 0.0547
Brugia malayi beta-lactamase family protein 0.0107 0.1146 0.3108
Schistosoma mansoni alpha-glucosidase 0.0135 0.1498 0.1491
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0053 0.0152
Brugia malayi nuclear receptor NHR-88 0.002 0.0087 0.0237
Loa Loa (eye worm) hypothetical protein 0.0034 0.0254 0.0688
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0485 0.3742
Schistosoma mansoni thyroid hormone receptor 0.002 0.0087 0.0079
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1766 0.1759
Schistosoma mansoni inositol transporter 0.0038 0.0307 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Loa Loa (eye worm) hypothetical protein 0.0029 0.0202 0.0547
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0575 0.1777
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0087 0.0079
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0318 0.031
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1146 0.1138
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0104 0.0401
Brugia malayi beta-lactamase family protein 0.0107 0.1146 0.3108
Trypanosoma brucei polo-like protein kinase 0.0096 0.1021 0.8909
Loa Loa (eye worm) carboxylesterase 0.0068 0.0678 0.1839
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0019 0.001
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.1236 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0485 0.4224
Loa Loa (eye worm) hypothetical protein 0.0148 0.1651 0.4478
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0254 0.1916
Schistosoma mansoni FFA transport protein 0.0223 0.2564 0.2558
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0485 0.1314
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1146 0.3108
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0202 0.0193
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0202 0.174
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0304 0.0296
Brugia malayi beta-lactamase 0.0107 0.1146 0.3108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0485 0.1887
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0575 0.1777
Leishmania major hypothetical protein, conserved 0.0107 0.1146 0.4531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Giardia lamblia GTOR 0.0018 0.0063 0.0106
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0254 0.0581
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0304 0.0296
Schistosoma mansoni high-affinity choline transporter 0.0038 0.0307 0.0299
Leishmania major hypothetical protein, conserved 0.003 0.0214 0.0843
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0485 0.0476
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0075 0.0203
Loa Loa (eye worm) oxidoreductase 0.0021 0.0097 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0087 0.0237
Giardia lamblia PHD finger protein 15 0.0029 0.0202 0.1536
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0575 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0087 0.0237
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0063 0.0209
Onchocerca volvulus Huntingtin homolog 0.0121 0.1321 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0157 0.1766 0.4792
Brugia malayi hypothetical protein 0.0121 0.1321 0.3583
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0488 0.1902
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1146 0.1336
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0022
Brugia malayi Bromodomain containing protein 0.0033 0.0245 0.0665
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0087 0.0237
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0364 0.3174
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0884 0.1013
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1146 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0214 0.1861
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Onchocerca volvulus 0.0091 0.0955 0.7227
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.9633 0.9633
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0097 0.0264
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0298 0.2586
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0264
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.1 0.1156
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0097 0.0845
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0097 0.0264
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0097 0.0044
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.1021 0.4036
Entamoeba histolytica hypothetical protein 0.0259 0.3003 1
Echinococcus multilocularis neuropeptide receptor A26 0.0468 0.5559 0.5555
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0097 0.0383
Plasmodium falciparum cysteine repeat modular protein 1 0.0016 0.0035 0.0661
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1569 0.1562
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.1021 0.277
Loa Loa (eye worm) hypothetical protein 0.0079 0.0805 0.2184
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0314 0.3687 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.2094 0.2087
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0805 0.2184
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.1605 0.4353
Schistosoma mansoni hypothetical protein 0.0665 0.798 0.7978
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0063 0.0244
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1146 0.3902
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0003 0.0022
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0146 0.0138
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0063 0.0172
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1021 0.8909
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0097 0.0264
