TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 359.873 | Formula: C18H18ClN3OS
H donors: 0 H acceptors: 1 LogP: 4.39 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: C/N=C/1\S/C(=C\c2cc(n(c2C)c2ccccc2Cl)C)/C(=O)N1C
InChi: 1S/C18H18ClN3OS/c1-11-9-13(10-16-17(23)21(4)18(20-3)24-16)12(2)22(11)15-8-6-5-7-14(15)19/h5-10H,1-4H3/b16-10-,20-18-
InChiKey: FQFUFWASTIPVGU-XXUJCTABSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	Plekhf2 protein	0.0085	0.0255	0.0052
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0442	0.2953	0.2807
Trypanosoma brucei	rac serine-threonine kinase, putative	0.1374	1	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0126	0.0563	0.0837
Echinococcus multilocularis	Oxysterol binding protein 11	0.0085	0.0255	0.0378
Schistosoma mansoni	serine/threonine protein kinase	0.0442	0.2953	0.4212
Schistosoma mansoni	serine/threonine protein kinase	0.0442	0.2953	0.4212
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0094	0.0327	0.0111
Echinococcus multilocularis	GRB2 associated binding protein 3	0.0085	0.0255	0.0378
Schistosoma mansoni	hypothetical protein	0.0085	0.0255	0.0079
Trypanosoma cruzi	Protein kinase B	0.0942	0.6732	1
Schistosoma mansoni	hypothetical protein	0.0085	0.0255	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0442	0.2953	0.2769
Brugia malayi	Pleckstrin Homology Domain	0.0085	0.0255	0.0052
Giardia lamblia	Kinase, AGC PKA	0.0857	0.6091	0.5
Brugia malayi	PH domain containing protein	0.0085	0.0255	0.0052
Brugia malayi	PH domain containing protein	0.0085	0.0255	0.0052
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0094	0.0327	0.021
Toxoplasma gondii	AtPH1 family protein	0.0085	0.0255	0.0056
Echinococcus multilocularis	collagen type iv alpha 3 binding protein	0.0085	0.0255	0.0378
Schistosoma mansoni	goodpasture antigen-binding protein	0.0085	0.0255	0.0079
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0942	0.6732	0.6647
Echinococcus granulosus	ras specific guanine nucleotide releasing factor	0.0085	0.0255	0.0378
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0327	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Entamoeba histolytica	protein kinase, putative	0.1289	0.9359	0.9342
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0094	0.0327	0.0111
Echinococcus multilocularis	Glutaredoxin protein 5	0.0847	0.6019	0.8941
Schistosoma mansoni	serine/threonine protein kinase	0.0442	0.2953	0.4212
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0203	0.5
Schistosoma mansoni	phosphoinositol 4-phosphate adaptor protein	0.0085	0.0255	0.0079
Schistosoma mansoni	vav2	0.0085	0.0255	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0442	0.2953	0.2807
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0442	0.2953	0.2807
Echinococcus granulosus	protein kinase c iota type	0.0442	0.2953	0.4386
Schistosoma mansoni	oxysterol-binding protein 1	0.0085	0.0255	0.0079
Plasmodium vivax	oxysterol-binding protein/PH domain containing protein	0.0085	0.0255	0.0087
Toxoplasma gondii	phosphatidylinositol transfer protein	0.0085	0.0255	0.0056
Brugia malayi	Plekhf2 protein	0.0085	0.0255	0.0052
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0085	0.0255	0.0087
Entamoeba histolytica	protein kinase, putative	0.1374	1	1
Echinococcus granulosus	protein kinase c epsilon type	0.0442	0.2953	0.4386
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0563	1
Trichomonas vaginalis	AGC family protein kinase	0.1374	1	1
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0094	0.0327	0.0074
Trypanosoma cruzi	NIMA-related kinase, putative	0.0094	0.0327	0.0111
Echinococcus multilocularis	cytohesin 1	0.0085	0.0255	0.0378
Echinococcus granulosus	cytohesin 1	0.0085	0.0255	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Schistosoma mansoni	hypothetical protein	0.0085	0.0255	0.0079
Echinococcus granulosus	Pleckstrin y	0.0085	0.0255	0.0378
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0094	0.0327	0.0111
Echinococcus granulosus	FERM and pleckstrin domain containing protein	0.0085	0.0255	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0094	0.0327	0.0135
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.0203	0.0302
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Echinococcus multilocularis	Ras associated and pleckstrin y	0.0085	0.0255	0.0378
