Detailed information for compound 1627509

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.351 | Formula: C16H33IN2
  • H donors: 0 H acceptors: 0 LogP: 3.9 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[N+](CCCN1C[C@H]2CC[C@@](C1)(C2(C)C)C)(C)C.[I-]
  • InChi: 1S/C16H33N2.HI/c1-15(2)14-8-9-16(15,3)13-17(12-14)10-7-11-18(4,5)6;/h14H,7-13H2,1-6H3;1H/q+1;/p-1/t14-,16+;/m1./s1
  • InChiKey: PQMKTUYBYYEEBW-XMZRARIVSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0195 0.0193
Brugia malayi ecdysteroid receptor 0.0029 0.0283 0.0487
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0293 0.0505
Echinococcus granulosus pyruvate kinase 0.0019 0.0151 0.0149
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0487
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0156 0.0266
Brugia malayi jmjC domain containing protein 0.0016 0.0104 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0283 0.0487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0283 0.0282
Schistosoma mansoni microtubule-associated protein tau 0.0774 0.986 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0246 0.1896
Echinococcus granulosus expressed protein 0.0008 0.001 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1279 0.2231
Loa Loa (eye worm) hypothetical protein 0.005 0.0551 0.0957
Echinococcus multilocularis lamin 0.003 0.0293 0.0289
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0134 0.1634 0.1876
Echinococcus multilocularis geminin 0.019 0.2349 0.2345
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0141 0.1067
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0145 0.0245
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.003 0.0293 0.0505
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0452 0.5718 1
Schistosoma mansoni caspase-7 (C14 family) 0.0113 0.136 0.138
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0141 0.0138
Trichomonas vaginalis rotamase, putative 0.0037 0.0375 0.0648
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0174
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0156 0.0266
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0104 0.0101
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0042
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0386 0.0667
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0235 0.0403
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0174
Schistosoma mansoni DNA helicase recq5 0.002 0.0156 0.0159
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0033 0.0049
Plasmodium vivax SET domain protein, putative 0.003 0.0293 0.2263
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0455 0.0788
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0083 0.0079
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0083 0.0137
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0283 0.0952
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0016 0.0109 0.0814
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0283 0.0282
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0104 0.0101
Schistosoma mansoni hypothetical protein 0.0023 0.0195 0.0197
Schistosoma mansoni ap endonuclease 0.0019 0.0145 0.0147
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0083 0.0137
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0083 0.0079
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0374 0.4369
Loa Loa (eye worm) hypothetical protein 0.0107 0.1279 0.2231
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0104 0.0099
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0016 0.0109 0.0814
Schistosoma mansoni serine/threonine protein kinase 0.0452 0.5718 0.58
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.024 0.2781
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0083 0.0137
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0083 0.0078
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0551 0.429
Loa Loa (eye worm) MH2 domain-containing protein 0.0134 0.1627 0.2839
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0374 0.2899
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0283 0.0487
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0156 0.0152
Schistosoma mansoni cpg binding protein 0.0032 0.0319 0.0323
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0134 0.1634 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0293 0.0505
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0104 0.0174
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0083 0.0078
Schistosoma mansoni ferritin 0.0008 0.001 0.001
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0283 0.0952
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0104 0.0174
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0452 0.5718 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.016 0.0783
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0141 0.0238
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0551 0.0957
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0283 0.0487
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0283 0.0278
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0127 0.0123
Echinococcus granulosus cytochrome P450 2K1 0.0016 0.0109 0.0105
Schistosoma mansoni ferritin 0.0008 0.001 0.001
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0037 0.0375 0.0648
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.005 0.0079
Entamoeba histolytica hypothetical protein 0.004 0.0423 0.495
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0586 0.1018
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0104 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0141 0.0238
Loa Loa (eye worm) hypothetical protein 0.0107 0.1279 0.2231
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.1279 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0145 0.1097
Trichomonas vaginalis bromodomain-containing protein, putative 0.0048 0.0519 0.09
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0145 0.0245
Plasmodium vivax metacaspase 1, putative 0.0043 0.0455 0.3533
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0021 0.0017
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0104 0.0099
Echinococcus granulosus ferritin 0.0008 0.001 0.0005
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.1279 0.1468
