Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0423 | 0.1072 | 0.1059 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0559 | 0.1627 | 0.1627 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0787 | 0.2559 | 0.2559 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0526 | 0.1493 | 0.1481 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0526 | 0.1493 | 0.1481 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0423 | 0.1072 | 0.1072 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0492 | 0.1351 | 0.1351 |
Loa Loa (eye worm) | acyl carrier protein | 0.0242 | 0.0328 | 0.0153 |
Onchocerca volvulus | 0.0492 | 0.1351 | 0.3854 | |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0526 | 0.1493 | 0.1493 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0559 | 0.1627 | 0.1627 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0205 | 0.0178 | 0.0164 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0526 | 0.1493 | 0.1493 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0423 | 0.1072 | 0.1072 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0299 | 0.0563 | 0.0563 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0526 | 0.1493 | 0.1493 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0559 | 0.1627 | 0.1615 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0378 | 0.0886 | 0.0886 |
Mycobacterium ulcerans | polyketide synthase | 0.0526 | 0.1493 | 0.1493 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 0.0545 | 0.0374 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0439 | 0.1133 | 0.1133 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0213 | 0.0209 | 0.0209 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0526 | 0.1493 | 0.1493 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0439 | 0.1133 | 0.1121 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0526 | 0.1493 | 0.1493 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1252 | 0.4466 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0884 | 0.2958 | 0.2831 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0526 | 0.1493 | 0.1493 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0787 | 0.2559 | 0.2559 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0787 | 0.2559 | 0.2548 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0559 | 0.1627 | 0.2971 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0165 | 0.0014 | 0.0014 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0348 | 0.0763 | 0.0763 |
Mycobacterium ulcerans | thioesterase | 0.0439 | 0.1133 | 0.1133 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0205 | 0.0178 | 0.0178 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1252 | 0.4466 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0348 | 0.0763 | 0.0749 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.051 | 0.1427 | 0.1427 |
Brugia malayi | AMP-binding enzyme family protein | 0.0492 | 0.1351 | 0.1351 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0375 | 0.0872 | 0.1102 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0165 | 0.0014 | 0.0014 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1252 | 0.4466 | 0.5 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0559 | 0.1627 | 0.1627 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0526 | 0.1493 | 0.1493 |
Loa Loa (eye worm) | fatty acid synthase | 0.0519 | 0.1464 | 0.131 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0492 | 0.1351 | 0.1195 |
Mycobacterium ulcerans | thioesterase TesA | 0.0439 | 0.1133 | 0.1133 |
Mycobacterium ulcerans | polyketide synthase | 0.0559 | 0.1627 | 0.1627 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1252 | 0.4466 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0559 | 0.1627 | 0.1627 |
Brugia malayi | thymidylate synthase | 0.0205 | 0.0178 | 0.0178 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0559 | 0.1627 | 0.1627 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0559 | 0.1627 | 0.1615 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0181 | 0.0078 | 0.0078 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0348 | 0.0763 | 0.0763 |
Mycobacterium ulcerans | thymidylate synthase | 0.0205 | 0.0178 | 0.0178 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0787 | 0.2559 | 0.2559 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.043 | 0.11 | 0.11 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0526 | 0.1493 | 0.1493 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0341 | 0.0736 | 0.0765 |
Onchocerca volvulus | 0.0916 | 0.3089 | 0.956 | |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0998 | 0.3423 | 0.3423 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1252 | 0.4466 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0949 | 0.3223 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1252 | 0.4466 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0559 | 0.1627 | 0.1615 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.051 | 0.1427 | 0.1427 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.