Detailed information for compound 1621825

Basic information

Technical information
  • TDR Targets ID: 1621825
  • Name: 4-(carbamothioylhydrazinylidene)-N,1-bis(3-ni trophenyl)-2,5-dioxopyrrolidine-3-carboxamide
  • MW: 471.404 | Formula: C18H13N7O7S
  • H donors: 3 H acceptors: 7 LogP: 1.98 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=C\1/C(C(=O)Nc2cccc(c2)[N+](=O)[O-])C(=O)N(C1=O)c1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C18H13N7O7S/c19-18(33)22-21-14-13(15(26)20-9-3-1-5-11(7-9)24(29)30)16(27)23(17(14)28)10-4-2-6-12(8-10)25(31)32/h1-8,13H,(H,20,26)(H3,19,22,33)/b21-14-
  • InChiKey: YIHDQTGXWLBMOO-STZFKDTASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (4Z)-4-(carbamothioylhydrazinylidene)-N,1-bis(3-nitrophenyl)-2,5-dioxopyrrolidine-3-carboxamide
  • 4-(carbamothioylhydrazono)-N,1-bis(3-nitrophenyl)-2,5-dioxo-pyrrolidine-3-carboxamide
  • (4Z)-4-(carbamothioylhydrazono)-N,1-bis(3-nitrophenyl)-2,5-dioxo-pyrrolidine-3-carboxamide
  • 4-(carbamothioylhydrazono)-N,1-bis(3-nitrophenyl)-2,5-dioxo-3-pyrrolidinecarboxamide
  • (4Z)-4-(carbamothioylhydrazono)-N,1-bis(3-nitrophenyl)-2,5-dioxo-3-pyrrolidinecarboxamide
  • 2,5-diketo-N,1-bis(3-nitrophenyl)-4-(thiocarbamoylhydrazono)pyrrolidine-3-carboxamide
  • (4Z)-2,5-diketo-N,1-bis(3-nitrophenyl)-4-(thiocarbamoylhydrazono)pyrrolidine-3-carboxamide
  • (4Z)-4-(carbamothioylhydrazinylidene)-N,1-bis(3-nitrophenyl)-2,5-dioxo-pyrrolidine-3-carboxamide
  • 4-(carbamothioylhydrazinylidene)-N,1-bis(3-nitrophenyl)-2,5-dioxo-pyrrolidine-3-carboxamide
  • 4-((Aminocarbothioyl)hydrazono)-N,1-bis(3-(hydroxy(oxido)amino)phenyl)-2,5-dioxo-3-pyrrolidinecarboxamide
  • AIDS-131475
  • AIDS131475
  • NSC623868
  • NCI60_007110

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus RNA directed DNA polymerase 0.3357 0.7085 0.7064
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Onchocerca volvulus 0.0127 0.0114 0.0396
Trichomonas vaginalis synaptotagmin, putative 0.0107 0.0071 0.031
Loa Loa (eye worm) C2 domain-containing protein 0.0107 0.0071 0.0086
Brugia malayi Cyclin, N-terminal domain containing protein 0.0127 0.0114 0.0052
Toxoplasma gondii diacylglycerol kinase, putative 0.0515 0.095 0.6551
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0729 0.1414 0.1353
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Echinococcus granulosus protein kinase c eta type 0.0515 0.095 0.0886
Trichomonas vaginalis synaptotagmin, putative 0.0107 0.0071 0.031
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Schistosoma mansoni protein kinase C mu 0.0532 0.0987 0.0923
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Loa Loa (eye worm) C2 domain-containing protein 0.0107 0.0071 0.0086
Brugia malayi Hr1 repeat family protein 0.0729 0.1414 0.16
Echinococcus granulosus protein kinase c iota type 0.1244 0.2524 0.2471
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Plasmodium vivax ferlin, putative 0.0107 0.0071 0.5
Echinococcus multilocularis RNA directed DNA polymerase 0.3357 0.7085 0.7064
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Brugia malayi Ras association domain family 1 isoform A 0.0515 0.095 0.1048
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0712 0.1377 0.9734
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0565 0.1058 0.1291
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.3357 0.7085 0.7064
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Trichomonas vaginalis cyclin B, putative 0.0127 0.0114 0.0627
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Schistosoma mansoni unc-13 (munc13) 0.0622 0.1181 0.1118
Echinococcus multilocularis serine:threonine protein kinase 38 0.0729 0.1414 0.1353
Loa Loa (eye worm) phosphatidylinositol 3-kinase catalytic subunit gamma 0.0107 0.0071 0.0086
Echinococcus granulosus unc 13 munc13 0.0622 0.1181 0.1118
Entamoeba histolytica protein kinase, putative 0.0729 0.1414 1
Trypanosoma cruzi cyclin, putative 0.0127 0.0114 1
Brugia malayi RhoGEF domain containing protein 0.0515 0.095 0.1048
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0107 0.0071 0.031
Brugia malayi Protein kinase domain containing protein 0.0729 0.1414 0.16
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Trichomonas vaginalis Circumsporozoite protein precursor, putative 0.0107 0.0071 0.031