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0129 0.035
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0097 0.0377
Loa Loa (eye worm) hypothetical protein 0.0249 0.2887 0.7832
Loa Loa (eye worm) hypothetical protein 0.0107 0.1146 0.3108
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Loa Loa (eye worm) hypothetical protein 0.0107 0.1146 0.3108
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0063 0.0244
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0343 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0488 0.048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Trypanosoma brucei trypanothione reductase 0.0037 0.0298 0.2599
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0364 0.3174
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0805 0.0797
Brugia malayi Sodium:solute symporter family protein 0.0038 0.0307 0.0834
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.0488 0.048
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0364 0.274
Leishmania major adenosine kinase, putative 0.0105 0.1127 0.4455
Loa Loa (eye worm) hypothetical protein 0.003 0.0214 0.058
Echinococcus granulosus acetylcholinesterase 0.0068 0.0678 0.067
Schistosoma mansoni hypothetical protein 0.0831 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1146 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0488 0.1624
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0298 0.0291
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0087 0.0079
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0488 0.1325
Onchocerca volvulus 0.0038 0.0307 0.2322
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0075 0.029
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.0488 0.1325
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0575 0.0632
Schistosoma mansoni hypothetical protein 0.0259 0.3003 0.2997
Chlamydia trachomatis pyruvate kinase 0.0034 0.0254 0.5
Plasmodium vivax protein kinase Crk2 0.0053 0.0488 0.4247
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0097 0.0044
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0097 0.1949
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0884 0.1013
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1146 1
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0063 0.0055
Brugia malayi steroid hormone receptor 0.002 0.0087 0.0237
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0884 0.3234
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0021 0.0097 0.0044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0249 0.2887 0.7832
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0075 0.0333
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1146 0.1138
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0097 0.0377
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0062 0.0054
Echinococcus granulosus adenosine kinase 0.0105 0.1127 0.1119
Brugia malayi MH2 domain containing protein 0.0144 0.1605 0.4353
Echinococcus multilocularis pyruvate kinase 0.0034 0.0254 0.0245
Plasmodium falciparum pyruvate kinase 0.0034 0.0254 0.5167
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0087 0.0237
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0087 0.0079
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0087 0.0079
Echinococcus granulosus peregrin 0.0033 0.0245 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0269 0.1046
Echinococcus multilocularis tissue type plasminogen activator 0.0016 0.0035 0.0026
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0214 0.0832
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0087 0.0079
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0022
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0485 0.4224
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0214 0.1489
Echinococcus granulosus sodium:glucose cotransporter 2 0.0038 0.0307 0.0299
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0075 0.0648
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0087 0.0079
Loa Loa (eye worm) hypothetical protein 0.0107 0.1146 0.3108
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0019 0.001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0035 0.0095
Entamoeba histolytica hypothetical protein 0.0259 0.3003 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0678 0.1839
Loa Loa (eye worm) acetyltransferase 0.0145 0.1619 0.4391
Plasmodium falciparum phd finger protein, putative 0.0029 0.0202 0.4098
Brugia malayi jmjC domain containing protein 0.0039 0.0318 0.0863
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0087 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0214 0.4347
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0087 0.0237
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0097 0.0383
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0254 0.0987
Entamoeba histolytica hypothetical protein 0.0025 0.0146 0.0484
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0146 0.0138
Echinococcus multilocularis dnaJ subfamily B 0.0831 1 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0097 0.0383
Onchocerca volvulus 0.0107 0.1146 0.8674
Brugia malayi Carboxylesterase family protein 0.0068 0.0678 0.1839
Loa Loa (eye worm) hypothetical protein 0.0148 0.1651 0.4478
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0254 0.0688
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD6 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.022 0.2528 0.304
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0063 0.0055
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0087 0.0079
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0314 0.3687 0.3681
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0254 0.0643
