Detailed information for compound 1625868

Basic information

Technical information
  • TDR Targets ID: 1625868
  • Name: NCI60_006963
  • MW: 394.505 | Formula: C28H26O2
  • H donors: 0 H acceptors: 0 LogP: 7.92 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C12Cc3c(OC2(C)Oc2c(C1)c1ccccc1cc2)ccc1c3cccc1)C
  • InChi: 1S/C28H26O2/c1-18(2)28-16-23-21-10-6-4-8-19(21)12-14-25(23)29-27(28,3)30-26-15-13-20-9-5-7-11-22(20)24(26)17-28/h4-15,18H,16-17H2,1-3H3
  • InChiKey: RSRWBILJBVEIQE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NSC623505

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0089 0.0131
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0033 0.0094 0.0139
Echinococcus multilocularis Rho GTPase activating protein 24 0.0045 0.0266 0.0347
Echinococcus multilocularis GRB2 associated binding protein 3 0.0045 0.0266 0.0347
Loa Loa (eye worm) hypothetical protein 0.0061 0.0495 0.0463
Echinococcus granulosus Glutaredoxin protein 5 0.0446 0.5978 0.8837
Echinococcus granulosus fibroblast growth factor receptor 4 0.0122 0.1375 0.2008
Echinococcus multilocularis tyrosine protein kinase csk 0.0045 0.0268 0.0349
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0055 0.0415 0.0229
Echinococcus multilocularis nervana 2 0.0446 0.5978 0.8835
Schistosoma mansoni dynamin 0.0045 0.0266 0.0394
Echinococcus granulosus Pleckstrin y 0.0045 0.0266 0.0364
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.0089 0.0083
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0055 0.0415 0.0229
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.3017 0.4462
Brugia malayi PH domain containing protein 0.0045 0.0266 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0238 0.3017 0.2951
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0045 0.0266 0.0259
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Brugia malayi Protein kinase domain containing protein 0.0238 0.3017 0.2994
Trypanosoma cruzi NIMA-related kinase, putative 0.0055 0.0415 0.0229
Echinococcus multilocularis cyclin dependent kinase 0.0413 0.5515 0.8146
Echinococcus granulosus DCC interacting protein 13 beta 0.0045 0.0266 0.0364
Schistosoma mansoni goodpasture antigen-binding protein 0.0045 0.0266 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Loa Loa (eye worm) Plekhf2 protein 0.0045 0.0266 0.0234
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Leishmania major protein kinase, putative 0.0055 0.0415 0.0601
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0238 0.3017 0.4435
Schistosoma mansoni tyrosine kinase 0.0028 0.0033 0.0049
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0238 0.3017 0.2994
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0413 0.5515 0.55
Echinococcus multilocularis oxysterol binding protein 3 0.0045 0.0266 0.0347
Trypanosoma cruzi cdc2-related kinase 1 0.0413 0.5515 0.8079
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0415 0.0407
Trichomonas vaginalis centaurin/arf, putative 0.0045 0.0266 0.0174
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0055 0.0415 0.0254
Entamoeba histolytica hypothetical protein 0.0045 0.0266 0.0259
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0213 0.2667 0.3925
Brugia malayi Dynamin 0.0045 0.0266 0.0234
Schistosoma mansoni voltage-gated potassium channel 0.018 0.2187 0.3234
Schistosoma mansoni tyrosine kinase 0.016 0.191 0.2825
Echinococcus multilocularis serine threonine protein kinase 0.0238 0.3017 0.4435
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Leishmania major serine/threonine-protein kinase a, putative 0.0055 0.0415 0.0601
Brugia malayi Uncoordinated protein 104 0.0045 0.0266 0.0234
Schistosoma mansoni syntrophin 0.0045 0.0266 0.0394
Echinococcus multilocularis oxysterol binding protein 9 0.0045 0.0266 0.0347
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0164 0.1972 0.1945
Echinococcus granulosus insulin receptor 0.0213 0.2667 0.3925
Trichomonas vaginalis centaurin/arf, putative 0.0045 0.0266 0.0174
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.0089 0.01
Echinococcus multilocularis Oxysterol binding protein 11 0.0045 0.0266 0.0347
Echinococcus multilocularis cyclin dependent kinase 5 0.0413 0.5515 0.8146