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0423 0.0419
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0283 0.0278
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0016 0.0109 0.0814
Schistosoma mansoni hypothetical protein 0.0016 0.0109 0.011
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.1279 0.1468
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.1279 0.2231
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0235 0.0403
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0283 0.0287
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0423 0.0425
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0246 0.1896
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0113 0.136 0.1376
Brugia malayi nuclear receptor NHR-67 0.0014 0.0083 0.0137
Loa Loa (eye worm) acetyltransferase 0.0162 0.1995 0.3484
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0141 0.0238
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0653 0.0662
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0033 0.0221
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0386 0.0667
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0455 0.0788
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0016 0.0109 0.012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0083 0.0079
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0104 0.0105
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0016 0.0109 0.012
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0386 0.0667
Schistosoma mansoni cytochrome P450 0.0016 0.0109 0.011
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0374 0.037
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0051 0.0081
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0132 0.0223
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0455 0.0788
Mycobacterium tuberculosis Conserved protein 0.0107 0.1279 0.1468
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0283 0.0282
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0141 0.1067
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0455 0.0788
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0104 0.01
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0156 0.2609
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0438 0.0758
Echinococcus granulosus cpg binding protein 0.0034 0.0342 0.0342
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0156 0.0266
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0195 0.019
Trichomonas vaginalis CMGC family protein kinase 0.0452 0.5718 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0156 0.0266
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0452 0.5718 1
Leishmania major hypothetical protein, conserved 0.005 0.0551 0.0957
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0386 0.0439
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0283 0.0487
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.001 0.0033 0.0049
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0104 0.0105
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0283 0.0287
Schistosoma mansoni alpha glucosidase 0.0074 0.085 0.0863
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0132 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0283 0.0487
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0146 0.0163
Trichomonas vaginalis ferritin, putative 0.0008 0.001 0.0009
Brugia malayi follicle stimulating hormone receptor 0.0229 0.2851 0.4982
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0141 0.0238
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0659 0.1145
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0104 0.0174
Echinococcus multilocularis mitogen activated protein kinase 3 0.0452 0.5718 0.5716
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0132 0.0128
Loa Loa (eye worm) DR-78 0.0014 0.0083 0.0137
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0246 0.1896
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0145 0.3697
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0283 0.0282
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.1279 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.001 0.004
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0455 0.0788
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0132 0.0128
Schistosoma mansoni ferritin light chain 0.0008 0.001 0.001
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.085 1
Brugia malayi MH2 domain containing protein 0.0134 0.1627 0.2839
Chlamydia trachomatis pyruvate kinase 0.0037 0.0386 1
Brugia malayi beta-lactamase family protein 0.0107 0.1279 0.2231
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.146 0.1676
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.024 0.0412
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0246 0.0423
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0037 0.0375 0.0648
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0016 0.0109 0.0814
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0283 0.0487
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0386 0.0667
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0235 0.0403
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0586 0.0582
Leishmania major alpha glucosidase II subunit, putative 0.0074 0.085 0.148
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1279 0.2231
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0455 0.0788
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0293 0.0505
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0104 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0283 0.0487
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0083 0.0084
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0141 0.0238
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0048 0.0519 0.09
Echinococcus multilocularis pyruvate kinase 0.0019 0.0151 0.0147
Schistosoma mansoni ferritin light chain 0.0008 0.001 0.001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0156 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1648 0.1668
Echinococcus multilocularis pyruvate kinase 0.0019 0.0151 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0455 0.0788
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0021 0.0022
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2927 0.5115