Entamoeba histolytica	p21-activated kinase	0.0094	0.0327	0.0074
Brugia malayi	Dynamin	0.0085	0.0255	0.0052
Echinococcus granulosus	Oxysterol binding protein 11	0.0085	0.0255	0.0378
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0126	0.0563	0.3814
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Brugia malayi	Protein kinase domain containing protein	0.0442	0.2953	0.2807
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Entamoeba histolytica	protein kinase, putative	0.0442	0.2953	0.2769
Schistosoma mansoni	serine/threonine protein kinase	0.0442	0.2953	0.4212
Onchocerca volvulus	Abnormal cell migration protein 10 homolog	0.0085	0.0255	0.5
Echinococcus granulosus	serine threonine protein kinase nrc	0.0857	0.6091	0.9048
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Toxoplasma gondii	Oxysterol-binding protein	0.0085	0.0255	0.0056
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Trypanosoma brucei	protein kinase, putative	0.0094	0.0327	0.0074
Schistosoma mansoni	oxysterol-binding protein 1	0.0085	0.0255	0.0079
Brugia malayi	MAX-1A	0.0085	0.0255	0.0052
Toxoplasma gondii	aldehyde dehydrogenase	0.0126	0.0563	0.0393
Echinococcus multilocularis	Rho GTPase activating protein 24	0.0085	0.0255	0.0378
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0442	0.2953	0.2807
Brugia malayi	Cadps2 protein	0.0085	0.0255	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Brugia malayi	Cytohesin 3	0.0085	0.0255	0.0052
Brugia malayi	Syntrophin-1	0.0085	0.0255	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Echinococcus multilocularis	nervana 2	0.0847	0.6019	0.8941
Trichomonas vaginalis	AGC family protein kinase	0.1374	1	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0942	0.6732	0.6647
Echinococcus multilocularis	pdz domain containing protein	0.0085	0.0255	0.0378
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0085	0.0255	0.0052
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.1289	0.9359	0.9345
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0442	0.2953	0.2807
Echinococcus multilocularis	FERM and pleckstrin domain containing protein	0.0085	0.0255	0.0378
Schistosoma mansoni	dynamin	0.0085	0.0255	0.0079
Loa Loa (eye worm)	rho-GTPase-activating	0.0085	0.0255	0.0052
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0085	0.0255	0.0052
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0442	0.2953	0.2807
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Leishmania major	protein kinase, putative	0.0094	0.0327	0.2334
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0442	0.2953	0.4386
Echinococcus granulosus	Pleckstrin domain containing protein family B	0.0085	0.0255	0.0378
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0942	0.6732	1
Onchocerca volvulus		0.0085	0.0255	0.5
Echinococcus granulosus	oxysterol binding protein 1	0.0085	0.0255	0.0378
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Echinococcus granulosus	serine:threonine protein kinase N2	0.0442	0.2953	0.4386
Onchocerca volvulus	Putative zinc finger protein	0.0085	0.0255	0.5
Schistosoma mansoni	rho gtpase activating protein	0.0085	0.0255	0.0079
Echinococcus granulosus	oxysterol binding protein 3	0.0085	0.0255	0.0378
Schistosoma mansoni	serine/threonine protein kinase	0.0442	0.2953	0.4212
Schistosoma mansoni	centaurin alpha	0.0085	0.0255	0.0079
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0442	0.2953	0.4386
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.0563	0.0552
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Brugia malayi	Variant SH3 domain containing protein	0.0085	0.0255	0.0052
Echinococcus granulosus	Pleckstrin y	0.0085	0.0255	0.0378
Schistosoma mansoni	syntrophin	0.0085	0.0255	0.0079
Echinococcus granulosus	type II inositol 34 bisphosphate 4 phosphatase	0.0085	0.0255	0.0378
Brugia malayi	PH domain containing protein	0.0085	0.0255	0.0052
Loa Loa (eye worm)	RhoGEF domain-containing protein	0.0085	0.0255	0.0052
Entamoeba histolytica	protein kinase, putative	0.0094	0.0327	0.0074
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0094	0.0327	0.021
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0094	0.0327	0.0111
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0094	0.0327	0.2334
