Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | pyruvate carboxylase | 0.0383 | 0.2839 | 0.2839 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0383 | 0.2839 | 0.5074 |
Mycobacterium tuberculosis | Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie | 0.0383 | 0.2839 | 1 |
Mycobacterium tuberculosis | Probable pyruvate carboxylase Pca (pyruvic carboxylase) | 0.0383 | 0.2839 | 1 |
Brugia malayi | Carboxyl transferase domain containing protein | 0.0971 | 0.9595 | 1 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0194 | 0.0656 | 0.0656 |
Chlamydia trachomatis | biotin carboxylase | 0.0348 | 0.2433 | 1 |
Mycobacterium ulcerans | bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 | 0.0383 | 0.2839 | 1 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0383 | 0.2839 | 0.2839 |
Toxoplasma gondii | pyruvate carboxylase | 0.0383 | 0.2839 | 0.2839 |
Echinococcus multilocularis | acetyl coenzyme A carboxylase 1 | 0.1007 | 1 | 1 |
Giardia lamblia | Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative | 0.0172 | 0.0405 | 0.5 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0383 | 0.2839 | 0.2839 |
Leishmania major | carboxylase, putative | 0.0383 | 0.2839 | 0.2839 |
Trypanosoma cruzi | 3-methylcrotonyl-CoA carboxylase, putative | 0.0383 | 0.2839 | 0.5074 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.036 | 0.2571 | 0.2571 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 | 0.0383 | 0.2839 | 1 |
Mycobacterium leprae | Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) | 0.0383 | 0.2839 | 1 |
Schistosoma mansoni | methylcrotonyl-CoA carboxylase | 0.0383 | 0.2839 | 0.2839 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0633 | 0.0633 |
Leishmania major | methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein | 0.0383 | 0.2839 | 0.2839 |
Trypanosoma brucei | 3-methylcrotonyl-CoA carboxylase alpha subunit, putative | 0.0383 | 0.2839 | 0.2839 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0194 | 0.0656 | 0.0656 |
Toxoplasma gondii | acetyl-coA carboxylase ACC2 | 0.1007 | 1 | 1 |
Mycobacterium ulcerans | acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 | 0.0383 | 0.2839 | 1 |
Mycobacterium ulcerans | pyruvate carboxylase | 0.0383 | 0.2839 | 1 |
Entamoeba histolytica | acetyl-coA carboxylase, putative | 0.0172 | 0.0405 | 0.5 |
Plasmodium vivax | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0728 | 0.6803 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0633 | 0.0633 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.0656 | 0.0656 |
Echinococcus multilocularis | propionyl coenzyme A carboxylase alpha chain | 0.0383 | 0.2839 | 0.2839 |
Plasmodium falciparum | biotin carboxylase subunit of acetyl CoA carboxylase, putative | 0.0728 | 0.6803 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.036 | 0.2571 | 0.2571 |
Trypanosoma cruzi | acetyl-CoA carboxylase | 0.0623 | 0.5594 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0633 | 0.0633 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0194 | 0.0656 | 0.0656 |
Trypanosoma brucei | unspecified product | 0.0252 | 0.1329 | 0.1329 |
Echinococcus granulosus | epidermal growth factor receptor | 0.036 | 0.2571 | 0.2571 |
Trypanosoma brucei | acetyl-CoA carboxylase | 0.1007 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | Acetyl/propionyl-CoA carboxylase, alpha subunit | 0.0383 | 0.2839 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.0656 | 0.0656 |
Loa Loa (eye worm) | carboxyl transferase domain-containing protein | 0.0971 | 0.9595 | 1 |
Leishmania major | acetyl-CoA carboxylase, putative | 0.1007 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA carboxylase | 0.1007 | 1 | 1 |
Echinococcus granulosus | propionyl coenzyme A carboxylase alpha chain | 0.0383 | 0.2839 | 0.2839 |
Toxoplasma gondii | acetyl-CoA carboxylase ACC1 | 0.1007 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16.92 uM | Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/time-resolved fluorometric analysis | ChEMBL. | 22361272 |
IC50 (binding) | = 18.12 uM | Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/time-resolved fluorometric analysis | ChEMBL. | 22361272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.