TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 277.277 | Formula: C16H11N3O2
H donors: 2 H acceptors: 2 LogP: 1.97 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Oc1nc2[nH]c3c(n2c(=O)c1c1ccccc1)cccc3
InChi: 1S/C16H11N3O2/c20-14-13(10-6-2-1-3-7-10)15(21)19-12-9-5-4-8-11(12)17-16(19)18-14/h1-9,20H,(H,17,18)
InChiKey: NPAIMFCPLLPWJP-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0063	0.0518	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0294	0.3093	0.2769
Brugia malayi	Pleckstrin Homology Domain	0.0056	0.0448	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0294	0.3093	0.3093
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0294	0.3093	0.3093
Toxoplasma gondii	protein kinase domain-containing protein	0.0063	0.0518	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Schistosoma mansoni	syntrophin	0.0056	0.0448	0.035
Trypanosoma cruzi	NIMA-related kinase, putative	0.0063	0.0518	0.0111
Entamoeba histolytica	p21-activated kinase	0.0063	0.0518	0.0074
Echinococcus multilocularis	oxysterol binding protein 9	0.0056	0.0448	0.0334
Loa Loa (eye worm)	oxysterol binding protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0294	0.3093	0.3093
Entamoeba histolytica	protein kinase, putative	0.0063	0.0518	0.0074
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0056	0.0448	0.035
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Trichomonas vaginalis	AGC family protein kinase	0.0915	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Schistosoma mansoni	rho gtpase activating protein	0.0056	0.0448	0.035
Onchocerca volvulus		0.0056	0.0448	1
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0063	0.0518	0.0074
Loa Loa (eye worm)	hypothetical protein	0.003	0.0157	0.0157
Echinococcus multilocularis	Pleckstrin y	0.0056	0.0448	0.0334
Brugia malayi	MAX-1A	0.0056	0.0448	0.0448
Echinococcus granulosus	Oxysterol binding protein 11	0.0056	0.0448	0.035
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0056	0.0448	0.035
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0294	0.3093	0.3093
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Echinococcus granulosus	Protein kinase C brain isozyme	0.0294	0.3093	0.3534
Schistosoma mansoni	zinc finger protein	0.0056	0.0448	0.035
Trichomonas vaginalis	AGC family protein kinase	0.0351	0.3721	0.3427
Entamoeba histolytica	protein kinase, putative	0.0294	0.3093	0.2769
Trichomonas vaginalis	AGC family protein kinase	0.0915	1	1
Brugia malayi	TBC domain containing protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	syntrophin-1	0.0056	0.0448	0.0448
Trypanosoma cruzi	NIMA-related kinase, putative	0.0063	0.0518	0.0111
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0858	0.9371	0.9371
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0056	0.0448	0.0334
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0063	0.0518	0.0074
Brugia malayi	Syntrophin-1	0.0056	0.0448	0.0448
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0627	0.6797	0.6647
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0063	0.0518	0.0074
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.0374	0.0374
Schistosoma mansoni	hypothetical protein	0.0034	0.0199	0.005
Echinococcus granulosus	nervana 2	0.0564	0.6098	0.7151
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0294	0.3093	0.3376
Schistosoma mansoni	oxysterol-binding protein 1	0.0056	0.0448	0.035
Schistosoma mansoni	serine/threonine-protein kinase	0.0627	0.6797	0.7993
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0056	0.0448	0.0334
Brugia malayi	intermediate filament protein	0.003	0.0157	0.0157
Schistosoma mansoni	growth factor receptor-bound protein	0.0056	0.0448	0.035
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Echinococcus granulosus	GRB2 associated binding protein 3	0.0056	0.0448	0.035
Echinococcus multilocularis	oxysterol binding protein 3	0.0056	0.0448	0.0334
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0294	0.3093	0.3534
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0294	0.3093	0.3376
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0056	0.0448	0.0334
Onchocerca volvulus	Protein melted homolog	0.0056	0.0448	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0151	0.0151
Brugia malayi	protein kinase C II.	0.0294	0.3093	0.3093
Echinococcus granulosus	oxysterol binding protein 9	0.0056	0.0448	0.035
Echinococcus multilocularis	microtubule associated protein 2	0.0777	0.8465	0.9553
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0056	0.0448	0.0334
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Entamoeba histolytica	protein kinase, putative	0.0915	1	1
Schistosoma mansoni	hypothetical protein	0.0056	0.0448	0.035
Echinococcus granulosus	protein kinase C gamma type	0.0294	0.3093	0.3534
