TDR Targets

Basic information

Technical information

TDR Targets ID: 1621817
Name: 2-[[6-(4-chloro-3-nitrophenyl)imidazo[2,3-b][ 1,3]thiazol-5-yl]methylideneamino]guanidine
MW: 363.782 | Formula: C13H10ClN7O2S
H donors: 2 H acceptors: 3 LogP: 3.08 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: NC(=N)N/N=C/c1c(nc2n1ccs2)c1ccc(c(c1)[N+](=O)[O-])Cl
InChi: 1S/C13H10ClN7O2S/c14-8-2-1-7(5-9(8)21(22)23)11-10(6-17-19-12(15)16)20-3-4-24-13(20)18-11/h1-6H,(H4,15,16,19)/b17-6+
InChiKey: XOYZTUDMUAFNPF-UBKPWBPPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[[6-(4-chloro-3-nitro-phenyl)imidazo[2,3-b]thiazol-5-yl]methyleneamino]guanidine
2-[[6-(4-chloro-3-nitrophenyl)-5-imidazo[2,3-b]thiazolyl]methyleneamino]guanidine
2-[[6-(4-chloro-3-nitro-phenyl)imidazo[2,3-b][1,3]thiazol-5-yl]methylideneamino]guanidine
NCI60_038546

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	diacylglycerol kinase	0.0627	0.0646	0.0545
Entamoeba histolytica	protein kinase, putative	0.0906	0.1155	1
Loa Loa (eye worm)	raf kinase	0.0627	0.0646	0.0564
Schistosoma mansoni	protein kinase C	0.0757	0.0883	0.0883
Echinococcus granulosus	serine:threonine protein kinase N2	0.0906	0.1155	0.1026
Echinococcus granulosus	protein kinase c eta type	0.0627	0.0646	0.051
Echinococcus granulosus	Rac GTPase activating protein 1	0.0627	0.0646	0.051
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0627	0.0646	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0757	0.0883	0.0864
Echinococcus granulosus	unc 13 munc13	0.0757	0.0883	0.0751
Loa Loa (eye worm)	hypothetical protein	0.0906	0.1155	0.1208
Echinococcus granulosus	serine:threonine protein kinase:endoribonuclease	0.0513	0.0439	0.03
Loa Loa (eye worm)	IRE protein kinase	0.0513	0.0439	0.0302
Echinococcus multilocularis	serine:threonine protein kinase:endoribonuclease	0.0513	0.0439	0.03
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.1007	0.134	0.1213
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0627	0.0646	0.0564
Entamoeba histolytica	diacylglycerol kinase, putative	0.0627	0.0646	0.289
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0906	0.1155	0.1026
Schistosoma mansoni	rac gtpase activating protein	0.0627	0.0646	0.0646
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Echinococcus granulosus	N chimaerin	0.0627	0.0646	0.051
Entamoeba histolytica	diacylglycerol kinase, putative	0.0627	0.0646	0.289
Brugia malayi	Hr1 repeat family protein	0.0906	0.1155	0.1167
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0627	0.0646	0.051
Schistosoma mansoni	vav2	0.0627	0.0646	0.0646
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.1007	0.134	0.1441
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0627	0.0646	0.051
Echinococcus granulosus	protein kinase C gamma type	0.5124	0.8856	0.8839
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0648	0.0685	0.055
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Echinococcus granulosus	protein kinase c epsilon type	0.1662	0.2537	0.2428
Schistosoma mansoni	serine/threonine protein kinase	0.0906	0.1155	0.1155
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Entamoeba histolytica	protein kinase, putative	0.0906	0.1155	1
Echinococcus multilocularis	N chimaerin	0.0627	0.0646	0.051
Loa Loa (eye worm)	hypothetical protein	0.4088	0.6965	0.8554
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0648	0.0685	0.055
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0906	0.1155	0.1026
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0906	0.1155	0.1026
Schistosoma mansoni	serine/threonine protein kinase	0.1662	0.2537	0.2537
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Echinococcus granulosus	myotubularin protein 13	0.0627	0.0646	0.051
Echinococcus multilocularis	protein kinase c eta type	0.0627	0.0646	0.051
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0906	0.1155	0.1026
Schistosoma mansoni	serine/threonine protein kinase	0.0648	0.0685	0.0685
Echinococcus multilocularis	protein kinase c epsilon type	0.1662	0.2537	0.2428
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0627	0.0646	0.0564
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Schistosoma mansoni	serine/threonine protein kinase	0.1007	0.134	0.134
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.424	0.7242	0.8904
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Entamoeba histolytica	protein kinase, putative	0.0906	0.1155	1
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0627	0.0646	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0906	0.1155	0.1208
Schistosoma mansoni	serine/threonine protein kinase	0.0648	0.0685	0.0685
Schistosoma mansoni	serine/threonine kinase	0.0906	0.1155	0.1155
Brugia malayi	Protein kinase domain containing protein	0.0648	0.0685	0.0593
Schistosoma mansoni	atypical protein kinase C	0.1532	0.2299	0.2299