Entamoeba histolytica hypothetical protein 0.0045 0.0266 0.0259
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Leishmania major hypothetical protein, conserved 0.0045 0.0266 0.0327
Schistosoma mansoni hypothetical protein 0.0045 0.0266 0.0394
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Echinococcus granulosus tyrosine protein kinase Fyn 0.0028 0.0033 0.0018
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0413 0.5515 0.55
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Schistosoma mansoni tyrosine kinase 0.0122 0.1375 0.2033
Entamoeba histolytica protein kinase, putative 0.0684 0.9365 0.9364
Schistosoma mansoni serine/threonine-protein kinase 0.0501 0.6762 1
Trichomonas vaginalis AGC family protein kinase 0.0728 1 1
Trypanosoma brucei cdc2-related kinase 1 0.0413 0.5515 0.5392
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0055 0.0415 0.0153
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0122 0.1375 0.2008
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0413 0.5515 1
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0045 0.0266 0.0364
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.3017 0.4462
Echinococcus granulosus tyrosine protein kinase Src42A 0.0028 0.0033 0.0018
Echinococcus multilocularis Pleckstrin y 0.0045 0.0266 0.0347
Echinococcus multilocularis 0.0073 0.0677 0.0958
Entamoeba histolytica PH domain containing protein kinase, putative 0.0501 0.6762 0.676
Echinococcus multilocularis beta 1 syntrophin 0.0045 0.0266 0.0347
Giardia lamblia Kinase, CMGC CDK 0.0413 0.5515 0.8877
Brugia malayi MAX-1A 0.0045 0.0266 0.0234
Plasmodium vivax protein kinase Crk2 0.0413 0.5515 0.8955
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0049 0.0327 0.0437
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.3017 0.4462
Brugia malayi Dynamin 0.0045 0.0266 0.0234
Toxoplasma gondii hypothetical protein 0.0045 0.0266 0.0192
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0045 0.0266 0.0394
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0154 0.1818 0.174
Toxoplasma gondii Oxysterol-binding protein 0.0045 0.0266 0.0192
Brugia malayi PH domain containing protein 0.0045 0.0266 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0238 0.3017 0.2951
Plasmodium falciparum calcium-dependent protein kinase 7 0.0055 0.0415 0.054
Entamoeba histolytica PH domain containing protein 0.0045 0.0266 0.0259
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0055 0.0415 0.0324
Echinococcus granulosus serine threonine protein kinase nrc 0.0456 0.6127 0.9057
Echinococcus granulosus nervana 2 0.0446 0.5978 0.8837
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Schistosoma mansoni hypothetical protein 0.0045 0.0266 0.0394
Entamoeba histolytica p21-activated kinase 0.0055 0.0415 0.0407
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0045 0.0266 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Echinococcus granulosus tyrosine protein kinase csk 0.0045 0.0268 0.0366
Echinococcus granulosus cyclin dependent kinase 1 0.0073 0.0677 0.0973
Schistosoma mansoni hypothetical protein 0.0045 0.0266 0.0394
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0309 0.0457
Echinococcus granulosus dynamin 1 0.0045 0.0266 0.0364
Schistosoma mansoni atypical protein kinase C 0.0238 0.3017 0.4462
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0045 0.0266 0.0259
Echinococcus multilocularis dynamin 1 0.0045 0.0266 0.0347
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0045 0.0266 0.0259
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0049 0.0327 0.0454
Echinococcus multilocularis protein kinase c iota type 0.0238 0.3017 0.4435
Echinococcus granulosus NDR protein kinase 0.0238 0.3017 0.4445
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0055 0.0415 0.0229
Trichomonas vaginalis hypothetical protein 0.0045 0.0266 0.0174
Echinococcus granulosus epidermal growth factor receptor 0.0168 0.2023 0.297
Echinococcus granulosus protein kinase c epsilon type 0.0238 0.3017 0.4445
Brugia malayi PH domain containing protein 0.0045 0.0266 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Brugia malayi Hr1 repeat family protein 0.0238 0.3017 0.2994
