Detailed information for compound 1621809

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 297.355 | Formula: C16H19N5O
  • H donors: 2 H acceptors: 3 LogP: 1.36 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nccc(n1)c1ccc(c(c1)N1CCCCC1)C(=O)N
  • InChi: 1S/C16H19N5O/c17-15(22)12-5-4-11(13-6-7-19-16(18)20-13)10-14(12)21-8-2-1-3-9-21/h4-7,10H,1-3,8-9H2,(H2,17,22)(H2,18,19,20)
  • InChiKey: WLVIONDQKHZQTJ-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase kinase kinase kinase 4 Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL No references
Homo sapiens interleukin-1 receptor-associated kinase 4 Starlite/ChEMBL No references
Homo sapiens cell division cycle 7 Starlite/ChEMBL No references
Homo sapiens Rho-associated, coiled-coil containing protein kinase 2 Starlite/ChEMBL No references
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL No references
Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase Starlite/ChEMBL No references
Homo sapiens homeodomain interacting protein kinase 2 Starlite/ChEMBL No references
Homo sapiens protein kinase, cAMP-dependent, catalytic, alpha Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_128641 All targets in OG5_128641
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium parvum protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02214 cell division control protein CDC7, putative Get druggable targets OG5_129189 All targets in OG5_129189
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cAMP-dependent protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128641 All targets in OG5_128641
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum ko:K04345 protein kinase A, putative Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08282 non-specific serine/threonine protein kinase [EC2.7.11.1], putative Get druggable targets OG5_128641 All targets in OG5_128641
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, AGC PKA Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Serine/threonine-protein kinase Pim-3 Get druggable targets OG5_134863 All targets in OG5_134863
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) STE/STE20/MSN protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania braziliensis protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum Serine/threonine-protein kinase mig-15, putative Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania mexicana protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus rho-associated protein kinase 1 Get druggable targets OG5_131020 All targets in OG5_131020
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major protein kinase A catalytic subunit isoform 2 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi probable protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Serine\/threonine protein kinase homolog Get druggable targets OG5_134863 All targets in OG5_134863
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans cAMP-dependent protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129189 All targets in OG5_129189
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase A catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Mitogen-activated protein kinase kinase kinase kinase 4, putative Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 1,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans protein kinase A Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Giardia lamblia Kinase, CDC7 Get druggable targets OG5_129189 All targets in OG5_129189
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus serine:threonine protein kinase mig 15 Get druggable targets OG5_128641 All targets in OG5_128641
Neospora caninum AGC kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Theileria parva cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii AGC kinase Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani protein kinase A catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus homeodomain interacting protein kinase 3 Get druggable targets OG5_129272 All targets in OG5_129272
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08826 homeodomain interacting protein kinase, putative Get druggable targets OG5_129272 All targets in OG5_129272
Brugia malayi Homeodomain interacting protein kinase protein 1 Get druggable targets OG5_129272 All targets in OG5_129272
Onchocerca volvulus Get druggable targets OG5_131020 All targets in OG5_131020
Echinococcus multilocularis enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR000719,Protein kinase;IPR011009,Protein kinase-like,domain-containing Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis rho associated protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_129272 All targets in OG5_129272
Candida albicans protein serine/threonine kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma brucei gambiense protein kinase A catalytic subunit isoform 2,protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma japonicum IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing Get druggable targets OG5_131020 All targets in OG5_131020