Schistosoma mansoni	myotubularin-related protein	0.0085	0.0255	0.0079
Echinococcus multilocularis	arf GAP with SH3 domain, ANK repeat and PH	0.0085	0.0255	0.0378
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0442	0.2953	0.4386
Toxoplasma gondii	hypothetical protein	0.0085	0.0255	0.0056
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0203	0.5
Onchocerca volvulus	Protein melted homolog	0.0085	0.0255	0.5
Echinococcus granulosus	nervana 2	0.0847	0.6019	0.8941
Loa Loa (eye worm)	uncoordinated protein 104	0.0085	0.0255	0.0052
Echinococcus granulosus	arf GAP with SH3 domain ANK repeat and PH	0.0085	0.0255	0.0378
Brugia malayi	Oxysterol binding protein	0.0085	0.0255	0.0052
Echinococcus granulosus	NDR protein kinase	0.0442	0.2953	0.4386
Brugia malayi	PH domain containing protein	0.0085	0.0255	0.0052
Entamoeba histolytica	protein kinase, putative	0.0094	0.0327	0.0074
Entamoeba histolytica	protein kinase, putative	0.0094	0.0327	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Schistosoma mansoni	zinc finger protein	0.0085	0.0255	0.0079
Brugia malayi	Oxysterol-binding protein	0.0085	0.0255	0.0052
Echinococcus granulosus	Glutaredoxin protein 5	0.0847	0.6019	0.8941
Brugia malayi	GTPase-activator protein for Ras-like GTPase containing protein	0.0085	0.0255	0.0052
Schistosoma mansoni	serine/threonine protein kinase	0.0442	0.2953	0.4212
Echinococcus multilocularis	rac serine:threonine kinase	0.0942	0.6732	1
Entamoeba histolytica	protein kinase, putative	0.1374	1	1
Echinococcus multilocularis	Pleckstrin y	0.0085	0.0255	0.0378
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0442	0.2953	0.4386
Trypanosoma cruzi	NIMA-related kinase, putative	0.0094	0.0327	0.0111
Echinococcus multilocularis	oxysterol binding protein 1	0.0085	0.0255	0.0378
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0085	0.0255	0.0087
Leishmania major	protein kinase, putative	0.0094	0.0327	0.2334
Schistosoma mansoni	rhogef and pleckstrin domain protein	0.0085	0.0255	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Brugia malayi	p70 ribosomal S6 kinase beta	0.1289	0.9359	0.9345
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0094	0.0327	0.0111
Echinococcus multilocularis	Pleckstrin y	0.0085	0.0255	0.0378
Onchocerca volvulus		0.0085	0.0255	0.5
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0126	0.0563	0.0837
Echinococcus granulosus	DCC interacting protein 13 beta	0.0085	0.0255	0.0378
Onchocerca volvulus		0.0085	0.0255	0.5
Entamoeba histolytica	protein kinase 2, putative	0.0857	0.6091	0.5989
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0085	0.0255	0.0087
Echinococcus granulosus	protein kinase C gamma type	0.0442	0.2953	0.4386
Echinococcus multilocularis	oxysterol binding protein 9	0.0085	0.0255	0.0378
Brugia malayi	probable spectrin beta chain	0.0085	0.0255	0.0052
Echinococcus granulosus	Protein kinase C brain isozyme	0.0442	0.2953	0.4386
Entamoeba histolytica	hypothetical protein	0.0094	0.0327	0.0074
Echinococcus multilocularis	pleckstrin y domain containing family A	0.0085	0.0255	0.0378
Trichomonas vaginalis	AGC family protein kinase	0.0442	0.2953	0.2769
Plasmodium vivax	PH domain containing protein	0.0085	0.0255	0.0087
Loa Loa (eye worm)	oxysterol binding protein	0.0085	0.0255	0.0052
Schistosoma mansoni	serine/threonine protein kinase	0.0442	0.2953	0.4212
Echinococcus multilocularis	Arf GAP and Pleckstrin domain containing protein	0.0085	0.0255	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0442	0.2953	0.4386
Trichomonas vaginalis	AGC family protein kinase	0.1374	1	1
Plasmodium falciparum	oxysterol-binding protein, putative	0.0085	0.0255	0.0087
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0432	0.2881	0.2695
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Brugia malayi	Dynamin	0.0085	0.0255	0.0052
Schistosoma mansoni	serine/threonine kinase	0.0442	0.2953	0.4212
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0442	0.2953	0.4386
Echinococcus multilocularis	arf GAP with coiled coil, ANK repeat and PH	0.0085	0.0255	0.0378
Trichomonas vaginalis	AGC family protein kinase	0.1374	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0085	0.0255	0.0052
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0563	1