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0677 0.1001
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0045 0.0266 0.0259
Trichomonas vaginalis CMGC family protein kinase 0.0413 0.5515 0.5472
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0413 0.5515 1
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0033 0.0094 0.0139
Schistosoma mansoni tyrosine kinase 0.0028 0.0033 0.0049
Echinococcus granulosus beta 1 syntrophin 0.0045 0.0266 0.0364
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0028 0.0033 0.0018
Schistosoma mansoni tyrosine kinase 0.0255 0.3256 0.4815
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0045 0.0266 0.0347
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0045 0.0266 0.0259
Brugia malayi protein kinase C II. 0.0238 0.3017 0.2994
Echinococcus multilocularis cyclin dependent kinase 1 0.0413 0.5515 0.8146
Trichomonas vaginalis AGC family protein kinase 0.0728 1 1
Trichomonas vaginalis kinesin light chain, putative 0.0045 0.0266 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0045 0.0266 0.0294
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0045 0.0266 0.0234
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0055 0.0415 0.0229
Leishmania major protein kinase, putative 0.0055 0.0415 0.0601
Echinococcus granulosus cytohesin 1 0.0045 0.0266 0.0364
Echinococcus granulosus oxysterol binding protein 3 0.0045 0.0266 0.0364
Schistosoma mansoni serine/threonine protein kinase 0.0413 0.5515 0.8155
Echinococcus granulosus cyclin dependent kinase 0.0413 0.5515 0.8149
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0055 0.0415 0.0229
Schistosoma mansoni tyrosine kinase 0.0271 0.3484 0.5153
Loa Loa (eye worm) hypothetical protein 0.0238 0.3017 0.2994
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0045 0.0266 0.0347
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0164 0.1972 0.1945
Loa Loa (eye worm) TK/CSK protein kinase 0.0045 0.0268 0.0236
Echinococcus granulosus Rho GTPase activating protein 24 0.0045 0.0266 0.0364
Echinococcus granulosus oxysterol binding protein 9 0.0045 0.0266 0.0364
Schistosoma mansoni vav2 0.0061 0.0495 0.0731
Loa Loa (eye worm) PH domain-containing protein 0.0045 0.0266 0.0234
Echinococcus granulosus Oxysterol binding protein 11 0.0045 0.0266 0.0364
Echinococcus granulosus tyrosine protein kinase Lyn 0.0039 0.0182 0.0238
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0028 0.0033 0.0018
Entamoeba histolytica protein kinase, putative 0.0055 0.0415 0.0407
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Brugia malayi Immunoglobulin I-set domain containing protein 0.0126 0.1424 0.1395
Loa Loa (eye worm) hypothetical protein 0.0143 0.1663 0.1635
Schistosoma mansoni zinc finger protein 0.0045 0.0266 0.0394
Loa Loa (eye worm) AGC/AKT protein kinase 0.0728 1 1
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0238 0.3017 0.4445
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Brugia malayi Syntrophin-1 0.0045 0.0266 0.0234
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Trypanosoma brucei protein kinase, putative 0.0055 0.0415 0.0153
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0048 0.0309 0.0427
Echinococcus multilocularis oxysterol binding protein 1 0.0045 0.0266 0.0347
Brugia malayi Cytohesin 3 0.0045 0.0266 0.0234
Loa Loa (eye worm) TK protein kinase 0.0126 0.1424 0.1395
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0089 0.0131
Brugia malayi PH domain containing protein 0.0045 0.0266 0.0234
Entamoeba histolytica protein kinase 2, putative 0.0456 0.6127 0.6124
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Schistosoma mansoni myotubularin-related protein 0.0045 0.0266 0.0394
Brugia malayi PH domain containing protein 0.0045 0.0266 0.0234
Trichomonas vaginalis centaurin alpha, putative 0.0045 0.0266 0.0174
Loa Loa (eye worm) uncoordinated protein 104 0.0045 0.0266 0.0234
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Echinococcus granulosus Pleckstrin y 0.0045 0.0266 0.0364
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0045 0.0266 0.0174
Entamoeba histolytica cell division protein kinase 2, putative 0.0413 0.5515 0.5511
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0045 0.0266 0.0174