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0757	0.0883	0.0751
Brugia malayi	Protein kinase c protein 2	0.4866	0.8386	1
Schistosoma mansoni	diacylglycerol kinase theta	0.0627	0.0646	0.0646
Schistosoma mansoni	unc-13 (munc13)	0.0757	0.0883	0.0883
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0906	0.1155	0.1208
Brugia malayi	Variant SH3 domain containing protein	0.0627	0.0646	0.0545
Schistosoma mansoni	serine/threonine protein kinase	0.0627	0.0646	0.0646
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0627	0.0646	0.051
Onchocerca volvulus		0.0757	0.0883	1
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0906	0.1155	0.1026
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0648	0.0685	0.0593
Brugia malayi	RhoGAP domain containing protein	0.0627	0.0646	0.0545
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0627	0.0646	0.051
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0757	0.0883	0.0751
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0906	0.1155	0.1026
Loa Loa (eye worm)	hypothetical protein	0.4714	0.8109	1
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0906	0.1155	0.5
Brugia malayi	protein kinase C II.	0.1662	0.2537	0.2855
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0627	0.0646	0.051
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0906	0.1155	0.1026
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.4088	0.6965	0.6921
Echinococcus multilocularis	myotubularin protein 13	0.0627	0.0646	0.051
Entamoeba histolytica	protein kinase, putative	0.0906	0.1155	1
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Brugia malayi	RhoGAP domain containing protein	0.0627	0.0646	0.0545
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0648	0.0685	0.0614
Schistosoma mansoni	diacylglycerol kinase theta	0.0627	0.0646	0.0646
Brugia malayi	diacylglycerol kinase	0.0627	0.0646	0.0545
Schistosoma mansoni	serine/threonine protein kinase	0.0906	0.1155	0.1155
Brugia malayi	RhoGEF domain containing protein	0.0627	0.0646	0.0545
Entamoeba histolytica	hypothetical protein	0.0627	0.0646	0.289
Brugia malayi	Pleckstrin Homology Domain	0.0627	0.0646	0.0545
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Echinococcus granulosus	NDR protein kinase	0.0906	0.1155	0.1026
Schistosoma mansoni	protein kinase C mu	0.0627	0.0646	0.0646
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0648	0.0685	0.0614
Toxoplasma gondii	AGC kinase	0.0906	0.1155	1
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0906	0.1155	0.1208
Schistosoma mansoni	hypothetical protein	0.0627	0.0646	0.0646
Brugia malayi	Ras association domain family 1 isoform A	0.0627	0.0646	0.0545
Echinococcus multilocularis	RNA directed DNA polymerase	0.4088	0.6965	0.6921
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.1007	0.134	0.1213
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0906	0.1155	0.1208
Brugia malayi	Protein kinase domain containing protein	0.0906	0.1155	0.1167
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Echinococcus multilocularis	serine threonine protein kinase	0.5124	0.8856	0.8839
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0906	0.1155	0.1208
Echinococcus granulosus	protein kinase c iota type	0.1532	0.2299	0.2187
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0627	0.0646	0.051
Echinococcus multilocularis	unc 13 (munc13)	0.0757	0.0883	0.0751
Brugia malayi	p70 ribosomal S6 kinase beta	0.0906	0.1155	0.1167
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0627	0.0646	0.0646
Schistosoma mansoni	protein kinase C mu	0.0648	0.0685	0.0685
Echinococcus multilocularis	protein kinase c iota type	0.1532	0.2299	0.2187
Schistosoma mansoni	serine/threonine protein kinase	0.0906	0.1155	0.1155
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Echinococcus granulosus	Diacylglycerol kinase theta	0.0627	0.0646	0.051
Brugia malayi	Protein kinase domain containing protein	0.0906	0.1155	0.1167
Brugia malayi	Protein kinase domain containing protein	0.0906	0.1155	0.1167
Brugia malayi	Ribonuclease 2-5A family protein	0.0513	0.0439	0.0292
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.1662	0.2537	0.2955
Brugia malayi	C1-like domain containing protein	0.0648	0.0685	0.0593
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0627	0.0646	0.0564
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Loa Loa (eye worm)	hypothetical protein	0.0627	0.0646	0.0564
Echinococcus granulosus	RNA directed DNA polymerase	0.4088	0.6965	0.6921
Brugia malayi	protein kinase C3,putative	0.0648	0.0685	0.0593
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0906	0.1155	0.1208
Trichomonas vaginalis	AGC family protein kinase	0.0906	0.1155	1
Schistosoma mansoni	unc-13 (munc13)	0.0757	0.0883	0.0883

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1962738

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1621817