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus CDC7 cell division cycle 7 Get druggable targets OG5_129189 All targets in OG5_129189
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni protein kinase Get druggable targets OG5_128641 All targets in OG5_128641
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Schistosoma japonicum Rho-associated protein kinase 1, putative Get druggable targets OG5_131020 All targets in OG5_131020
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum cAMP-dependent protein kinase catalytic subunit alpha, putative Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CDC7 protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Schistosoma japonicum Protein kinase DC2, putative Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) AGC/PKA protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit isoform 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Trypanosoma congolense cAMP-dependent protein kinase catalytic subunit 1 Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126748 All targets in OG5_126748
Loa Loa (eye worm) CAMK/PIM protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_129189 All targets in OG5_129189
Echinococcus granulosus enhancer of mRNA decapping protein 4 Get druggable targets OG5_126748 All targets in OG5_126748
Cryptosporidium hominis protein kinase (EC 2.7.1.37), cAMP-dependent, catalytic chain Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium knowlesi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase A catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 Get druggable targets OG5_126748 All targets in OG5_126748
Echinococcus multilocularis proto oncogene serine:threonine protein kinase Get druggable targets OG5_134863 All targets in OG5_134863
Candida albicans similar to C terminus of S. cerevisiae YAK1 (YJL141C) serine-threonine protein kinase Get druggable targets OG5_129272 All targets in OG5_129272
Schistosoma japonicum expressed protein Get druggable targets OG5_129272 All targets in OG5_129272
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase Get druggable targets OG5_131020 All targets in OG5_131020
Schistosoma japonicum IPR000437,Prokaryotic membrane lipoprotein lipid attachment site,domain-containing Get druggable targets OG5_128641 All targets in OG5_128641
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit Get druggable targets OG5_126748 All targets in OG5_126748
Entamoeba histolytica PH domain containing protein kinase, putative Get druggable targets OG5_126748 All targets in OG5_126748
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0762 0.5348 0.6888
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0073 0.0004 0.0002
Loa Loa (eye worm) CDC7 protein kinase 0.0073 0.0004 0.0003
Mycobacterium ulcerans polyketide synthase Pks13 0.1074 0.7762 1
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.1055 0.9408
Entamoeba histolytica protein kinase domain containing protein 0.0208 0.1055 1
Echinococcus granulosus acyl carrier protein mitochondrial 0.0073 0.0004 0.0034
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0208 0.1055 0.1198
Brugia malayi AMP-binding enzyme family protein 0.0673 0.4655 0.4653
Mycobacterium ulcerans Type I modular polyketide synthase 0.0718 0.5001 0.6442
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0098 0.02 0.1785
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.06 0.4092 0.5269
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0208 0.1055 1
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0037 0.0333
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0245 0.1338 0.172
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.1121 1
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0181 0.0841 1
Echinococcus multilocularis 0.0077 0.0035 0.0332
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0073 0.0004 0.0034
Mycobacterium ulcerans thioesterase TesA 0.06 0.4092 0.5269
Mycobacterium ulcerans polyketide synthase 0.0762 0.5348 0.6888
Brugia malayi Protein kinase domain containing protein 0.0077 0.0037 0.0034
Leishmania major hypothetical protein, conserved 0.0217 0.1121 1
Echinococcus granulosus NADH dehydrogenase 0.0073 0.0004 0.0034
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.055 0.3706 0.4212
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0474 0.3111 0.4004
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0181 0.0841 0.7498
Loa Loa (eye worm) hypothetical protein 0.0102 0.0234 0.0264
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0718 0.5001 0.5
Onchocerca volvulus 0.018 0.0836 0.0876
Mycobacterium tuberculosis Hypothetical protein 0.0217 0.1121 0.1441
Echinococcus granulosus AMP dependent ligase 0.0073 0.0004 0.0034
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0197 0.0963 0.096
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0197 0.0963 0.913
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0102 0.0234 0.2218
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0577 0.3911 0.5036
Mycobacterium ulcerans polyketide synthase Pks9 0.0474 0.3111 0.4004