Schistosoma mansoni	guanyl-nucleotide exchange factor	0.0085	0.0255	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0857	0.6091	0.9048
Echinococcus granulosus	Arf GAP and Pleckstrin domain containing protein	0.0085	0.0255	0.0378
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0442	0.2953	0.4386
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.0203	0.0302
Plasmodium falciparum	PH domain-containing protein, putative	0.0085	0.0255	0.0087
Onchocerca volvulus	outspread protein homolog	0.0085	0.0255	0.5
Toxoplasma gondii	protein kinase domain-containing protein	0.0094	0.0327	0.0135
Trichomonas vaginalis	AGC family protein kinase	0.0442	0.2953	0.2769
Echinococcus granulosus	pleckstrin y domain containing family A	0.0085	0.0255	0.0378
Echinococcus multilocularis	ras specific guanine nucleotide releasing factor	0.0085	0.0255	0.0378
Brugia malayi	GTP-ase activating protein for Arf containing protein	0.0085	0.0255	0.0052
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.0203	1
Schistosoma mansoni	atypical protein kinase C	0.0442	0.2953	0.4212
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0094	0.0327	0.0111
Trichomonas vaginalis	AGC family protein kinase	0.0527	0.3594	0.3427
Brugia malayi	PH domain containing protein	0.0085	0.0255	0.0052
Echinococcus granulosus	Pleckstrin y	0.0085	0.0255	0.0378
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0126	0.0563	1
Echinococcus granulosus	nervana 2	0.0847	0.6019	0.8941
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0094	0.0327	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0247	0.1477	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0085	0.0255	0.0052
Brugia malayi	hypothetical protein	0.0085	0.0255	0.0052
Schistosoma mansoni	serine/threonine-protein kinase	0.0942	0.6732	1
Toxoplasma gondii	hypothetical protein	0.0085	0.0255	0.0056
Echinococcus multilocularis	beta 1 syntrophin	0.0085	0.0255	0.0378
Echinococcus multilocularis	dynamin 1	0.0085	0.0255	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Brugia malayi	Hr1 repeat family protein	0.0442	0.2953	0.2807
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0857	0.6091	0.901
Loa Loa (eye worm)	AGC/AKT protein kinase	0.1374	1	1
Echinococcus granulosus	myotubularin protein 13	0.0085	0.0255	0.0378
Toxoplasma gondii	AGC kinase	0.1289	0.9359	1
Echinococcus multilocularis	myotubularin protein 13	0.0085	0.0255	0.0378
Echinococcus granulosus	calcium dependent secretion activator 1	0.0085	0.0255	0.0378
Echinococcus multilocularis	protein kinase c iota type	0.0442	0.2953	0.4386
Loa Loa (eye worm)	syntrophin-1	0.0085	0.0255	0.0052
Trichomonas vaginalis	AGC family protein kinase	0.1374	1	1
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0094	0.0327	0.0111
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0442	0.2953	0.4386
Loa Loa (eye worm)	PH domain-containing protein	0.0085	0.0255	0.0052
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Entamoeba histolytica	protein kinase, putative	0.0094	0.0327	0.0074
Schistosoma mansoni	aldehyde dehydrogenase	0.0126	0.0563	0.0552
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0203	0.5
Echinococcus granulosus	pdz domain containing protein	0.0085	0.0255	0.0378
Loa Loa (eye worm)	cytohesin 3	0.0085	0.0255	0.0052
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0094	0.0327	0.0074
Brugia malayi	PH domain containing protein	0.0085	0.0255	0.0052
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0847	0.6019	0.8941
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0094	0.0327	0.0074
Echinococcus multilocularis	nervana 2	0.0847	0.6019	0.8941
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0094	0.0327	0.0074
Echinococcus multilocularis	type II inositol 3,4 bisphosphate 4 phosphatase	0.0085	0.0255	0.0378
Plasmodium vivax	hypothetical protein, conserved	0.0085	0.0255	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0442	0.2953	0.2807
Echinococcus granulosus	collagen type iv alpha 3 binding protein	0.0085	0.0255	0.0378
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Echinococcus granulosus	beta 1 syntrophin	0.0085	0.0255	0.0378
Echinococcus multilocularis	protein kinase c epsilon type	0.0442	0.2953	0.4386
Brugia malayi	TBC domain containing protein	0.0085	0.0255	0.0052
Brugia malayi	protein kinase C II.	0.0442	0.2953	0.2807