Onchocerca volvulus 0.0054 0.06 0.2037
Echinococcus multilocularis Smad4 0.0009 0.0022 0.0017
Brugia malayi nuclear receptor RXR 0.0014 0.0083 0.0137
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0386 0.1303
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0092 0.0089
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0246 0.1896
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0257 0.0441
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0132 0.0134
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0156 0.0154
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0104 0.1704
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0022 0.003
Onchocerca volvulus 0.0107 0.1279 0.4361
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0386 0.0667
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0016 0.0109 0.012
Schistosoma mansoni lamin 0.003 0.0293 0.0298
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0386 0.1303
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0257 0.0441
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0374 0.0647
Onchocerca volvulus 0.0032 0.0319 0.1074
Brugia malayi hypothetical protein 0.0265 0.3316 0.5795
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0438 0.0758
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0141 0.0238
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0132 0.0128
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0083 0.0084
Brugia malayi MAP kinase sur-1 0.0452 0.5718 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0283 0.0278
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0132 0.0223
Brugia malayi hypothetical protein 0.005 0.0551 0.0957
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0074 0.085 0.148
Echinococcus granulosus geminin 0.019 0.2349 0.2379
Onchocerca volvulus 0.004 0.0417 0.1411
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.0754 0.1312
Loa Loa (eye worm) intermediate filament protein 0.003 0.0293 0.0505
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0257 0.0441
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0452 0.5718 1
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.1279 0.2231
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0283 0.0287
Schistosoma mansoni caspase-7 (C14 family) 0.0083 0.0968 0.0982
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0132 0.1
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0132 0.0223
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0083 0.0078
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0048 0.0519 0.4037
Loa Loa (eye worm) hypothetical protein 0.0041 0.0438 0.0758
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0283 0.0278
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0487
Mycobacterium leprae conserved hypothetical protein 0.0107 0.1279 0.7823
Echinococcus multilocularis pyruvate kinase 0.0037 0.0386 0.0381
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0016 0.0109 0.0814
Echinococcus multilocularis tumor protein p63 0.0379 0.4779 0.4776
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0016 0.0109 0.0814
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0132 0.0223
Schistosoma mansoni apoferritin-2 0.0008 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0455 0.0788
Echinococcus multilocularis pyruvate kinase 0.0019 0.0151 0.0147
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0083 0.0268
Loa Loa (eye worm) beta-lactamase 0.0107 0.1279 0.2231
Schistosoma mansoni hypothetical protein 0.019 0.2349 0.2382
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0438 0.0758
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0283 0.0287
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0048 0.0519 0.09
Echinococcus multilocularis caspase 0.0113 0.136 0.1356
Treponema pallidum NADH oxidase 0.0018 0.0141 0.9713
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0051 0.0081
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0386 0.0667
Brugia malayi Glycosyl hydrolases family 31 protein 0.0074 0.085 0.148
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0022 0.003
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0156 0.0266
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0293 0.0505
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0145 0.2404
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0083 0.0079
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0048 0.0519 0.09
Trypanosoma brucei trypanothione reductase 0.0053 0.0586 0.1018
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0156 0.0266
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.016 0.1217
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.146 0.1676
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0016 0.0109 0.012
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.1279 0.1275
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0438 0.0758
Toxoplasma gondii PPIC-type PPIASE domain-containing protein 0.0011 0.0051 0.0081
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0104 0.0099
Brugia malayi pyruvate kinase, muscle isozyme 0.0008 0.0006 0.0002
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0438 0.0433
Brugia malayi MH2 domain containing protein 0.0009 0.0022 0.003
Brugia malayi beta-lactamase family protein 0.0107 0.1279 0.2231
Mycobacterium tuberculosis Probable oxidoreductase 0.0134 0.1634 0.1876
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0014 0.0083 0.0268
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2561 0.4475
Echinococcus multilocularis lamin dm0 0.003 0.0293 0.0289
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0487
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0283 0.0487
Loa Loa (eye worm) cytochrome P450 0.0016 0.0109 0.0182
Plasmodium falciparum histone acetyltransferase GCN5 0.0044 0.0468 0.7963
Mycobacterium leprae Probable lipase LipE 0.0107 0.1279 0.7823
Leishmania major pyruvate kinase 0.0037 0.0386 0.0667
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0132 0.0128
Trypanosoma brucei Metacaspase-4 0.0043 0.0455 0.0788
Brugia malayi CXXC zinc finger family protein 0.0032 0.0319 0.0549
Plasmodium falciparum pyruvate kinase 0.0037 0.0386 0.6546
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1279 0.2231
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0141 0.359