Echinococcus multilocularis N chimaerin 0.0515 0.095 0.0886
Onchocerca volvulus 0.0515 0.095 0.7923
Loa Loa (eye worm) hypothetical protein 0.0127 0.0114 0.014
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Loa Loa (eye worm) hypothetical protein 0.0622 0.1181 0.1441
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0532 0.0987 0.1205
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0729 0.1414 0.1353
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Trichomonas vaginalis synaptotagmin, putative 0.0107 0.0071 0.031
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Loa Loa (eye worm) Nedd4-PD 0.0107 0.0071 0.0086
Brugia malayi p70 ribosomal S6 kinase beta 0.0729 0.1414 0.16
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0729 0.1414 0.1725
Schistosoma mansoni diacylglycerol kinase theta 0.0515 0.095 0.0886
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Loa Loa (eye worm) hypothetical protein 0.0127 0.0114 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.1351 0.2755 0.3361
Trichomonas vaginalis synaptotagmin, putative 0.0107 0.0071 0.031
Schistosoma mansoni hypothetical protein 0.0515 0.095 0.0886
Trichomonas vaginalis copine, putative 0.0107 0.0071 0.031
Echinococcus multilocularis serine threonine protein kinase 0.4194 0.8889 0.8882
Echinococcus multilocularis Rac GTPase activating protein 1 0.0515 0.095 0.0886
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0107 0.0071 0.031
Schistosoma mansoni serine/threonine kinase 0.0729 0.1414 0.1353
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0729 0.1414 0.1725
Brugia malayi Protein kinase domain containing protein 0.0532 0.0987 0.1092
Trichomonas vaginalis cyclin B, putative 0.0127 0.0114 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Plasmodium falciparum ferlin, putative 0.0107 0.0071 0.5
Loa Loa (eye worm) synaptotagmin-1 0.0107 0.0071 0.0086
Trypanosoma cruzi cyclin, putative 0.0127 0.0114 1
Trichomonas vaginalis ion channel nompc, putative 0.0107 0.0071 0.031
Trichomonas vaginalis splicing factor 3A subunit, putative 0.0107 0.0071 0.031
Schistosoma mansoni vav2 0.0515 0.095 0.0886
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0729 0.1414 0.1353
Toxoplasma gondii AGC kinase 0.0729 0.1414 1
Loa Loa (eye worm) C2 domain-containing protein 0.0107 0.0071 0.0086
Plasmodium falciparum ferlin, putative 0.0107 0.0071 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Loa Loa (eye worm) raf kinase 0.0515 0.095 0.116
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Loa Loa (eye worm) C2 domain-containing protein 0.0107 0.0071 0.0086
Trichomonas vaginalis cyclin B, putative 0.0127 0.0114 0.0627
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0729 0.1414 0.1353
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Schistosoma mansoni serine/threonine protein kinase 0.0729 0.1414 0.1353
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0532 0.0987 0.0923
Trichomonas vaginalis cyclin A, putative 0.0127 0.0114 0.0627
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Schistosoma mansoni serine/threonine protein kinase 0.0729 0.1414 0.1353
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Trichomonas vaginalis cyclins, putative 0.0127 0.0114 0.0627
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0729 0.1414 0.1353
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0532 0.0987 0.1092
Brugia malayi Variant SH3 domain containing protein 0.0515 0.095 0.1048
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Brugia malayi protein kinase C3,putative 0.0532 0.0987 0.1092
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0532 0.0987 0.0923
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0729 0.1414 0.1725
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0622 0.1181 0.1118
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Echinococcus multilocularis serine:threonine protein kinase N2 0.0729 0.1414 0.1353
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0622 0.1181 0.1118
Trichomonas vaginalis vab10 spectraplakin, putative 0.0107 0.0071 0.031
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0107 0.0071 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Echinococcus multilocularis serine:threonine protein kinase N2 0.0729 0.1414 0.1353
Schistosoma mansoni serine/threonine protein kinase 0.1351 0.2755 0.2703
