Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0588 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0588 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0077 | 0.1172 | 0.1119 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0588 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.006 | 0.006 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0588 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.006 | 0.5 |
Loa Loa (eye worm) | TTK protein kinase | 0.0077 | 0.1172 | 0.1172 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.006 | 0.006 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0588 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0588 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.006 | 0.006 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0588 | 1 | 1 |
Trypanosoma brucei | protein kinase, putative | 0.0588 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0588 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0588 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0588 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0588 | 1 | 1 |
Onchocerca volvulus | Dual specificity protein kinase TTK homolog | 0.0077 | 0.1172 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0588 | 1 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0588 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0588 | 1 | 1 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0588 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0588 | 1 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0588 | 1 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0588 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0588 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.