Onchocerca volvulus Huntingtin homolog 0.0121 0.1321 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0063 0.0547
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0269 0.234
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1146 0.1336
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0237
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0585 0.1588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Onchocerca volvulus 0.0107 0.1146 0.8674
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0575 0.4493
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0075 0.0066
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1146 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0001 0.0002
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1146 0.1138
Brugia malayi Kringle domain containing protein 0.0016 0.0035 0.0095
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0146 0.0926
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0485 0.1887
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0097 0.0264
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0432 0.3764
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1355 0.1347
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0087 0.0237
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1146 0.4468
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0087 0.0656
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0884 0.1013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.2094 0.2087
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0063 0.0055
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0254 0.2209
Brugia malayi hypothetical protein 0.0148 0.1651 0.4478
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0237
Schistosoma mansoni pyruvate kinase 0.0034 0.0254 0.0245
Schistosoma mansoni hypothetical protein 0.0029 0.0202 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0087 0.0237
Echinococcus granulosus neuropeptide receptor A26 0.0468 0.5559 0.5555
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0063 0.0244
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0021 0.0097 0.0044
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0068 0.0678 0.067
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0364 0.3161
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0097 0.0089
Echinococcus granulosus pyruvate kinase 0.0017 0.0053 0.0045
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.0488 0.048
Schistosoma mansoni hypothetical protein 0.0079 0.0805 0.0797
Brugia malayi Carboxylesterase family protein 0.0068 0.0678 0.1839
Echinococcus granulosus neuropeptide s receptor 0.0468 0.5559 0.5555
Loa Loa (eye worm) hypothetical protein 0.0309 0.3621 0.9822
Schistosoma mansoni nuclear hormone receptor 0.002 0.0087 0.0079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0137 0.0128
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0269 0.234
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1021 0.398
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0063 0.0244
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0021 0.0097 0.0044
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0223 0.2564 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0087 0.0237
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0214 0.4347
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.1 0.1156
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0314 0.3687 0.3681
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0064 0.0246
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0177 0.0481
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0063 0.0172
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1146 0.1336
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0063 0.0055
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0087 0.0079
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1619 0.4391
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.0488 0.1929
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.1021 0.1013
Schistosoma mansoni hypothetical protein 0.0016 0.0035 0.0026
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0038 0.0307 0.0299
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.0488 0.048
Echinococcus granulosus high affinity choline transporter 1 0.0038 0.0307 0.0299
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0022
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0269 0.234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1146 0.3108
Brugia malayi MAP kinase sur-1 0.0053 0.0485 0.1314
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0063 0.0244
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0214 0.1846
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0022
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0485 0.0476
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0087 0.0079
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.0488 0.1929
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0087 0.0079
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0269 0.234
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0237
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0805 0.0797
Brugia malayi follicle stimulating hormone receptor 0.0236 0.2725 0.7391
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0075 0.0066
Onchocerca volvulus 0.0058 0.0555 0.4197
Echinococcus multilocularis solute carrier family 5 0.0038 0.0307 0.0299
Onchocerca volvulus 0.0021 0.0097 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0097 0.0044
Loa Loa (eye worm) beta-lactamase 0.0107 0.1146 0.3108
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0087 0.0237