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Schistosoma mansoni	dynamin	0.0056	0.0448	0.035
Schistosoma mansoni	serine/threonine protein kinase	0.0294	0.3093	0.3534
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Schistosoma mansoni	hypothetical protein	0.0056	0.0448	0.035
Echinococcus granulosus	nervana 2	0.0564	0.6098	0.7151
Trypanosoma brucei	protein kinase, putative	0.0063	0.0518	0.0074
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0157	0.0157
Schistosoma mansoni	dynamin	0.0056	0.0448	0.035
Echinococcus multilocularis	beta 1 syntrophin	0.0056	0.0448	0.0334
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0564	0.6098	0.7151
Loa Loa (eye worm)	PH domain-containing protein	0.0056	0.0448	0.0448
Brugia malayi	PH domain containing protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	actin binding protein anillin	0.0056	0.0448	0.0334
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0063	0.0518	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Schistosoma mansoni	zinc finger protein	0.0056	0.0448	0.035
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0056	0.0448	0.0334
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0294	0.3093	0.3534
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0063	0.0518	0.0111
Echinococcus granulosus	beta 1 syntrophin	0.0056	0.0448	0.035
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0063	0.0518	0.0111
Schistosoma mansoni	goodpasture antigen-binding protein	0.0056	0.0448	0.035
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Schistosoma mansoni	goodpasture antigen-binding protein	0.0056	0.0448	0.035
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0288	0.3022	0.2695
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0294	0.3093	0.3376
Loa Loa (eye worm)	hypothetical protein	0.005	0.0374	0.0374
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	cytohesin 3	0.0056	0.0448	0.0448
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0812	0.8854	1
Echinococcus multilocularis	nervana 2	0.0564	0.6098	0.6831
Echinococcus granulosus	oxysterol binding protein 1	0.0056	0.0448	0.035
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.0374	0.0374
Brugia malayi	PH domain containing protein	0.0056	0.0448	0.0448
Echinococcus granulosus	protein kinase c epsilon type	0.0294	0.3093	0.3534
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0294	0.3093	0.3093
Entamoeba histolytica	protein kinase, putative	0.0063	0.0518	0.0074
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0157	0.0157
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0056	0.0448	0.035
Brugia malayi	Uncoordinated protein 104	0.0056	0.0448	0.0448
Entamoeba histolytica	protein kinase, putative	0.0858	0.9371	0.9342
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0056	0.0448	0.0334
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0564	0.6098	0.6831
Trichomonas vaginalis	AGC family protein kinase	0.0915	1	1
Schistosoma mansoni	microtubule-associated protein tau	0.0777	0.8465	1
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0056	0.0448	0.0334
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0063	0.0518	0.0123
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0063	0.0518	0.0111
Brugia malayi	PH domain containing protein	0.0056	0.0448	0.0448
Schistosoma mansoni	serine/threonine protein kinase	0.0294	0.3093	0.3534
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	Plekhf2 protein	0.0056	0.0448	0.0448
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0056	0.0448	0.0448
Echinococcus granulosus	Pleckstrin y	0.0056	0.0448	0.035
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.057	0.6169	1
Onchocerca volvulus	outspread protein homolog	0.0056	0.0448	1
Onchocerca volvulus		0.0056	0.0448	1
Entamoeba histolytica	protein kinase, putative	0.0063	0.0518	0.0074
Schistosoma mansoni	hypothetical protein	0.0056	0.0448	0.035
Onchocerca volvulus		0.0056	0.0448	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0627	0.6797	1
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0294	0.3093	0.3376
Echinococcus granulosus	DCC interacting protein 13 beta	0.0056	0.0448	0.035
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0294	0.3093	0.3093
Brugia malayi	probable spectrin beta chain	0.0056	0.0448	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0157	0.0157
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.0374	0.0374
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0056	0.0448	0.035
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.057	0.6169	0.7236
Echinococcus granulosus	dynamin 1	0.0056	0.0448	0.035
Echinococcus multilocularis	nervana 2	0.0564	0.6098	0.6831
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0063	0.0518	0.0074
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0056	0.0448	0.035
