Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0258 | 0.2969 | 0.3792 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0103 | 0.0042 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0103 | 0.0042 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.017 | 0.1301 | 0.1264 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0631 | 1 | 1 |
Brugia malayi | protein kinase C II. | 0.0258 | 0.2969 | 0.3637 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0258 | 0.2969 | 0.2939 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0177 | 0.1423 | 0.1387 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0177 | 0.1423 | 0.1387 |
Entamoeba histolytica | protein kinase, putative | 0.0103 | 0.0042 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0439 | 0.6379 | 0.8211 |
Entamoeba histolytica | protein kinase, putative | 0.0103 | 0.0042 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0631 | 1 | 1 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0439 | 0.6379 | 0.6364 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0258 | 0.2969 | 0.2939 |
Toxoplasma gondii | AGC kinase | 0.0103 | 0.0042 | 0.5 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0439 | 0.6379 | 0.6364 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0258 | 0.2969 | 0.2939 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0631 | 1 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0439 | 0.6379 | 0.6364 |
Brugia malayi | Protein kinase c protein 2 | 0.053 | 0.8089 | 1 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0457 | 0.6708 | 0.8637 |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 0.776 | 1 |
Echinococcus granulosus | protein kinase C gamma type | 0.0558 | 0.8619 | 0.8613 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0103 | 0.0042 | 0.5 |
Schistosoma mansoni | atypical protein kinase C | 0.0177 | 0.1423 | 0.1387 |
Trichomonas vaginalis | AGC family protein kinase | 0.0103 | 0.0042 | 1 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0558 | 0.8619 | 0.8613 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | > -4 | The logarithmic molar concentration inhibiting 50% net cell growth was measured on HCT-116(M) colon cancer cell lines. | ChEMBL. | 10425100 |
IC50 (binding) | = 80 uM | In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes. | ChEMBL. | 10425100 |
IC50 (binding) | = 80 uM | In vitro inhibitory activity against cyclin-dependent kinase 1-cyclin B (Cyclin-Dependent Kinase) harvested from starfish oocytes. | ChEMBL. | 10425100 |
Log GI50 (functional) | > -4 | The logarithmic molar concentration inhibiting 50% net cell growth was measured on HCT-116(M) colon cancer cell lines. | ChEMBL. | 10425100 |
Log GI50 (functional) | = -4 | Antitumor activity for each out of 60 human tumor cell lines. | ChEMBL. | 10425100 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.