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0141 0.1067
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0487
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0037 0.0386 0.0668
Loa Loa (eye worm) hypothetical protein 0.0026 0.024 0.0412
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0438 0.0439
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0145 0.1653
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0283 0.0287
Brugia malayi tailless protein 0.0014 0.0083 0.0137
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0016 0.0109 0.0814
Onchocerca volvulus 0.003 0.0293 0.0988
Echinococcus granulosus bloom syndrome protein 0.002 0.0156 0.0154
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0022 0.0017
Mycobacterium tuberculosis Probable reductase 0.0121 0.146 0.1676
Schistosoma mansoni hypothetical protein 0.004 0.0417 0.0423
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1648 0.1672
Echinococcus multilocularis expressed protein 0.0037 0.0386 0.0382
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0021 0.0016
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0257 0.0441
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0141 0.1067
Schistosoma mansoni smad 0.0009 0.0022 0.0022
Leishmania major pyruvate kinase 0.0037 0.0386 0.0667
Loa Loa (eye worm) hypothetical protein 0.0027 0.0246 0.0423
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.1279 0.1468
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0455 0.0788
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0016 0.0109 0.012
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0487
Mycobacterium ulcerans hypothetical protein 0.0027 0.0246 0.1896
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.085 0.148
Brugia malayi beta-lactamase 0.0107 0.1279 0.2231
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0551 0.0957
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0257 0.0441
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.085 0.148
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0452 0.5718 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0246 0.1896
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.146 0.1676
Echinococcus multilocularis caspase 3 0.007 0.081 0.0805
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0104 0.0106
Echinococcus granulosus mitogen activated protein kinase 0.0452 0.5718 0.5798
Brugia malayi hypothetical protein 0.0014 0.0083 0.0137
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0283 0.0278
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0016 0.0109 0.012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Plasmodium vivax JmjC domain containing protein 0.0016 0.0104 0.0778
Trichomonas vaginalis CMGC family protein kinase 0.0452 0.5718 1
Toxoplasma gondii thioredoxin reductase 0.0053 0.0586 0.1018
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0083 0.0137
Plasmodium falciparum glutathione reductase 0.0053 0.0586 1
Leishmania major cytochrome p450-like protein 0.0016 0.0109 0.0182
Brugia malayi nuclear receptor NHR-88 0.0014 0.0083 0.0137
Echinococcus multilocularis mitogen activated protein kinase 0.0452 0.5718 0.5716
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.146 0.8934
Brugia malayi acetyltransferase, GNAT family protein 0.0162 0.1995 0.3484
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1279 0.1297
Leishmania major hypothetical protein, conserved 0.0016 0.0104 0.0174
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0141 0.1067
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0174
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0283 0.0487
Echinococcus granulosus phd:f box containing protein 0.0016 0.0104 0.0101
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0797 0.0808
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0283 0.0287
Plasmodium falciparum glutathione reductase 0.0018 0.0141 0.2337
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0104 0.0174
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0272
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0283 0.0952
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0455 0.0788
Brugia malayi MH2 domain containing protein 0.0009 0.0022 0.003
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0151 0.115
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0016 0.0109 0.0814
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.1279 0.2231
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0049
Schistosoma mansoni caspase-3 (C14 family) 0.0113 0.136 0.138
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0438 0.0444
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1648 0.1644
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0113 0.136 0.1356
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0049
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0156 0.2609
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.06 0.1042
Brugia malayi hypothetical protein 0.004 0.0417 0.0722
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0283 0.0487
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0283 0.0282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0141 0.0238
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.1279 0.1468
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0246 0.0423
Brugia malayi Cytochrome P450 family protein 0.0059 0.0659 0.1145
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.0257 0.0862
Loa Loa (eye worm) hypothetical protein 0.0015 0.0092 0.0153
Brugia malayi jmjC domain containing protein 0.0058 0.0653 0.1134
Echinococcus multilocularis microtubule associated protein 2 0.0774 0.986 0.986
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0246 0.0278
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0386 0.0667
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0438 0.0758
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.001 0.0006
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0455 0.0788
Schistosoma mansoni hypothetical protein 0.0054 0.06 0.0609
Echinococcus granulosus tumor protein p63 0.0379 0.4779 0.4844
Schistosoma mansoni intermediate filament proteins 0.003 0.0293 0.0298
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0438 0.0444