Giardia lamblia Kinase, CMGC CLK 0.0077 0.0037 0.0295
Loa Loa (eye worm) hypothetical protein 0.0401 0.2547 0.2894
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0181 0.0841 0.749
Brugia malayi AMP-binding enzyme family protein 0.0221 0.1156 0.1153
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0181 0.0841 0.797
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0718 0.5001 0.6442
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0077 0.0037 0.0404
Loa Loa (eye worm) hypothetical protein 0.011 0.0296 0.0335
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0474 0.3111 0.4004
Echinococcus granulosus dual specificity protein kinase clk2 0.0077 0.0037 0.0354
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0762 0.5348 0.6888
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0077 0.0037 0.0404
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1074 0.7762 1
Onchocerca volvulus 0.0073 0.0004 0.0001
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0181 0.0841 0.1079
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0077 0.0037 0.0404
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.011 0.0296 0.0377
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0181 0.0841 0.0954
Echinococcus granulosus protein kinase 0.0077 0.0035 0.0332
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.011 0.0296 0.0377
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0577 0.3911 0.5036
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0181 0.0841 1
Brugia malayi Protein kinase domain containing protein 0.0073 0.0004 0.0001
Mycobacterium tuberculosis Probable thioesterase TesA 0.06 0.4092 0.5269
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0103 0.024 0.2822
Brugia malayi Protein kinase domain containing protein 0.055 0.3706 0.3704
Trichomonas vaginalis CMGC family protein kinase 0.0077 0.0037 0.0295
Echinococcus granulosus hypothetical protein 0.0072 0.0001 0.0013
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.0963 0.1094
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0364 0.2261 0.4224
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0197 0.0963 0.101
Echinococcus granulosus rho-associated protein kinase 1 0.018 0.0836 0.792
Mycobacterium ulcerans Type I modular polyketide synthase 0.0718 0.5001 0.6442
Brugia malayi probable protein kinase 0.0107 0.027 0.0266
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0762 0.5348 0.6888
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0673 0.4655 0.5291
Echinococcus multilocularis AMP dependent ligase 0.0073 0.0004 0.0034
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0077 0.0037 0.0063
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0467 0.3061 0.5721
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0077 0.0037 0.0404
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0586 0.3984 0.5131
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0181 0.0841 0.1079
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1074 0.7762 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0698 0.4851 0.6248
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0004 0.004
Plasmodium vivax hypothetical protein, conserved 0.0103 0.024 0.2822
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0208 0.1055 0.1052
Mycobacterium ulcerans Type I modular polyketide synthase 0.0718 0.5001 0.6442
Brugia malayi Methyltransferase-like protein 4 0.0217 0.1121 0.1118
Echinococcus multilocularis rho associated protein kinase 0.018 0.0836 0.792
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0718 0.5001 0.6442
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0208 0.1055 1
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0226 0.1193 0.1533
Treponema pallidum acyl carrier protein 0.0073 0.0004 0.5
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0718 0.5001 0.6442
Schistosoma mansoni protein kinase 0.0077 0.0035 0.0313
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0077 0.0037 0.0041
Loa Loa (eye worm) hypothetical protein 0.011 0.0296 0.0335
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0197 0.0963 0.1094
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.0963 0.859
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.011 0.0296 0.0377
Giardia lamblia Methyltransferase like 2 0.0217 0.1121 1
Toxoplasma gondii type I fatty acid synthase, putative 0.0513 0.3413 0.638
Loa Loa (eye worm) glutamate receptor 0.0086 0.0109 0.0122
Echinococcus granulosus CDC7 cell division cycle 7 0.0073 0.0004 0.0042
Onchocerca volvulus 0.0673 0.4655 0.4897
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0181 0.0841 1
Schistosoma mansoni methyltransferase-related 0.0217 0.1121 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.011 0.0296 0.0377
Mycobacterium tuberculosis Conserved protein 0.0217 0.1121 0.1441
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0762 0.5348 0.6888
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0762 0.5348 0.6888
Toxoplasma gondii type I fatty acid synthase 0.011 0.0296 0.0547
Echinococcus multilocularis 0.0072 0.0001 0.0013