Trichomonas vaginalis helicase, putative 0.0013 0.0003 0.0022
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0254 0.2209
Loa Loa (eye worm) glutathione reductase 0.0037 0.0298 0.0809
Echinococcus granulosus sodium:myo inositol cotransporter 0.0038 0.0307 0.0299
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0241 0.2784 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0269 0.026
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0097 0.0044
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0269 0.234
Toxoplasma gondii ABC1 family protein 0.0107 0.1146 0.9247
Onchocerca volvulus 0.002 0.0087 0.0656
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1619 0.1611
Plasmodium falciparum thioredoxin reductase 0.0037 0.0298 0.6088
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0087 0.0656
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0269 0.0893
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0097 0.0044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0003 0.0022
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0321 0.1066
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0087 0.0079
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1021 0.8909
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1146 1
Echinococcus granulosus carboxylesterase 5A 0.0068 0.0678 0.067
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0264
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0488 0.4258
Echinococcus granulosus pyruvate kinase 0.0034 0.0254 0.0245
Brugia malayi nuclear hormone receptor 0.002 0.0087 0.0237
Echinococcus granulosus lysosomal alpha glucosidase 0.0157 0.1766 0.1759
Schistosoma mansoni pyruvate kinase 0.0017 0.0053 0.0045
Echinococcus granulosus FTZ F1 alpha 0.002 0.0087 0.0079
Schistosoma mansoni cpg binding protein 0.0062 0.0596 0.0587
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.1021 0.1013
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0237
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0087 0.0237
Leishmania major hypothetical protein, conserved 0.0016 0.0035 0.0135
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0269 0.234
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.0488 0.048
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0019 0.0075 0.0016
Trypanosoma brucei glucosidase, putative 0.0035 0.0269 0.234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0184 0.2094 0.2087
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0022
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0075 0.0066
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0269 0.234
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.0488 0.4258
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0022
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0097 0.0264
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0214 0.0832
Onchocerca volvulus Alhambra homolog 0.0029 0.0202 0.1523
Brugia malayi Glycosyl hydrolases family 31 protein 0.0157 0.1766 0.4792
Echinococcus multilocularis neuropeptide s receptor 0.0468 0.5559 0.5555
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0022
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0097 0.0089
Schistosoma mansoni coup transcription factor 0.002 0.0087 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0087 0.0237
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0184 0.2094 0.568
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0097 0.0845
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0087 0.0079
Echinococcus multilocularis pyruvate kinase 0.0034 0.0254 0.0245
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0097 0.0377
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.3621 0.3615
Plasmodium vivax glutathione reductase, putative 0.0037 0.0298 0.2586
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.0488 0.1325
Leishmania major pyruvate kinase 0.0034 0.0254 0.1001
Giardia lamblia Kinase, PLK 0.0096 0.1021 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0064 0.025
Onchocerca volvulus 0.0016 0.0035 0.0259
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0805 0.0797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.1021 0.277
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0254 0.1821
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0087 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0087 0.0237
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0087 0.0237
Mycobacterium tuberculosis Probable reductase 0.0085 0.0884 0.1013
Brugia malayi hypothetical protein 0.002 0.0082 0.0222
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0062 0.0054
Toxoplasma gondii kinase, pfkB family protein 0.0105 0.1127 0.9089
Trypanosoma brucei protein kinase, putative 0.0053 0.0485 0.4224
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0254 0.1916
Echinococcus multilocularis pyruvate kinase 0.0017 0.0053 0.0045
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0264
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.1021 0.398
Echinococcus multilocularis pyruvate kinase 0.0017 0.0053 0.0045
Onchocerca volvulus 0.0093 0.098 0.7421
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0097 0.0383
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0097 0.0377
Schistosoma mansoni pyruvate kinase 0.0034 0.0254 0.0245
Echinococcus granulosus long chain fatty acid transport protein 4 0.0223 0.2564 0.2558
Echinococcus multilocularis adenosine kinase 0.0105 0.1127 0.1119
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.0488 0.4258
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0241 0.2784 0.7553
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0237
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0053 0.044