Onchocerca volvulus	Putative zinc finger protein	0.0056	0.0448	1
Echinococcus multilocularis	myotubularin protein 13	0.0056	0.0448	0.0334
Schistosoma mansoni	serine/threonine kinase	0.0294	0.3093	0.3534
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0063	0.0518	0.0074
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0063	0.0518	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0294	0.3093	0.2769
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0294	0.3093	0.3376
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Brugia malayi	Cytohesin 3	0.0056	0.0448	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0056	0.0448	0.035
Brugia malayi	Variant SH3 domain containing protein	0.0056	0.0448	0.0448
Schistosoma mansoni	serine/threonine protein kinase	0.0294	0.3093	0.3534
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.057	0.6169	0.6912
Leishmania major	protein kinase, putative	0.0063	0.0518	1
Echinococcus granulosus	myotubularin protein 13	0.0056	0.0448	0.035
Echinococcus granulosus	Pleckstrin y	0.0056	0.0448	0.035
Entamoeba histolytica	hypothetical protein	0.0063	0.0518	0.0074
Echinococcus granulosus	protein kinase c iota type	0.0294	0.3093	0.3534
Echinococcus multilocularis	Glutaredoxin protein 5	0.0564	0.6098	0.6831
Brugia malayi	Hr1 repeat family protein	0.0294	0.3093	0.3093
Echinococcus granulosus	pdz domain containing protein	0.0056	0.0448	0.035
Trichomonas vaginalis	AGC family protein kinase	0.0915	1	1
Loa Loa (eye worm)	rho-GTPase-activating	0.0056	0.0448	0.0448
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Schistosoma mansoni	oxysterol-binding protein 1	0.0056	0.0448	0.035
Brugia malayi	Cadps2 protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0294	0.3093	0.3093
Echinococcus granulosus	pleckstrin y domain containing family A	0.0056	0.0448	0.035
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0056	0.0448	0.0334
Trichomonas vaginalis	AGC family protein kinase	0.0915	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0294	0.3093	0.3534
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0294	0.3093	0.3534
Echinococcus multilocularis	Pleckstrin y	0.0056	0.0448	0.0334
Brugia malayi	Plekhf2 protein	0.0056	0.0448	0.0448
Trypanosoma cruzi	Protein kinase B	0.0627	0.6797	1
Brugia malayi	PH domain containing protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	protein kinase c epsilon type	0.0294	0.3093	0.3376
Entamoeba histolytica	protein kinase, putative	0.0063	0.0518	0.0074
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0056	0.0448	0.035
Echinococcus multilocularis	Pleckstrin y	0.0056	0.0448	0.0334
Schistosoma mansoni	vav2	0.0056	0.0448	0.035
Schistosoma mansoni	serine/threonine protein kinase	0.0294	0.3093	0.3534
Echinococcus multilocularis	dynamin 1	0.0056	0.0448	0.0334
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Brugia malayi	p70 ribosomal S6 kinase beta	0.0858	0.9371	0.9371
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0063	0.0518	0.0123
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0063	0.0518	0.0111
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0056	0.0448	0.035
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0056	0.0448	0.0334
Trichomonas vaginalis	AGC family protein kinase	0.0915	1	1
Echinococcus multilocularis	rac serine:threonine kinase	0.0627	0.6797	0.7635
Brugia malayi	Dynamin	0.0056	0.0448	0.0448
Schistosoma mansoni	atypical protein kinase C	0.0294	0.3093	0.3534
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0056	0.0448	0.0334
Schistosoma mansoni	serine/threonine protein kinase	0.0294	0.3093	0.3534
Brugia malayi	PH domain containing protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	Oxysterol binding protein 11	0.0056	0.0448	0.0334
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0063	0.0518	0.0079
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0056	0.0448	0.035
Brugia malayi	PH domain containing protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	pdz domain containing protein	0.0056	0.0448	0.0334
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0063	0.0518	0.0074
Brugia malayi	PH domain containing protein	0.0056	0.0448	0.0448
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0063	0.0518	0.0111
Echinococcus granulosus	microtubule associated protein 2	0.0777	0.8465	1
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0056	0.0448	0.035
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0915	1	1
Entamoeba histolytica	protein kinase, putative	0.0063	0.0518	0.0074
Echinococcus granulosus	cytohesin 1	0.0056	0.0448	0.035
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0056	0.0448	0.0334
Echinococcus granulosus	oxysterol binding protein 3	0.0056	0.0448	0.035
Brugia malayi	Dynamin	0.0056	0.0448	0.0448
