Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | protein KINase family member (kin 25) | 0.1742 | 0.3803 | 0.379 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0082 | 0.0054 | 0.0034 |
Schistosoma mansoni | tyrosine kinase | 0.0082 | 0.0054 | 0.0087 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.2803 | 0.6198 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.2803 | 0.6198 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.2803 | 0.6198 | 0.5 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.4487 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0153 | 0.0214 | 0.0195 |
Brugia malayi | MAP kinase sur-1 | 0.2803 | 0.6198 | 0.6189 |
Loa Loa (eye worm) | hypothetical protein | 0.1718 | 0.3749 | 0.3734 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2803 | 0.6198 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0095 | 0.0083 | 0.006 |
Schistosoma mansoni | tyrosine kinase | 0.1742 | 0.3803 | 0.6136 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0153 | 0.0214 | 0.0192 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.0029 | 0.0006 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2803 | 0.6198 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0153 | 0.0214 | 0.0346 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.4487 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.2803 | 0.6198 | 0.619 |
Echinococcus granulosus | insulin receptor | 0.0153 | 0.0214 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.4487 | 1 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2803 | 0.6198 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.2803 | 0.6198 | 0.619 |
Schistosoma mansoni | tyrosine kinase | 0.0153 | 0.0214 | 0.0346 |
Schistosoma mansoni | tyrosine kinase | 0.0082 | 0.0054 | 0.0087 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2803 | 0.6198 | 0.5 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0153 | 0.0214 | 0.0195 |
Brugia malayi | Protein kinase domain containing protein | 0.0153 | 0.0214 | 0.0192 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0082 | 0.0054 | 0.0034 |
Giardia lamblia | Kinase, CMGC MAPK | 0.2803 | 0.6198 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4463 | 0.9946 | 0.9946 |
Echinococcus multilocularis | transfer RNA-Thr | 0.4487 | 1 | 1 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0082 | 0.0054 | 0.0031 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0082 | 0.0054 | 0.0034 |
Echinococcus multilocularis | insulin receptor | 0.0153 | 0.0214 | 0.0195 |
Schistosoma mansoni | tyrosine kinase | 0.0067 | 0.002 | 0.0032 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.2803 | 0.6198 | 0.6189 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.4487 | 1 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.2803 | 0.6198 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.2803 | 0.6198 | 0.619 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0082 | 0.0054 | 0.0034 |
Loa Loa (eye worm) | hypothetical protein | 0.1742 | 0.3803 | 0.3788 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.2803 | 0.6198 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2803 | 0.6198 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.2803 | 0.6198 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.2803 | 0.6198 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0082 | 0.0054 | 0.0087 |
Loa Loa (eye worm) | hypothetical protein | 0.1718 | 0.3749 | 0.3734 |
Echinococcus granulosus | mitogen activated protein kinase | 0.2803 | 0.6198 | 0.619 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.2803 | 0.6198 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0082 | 0.0054 | 0.0031 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0082 | 0.0054 | 0.0034 |
Trichomonas vaginalis | CMGC family protein kinase | 0.2803 | 0.6198 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.1742 | 0.3803 | 0.379 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.835 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.774 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.746 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.621 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.6 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.541 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.483 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.383 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.