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0515 0.095 0.0886
Echinococcus granulosus Rac GTPase activating protein 1 0.0515 0.095 0.0886
Trichomonas vaginalis calcium-dependent lipid-binding protein, putative 0.0107 0.0071 0.031
Brugia malayi Protein kinase domain containing protein 0.0729 0.1414 0.16
Loa Loa (eye worm) AGC/PKN protein kinase 0.0729 0.1414 0.1725
Entamoeba histolytica protein kinase, putative 0.0124 0.0107 0.0275
Brugia malayi C1-like domain containing protein 0.0532 0.0987 0.1092
Brugia malayi diacylglycerol kinase 0.0515 0.095 0.1048
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Trichomonas vaginalis synaptotagmin 1,2, putative 0.0107 0.0071 0.031
Trichomonas vaginalis copine, putative 0.0107 0.0071 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0518 0.0957 0.0893
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0515 0.095 0.0886
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Loa Loa (eye worm) C2 domain-containing protein 0.0107 0.0071 0.0086
Loa Loa (eye worm) hypothetical protein 0.0729 0.1414 0.1725
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Trypanosoma cruzi cyclin 6, putative 0.0127 0.0114 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0515 0.095 0.0886
Plasmodium vivax ferlin, putative 0.0107 0.0071 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0107 0.0071 0.5
Brugia malayi diacylglycerol kinase 0.0515 0.095 0.1048
Schistosoma mansoni serine/threonine protein kinase 0.0729 0.1414 0.1353
Echinococcus multilocularis raf serine:threonine protein kinase 0.0515 0.095 0.0886
Schistosoma mansoni serine/threonine protein kinase 0.0532 0.0987 0.0923
Loa Loa (eye worm) copine family protein 0.0107 0.0071 0.0086
Echinococcus granulosus Diacylglycerol kinase theta 0.0515 0.095 0.0886
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Leishmania major cyclin 0.0127 0.0114 1
Trichomonas vaginalis cyclins, putative 0.0127 0.0114 0.0627
Echinococcus granulosus NDR protein kinase 0.0729 0.1414 0.1353
Echinococcus multilocularis unc 13 (munc13) 0.0622 0.1181 0.1118
Schistosoma mansoni diacylglycerol kinase theta 0.0515 0.095 0.0886
Entamoeba histolytica protein kinase, putative 0.0124 0.0107 0.0275
Entamoeba histolytica hypothetical protein 0.0515 0.095 0.6551
Loa Loa (eye worm) AGC/AKT protein kinase 0.0729 0.1414 0.1725
Loa Loa (eye worm) AGC/NDR protein kinase 0.0729 0.1414 0.1725
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Entamoeba histolytica protein kinase, putative 0.0729 0.1414 1
Trichomonas vaginalis copine, putative 0.0107 0.0071 0.031
Loa Loa (eye worm) hypothetical protein 0.3872 0.8196 1
Echinococcus multilocularis cyclin B 0.0127 0.0114 0.0044
Brugia malayi serine/threonine-protein kinase PAK 7 0.0565 0.1058 0.1177
Loa Loa (eye worm) C2 domain-containing protein 0.0107 0.0071 0.0086
Trichomonas vaginalis copine, putative 0.0107 0.0071 0.031
Brugia malayi Cyclin, N-terminal domain containing protein 0.0127 0.0114 0.0052
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Echinococcus granulosus myotubularin protein 13 0.0515 0.095 0.0886
Entamoeba histolytica diacylglycerol kinase, putative 0.0515 0.095 0.6551
Trichomonas vaginalis synaptotagmin, putative 0.0107 0.0071 0.031
Trypanosoma brucei mitotic cyclin 6 0.0127 0.0114 0.0327
Echinococcus multilocularis protein kinase c epsilon type 0.1351 0.2755 0.2703
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Trichomonas vaginalis cyclin B, putative 0.0127 0.0114 0.0627
Schistosoma mansoni unc-13 (munc13) 0.0622 0.1181 0.1118
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Onchocerca volvulus 0.0622 0.1181 1
Entamoeba histolytica cyclin, putative 0.0127 0.0114 0.0327
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0107 0.0071 0.031
Schistosoma mansoni protein kinase C mu 0.0515 0.095 0.0886
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0729 0.1414 0.1353
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0729 0.1414 0.1725
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0532 0.0987 0.1205
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Echinococcus granulosus N chimaerin 0.0515 0.095 0.0886
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0729 0.1414 0.1353
Schistosoma mansoni serine/threonine protein kinase 0.0729 0.1414 0.1353