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1146 0.1138
Toxoplasma gondii thioredoxin reductase 0.0037 0.0298 0.2193
Brugia malayi PHD-finger family protein 0.0029 0.0202 0.0547
Onchocerca volvulus 0.0021 0.0097 0.0733
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0485 0.1914
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0146 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Brugia malayi ecdysteroid receptor 0.002 0.0087 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0254 0.0236
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0087 0.0079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0681 0.8175 1
Schistosoma mansoni transcription factor LCR-F1 0.0259 0.3003 0.2997
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0254 0.0688
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.2094 0.2087
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0022
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0097 0.0264
Loa Loa (eye worm) hypothetical protein 0.005 0.0459 0.1245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Echinococcus multilocularis pyruvate kinase 0.0017 0.0053 0.0045
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0087 0.0237
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0485 0.1887
Loa Loa (eye worm) hypothetical protein 0.0107 0.1146 0.3108
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1146 0.4468
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0249 0.2887 0.7832
Brugia malayi AMP-binding enzyme family protein 0.0241 0.2784 0.7553
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0269 0.0729
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0485 0.4457
Brugia malayi glutathione reductase 0.0037 0.0298 0.0809
Loa Loa (eye worm) hypothetical protein 0.0121 0.1321 0.3583
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0485 0.4224
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0075 0.0066
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0063 0.0547
Loa Loa (eye worm) hypothetical protein 0.0107 0.1146 0.3108
Mycobacterium tuberculosis Conserved protein 0.0107 0.1146 0.1336
Brugia malayi hypothetical protein 0.0259 0.3003 0.8147
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0318 0.031
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0269 0.106
Schistosoma mansoni hypothetical protein 0.0079 0.0805 0.0797
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0884 0.1013
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1021 0.8909
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0097 0.0264
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0021 0.0097 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0022
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1146 1
Echinococcus granulosus pyruvate kinase 0.0034 0.0254 0.0245
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0884 0.1013
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1619 0.1611
Echinococcus multilocularis peregrin 0.0033 0.0245 0.0237
Echinococcus multilocularis pyruvate kinase 0.0027 0.0167 0.0158
Schistosoma mansoni cpg binding protein 0.0058 0.0555 0.0547
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0075 0.0648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0259 0.3003 0.2997
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0779 0.0771
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0254 0.0688
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0834
Echinococcus granulosus sodium:glucose cotransporter 0.0038 0.0307 0.0299
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0075 0.1486
Loa Loa (eye worm) hypothetical protein 0.0068 0.0678 0.1839
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.1127 0.4394
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0555 0.1505
Brugia malayi GH02984p 0.0038 0.0307 0.0834
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1146 1
Mycobacterium leprae Probable lipase LipE 0.0107 0.1146 0.4313
Schistosoma mansoni kinase 0.005 0.0447 0.0439
Loa Loa (eye worm) hypothetical protein 0.0024 0.0129 0.035
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0063 0.0209
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0097 0.0089
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0485 0.0476
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.1021 0.1013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1146 0.1336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0087 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0022
Entamoeba histolytica acyl-coA synthetase, putative 0.0021 0.0097 0.0322
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0087 0.0237
Echinococcus multilocularis GPCR, family 2 0.0079 0.0805 0.0797
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.3621 0.3615
Echinococcus granulosus pyruvate kinase 0.0017 0.0053 0.0045
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Brugia malayi isocitrate dehydrogenase 0.0019 0.0075 0.0203
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0097 0.0322
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0202 0.1389
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0254 0.0688
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0097 0.0383
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0575 0.0567
Loa Loa (eye worm) hypothetical protein 0.0052 0.0472 0.128
Loa Loa (eye worm) hypothetical protein 0.0021 0.0104 0.0281
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1146 0.1336
Onchocerca volvulus 0.0107 0.1146 0.8674
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0097 0.0521
Onchocerca volvulus 0.0021 0.0097 0.0733
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0254 0.0688