Mycobacterium leprae Polyketide synthase Pks13 0.1074 0.7762 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0263 0.0298
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0517 0.345 0.4442
Schistosoma mansoni protein kinase 0.0107 0.027 0.2407
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0762 0.5348 0.6888
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0409 0.2613 0.3364
Brugia malayi Protein kinase domain containing protein 0.0197 0.0963 0.096
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0673 0.4655 0.5996
Mycobacterium ulcerans fatty acid synthase Fas 0.0226 0.1193 0.1533
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0077 0.0037 0.0404
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0197 0.0963 0.913
Echinococcus multilocularis NADH dehydrogenase 0.0073 0.0004 0.0034
Schistosoma mansoni acyl carrier protein 0.0073 0.0004 0.0032
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0181 0.0841 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0698 0.4851 0.6248
Schistosoma mansoni hypothetical protein 0.0073 0.0004 0.0032
Onchocerca volvulus Fatty acid synthase homolog 0.1298 0.9503 1
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0106 0.0263 0.2494
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0181 0.0841 1
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0181 0.0841 0.1567
Loa Loa (eye worm) hypothetical protein 0.1207 0.8797 1
Echinococcus granulosus metabotropic glutamate receptor 5 0.0106 0.0263 0.2494
Loa Loa (eye worm) acyl carrier protein 0.0331 0.2007 0.228
Leishmania major protein kinase, putative 0.0077 0.0037 0.0302
Brugia malayi Metabotropic glutamate receptor precursor. 0.0086 0.0109 0.0105
Onchocerca volvulus 0.0073 0.0004 0.0001
Mycobacterium ulcerans polyketide synthase MbtD 0.0221 0.1156 0.1485
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0181 0.0841 1
Echinococcus multilocularis dual specificity protein kinase clk2 0.0077 0.0037 0.0354
Mycobacterium leprae Probable polyketide synthase Pks1 0.0762 0.5348 0.6888
Toxoplasma gondii type I fatty acid synthase, putative 0.0762 0.5348 1
Mycobacterium ulcerans thioesterase 0.06 0.4092 0.5269
Mycobacterium ulcerans polyketide synthase MbtC 0.0181 0.0841 0.1079
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0718 0.5001 0.6442
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.011 0.0296 0.0377
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0226 0.1193 0.1533
Plasmodium vivax serine/threonine kinase-1, putative 0.0077 0.0037 0.0404
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0078 0.0046 0.0042
Echinococcus multilocularis CDC7 cell division cycle 7 0.0073 0.0004 0.0042
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0291 0.1697 0.2183
Plasmodium falciparum protein serine/threonine kinase-1 0.0077 0.0037 0.0404
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0718 0.5001 0.6442
Loa Loa (eye worm) fatty acid synthase 0.0711 0.4948 0.5624
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0762 0.5348 0.6888
Onchocerca volvulus 0.0175 0.08 0.0838
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0577 0.3911 0.5036
Schistosoma mansoni serine/threonine protein kinase 0.0077 0.0037 0.0333
Mycobacterium ulcerans polyketide synthase 0.0718 0.5001 0.6442
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0077 0.0035 0.0038
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0181 0.0841 0.797
Onchocerca volvulus 0.1254 0.9156 0.9635
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0221 0.1156 0.1485
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0176 0.0804 0.1031
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0181 0.0841 0.0838
Loa Loa (eye worm) acyl carrier protein 0.0073 0.0004 0.0002
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0181 0.0841 1
Leishmania major protein kinase, putative 0.0077 0.0037 0.0302
Schistosoma mansoni serine/threonine protein kinase 0.018 0.0836 0.7451
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0077 0.0037 0.0404
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0718 0.5001 0.6442

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) > 5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PIM1 ChEMBL. No reference
Ki (functional) > 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 5.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: IRAK4 ChEMBL. No reference
Ki (functional) > 5.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: HIPK2 ChEMBL. No reference
Ki (functional) = 5.8 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: ROCK2 ChEMBL. No reference
Ki (functional) = 5.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: MAP4K4 ChEMBL. No reference
Ki (functional) = 5.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK2 ChEMBL. No reference
Ki (functional) = 6 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B ChEMBL. No reference
Ki (functional) = 8.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDC7 ChEMBL. No reference
Ki (functional) = 8.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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