Trichomonas vaginalis copine, putative 0.0107 0.0071 0.031
Echinococcus multilocularis Diacylglycerol kinase theta 0.0515 0.095 0.0886
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Trichomonas vaginalis synaptotagmin 1, 3, C.elegans, putative 0.0107 0.0071 0.031
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0515 0.095 0.116
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Schistosoma mansoni serine/threonine protein kinase 0.0515 0.095 0.0886
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0515 0.095 0.116
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Brugia malayi Protein kinase c protein 2 0.3996 0.8463 1
Echinococcus granulosus raf serine:threonine protein kinase 0.0515 0.095 0.0886
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Loa Loa (eye worm) hypothetical protein 0.3357 0.7085 0.8645
Schistosoma mansoni atypical protein kinase C 0.1244 0.2524 0.2471
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0518 0.0957 0.0893
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Schistosoma mansoni rac gtpase activating protein 0.0515 0.095 0.0886
Trypanosoma brucei rac serine-threonine kinase, putative 0.0729 0.1414 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0515 0.095 0.116
Giardia lamblia G2/mitotic-specific cyclin B 0.0127 0.0114 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0071 0.5
Trichomonas vaginalis synaptotagmin, putative 0.0107 0.0071 0.031
Brugia malayi protein kinase C II. 0.1351 0.2755 0.3198
Entamoeba histolytica protein kinase, putative 0.0729 0.1414 1
Brugia malayi RhoGAP domain containing protein 0.0515 0.095 0.1048
Brugia malayi RhoGAP domain containing protein 0.0515 0.095 0.1048
Echinococcus granulosus protein kinase C gamma type 0.4194 0.8889 0.8882
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Entamoeba histolytica protein kinase, putative 0.0729 0.1414 1
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Trypanosoma cruzi CYC2-like cyclin, putative 0.0127 0.0114 1
Plasmodium falciparum double C2-like domain-containing protein 0.0107 0.0071 0.5
Brugia malayi Pleckstrin Homology Domain 0.0515 0.095 0.1048
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0515 0.095 0.116
Echinococcus granulosus cyclin B 0.0127 0.0114 0.0044
Brugia malayi Protein kinase domain containing protein 0.0729 0.1414 0.16
Schistosoma mansoni cyclin B 0.0127 0.0114 0.0044
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Loa Loa (eye worm) hypothetical protein 0.0515 0.095 0.116
Onchocerca volvulus 0.0515 0.095 0.7923
Echinococcus multilocularis protein kinase c eta type 0.0515 0.095 0.0886
Trichomonas vaginalis cyclins, putative 0.0127 0.0114 0.0627
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0515 0.095 0.0886
Echinococcus granulosus protein kinase c epsilon type 0.1351 0.2755 0.2703
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Plasmodium vivax double C2-like domain-containing protein, putative 0.0107 0.0071 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Schistosoma mansoni protein kinase C 0.0622 0.1181 0.1118
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Echinococcus multilocularis protein kinase c iota type 0.1244 0.2524 0.2471
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0107 0.0071 0.0086
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.3481 0.7353 0.8971
Loa Loa (eye worm) phosphatidylinositol-specific phospholipase C 0.0107 0.0071 0.0086
Entamoeba histolytica diacylglycerol kinase, putative 0.0515 0.095 0.6551
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0071 0.031
Schistosoma mansoni serine/threonine protein kinase 0.0532 0.0987 0.0923
Trichomonas vaginalis annexin VII, putative 0.0107 0.0071 0.031
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0127 0.0114 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Loa Loa (eye worm) hypothetical protein 0.0107 0.0071 0.0086
Echinococcus multilocularis myotubularin protein 13 0.0515 0.095 0.0886
Trichomonas vaginalis AGC family protein kinase 0.0729 0.1414 1
Trichomonas vaginalis cyclins, putative 0.0127 0.0114 0.0627
Trichomonas vaginalis Proline-rich protein, putative 0.0107 0.0071 0.031
Trichomonas vaginalis synaptotagmin, putative 0.0107 0.0071 0.031

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.416 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.