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0087 0.0237
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0485 0.1887
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0003 0.0022
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.3621 0.3615
Loa Loa (eye worm) hypothetical protein 0.0038 0.0307 0.0834
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0087 0.0079
Schistosoma mansoni hypothetical protein 0.0079 0.0805 0.0797
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0097 0.0521
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0097 0.0322
Echinococcus granulosus cyclin dependent kinase 0.0053 0.0488 0.048
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0318 0.0863
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0087 0.0079
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.1 0.1156
Entamoeba histolytica acyl-CoA synthetase, putative 0.0021 0.0097 0.0322
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0087 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0237
Brugia malayi Protein kinase domain containing protein 0.0016 0.0035 0.0095
Echinococcus multilocularis lysosomal alpha glucosidase 0.0157 0.1766 0.1759
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0343 0.0335
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0254 0.1916
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0298 0.1161
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0097 0.0264
Entamoeba histolytica hypothetical protein 0.0259 0.3003 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0488 0.4258
Brugia malayi Thioredoxin reductase 0.0037 0.0298 0.0809
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1021 0.8909
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0488 0.1902
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.0488 0.1624
Schistosoma mansoni cpg binding protein 0.0062 0.0596 0.0587
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1146 0.1336
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0364 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0087 0.0079
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0097 0.0044
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0097 0.0044
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0053 0.1036
Trypanosoma cruzi adenosine kinase, putative 0.0105 0.1127 0.4394
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0202 0.1389
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0314 0.3687 1
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0038 0.0307 0.0299
Echinococcus granulosus pyruvate kinase 0.0017 0.0053 0.0045
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0097 0.0845
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0016 0.0035 0.0281
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.2725 0.7391
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0321 0.6547
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0075 0.029
Giardia lamblia Pyruvate kinase 0.0034 0.0254 0.2072
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0097 0.0521
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0575 0.1777
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.1924 0.5218
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0075 0.0294
Echinococcus multilocularis carboxylesterase 5A 0.0068 0.0678 0.067
Schistosoma mansoni adenosine kinase 0.0105 0.1127 0.1119
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0021 0.0097 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0087 0.0237
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0805 0.2184
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0035 0.0133
Brugia malayi hypothetical protein 0.003 0.0214 0.058
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.0488 0.1902
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0038 0.0307 0.0299
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0254 0.0987
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0237
Mycobacterium ulcerans hypothetical protein 0.0107 0.1146 0.3902
Schistosoma mansoni sodium/solute symporter 0.0038 0.0307 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Trypanosoma brucei adenosine kinase, putative 0.0105 0.1127 0.9834
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0146 0.0397
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0488 0.048
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0063 0.0172
Schistosoma mansoni alpha glucosidase 0.0035 0.0269 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0146 0.127
Loa Loa (eye worm) TK/ROR protein kinase 0.0016 0.0035 0.0095
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0087 0.0079
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0021 0.0097 0.0044
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0087 0.0079
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0146 0.127
Loa Loa (eye worm) hypothetical protein 0.017 0.1924 0.5218
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0269 0.1946
Echinococcus multilocularis long chain fatty acid transport protein 4 0.0223 0.2564 0.2558
Brugia malayi CXXC zinc finger family protein 0.0058 0.0555 0.1505
Schistosoma mansoni alpha-glucosidase 0.0135 0.1498 0.1491
Mycobacterium ulcerans lipase LipD 0.0107 0.1146 0.3902
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0488 0.4258
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0485 0.4224
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0488 0.4496
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0485 0.0476
Mycobacterium leprae possible long-chain acyl-CoA synthase 0.022 0.2528 1
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0063 0.0547
Leishmania major trypanothione reductase 0.0037 0.0298 0.1178
