Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | diacylglycerol kinase | 0.0627 | 0.0646 | 0.0545 |
Entamoeba histolytica | protein kinase, putative | 0.0906 | 0.1155 | 1 |
Loa Loa (eye worm) | raf kinase | 0.0627 | 0.0646 | 0.0564 |
Schistosoma mansoni | protein kinase C | 0.0757 | 0.0883 | 0.0883 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0906 | 0.1155 | 0.1026 |
Echinococcus granulosus | protein kinase c eta type | 0.0627 | 0.0646 | 0.051 |
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0627 | 0.0646 | 0.051 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0627 | 0.0646 | 0.0646 |
Loa Loa (eye worm) | hypothetical protein | 0.0757 | 0.0883 | 0.0864 |
Echinococcus granulosus | unc 13 munc13 | 0.0757 | 0.0883 | 0.0751 |
Loa Loa (eye worm) | hypothetical protein | 0.0906 | 0.1155 | 0.1208 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0513 | 0.0439 | 0.03 |
Loa Loa (eye worm) | IRE protein kinase | 0.0513 | 0.0439 | 0.0302 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0513 | 0.0439 | 0.03 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.1007 | 0.134 | 0.1213 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0627 | 0.0646 | 0.0564 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0627 | 0.0646 | 0.289 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0906 | 0.1155 | 0.1026 |
Schistosoma mansoni | rac gtpase activating protein | 0.0627 | 0.0646 | 0.0646 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Echinococcus granulosus | N chimaerin | 0.0627 | 0.0646 | 0.051 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0627 | 0.0646 | 0.289 |
Brugia malayi | Hr1 repeat family protein | 0.0906 | 0.1155 | 0.1167 |
Echinococcus granulosus | guanine nucleotide exchange factor VAV2 | 0.0627 | 0.0646 | 0.051 |
Schistosoma mansoni | vav2 | 0.0627 | 0.0646 | 0.0646 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.1007 | 0.134 | 0.1441 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0627 | 0.0646 | 0.051 |
Echinococcus granulosus | protein kinase C gamma type | 0.5124 | 0.8856 | 0.8839 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0648 | 0.0685 | 0.055 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Echinococcus granulosus | protein kinase c epsilon type | 0.1662 | 0.2537 | 0.2428 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0906 | 0.1155 | 0.1155 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0906 | 0.1155 | 1 |
Echinococcus multilocularis | N chimaerin | 0.0627 | 0.0646 | 0.051 |
Loa Loa (eye worm) | hypothetical protein | 0.4088 | 0.6965 | 0.8554 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0648 | 0.0685 | 0.055 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0906 | 0.1155 | 0.1026 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0906 | 0.1155 | 0.1026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1662 | 0.2537 | 0.2537 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Echinococcus granulosus | myotubularin protein 13 | 0.0627 | 0.0646 | 0.051 |
Echinococcus multilocularis | protein kinase c eta type | 0.0627 | 0.0646 | 0.051 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0906 | 0.1155 | 0.1026 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0648 | 0.0685 | 0.0685 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.1662 | 0.2537 | 0.2428 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Loa Loa (eye worm) | RasGEF domain-containing protein | 0.0627 | 0.0646 | 0.0564 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1007 | 0.134 | 0.134 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.424 | 0.7242 | 0.8904 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Entamoeba histolytica | protein kinase, putative | 0.0906 | 0.1155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0627 | 0.0646 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0906 | 0.1155 | 0.1208 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0648 | 0.0685 | 0.0685 |
Schistosoma mansoni | serine/threonine kinase | 0.0906 | 0.1155 | 0.1155 |
Brugia malayi | Protein kinase domain containing protein | 0.0648 | 0.0685 | 0.0593 |
Schistosoma mansoni | atypical protein kinase C | 0.1532 | 0.2299 | 0.2299 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0757 | 0.0883 | 0.0751 |
Brugia malayi | Protein kinase c protein 2 | 0.4866 | 0.8386 | 1 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0627 | 0.0646 | 0.0646 |
Schistosoma mansoni | unc-13 (munc13) | 0.0757 | 0.0883 | 0.0883 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0906 | 0.1155 | 0.1208 |
Brugia malayi | Variant SH3 domain containing protein | 0.0627 | 0.0646 | 0.0545 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0627 | 0.0646 | 0.0646 |