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0442	0.2953	0.4386
Schistosoma mansoni	development and differentiation-enhancing factor ddef	0.0085	0.0255	0.0079
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0857	0.6091	0.9048
Entamoeba histolytica	protein kinase, putative	0.0094	0.0327	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Echinococcus multilocularis	calcium dependent secretion activator 1	0.0085	0.0255	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Echinococcus multilocularis	Pleckstrin y	0.0085	0.0255	0.0378
Brugia malayi	Uncoordinated protein 104	0.0085	0.0255	0.0052
Onchocerca volvulus		0.0085	0.0255	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0126	0.0563	1
Echinococcus multilocularis	serine threonine protein kinase	0.0442	0.2953	0.4386
Onchocerca volvulus		0.0085	0.0255	0.5
Onchocerca volvulus		0.0085	0.0255	0.5
Trichomonas vaginalis	AGC family protein kinase	0.1374	1	1
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0094	0.0327	0.0074
Loa Loa (eye worm)	GTP-ase activating protein for Arf containing protein	0.0085	0.0255	0.0052
Schistosoma mansoni	hypothetical protein	0.0085	0.0255	0.0079
Echinococcus multilocularis	DCC interacting protein 13 beta	0.0085	0.0255	0.0378
Brugia malayi	PH domain containing protein	0.0085	0.0255	0.0052
Echinococcus multilocularis	actin binding protein anillin	0.0085	0.0255	0.0378
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0857	0.6091	1
Plasmodium falciparum	acylated pleckstrin-homology domain-containing protein, putative	0.0085	0.0255	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0327	0.0074
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0847	0.6019	0.8941
Onchocerca volvulus		0.0085	0.0255	0.5
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Brugia malayi	PH domain containing protein	0.0085	0.0255	0.0052
Onchocerca volvulus	Putative neuronal RhoA GEF protein	0.0085	0.0255	0.5
Schistosoma mansoni	hypothetical protein	0.0085	0.0255	0.0079
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0094	0.0327	0.2334
Echinococcus granulosus	Rho GTPase activating protein 24	0.0085	0.0255	0.0378
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0442	0.2953	0.2807
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0442	0.2953	0.4386
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0327	0.0074
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0094	0.0327	0.0074
Leishmania major	serine/threonine-protein kinase a, putative	0.0094	0.0327	0.2334
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0857	0.6091	1
Echinococcus granulosus	arf GAP with coiled coil ANK repeat and PH	0.0085	0.0255	0.0378
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Schistosoma mansoni	serine/threonine-protein kinase	0.0942	0.6732	1
Schistosoma mansoni	dynamin	0.0085	0.0255	0.0079
Echinococcus multilocularis	Pleckstrin domain containing protein, family B	0.0085	0.0255	0.0378
Echinococcus granulosus	dynamin 1	0.0085	0.0255	0.0378
Trichomonas vaginalis	AGC family protein kinase	0.0094	0.0327	0.0074
Schistosoma mansoni	zinc finger protein	0.0085	0.0255	0.0079
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0255	0.0052
Leishmania major	folate/biopterin transporter, putative	0.0094	0.0327	0.2334
Echinococcus granulosus	oxysterol binding protein 9	0.0085	0.0255	0.0378
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0094	0.0327	0.0111
Echinococcus granulosus	GRB2 associated binding protein 3	0.0085	0.0255	0.0378
Plasmodium falciparum	phosphatidylinositol transfer protein, putative	0.0085	0.0255	0.0087
Schistosoma mansoni	growth factor receptor-bound protein	0.0085	0.0255	0.0079
Trichomonas vaginalis	AGC family protein kinase	0.1374	1	1
Entamoeba histolytica	hypothetical protein	0.0094	0.0327	0.0074
Echinococcus multilocularis	oxysterol binding protein 3	0.0085	0.0255	0.0378
Brugia malayi	PH domain containing protein	0.0085	0.0255	0.0052
Echinococcus granulosus	serine/threonine protein kinase	0.0942	0.6732	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.0203	0.5
Schistosoma mansoni	goodpasture antigen-binding protein	0.0085	0.0255	0.0079

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1910670

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1625221