Echinococcus granulosus	serine/threonine protein kinase	0.0627	0.6797	0.7993
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0056	0.0448	1
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0063	0.0518	1
Echinococcus granulosus	serine threonine protein kinase nrc	0.057	0.6169	0.7236
Brugia malayi	PH domain containing protein	0.0056	0.0448	0.0448
Onchocerca volvulus		0.0056	0.0448	1
Echinococcus granulosus	Pleckstrin y	0.0056	0.0448	0.035
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0199	0.0199
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0056	0.0448	0.0448
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0056	0.0448	0.035
Echinococcus multilocularis	protein kinase c iota type	0.0294	0.3093	0.3376
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	serine threonine protein kinase	0.0294	0.3093	0.3376
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0063	0.0518	0.0111
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0056	0.0448	0.0334
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0627	0.6797	0.6647
Echinococcus granulosus	Rho GTPase activating protein 24	0.0056	0.0448	0.035
Echinococcus multilocularis	oxysterol binding protein 1	0.0056	0.0448	0.0334
Brugia malayi	Oxysterol binding protein	0.0056	0.0448	0.0448
Schistosoma mansoni	hypothetical protein	0.0056	0.0448	0.035
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0056	0.0448	0.0448
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.057	0.6169	0.901
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0063	0.0518	0.0074
Loa Loa (eye worm)	uncoordinated protein 104	0.0056	0.0448	0.0448
Brugia malayi	Oxysterol-binding protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0056	0.0448	0.0334
Echinococcus multilocularis	cytohesin 1	0.0056	0.0448	0.0334
Onchocerca volvulus		0.0056	0.0448	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0294	0.3093	0.3376
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0056	0.0448	0.0448
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0063	0.0518	0.0111
Entamoeba histolytica	protein kinase, putative	0.0915	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0063	0.0518	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0294	0.3093	0.2769
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Giardia lamblia	Kinase, AGC PKA	0.057	0.6169	0.5
Leishmania major	protein kinase, putative	0.0063	0.0518	1
Echinococcus granulosus	Glutaredoxin protein 5	0.0564	0.6098	0.7151
Echinococcus granulosus	calcium dependent secretion activator 1	0.0056	0.0448	0.035
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0056	0.0448	0.035
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.057	0.6169	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0199	0.0199
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0063	0.0518	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Leishmania major	serine/threonine-protein kinase a, putative	0.0063	0.0518	1
Brugia malayi	Protein kinase domain containing protein	0.0294	0.3093	0.3093
Echinococcus granulosus	serine:threonine protein kinase N2	0.0294	0.3093	0.3534
Brugia malayi	PH domain containing protein	0.0056	0.0448	0.0448
Brugia malayi	Protein kinase domain containing protein	0.0294	0.3093	0.3093
Brugia malayi	Variant SH3 domain containing protein	0.0056	0.0448	0.0448
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Entamoeba histolytica	hypothetical protein	0.0063	0.0518	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0063	0.0518	0.0074
Schistosoma mansoni	myotubularin-related protein	0.0056	0.0448	0.035
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0056	0.0448	1
Schistosoma mansoni	serine/threonine protein kinase	0.0294	0.3093	0.3534
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0448	0.0448
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0915	1	1
Entamoeba histolytica	protein kinase 2, putative	0.057	0.6169	0.5989
Brugia malayi	hypothetical protein	0.0056	0.0448	0.0448
Schistosoma mansoni	hypothetical protein	0.0056	0.0448	0.035
Schistosoma mansoni	serine/threonine-protein kinase	0.0627	0.6797	0.7993
Leishmania major	folate/biopterin transporter, putative	0.0063	0.0518	1
Onchocerca volvulus		0.0056	0.0448	1
Echinococcus granulosus	NDR protein kinase	0.0294	0.3093	0.3534
Trichomonas vaginalis	AGC family protein kinase	0.0915	1	1
Schistosoma mansoni	centaurin alpha	0.0056	0.0448	0.035
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0056	0.0448	0.0334
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0294	0.3093	0.3376
Toxoplasma gondii	AGC kinase	0.0858	0.9371	1
Onchocerca volvulus		0.0056	0.0448	1

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1964744

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1622953