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0257 0.2979
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0257 0.0441
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0141 0.0238
Mycobacterium tuberculosis Conserved protein 0.0107 0.1279 0.1468
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0272
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0113 0.0189
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0653 0.0657
Schistosoma mansoni alpha-glucosidase 0.0285 0.3574 0.3625
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0283 0.0487
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1279 0.2231
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0145 0.0245
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0283 0.0278
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0141 0.0136
Loa Loa (eye worm) hypothetical protein 0.0083 0.0968 0.1686
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0293 0.0293
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.146 0.1676
Echinococcus granulosus intermediate filament protein 0.003 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0174
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0141 0.0238
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.1279 0.1468
Loa Loa (eye worm) hypothetical protein 0.0107 0.1279 0.2231
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0083 0.0137
Brugia malayi steroid hormone receptor 0.0029 0.0283 0.0487
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0246 0.1896
Echinococcus granulosus lysosomal alpha glucosidase 0.0331 0.4168 0.4225
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0386 0.2988
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0141 0.0238
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0141 0.0157
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Schistosoma mansoni Smad4 0.0009 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0455 0.0788
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0078 0.0128
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0374 0.0647
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0174
Brugia malayi glutathione reductase 0.0053 0.0586 0.1018
Schistosoma mansoni inositol monophosphatase 0.0037 0.0374 0.038
Brugia malayi cytochrome P450 0.0016 0.0109 0.0182
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.0417 0.0419
Echinococcus granulosus neutral alpha glucosidase AB 0.0074 0.085 0.0858
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0104 0.0174
Echinococcus granulosus caspase 8 0.0043 0.0455 0.0457
Echinococcus granulosus expressed protein 0.0037 0.0386 0.0387
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0551 0.0957
Echinococcus granulosus microtubule associated protein 2 0.0774 0.986 1
Trichomonas vaginalis esterase, putative 0.0107 0.1279 0.2231
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.016 0.1217
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0455 0.0788
Loa Loa (eye worm) hypothetical protein 0.0037 0.0386 0.0667
Onchocerca volvulus 0.0029 0.0283 0.0952
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0145 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0016 0.0109 0.012
Trypanosoma brucei metacaspase 0.0043 0.0455 0.0788
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0037 0.0386 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0283 0.0487
Brugia malayi intermediate filament protein 0.003 0.0293 0.0505
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0135 0.1648 0.1668
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0455 0.0788
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0078 0.0128
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0022 0.0017
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0151 0.252
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0083 0.0079
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0487
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0246 0.0423
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.085 0.148
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0551 0.9399
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0016 0.0109 0.0814
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0156 0.0266
Loa Loa (eye worm) glutathione reductase 0.0053 0.0586 0.1018
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0014 0.0085 0.014
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0455 0.0788
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0016 0.0109 0.012
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0174
Entamoeba histolytica recQ family helicase, putative 0.001 0.0028 0.0275
Schistosoma mansoni pyruvate kinase 0.0037 0.0386 0.0391
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0293 0.0297
Toxoplasma gondii peptidylprolyl isomerase 0.0037 0.0375 0.0648
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0455 0.3533
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0257 0.0441
Echinococcus granulosus mitogen activated protein kinase 3 0.0452 0.5718 0.5798
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0386 0.1303
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0438 0.0533
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.085 0.148
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0438 0.0433
Brugia malayi ecdysone receptor 0.0014 0.0083 0.0137
Echinococcus granulosus histone acetyltransferase KAT2B 0.0048 0.0519 0.0522
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0046 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0146 0.0163
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0374 0.0375
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0141 0.0238
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0283 0.0487
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0246 0.2857
Mycobacterium ulcerans lipase LipD 0.0107 0.1279 1
Echinococcus granulosus caspase 2 0.0083 0.0968 0.0977
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0283 0.0487
Giardia lamblia Kinase, CMGC MAPK 0.0452 0.5718 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0132 0.0223
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0283 0.0487
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0016 0.0109 0.0814
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.3316 0.336