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0446 0.5978 0.8835
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0045 0.0266 0.0259
Schistosoma mansoni tyrosine kinase 0.0213 0.2667 0.3944
Toxoplasma gondii AGC kinase 0.0684 0.9365 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0415 0.0407
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0238 0.3017 0.2994
Echinococcus multilocularis serine:threonine protein kinase 38 0.0238 0.3017 0.4435
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0045 0.0266 0.0234
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0033 0.0094 0.0108
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0501 0.6762 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0033 0.0094 0.0108
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0415 0.0407
Echinococcus granulosus protein kinase c iota type 0.0238 0.3017 0.4445
Entamoeba histolytica protein kinase, putative 0.0728 1 1
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0055 0.0415 0.0601
Trypanosoma brucei cdc2-related kinase 3 0.0413 0.5515 0.5392
Entamoeba histolytica hypothetical protein 0.0045 0.0266 0.0259
Entamoeba histolytica PH domain containing protein 0.0045 0.0266 0.0259
Schistosoma mansoni zinc finger protein 0.0045 0.0266 0.0394
Brugia malayi PH domain containing protein 0.0045 0.0266 0.0234
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0045 0.0266 0.0364
Brugia malayi Oxysterol binding protein 0.0045 0.0266 0.0234
Echinococcus granulosus pdz domain containing protein 0.0045 0.0266 0.0364
Echinococcus multilocularis epidermal growth factor receptor 0.0248 0.3165 0.4654
Schistosoma mansoni growth factor receptor-bound protein 0.0045 0.0266 0.0394
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Echinococcus granulosus calcium dependent secretion activator 1 0.0045 0.0266 0.0364
Echinococcus multilocularis rac serine:threonine kinase 0.0501 0.6762 1
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0055 0.0415 0.0153
Schistosoma mansoni tyrosine kinase 0.0168 0.2023 0.2992
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0033 0.0094 0.0108
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Brugia malayi PH domain containing protein 0.0045 0.0266 0.0234
Trichomonas vaginalis CMGC family protein kinase 0.0413 0.5515 0.5472
Brugia malayi Plekhf2 protein 0.0045 0.0266 0.0234
Entamoeba histolytica cell division protein kinase 2, putative 0.0413 0.5515 0.5511
Echinococcus granulosus tyrosine protein kinase csk 0.0045 0.0268 0.0366
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Entamoeba histolytica hypothetical protein 0.0055 0.0415 0.0407
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0055 0.0415 0.0153
Echinococcus granulosus serine/threonine protein kinase 0.0501 0.6762 1
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0045 0.0266 0.0234
Echinococcus multilocularis hyperpolarization activated cyclic 0.0033 0.0094 0.0091
Echinococcus granulosus Pleckstrin y 0.0045 0.0266 0.0364
Toxoplasma gondii AtPH1 family protein 0.0045 0.0266 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0033 0.0094 0.0061
Echinococcus granulosus tyrosine protein kinase csk 0.0045 0.0268 0.0366
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0456 0.6127 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0213 0.2667 0.3914
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0238 0.3017 0.2994
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0032 0.0089 0.0083
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0238 0.3017 0.4435
Echinococcus multilocularis Ras associated and pleckstrin y 0.0045 0.0266 0.0347
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0055 0.0415 0.0601
Trypanosoma cruzi Protein kinase B 0.0501 0.6762 1
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0045 0.0266 0.0234
Schistosoma mansoni hypothetical protein 0.0045 0.0266 0.0394
Echinococcus granulosus serine:threonine protein kinase N2 0.0238 0.3017 0.4445
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0048 0.0309 0.041
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Trypanosoma brucei rac serine-threonine kinase, putative 0.0728 1 1