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.1021 0.3398
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.1021 0.1013
Schistosoma mansoni hypothetical protein 0.0665 0.798 0.7978
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0087 0.0079
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0269 0.026
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0063 0.0055
Mycobacterium leprae conserved hypothetical protein 0.0107 0.1146 0.4313
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0097 0.0828
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0038 0.0307 0.2267
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0087 0.0656
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0202 0.0193
Echinococcus granulosus solute carrier family 5 0.0038 0.0307 0.0299
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0805 0.0797
Schistosoma mansoni adenosine kinase 0.0105 0.1127 0.1119
Schistosoma mansoni thyroid hormone receptor 0.002 0.0087 0.0079
Trypanosoma cruzi fatty acid transporter protein-like, putative 0.0223 0.2564 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.1021 0.7728
Echinococcus multilocularis acetylcholinesterase 0.0068 0.0678 0.067
Echinococcus granulosus geminin 0.0665 0.798 0.7978
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0575 0.0567
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0254 0.2209
Loa Loa (eye worm) hypothetical protein 0.002 0.0087 0.0237
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0318 0.031
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.0488 0.3774
Schistosoma mansoni hypothetical protein 0.017 0.1924 0.1917
Mycobacterium tuberculosis Conserved protein 0.0107 0.1146 0.1336
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0075 0.0203
Onchocerca volvulus 0.0021 0.0097 0.0733
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0019 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0087 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Giardia lamblia Kinase, CMGC CDK 0.0053 0.0488 0.4496
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0087 0.0237
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0087 0.0079
Brugia malayi Protein kinase domain containing protein 0.0053 0.0488 0.1325
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0075 0.0333
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0184 0.2094 0.568
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0269 0.0729
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0022
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0063 0.0055
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0321 0.2764
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0146 0.0567
Loa Loa (eye worm) acetylcholinesterase 1 0.0068 0.0678 0.1839
Entamoeba histolytica hypothetical protein 0.0259 0.3003 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0087 0.0237
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0269 0.234
Mycobacterium tuberculosis Conserved protein 0.0107 0.1146 0.1336
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0063 0.0547
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.1021 0.8909
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0184 0.2094 0.2087
Echinococcus granulosus tissue type plasminogen activator 0.0016 0.0035 0.0026
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0087 0.0237
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0575 0.2271
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0087 0.0237
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0269 0.234
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0269 0.0893
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.0488 0.048
Leishmania major 4-coumarate:coa ligase-like protein 0.0021 0.0097 0.0383
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.1 0.3712
Schistosoma mansoni hypothetical protein 0.0079 0.0805 0.0797
Echinococcus granulosus GPCR family 2 0.0079 0.0805 0.0797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0249 0.2887 0.7832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0003 0.0022
Brugia malayi jmjC domain containing protein 0.0096 0.1021 0.277
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0063 0.0547
Echinococcus multilocularis high affinity choline transporter 1 0.0038 0.0307 0.0299
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0075 0.0066
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0075 0.0631
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.0488 0.048
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0087 0.0079
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0063 0.0248
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0485 0.4224
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0184 0.2094 0.2087
Loa Loa (eye worm) hypothetical protein 0.0107 0.1146 0.3108
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0202 0.0193
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1146 0.1336
Brugia malayi cell division control protein 2 homolog 0.0053 0.0488 0.1325
Schistosoma mansoni inositol transporter 0.0038 0.0307 0.0299
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0062 0.0169
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0364 0.274
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.0488 0.1902
Mycobacterium ulcerans beta-lactamase 0.0107 0.1146 0.3902
Plasmodium falciparum glutathione reductase 0.0037 0.0298 0.6088
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0485 0.1914
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0254 0.2209
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0269 0.1046
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0038 0.0307 0.0299