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0374 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0132 0.0128
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0033 0.0049
Echinococcus granulosus pyruvate kinase 0.0037 0.0386 0.0386
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0016 0.0109 0.012
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0145 0.0245
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.146 0.1676
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.1279 0.2231
Brugia malayi hypothetical protein 0.0032 0.0322 0.0555
Trypanosoma cruzi metacaspase, putative 0.0043 0.0455 0.0788
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Brugia malayi Pre-SET motif family protein 0.0206 0.2561 0.4475
Trypanosoma cruzi metacaspase, putative 0.0043 0.0455 0.0788
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.0005 0.0005
Loa Loa (eye worm) Smad1 0.0009 0.0022 0.003
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0455 0.0788
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0438 0.0758
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0438 0.5121
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0011 0.0051 0.0081
Onchocerca volvulus 0.0192 0.237 0.8095
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0141 0.0238
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0083 0.0084
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0156 0.0266
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0374 0.0647
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0452 0.5718 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.1279 0.1297
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0141 0.0238
Brugia malayi Inositol-1 0.0037 0.0374 0.0647
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.085 1
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.085 0.148
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0235 0.0403
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.027 0.0269
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0374 0.0647
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0092 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0283 0.0487
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0586 0.067
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0374 0.0647
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0016 0.0109 0.012
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0083 0.0137
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.085 0.148
Schistosoma mansoni lamin 0.003 0.0293 0.0298
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0083 0.0137
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0145 0.014
Loa Loa (eye worm) hypothetical protein 0.0014 0.0085 0.014
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0141 0.0238
Trypanosoma brucei glucosidase, putative 0.0074 0.085 0.148
Mycobacterium ulcerans beta-lactamase 0.0107 0.1279 1
Loa Loa (eye worm) inositol-1 0.0037 0.0374 0.0647
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0283 0.0287
Leishmania major metacaspase, putative 0.0043 0.0455 0.0788
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0022 0.0017
Schistosoma mansoni smad1 5 8 and 0.0009 0.0022 0.0022
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0145 0.0245
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0325 0.1966
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0283 0.0487
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.001 0.0031
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0016 0.0109 0.0814
Echinococcus multilocularis smad 0.0009 0.0022 0.0017
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0156 0.0154
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0257 0.0441
Leishmania major cytochrome p450-like protein 0.0026 0.0235 0.0403
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Schistosoma mansoni coup transcription factor 0.0029 0.0283 0.0287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1648 0.1672
Entamoeba histolytica recQ family DNA helicase 0.001 0.0033 0.0332
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0283 0.0487
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0452 0.5718 1
Plasmodium falciparum thioredoxin reductase 0.0053 0.0586 1
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.1279 0.2231
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0156 0.0266
Schistosoma mansoni cpg binding protein 0.0034 0.0342 0.0347
Trichomonas vaginalis sucrase-isomaltase, putative 0.0074 0.085 0.148
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0141 0.0238
Schistosoma mansoni cpg binding protein 0.0034 0.0342 0.0347
Echinococcus granulosus histone acetyltransferase KAT2B 0.0158 0.1937 0.196
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0104 0.0174
Loa Loa (eye worm) hypothetical protein 0.002 0.0156 0.0266
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.001 0.0006
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0156 0.0266
Entamoeba histolytica acetyltransferase, GNAT family 0.0044 0.0468 0.5478
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0374 0.0647
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0676 0.0681
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0283 0.0278
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0438 0.0439
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0141 0.0238
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0586 0.1018
Brugia malayi Thioredoxin reductase 0.0053 0.0586 0.1018
Onchocerca volvulus 0.0014 0.0083 0.0268
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0083 0.0084
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0141 0.0143
Echinococcus multilocularis lysosomal alpha glucosidase 0.0331 0.4168 0.4165
Schistosoma mansoni zinc finger protein 0.0014 0.0083 0.0084
Echinococcus granulosus caspase 3 0.007 0.081 0.0817
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0551 0.9399
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.2851 0.4982
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0141 0.359
Trypanosoma brucei protein kinase, putative 0.0452 0.5718 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.0257 0.0441
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0156 0.0028
Echinococcus multilocularis pyruvate kinase 0.0037 0.0386 0.0381