Toxoplasma gondii protein kinase domain-containing protein 0.0055 0.0415 0.0352
Echinococcus multilocularis cytohesin 1 0.0045 0.0266 0.0347
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0045 0.0266 0.0364
Loa Loa (eye worm) SH2 domain-containing protein 0.0053 0.0383 0.0351
Loa Loa (eye worm) oxysterol binding protein 0.0045 0.0266 0.0234
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0168 0.2023 0.297
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0033 0.0094 0.0139
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0045 0.0266 0.0234
Schistosoma mansoni tyrosine kinase 0.0213 0.2667 0.3944
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0061 0.0495 0.0463
Echinococcus granulosus Protein kinase C brain isozyme 0.0238 0.3017 0.4445
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Echinococcus multilocularis cyclin dependent kinase 1 0.0073 0.0677 0.0957
Echinococcus granulosus pleckstrin y domain containing family A 0.0045 0.0266 0.0364
Echinococcus granulosus nervana 2 0.0446 0.5978 0.8837
Brugia malayi Protein kinase domain containing protein 0.0238 0.3017 0.2994
Loa Loa (eye worm) hypothetical protein 0.0048 0.0309 0.0277
Giardia lamblia Kinase, AGC PKA 0.0456 0.6127 1
Brugia malayi Variant SH3 domain containing protein 0.0061 0.0495 0.0463
Leishmania major hypothetical protein, conserved 0.0045 0.0266 0.0327
Schistosoma mansoni voltage-gated potassium channel 0.0033 0.0094 0.0139
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0033 0.0094 0.0108
Trypanosoma cruzi mitogen activated protein kinase, putative 0.0063 0.0528 0.0403
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0045 0.0266 0.0364
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0045 0.0266 0.0174
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0055 0.0415 0.0229
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Echinococcus granulosus tyrosine protein kinase Fyn 0.0028 0.0033 0.0018
Trypanosoma cruzi cdc2-related kinase 3 0.0413 0.5515 0.8079
Plasmodium falciparum oxysterol-binding protein, putative 0.0045 0.0266 0.0294
Schistosoma mansoni hypothetical protein 0.0045 0.0266 0.0394
Trypanosoma cruzi cdc2-related kinase 1 0.0413 0.5515 0.8079
Loa Loa (eye worm) cytohesin 3 0.0045 0.0266 0.0234
Loa Loa (eye worm) TK/INSR protein kinase 0.0213 0.2667 0.2643
Echinococcus granulosus tyrosine protein kinase Src64B 0.0028 0.0033 0.0018
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0677 0.1001
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0045 0.0266 0.0259
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0045 0.0266 0.0174
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0048 0.0309 0.0277
Echinococcus granulosus oxysterol binding protein 1 0.0045 0.0266 0.0364
Echinococcus multilocularis serine:threonine protein kinase N2 0.0238 0.3017 0.4435
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0238 0.3017 0.4435
Echinococcus multilocularis insulin receptor 0.0213 0.2667 0.3914
Loa Loa (eye worm) rho-GTPase-activating 0.0045 0.0266 0.0234
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0456 0.6127 0.9022
Schistosoma mansoni oxysterol-binding protein 1 0.0045 0.0266 0.0394
Loa Loa (eye worm) TK/EGFR protein kinase 0.0248 0.3165 0.3142
Plasmodium falciparum protein kinase 5 0.0413 0.5515 0.8986
Echinococcus multilocularis pdz domain containing protein 0.0045 0.0266 0.0347
Schistosoma mansoni tyrosine kinase 0.0248 0.3165 0.468
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0227 0.2869 0.2801
Schistosoma mansoni oxysterol-binding protein 1 0.0045 0.0266 0.0394
Trichomonas vaginalis centaurin gamma, putative 0.0045 0.0266 0.0174
Echinococcus granulosus epidermal growth factor receptor 0.0248 0.3165 0.4663
Echinococcus multilocularis tyrosine protein kinase csk 0.0045 0.0268 0.0349
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0045 0.0266 0.0259
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0055 0.0415 0.0352
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0238 0.3017 0.4445
Leishmania major folate/biopterin transporter, putative 0.0055 0.0415 0.0601
Echinococcus multilocularis Glutaredoxin protein 5 0.0446 0.5978 0.8835
Schistosoma mansoni serine/threonine kinase 0.0238 0.3017 0.4462
