Detailed information for compound 1621768

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 300.748 | Formula: C10H17ClN8O
  • H donors: 4 H acceptors: 3 LogP: -0.12 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNCCN(c1nc(N)c(nc1Cl)C(=O)NC(=N)N)C
  • InChi: 1S/C10H17ClN8O/c1-15-3-4-19(2)8-6(11)16-5(7(12)17-8)9(20)18-10(13)14/h15H,3-4H2,1-2H3,(H2,12,17)(H4,13,14,18,20)
  • InChiKey: AFDRFWHVOFZFHD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0683 0.2267
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0046 0.0261 0.0478
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.0309
Schistosoma mansoni hypothetical protein 0.0035 0.0124 0.0478
Toxoplasma gondii ABC1 family protein 0.0037 0.0144 0.0081
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0335 1
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0234 0.26 0.9344
Brugia malayi beta-lactamase 0.0037 0.0144 0.0454
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0037 0.0145 0.0082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0144 0.0519
Entamoeba histolytica hypothetical protein 0.0071 0.0571 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0144 0.0519
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0157 0.1642 0.6021
Brugia malayi Latrophilin receptor protein 2 0.0032 0.008 0.0253
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0335 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0237 0.4866
Echinococcus multilocularis peptidase Clp (S14 family) 0.0153 0.1588 0.1588
Leishmania major hypothetical protein, conserved 0.0037 0.0144 0.0948
Loa Loa (eye worm) RNA binding protein 0.0064 0.048 0.1727
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0052 0.033 0.9752
Schistosoma mansoni tar DNA-binding protein 0.0064 0.048 0.1848
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0153 0.1588 0.5805
Trypanosoma brucei protein kinase, putative 0.0052 0.0335 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0571 0.2195
Mycobacterium tuberculosis Conserved protein 0.0045 0.0237 0.0419
Mycobacterium leprae Probable polyketide synthase Pks1 0.0157 0.1642 0.6124
Plasmodium falciparum flap endonuclease 1 0.0052 0.033 0.0835
Schistosoma mansoni peptidase Clp (S14 family) 0.0233 0.259 0.9962
Schistosoma mansoni bromodomain containing protein 0.0061 0.0445 0.1712
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0037 0.0145 0.0001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0144 0.0144
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0148 0.1527 0.5563
Mycobacterium ulcerans polyketide synthase Pks9 0.0098 0.0902 0.3098
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 0.0335 0.1206
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0144 0.0948
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0084 0.0731 0.2387
Echinococcus multilocularis GPCR, family 2 0.0032 0.008 0.008
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0233 0.259 1
Loa Loa (eye worm) hypothetical protein 0.0068 0.0535 0.1922
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0123 0.1219 0.4397
Echinococcus multilocularis tar DNA binding protein 0.0064 0.048 0.048
Loa Loa (eye worm) hypothetical protein 0.0233 0.259 0.9308
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.0309
Mycobacterium ulcerans Type I modular polyketide synthase 0.0148 0.1527 0.5655
Schistosoma mansoni serine/threonine protein kinase 0.0234 0.26 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 0.0335 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0157 0.1642 0.6124
Brugia malayi Bromodomain containing protein 0.0072 0.0586 0.1844
Loa Loa (eye worm) hypothetical protein 0.0041 0.0196 0.0704
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0119 0.1166 0.418
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0037 0.0145 0.0082
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 0.0335 1
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0221 0.244 0.9205
Mycobacterium ulcerans polyketide synthase Pks13 0.0221 0.244 0.9388
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0233 0.259 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0335 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0105 0.0995 0.3533
Mycobacterium ulcerans polyketide synthase 0.0157 0.1642 0.6124
Mycobacterium tuberculosis Conserved protein 0.0037 0.0144 0.0048
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0106 0.1007 0.349
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0144 0.0048
Toxoplasma gondii type I fatty acid synthase, putative 0.0157 0.1642 0.6155
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 0.0335 1
Schistosoma mansoni flap endonuclease-1 0.0047 0.0268 0.1031
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0037 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0035 0.0124 0.0447
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0144 0.0048
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0234 0.26 0.26
Mycobacterium tuberculosis Conserved protein 0.0037 0.0144 0.0048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0943 0.2965
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0943 0.2965
Mycobacterium ulcerans fatty acid synthase Fas 0.0046 0.0261 0.0478
Loa Loa (eye worm) hypothetical protein 0.0248 0.2782 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0153 0.1588 0.5902
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.008 0.0309
Loa Loa (eye worm) hypothetical protein 0.0037 0.0144 0.0519
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0121 0.1191 0.4222