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0075 0.0066
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0063 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0063 0.0547
Trypanosoma brucei adenosine kinase, putative 0.0105 0.1127 0.9834
Loa Loa (eye worm) hypothetical protein 0.0021 0.0097 0.0264
Loa Loa (eye worm) hypothetical protein 0.0105 0.1127 0.3057

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of mouse brain MAOA ChEMBL. 18834112
Activity (binding) Inhibition of mouse brain MAOB ChEMBL. 18834112
Activity (functional) = 0.0023 ug ml-1 Cytotoxicity against mouse P388 cells assessed as conentration required for 50% inhibition ChEMBL. 18327911
EC50 (functional) = 0.004 uM Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in normal human fibroblast (NHF) cells using MTS assay. ChEMBL. 11020285
EC50 (functional) = 0.005 uM Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay. ChEMBL. 11020285
EC50 (functional) = 0.005 uM Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in B16 mouse melanoma cells using MTS assay. ChEMBL. 11020285
EC50 (functional) = 0.012 uM Cytotoxicity that caused a 50% reduction in absorbance at 490 nm in human prostate cancer HTB-81 cells using MTS assay. ChEMBL. 11020285
IC50 (binding) = 0.509 Inhibition concentration against human adenosine kinase ChEMBL. 11958989
IC50 (binding) = 0.51 Concentration required for 50% inhibition of the adenosine kinase (AK) activity. ChEMBL. 15149648
IC50 (ADMET) = 0.000000004 M In vitro cytotoxicity was evaluated against the L1210 Murine leukemic cells ChEMBL. 2913300
IC50 (functional) = 0.0026 ug ml-1 Cytotoxicity against mouse L1210 cells ChEMBL. 2693614
IC50 (functional) = 0.004 uM Inhibition of L1210 murine leukemic cells proliferation in vitro ChEMBL. 7562947
IC50 (functional) < 0.01 uM Cytotoxicity against HFF cells, estimated by visual scoring of cells not affected by virus infection in the plaque reduction assay ChEMBL. 8632411
IC50 (functional) < 0.01 uM Cytotoxicity against HFF cells, estimated by visual scoring of cells not affected by virus infection in the plaque reduction assay ChEMBL. 8632411
IC50 (functional) = 0.03 uM Cytotoxic activity tested against exponentially growing KB cells, determined by staining method ChEMBL. 8632411
IC50 (functional) = 0.03 uM Cytotoxic activity tested against exponentially growing KB cells, determined by staining method ChEMBL. 8632411
IC50 (functional) = 0.03 uM Visual cytotoxicity scored on HFF cells at the time of HCMV plaque enumeration. ChEMBL. 7562947
IC50 (functional) = 0.03 uM In vitro inhibition of KB cell proliferation. ChEMBL. 7562947
IC50 (functional) = 0.05 uM Antiviral activity against Human Cytomegalovirus (HCMV) replication in a plaque reduction assay ChEMBL. 8632411
IC50 (functional) = 0.1 uM In vitro inhibition of KB cell proliferation. ChEMBL. 7562947
IC50 (functional) = 0.1 uM Inhibition of L1210 murine leukemic cells proliferation in vitro ChEMBL. 7562947
IC50 (functional) = 0.3 uM Visual cytotoxicity scored on HFF cells at the time of HCMV plaque enumeration. ChEMBL. 7562947
IC50 (binding) = 0.31 uM Inhibition of human adenosine kinase activity ChEMBL. 11958989
IC50 (binding) = 0.31 uM Inhibition of recombinant human adenosine kinase ChEMBL. 10956196
IC50 (binding) = 0.31 uM Inhibition of human adenosine kinase activity ChEMBL. 11958989
IC50 (binding) = 0.31 uM Inhibition of recombinant human adenosine kinase ChEMBL. 10956196
IC50 (functional) = 8 uM Tested in vitro for cytotoxicity against the normal human diploid cells (HFF cells). ChEMBL. 2175356
IC50 (functional) = 8 uM Visual cytotoxicity scored on HFF cells at the time of HCMV plaque enumeration. ChEMBL. 7562947
IC50 (functional) = 17 uM In vitro inhibition of KB cell proliferation. ChEMBL. 7562947
ID50 (functional) = 0.006 ug ml-1 Dose required to inhibit proliferation of L-1210 Cells by 50% ChEMBL. 6699874
IZ (functional) = 13 mm Antifungal activity against Candida albicans at 1.25 mg/6.4 mm disk ChEMBL. 2693614
Kd (binding) = 4.04 Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis ChEMBL. 27119979
Kd (binding) = 90 uM Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis ChEMBL. 27119979
Log IC50 (binding) = 0.5086 Inhibition concentration against human adenosine kinase ChEMBL. 11958989
log(10'3/IC50) (binding) = 3.51 Inhibition of adenosine kinase ChEMBL. 18359230
MCC (functional) > 0.4 ug ml-1 Concentration required to cause a microscopically detectable alteration in cell morphology in HeLa cell cultures. ChEMBL. 6699874
MIC50 (functional) = 0.006 ug ml-1 Inhibition of murine leukemia L1210 cell growth ChEMBL. 3820218
MIC50 (functional) = 0.039 ug ml-1 Minimum inhibitory concentration required to reduce incorporation of [4,5-3H]leucine into TCA-insoluble material from murine leukemia L1210 cells ChEMBL. 3820218
MIC50 (functional) = 0.07100000000000001 ug ml-1 Minimum inhibitory concentration required to reduce incorporation of [5-3H]-Urd into TCA-insoluble material from murine leukemia L1210 cells ChEMBL. 3820218
MIC50 (functional) = 38 ug ml-1 Minimum inhibitory concentration required to reduce incorporation of [methyl-3H]-dThd into TCA-insoluble material from murine leukemia L1210 cells ChEMBL. 3820218
MTC (functional) = 0.4 ug ml-1 Minimum cytotoxic concentration required to cause a microscopically detectable alteration of normal cell morphology in Hela cells ChEMBL. 3820218

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 2175356
Mus musculus ChEMBL23 11020285

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

9 literature references were collected for this gene.

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