Echinococcus multilocularis nervana 2 0.0446 0.5978 0.8835
Trichomonas vaginalis AGC family protein kinase 0.0728 1 1
Brugia malayi serine/threonine-protein kinase 0.0073 0.0677 0.0646
Brugia malayi Protein kinase domain containing protein 0.0213 0.2667 0.2643
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0033 0.0094 0.0108
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Schistosoma mansoni centaurin alpha 0.0045 0.0266 0.0394
Brugia malayi Cyclic-nucleotide gated cation channel 0.0033 0.0094 0.0061
Echinococcus multilocularis cyclin dependent kinase 1 0.0073 0.0677 0.0957
Echinococcus granulosus cyclin dependent kinase 5 0.0413 0.5515 0.8149
Echinococcus multilocularis c src tyrosine kinase 0.0065 0.0557 0.0779
Echinococcus multilocularis hyperpolarization activated cyclic 0.0033 0.0094 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.3017 0.4462
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Brugia malayi Variant SH3 domain containing protein 0.0045 0.0266 0.0234
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0045 0.0266 0.0294
Schistosoma mansoni tyrosine kinase 0.0065 0.0557 0.0823
Brugia malayi Oxysterol-binding protein 0.0045 0.0266 0.0234
Echinococcus granulosus c src tyrosine kinase 0.0065 0.0557 0.0795
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Echinococcus granulosus cyclin dependent kinase 1 0.0073 0.0677 0.0973
Entamoeba histolytica hypothetical protein 0.0055 0.0415 0.0407
Entamoeba histolytica protein kinase, putative 0.0055 0.0415 0.0407
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0413 0.5515 0.585
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Echinococcus multilocularis epidermal growth factor receptor 0.0168 0.2023 0.2958
Loa Loa (eye worm) hypothetical protein 0.0403 0.5366 0.5351
Entamoeba histolytica protein kinase, putative 0.0728 1 1
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0055 0.0415 0.0229
Loa Loa (eye worm) syntrophin-1 0.0045 0.0266 0.0234
Toxoplasma gondii phosphatidylinositol transfer protein 0.0045 0.0266 0.0192
Entamoeba histolytica protein kinase, putative 0.0055 0.0415 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0684 0.9365 0.9363
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0728 1 1
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0456 0.6127 0.9056
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Echinococcus multilocularis tyrosine protein kinase shark 0.0271 0.3484 0.5129
Brugia malayi Protein kinase domain containing protein 0.0091 0.0925 0.0895
Echinococcus granulosus hyperpolarization activated cyclic 0.0033 0.0094 0.0108
Brugia malayi Pleckstrin Homology Domain 0.0045 0.0266 0.0234
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0045 0.0266 0.0259
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0055 0.0415 0.0229
Loa Loa (eye worm) AGC/PKG protein kinase 0.0032 0.0089 0.0056
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0122 0.1375 0.1994
Entamoeba histolytica PH domain containing protein kinase, putative 0.0501 0.6762 0.676
Echinococcus multilocularis tyrosine protein kinase csk 0.0045 0.0268 0.0349
Loa Loa (eye worm) hypothetical protein 0.0083 0.0812 0.0781
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0045 0.0266 0.0174
Schistosoma mansoni tyrosine kinase 0.016 0.191 0.2825
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0045 0.0266 0.0347
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0045 0.0266 0.0259
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0045 0.0266 0.0259
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0045 0.0266 0.0259
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0045 0.0266 0.0347
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.3017 0.4462
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0238 0.3017 0.4445
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.3017 0.4462
Schistosoma mansoni serine/threonine protein kinase 0.0073 0.0677 0.1001
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0033 0.0094 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0089 0.0131
Echinococcus granulosus cyclin dependent kinase 1 0.0413 0.5515 0.8149