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0045 0.0249 0.0465
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0148 0.1527 0.5655
Loa Loa (eye worm) fatty acid synthase 0.0146 0.1503 0.5401
Mycobacterium ulcerans thioesterase TesA 0.0123 0.1219 0.4397
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0115 0.0442
Plasmodium vivax flap endonuclease 1, putative 0.0052 0.033 0.0835
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0157 0.1642 0.6124
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0233 0.259 1
Echinococcus granulosus mitogen activated protein kinase 0.0052 0.0335 0.1291
Loa Loa (eye worm) hypothetical protein 0.0037 0.0144 0.0519
Loa Loa (eye worm) hypothetical protein 0.0069 0.0544 0.1954
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 0.0335 1
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0249 0.0782
Onchocerca volvulus 0.0138 0.1406 0.4673
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0144 0.0948
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0148 0.1527 0.4802
Schistosoma mansoni hypothetical protein 0.0069 0.0544 0.2091
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0144 0.0048
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0233 0.259 0.9962
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0544 0.171
Mycobacterium leprae Polyketide synthase Pks13 0.0221 0.244 0.9388
Trichomonas vaginalis flap endonuclease-1, putative 0.0052 0.033 0.9726
Echinococcus granulosus tar DNA binding protein 0.0064 0.048 0.1848
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0096 0.0879 0.306
Mycobacterium ulcerans thioesterase 0.0123 0.1219 0.4397
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0335 0.1291
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0571 0.2195
Loa Loa (eye worm) flap endonuclease-1 0.0052 0.033 0.1187
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 0.0335 0.1291
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0148 0.1527 0.5655
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0153 0.1588 0.5805
Loa Loa (eye worm) hypothetical protein 0.0083 0.0715 0.2572
Onchocerca volvulus 0.0035 0.0124 0.0413
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0233 0.259 1
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0052 0.033 0.9726
Loa Loa (eye worm) hypothetical protein 0.0037 0.0144 0.0519
Loa Loa (eye worm) hypothetical protein 0.0037 0.0144 0.0519
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0052 0.033 0.0835
Brugia malayi RNA binding protein 0.0064 0.048 0.1511
Mycobacterium ulcerans polyketide synthase 0.0148 0.1527 0.5655
Onchocerca volvulus 0.0257 0.2894 0.9619
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0402 0.0402
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0148 0.1527 0.5563
Loa Loa (eye worm) hypothetical protein 0.0037 0.0144 0.0519
Entamoeba histolytica hypothetical protein 0.0071 0.0571 1
Echinococcus multilocularis mitogen activated protein kinase 0.0052 0.0335 0.0335
Brugia malayi Protein kinase domain containing protein 0.0035 0.0124 0.0391
Echinococcus granulosus flap endonuclease 1 0.0052 0.033 0.127
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.028 0.318 1
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0037 0.0145 0.0961
Entamoeba histolytica hypothetical protein 0.0071 0.0571 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.006 0.0428 0.1178
Loa Loa (eye worm) hypothetical protein 0.0032 0.008 0.0289
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.048 0.1727
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0233 0.259 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0144 0.0555
Brugia malayi MAP kinase sur-1 0.0052 0.0335 0.1055
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0144 0.0555
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0143 0.1471 0.5338
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.008 0.0309
Brugia malayi Flap endonuclease-1 0.0052 0.033 0.1039
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0115 0.0115
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0052 0.033 0.9752
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0037 0.0145 0.0961
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0138 0.1406 0.5053
Mycobacterium tuberculosis Hypothetical protein 0.0045 0.0237 0.0419
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0683 0.2267
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0075 0.0614 0.1987
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0157 0.1642 0.6021
Echinococcus granulosus c-Jun N-terminal kinases 0.0234 0.26 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0233 0.259 1
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0221 0.244 0.9205
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0233 0.259 1
Echinococcus granulosus peptidase Clp S14 family 0.0153 0.1588 0.6107
Giardia lamblia Kinase, CMGC MAPK 0.0052 0.0335 1
Onchocerca volvulus 0.0037 0.0144 0.048
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0037 0.0145 0.0556
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0144 0.0081
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0233 0.259 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.048 0.1511
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0144 0.0519
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0144 0.0454
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0037 0.0145 0.052
Loa Loa (eye worm) TK/ROR protein kinase 0.0035 0.0124 0.0447