Echinococcus multilocularis | Diacylglycerol kinase theta | 0.0627 | 0.0646 | 0.051 |
Onchocerca volvulus | 0.0757 | 0.0883 | 1 | |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0906 | 0.1155 | 0.1026 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0648 | 0.0685 | 0.0593 |
Brugia malayi | RhoGAP domain containing protein | 0.0627 | 0.0646 | 0.0545 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0627 | 0.0646 | 0.051 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0757 | 0.0883 | 0.0751 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0906 | 0.1155 | 0.1026 |
Loa Loa (eye worm) | hypothetical protein | 0.4714 | 0.8109 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0906 | 0.1155 | 0.5 |
Brugia malayi | protein kinase C II. | 0.1662 | 0.2537 | 0.2855 |
Echinococcus multilocularis | guanine nucleotide exchange factor VAV2 | 0.0627 | 0.0646 | 0.051 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0906 | 0.1155 | 0.1026 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.4088 | 0.6965 | 0.6921 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0627 | 0.0646 | 0.051 |
Entamoeba histolytica | protein kinase, putative | 0.0906 | 0.1155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Brugia malayi | RhoGAP domain containing protein | 0.0627 | 0.0646 | 0.0545 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0648 | 0.0685 | 0.0614 |
Schistosoma mansoni | diacylglycerol kinase theta | 0.0627 | 0.0646 | 0.0646 |
Brugia malayi | diacylglycerol kinase | 0.0627 | 0.0646 | 0.0545 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0906 | 0.1155 | 0.1155 |
Brugia malayi | RhoGEF domain containing protein | 0.0627 | 0.0646 | 0.0545 |
Entamoeba histolytica | hypothetical protein | 0.0627 | 0.0646 | 0.289 |
Brugia malayi | Pleckstrin Homology Domain | 0.0627 | 0.0646 | 0.0545 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Echinococcus granulosus | NDR protein kinase | 0.0906 | 0.1155 | 0.1026 |
Schistosoma mansoni | protein kinase C mu | 0.0627 | 0.0646 | 0.0646 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0648 | 0.0685 | 0.0614 |
Toxoplasma gondii | AGC kinase | 0.0906 | 0.1155 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0906 | 0.1155 | 0.1208 |
Schistosoma mansoni | hypothetical protein | 0.0627 | 0.0646 | 0.0646 |
Brugia malayi | Ras association domain family 1 isoform A | 0.0627 | 0.0646 | 0.0545 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.4088 | 0.6965 | 0.6921 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.1007 | 0.134 | 0.1213 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0906 | 0.1155 | 0.1208 |
Brugia malayi | Protein kinase domain containing protein | 0.0906 | 0.1155 | 0.1167 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Echinococcus multilocularis | serine threonine protein kinase | 0.5124 | 0.8856 | 0.8839 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0906 | 0.1155 | 0.1208 |
Echinococcus granulosus | protein kinase c iota type | 0.1532 | 0.2299 | 0.2187 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0627 | 0.0646 | 0.051 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0757 | 0.0883 | 0.0751 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0906 | 0.1155 | 0.1167 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0627 | 0.0646 | 0.0646 |
Schistosoma mansoni | protein kinase C mu | 0.0648 | 0.0685 | 0.0685 |
Echinococcus multilocularis | protein kinase c iota type | 0.1532 | 0.2299 | 0.2187 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0906 | 0.1155 | 0.1155 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Echinococcus granulosus | Diacylglycerol kinase theta | 0.0627 | 0.0646 | 0.051 |
Brugia malayi | Protein kinase domain containing protein | 0.0906 | 0.1155 | 0.1167 |
Brugia malayi | Protein kinase domain containing protein | 0.0906 | 0.1155 | 0.1167 |
Brugia malayi | Ribonuclease 2-5A family protein | 0.0513 | 0.0439 | 0.0292 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.1662 | 0.2537 | 0.2955 |
Brugia malayi | C1-like domain containing protein | 0.0648 | 0.0685 | 0.0593 |
Loa Loa (eye worm) | Ras association domain family 1 isoform A | 0.0627 | 0.0646 | 0.0564 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0627 | 0.0646 | 0.0564 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.4088 | 0.6965 | 0.6921 |
Brugia malayi | protein kinase C3,putative | 0.0648 | 0.0685 | 0.0593 |
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0906 | 0.1155 | 0.1208 |
Trichomonas vaginalis | AGC family protein kinase | 0.0906 | 0.1155 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0757 | 0.0883 | 0.0883 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.