Trichomonas vaginalis alpha chimerin, putative 0.0045 0.0266 0.0174
Echinococcus granulosus voltage gated potassium channel 0.0048 0.0309 0.0427
Brugia malayi Cadps2 protein 0.0045 0.0266 0.0234
Echinococcus multilocularis actin binding protein anillin 0.0045 0.0266 0.0347
Trypanosoma cruzi mitogen-activated protein kinase, putative 0.0073 0.0677 0.0632
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0033 0.0094 0.0091
Echinococcus granulosus cGMP dependent protein kinase 0.0032 0.0089 0.01
Echinococcus granulosus tyrosine protein kinase shark 0.0271 0.3484 0.5137
Brugia malayi hypothetical protein 0.0045 0.0266 0.0234
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0164 0.1972 0.2894
Onchocerca volvulus 0.0073 0.0677 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0033 0.0094 0.0061
Schistosoma mansoni voltage-gated potassium channel 0.0048 0.0309 0.0457
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0045 0.0266 0.0259
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Echinococcus multilocularis expressed conserved protein 0.0032 0.0089 0.0083
Entamoeba histolytica protein kinase, putative 0.0238 0.3017 0.3012
Loa Loa (eye worm) AGC/NDR protein kinase 0.0238 0.3017 0.2994
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Echinococcus granulosus GRB2 associated binding protein 3 0.0045 0.0266 0.0364
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0154 0.1818 0.174
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0055 0.0415 0.0324
Entamoeba histolytica hypothetical protein, conserved 0.0045 0.0266 0.0259
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0446 0.5978 0.8837
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0028 0.0033 0.0049
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Echinococcus multilocularis protein kinase c epsilon type 0.0238 0.3017 0.4435
Brugia malayi Egg laying defective protein 4 0.0032 0.0089 0.0056
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0045 0.0266 0.0394
Schistosoma mansoni tyrosine kinase 0.0168 0.2023 0.2992
Brugia malayi cell division control protein 2 homolog 0.0413 0.5515 0.55
Entamoeba histolytica hypothetical protein 0.0049 0.0327 0.0319
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0238 0.3017 0.2994
Loa Loa (eye worm) hypothetical protein 0.0045 0.0266 0.0234
Brugia malayi probable spectrin beta chain 0.0045 0.0266 0.0234
Trypanosoma cruzi NIMA-related kinase, putative 0.0055 0.0415 0.0229
Trichomonas vaginalis AGC family protein kinase 0.0728 1 1
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0045 0.0266 0.0364
Entamoeba histolytica hypothetical protein 0.0045 0.0266 0.0259
Trypanosoma cruzi cdc2-related kinase 3 0.0413 0.5515 0.8079
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0045 0.0266 0.0294
Brugia malayi Protein kinase domain containing protein 0.0413 0.5515 0.55
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0045 0.0266 0.0174
Loa Loa (eye worm) AGC/PKN protein kinase 0.0238 0.3017 0.2994
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0238 0.3017 0.4435
Echinococcus multilocularis pleckstrin y domain containing family A 0.0045 0.0266 0.0347
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0028 0.0033 0.0018
Echinococcus multilocularis voltage gated potassium channel 0.0048 0.0309 0.041
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0045 0.0266 0.0259
Schistosoma mansoni serine/threonine protein kinase 0.0413 0.5515 0.8155
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0045 0.0266 0.0347
Trichomonas vaginalis centaurin beta, putative 0.0045 0.0266 0.0174
Brugia malayi PH domain containing protein 0.0045 0.0266 0.0234
Echinococcus multilocularis DCC interacting protein 13 beta 0.0045 0.0266 0.0347
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0456 0.6127 1
Brugia malayi TBC domain containing protein 0.0045 0.0266 0.0234
Echinococcus multilocularis serine:threonine protein kinase N2 0.0238 0.3017 0.4435
Echinococcus granulosus myotubularin protein 13 0.0045 0.0266 0.0364
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0045 0.0266 0.0347
Trichomonas vaginalis protein transport protein sec7, putative 0.0045 0.0266 0.0174