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0173 0.0622
Mycobacterium ulcerans Type I modular polyketide synthase 0.0148 0.1527 0.5655
Brugia malayi beta-lactamase family protein 0.0037 0.0144 0.0454
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0571 0.0571
Onchocerca volvulus 0.0037 0.0144 0.048
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.0309
Mycobacterium ulcerans polyketide synthase MbtD 0.0045 0.0249 0.0427
Brugia malayi Probable ClpP-like protease 0.0233 0.259 0.8144
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 0.0335 0.0335
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0037 0.0145 0.0015
Echinococcus granulosus tissue type plasminogen activator 0.0035 0.0124 0.0478
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0335 1
Loa Loa (eye worm) acyl carrier protein 0.0068 0.053 0.1905
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0037 0.0145 0.0001
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 0.0335 0.0857
Toxoplasma gondii hypothetical protein 0.008 0.0683 0.2267
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0233 0.259 1
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0037 0.0145 0.0961
Brugia malayi AMP-binding enzyme family protein 0.0138 0.1406 0.4421
Onchocerca volvulus Fatty acid synthase homolog 0.0266 0.3009 1
Entamoeba histolytica hypothetical protein 0.0071 0.0571 1
Brugia malayi TAR-binding protein 0.0064 0.048 0.1511
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0144 0.0555
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0098 0.0902 0.3098
Schistosoma mansoni tar DNA-binding protein 0.0064 0.048 0.1848
Schistosoma mansoni tar DNA-binding protein 0.0064 0.048 0.1848
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0943 0.3389
Schistosoma mansoni hypothetical protein 0.0032 0.008 0.0309
Brugia malayi beta-lactamase family protein 0.0037 0.0144 0.0454
Giardia lamblia Flap structure-specific endonuclease 0.0052 0.033 0.9466
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0943 0.3389
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0143 0.1471 0.5338
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0233 0.259 0.259
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0037 0.0145 0.0082
Schistosoma mansoni methyltransferase-related 0.0045 0.0237 0.0913
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0233 0.259 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0144 0.0048
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0119 0.1166 0.418
Mycobacterium ulcerans polyketide synthase MbtC 0.0037 0.0145 0.0001
Brugia malayi Bromodomain containing protein 0.0037 0.0144 0.0451
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0037 0.0145 0.0455
Brugia malayi Stress-activated protein kinase jnk-1 0.0234 0.26 0.8175
Trichomonas vaginalis CMGC family protein kinase 0.0052 0.0335 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0144 0.0048
Leishmania major hypothetical protein, conserved 0.0045 0.0237 0.5353
Mycobacterium tuberculosis Probable thioesterase TesA 0.0123 0.1219 0.4336
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0148 0.1527 0.5655
Brugia malayi hypothetical protein 0.0071 0.0571 0.1794
Schistosoma mansoni tar DNA-binding protein 0.0064 0.048 0.1848
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0119 0.1166 0.418
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0157 0.1642 0.6021
Mycobacterium ulcerans Type I modular polyketide synthase 0.0148 0.1527 0.5655
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0402 0.1546
Echinococcus multilocularis tissue type plasminogen activator 0.0035 0.0124 0.0124
Schistosoma mansoni tar DNA-binding protein 0.0064 0.048 0.1848
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0233 0.259 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.008 0.0289
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0148 0.1527 0.5563
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.008 0.0683 0.2204
Brugia malayi Kringle domain containing protein 0.0035 0.0124 0.0391
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0037 0.0145 0.0556
Loa Loa (eye worm) TAR-binding protein 0.0064 0.048 0.1727
Onchocerca volvulus 0.0037 0.0144 0.048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.008 0.008
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.264 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0144 0.0048
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.008 0.0253
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.008 0.008
Loa Loa (eye worm) beta-lactamase 0.0037 0.0144 0.0519
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0144 0.0048
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0046 0.0261 0.0514
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0157 0.1642 0.6124
Schistosoma mansoni hypothetical protein 0.0071 0.0571 0.2195
Echinococcus multilocularis flap endonuclease 1 0.0052 0.033 0.033
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0098 0.0902 0.3098
Brugia malayi Methyltransferase-like protein 4 0.0045 0.0237 0.0746
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0157 0.1642 0.6124
Echinococcus granulosus GPCR family 2 0.0032 0.008 0.0309
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0138 0.1406 0.508
Mycobacterium tuberculosis Conserved protein 0.0037 0.0144 0.0048
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0051 0.0316 0.0732

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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