Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0217 | 0.0157 | 0.0506 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0263 | 0.0227 | 0.0227 |
Schistosoma mansoni | unc-13 (munc13) | 0.0263 | 0.0227 | 0.0731 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0219 | 0.0219 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0258 | 0.0219 | 0.6081 |
Echinococcus granulosus | nervana 2 | 0.0217 | 0.0157 | 0.0506 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0263 | 0.0227 | 0.0026 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0258 | 0.0219 | 0.6081 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0263 | 0.0227 | 0.5 |
Onchocerca volvulus | 0.6729 | 1 | 1 | |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0219 | 0.016 | 0.0518 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0263 | 0.0227 | 0.0731 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.033 | 0.0328 | 0.0328 |
Schistosoma mansoni | ribokinase | 0.0258 | 0.0219 | 0.0707 |
Entamoeba histolytica | protein kinase, putative | 0.0351 | 0.036 | 1 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2165 | 0.3101 | 1 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.2165 | 0.3101 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0258 | 0.0219 | 0.02 |
Echinococcus granulosus | pseudouridine metabolizing bifunctional protein | 0.0258 | 0.0219 | 0.0707 |
Trichomonas vaginalis | ribokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0263 | 0.0227 | 0.0227 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0217 | 0.0157 | 0.0506 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0351 | 0.036 | 0.049 |
Schistosoma mansoni | adenosine kinase | 0.0258 | 0.0219 | 0.0707 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0263 | 0.0227 | 0.6288 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0258 | 0.0219 | 0.6081 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.2165 | 0.3101 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0217 | 0.0157 | 0.0506 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.2165 | 0.3101 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.0219 | 0.016 | 0.4453 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Echinococcus multilocularis | adenosine kinase | 0.0258 | 0.0219 | 0.0707 |
Entamoeba histolytica | fructokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0263 | 0.0227 | 0.0731 |
Trypanosoma cruzi | ribokinase, putative | 0.0258 | 0.0219 | 0.02 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.033 | 0.0328 | 0.0328 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0263 | 0.0227 | 0.0227 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0263 | 0.0227 | 0.0731 |
Brugia malayi | Adenosine kinase-like | 0.0258 | 0.0219 | 0.0219 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0263 | 0.0227 | 0.0731 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0263 | 0.0227 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0263 | 0.0227 | 0.0227 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0241 | 0.0193 | 0.0623 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.2165 | 0.3101 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0258 | 0.0219 | 0.02 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2165 | 0.3101 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0351 | 0.036 | 0.036 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Mycobacterium tuberculosis | Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) | 0.0263 | 0.0227 | 0.0026 |
Trypanosoma cruzi | Protein kinase B | 0.0241 | 0.0193 | 0.0112 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0263 | 0.0227 | 0.0227 |
Echinococcus granulosus | ribokinase | 0.0258 | 0.0219 | 0.0707 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0263 | 0.0227 | 0.0227 |
Entamoeba histolytica | protein kinase, putative | 0.0351 | 0.036 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Toxoplasma gondii | AGC kinase | 0.033 | 0.0328 | 0.0376 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0258 | 0.0219 | 0.02 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0241 | 0.0193 | 0.0112 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0263 | 0.0227 | 0.0731 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.2165 | 0.3101 | 0.3101 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.2165 | 0.3101 | 0.3101 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.2165 | 0.3101 | 1 |
Echinococcus granulosus | adenosine kinase | 0.0258 | 0.0219 | 0.0707 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0241 | 0.0193 | 0.0623 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0241 | 0.0193 | 0.5363 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0217 | 0.0157 | 0.0506 |
Brugia malayi | Ribokinase | 0.0258 | 0.0219 | 0.0219 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0263 | 0.0227 | 0.0731 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0263 | 0.0227 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Echinococcus multilocularis | ribokinase | 0.0258 | 0.0219 | 0.0707 |
Schistosoma mansoni | adenosine kinase | 0.0258 | 0.0219 | 0.0707 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0219 | 0.016 | 0.0518 |
Giardia lamblia | Ribokinase | 0.0258 | 0.0219 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0217 | 0.0157 | 0.0506 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.2165 | 0.3101 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Echinococcus multilocularis | pseudouridine metabolizing bifunctional protein | 0.0258 | 0.0219 | 0.0707 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.2165 | 0.3101 | 0.3101 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.2165 | 0.3101 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.0258 | 0.0219 | 0.02 |
Entamoeba histolytica | protein kinase, putative | 0.033 | 0.0328 | 0.909 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0263 | 0.0227 | 0.0227 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.2165 | 0.3101 | 1 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0263 | 0.0227 | 0.6288 |
Loa Loa (eye worm) | hypothetical protein | 0.6729 | 1 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Entamoeba histolytica | ribokinase, putative | 0.0258 | 0.0219 | 0.6081 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0351 | 0.036 | 0.036 |
Trichomonas vaginalis | AGC family protein kinase | 0.0351 | 0.036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0219 | 0.0219 |
Echinococcus granulosus | nervana 2 | 0.0217 | 0.0157 | 0.0506 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0241 | 0.0193 | 0.0623 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0241 | 0.0193 | 0.0623 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0241 | 0.0193 | 0.5363 |
Trichomonas vaginalis | AGC family protein kinase | 0.0135 | 0.0033 | 0.091 |
Entamoeba histolytica | kinase, PfkB family | 0.0258 | 0.0219 | 0.6081 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0217 | 0.0157 | 0.0506 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0219 | 0.016 | 0.0518 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.74 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.729 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.704 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.699 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.688 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.645 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.623 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.532 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.528 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.465 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.446 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.