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Giardia lamblia Kinase, CMGC CDK 0.0413 0.5515 0.8877
Trichomonas vaginalis AGC family protein kinase 0.0238 0.3017 0.2951
Echinococcus multilocularis Pleckstrin y 0.0045 0.0266 0.0347
Schistosoma mansoni goodpasture antigen-binding protein 0.0045 0.0266 0.0394
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0045 0.0266 0.0364
Trichomonas vaginalis CMGC family protein kinase 0.0413 0.5515 0.5472
Entamoeba histolytica protein kinase, putative 0.0055 0.0415 0.0407
Schistosoma mansoni rho gtpase activating protein 0.0045 0.0266 0.0394
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0456 0.6127 0.9057
Echinococcus multilocularis Pleckstrin y 0.0045 0.0266 0.0347
Trypanosoma brucei mitogen-activated protein kinase 0.0073 0.0677 0.0422
Schistosoma mansoni dynamin 0.0045 0.0266 0.0394
Trichomonas vaginalis AGC family protein kinase 0.0728 1 1
Trichomonas vaginalis AGC family protein kinase 0.0282 0.3653 0.3592
Brugia malayi SH2 domain containing protein 0.0061 0.0496 0.0465
Entamoeba histolytica protein kinase, putative 0.0055 0.0415 0.0407
Entamoeba histolytica ARF GTPase activating protein, putative 0.0045 0.0266 0.0259
Echinococcus multilocularis cyclin dependent kinase 1 0.0413 0.5515 0.8146
Plasmodium falciparum PH domain-containing protein, putative 0.0045 0.0266 0.0294
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0122 0.1375 0.1994
Echinococcus granulosus cGMP dependent protein kinase 1 0.0032 0.0089 0.01
Brugia malayi PH domain containing protein 0.0045 0.0266 0.0234
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0049 0.0327 0.0484
Echinococcus multilocularis myotubularin protein 13 0.0045 0.0266 0.0347
Brugia malayi Furin-like cysteine rich region family protein 0.0248 0.3165 0.3142
Echinococcus multilocularis tyrosine protein kinase csk 0.0045 0.0268 0.0349
Leishmania major mitogen-activated protein kinase, putative,kinase, putative 0.0073 0.0677 0.1084
Schistosoma mansoni tyrosine kinase 0.016 0.191 0.2825
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0413 0.5515 0.55
Entamoeba histolytica PH domain containing protein kinase, putative 0.0055 0.0415 0.0407
Echinococcus multilocularis calcium dependent secretion activator 1 0.0045 0.0266 0.0347
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0045 0.0266 0.0294
Entamoeba histolytica PH domain containing protein 0.0045 0.0266 0.0259
Trichomonas vaginalis AGC family protein kinase 0.0728 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0033 0.0094 0.0139
Schistosoma mansoni serine/threonine-protein kinase 0.0501 0.6762 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0028 0.0033 0.0018
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0033 0.0094 0.0091
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0413 0.5515 0.8149
Loa Loa (eye worm) hypothetical protein 0.0033 0.0094 0.0061
Trichomonas vaginalis protein transport protein sec7, putative 0.0045 0.0266 0.0174
Schistosoma mansoni tyrosine kinase 0.0028 0.0033 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0266 0.0174
Echinococcus granulosus protein kinase C gamma type 0.0238 0.3017 0.4445
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0045 0.0266 0.0259
Trichomonas vaginalis AGC family protein kinase 0.0055 0.0415 0.0324
Toxoplasma gondii cyclin-dependent kinase family 5 protein 0.0073 0.0677 0.0634
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0045 0.0266 0.0234
Schistosoma mansoni voltage-gated potassium channel 0.018 0.2187 0.3234
Schistosoma mansoni serine/threonine protein kinase 0.0238 0.3017 0.4462
Onchocerca volvulus 0.0061 0.0496 0.5601
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0045 0.0266 0.0364
Brugia malayi p70 ribosomal S6 kinase beta 0.0684 0.9365 0.9363
Toxoplasma gondii hypothetical protein 0.0045 0.0266 0.0192
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0055 0.0415 0.0153
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0045 0.0266 0.0394
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0033 0.0094 0.0139
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0164 0.1972 0.2881

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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