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0455 0.0788
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0046 0.0073
Echinococcus granulosus lamin dm0 0.003 0.0293 0.0293
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0135 0.1648 0.1644
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0438 0.0439
Schistosoma mansoni smad1 5 8 and 0.0009 0.0022 0.0022
Brugia malayi hypothetical protein 0.0016 0.0104 0.0174
Echinococcus granulosus pyruvate kinase 0.0019 0.0151 0.0149
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0246 0.1483
Brugia malayi hypothetical protein 0.0014 0.0083 0.0137
Loa Loa (eye worm) hypothetical protein 0.0107 0.1279 0.2231
Echinococcus granulosus smad 0.0009 0.0022 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0146 0.0163
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0016 0.0109 0.0814
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.0417 0.0413
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.016 0.0179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0146 0.0163
Entamoeba histolytica hypothetical protein 0.004 0.0423 0.495
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0132 0.2192
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0272
Brugia malayi hypothetical protein 0.0016 0.0104 0.0174
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0104 0.0099
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0319 0.0549
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0135 0.1648 0.1672
Echinococcus granulosus pyruvate kinase 0.0037 0.0386 0.0386
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0016 0.0109 0.012
Plasmodium falciparum thioredoxin reductase 0.0018 0.0141 0.2337
Schistosoma mansoni inositol monophosphatase 0.0037 0.0374 0.038
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0455 0.0788
Treponema pallidum ATP-dependent DNA helicase 0.001 0.0033 0.1706
Plasmodium vivax hypothetical protein, conserved 0.0107 0.1279 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0141 0.0238
Brugia malayi hypothetical protein 0.004 0.0423 0.0733
Brugia malayi nuclear receptor RXR 0.0016 0.0104 0.0174
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0375 0.0648
Brugia malayi MH1 domain containing protein 0.0009 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0031 0.0045
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0145 0.0142
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0386 0.0667
Brugia malayi nuclear hormone receptor 0.0014 0.0083 0.0137
Wolbachia endosymbiont of Brugia malayi parvulin-like peptidyl-prolyl isomerase, PPID 0.0011 0.0051 0.1124
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0293 0.0297
Echinococcus multilocularis caspase 8 0.0043 0.0455 0.045
Echinococcus multilocularis cpg binding protein 0.0034 0.0342 0.0338
Brugia malayi Smad1 0.0009 0.0022 0.003
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0141 0.0238
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0283 0.0487
Brugia malayi Cell death protein 3 precursor 0.0083 0.0968 0.1686
Onchocerca volvulus Cell death protein 3 homolog 0.0083 0.0968 0.3296
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0141 0.0238
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0386 0.2337
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0016 0.0109 0.0182
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0016 0.0109 0.0814
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0145 0.0007
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0074 0.085 0.148
Schistosoma mansoni ap endonuclease 0.0019 0.0145 0.0147
Brugia malayi jmjC domain containing protein 0.0016 0.0104 0.0174
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0145 0.0245
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0156 0.0266
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0438 0.0433
Schistosoma mansoni nuclear receptor 0.0014 0.0083 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0455 0.0788
Schistosoma mansoni hypothetical protein 0.019 0.2349 0.2382
Giardia lamblia Pyruvate kinase 0.0019 0.0151 0.0019
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0487
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.001 0.004
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.1279 0.1468
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0083 0.0079
Onchocerca volvulus 0.0107 0.1279 0.4361
Schistosoma mansoni nuclear receptor 0.0014 0.0083 0.0084
Trypanosoma cruzi metacaspase, putative 0.0043 0.0455 0.0788
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0104 0.0174
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0016 0.0109 0.0182
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0246 0.2857
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0246 0.1896
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0135 0.1648 0.2876
Plasmodium falciparum acyl-CoA synthetase 0.002 0.016 0.2667
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.0257 0.0441
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0257 0.0441
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0028 0.0028
Trichomonas vaginalis CMGC family protein kinase 0.0452 0.5718 1
Onchocerca volvulus 0.003 0.0293 0.0987
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0156 0.0266
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0386 0.2988
Echinococcus multilocularis neutral alpha glucosidase AB 0.0074 0.085 0.0846
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0017
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0022 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0293 0.0297
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0455 0.0788
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0141 0.2337
Schistosoma mansoni survival motor neuron protein 0.0054 0.06 0.0609
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0016 0.0109 0.012
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0141 0.0238
Onchocerca volvulus 0.0014 0.0083 0.0268
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0141 0.0238
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0016 0.0109 0.012
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0145 0.0245
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0676 0.1175
Echinococcus multilocularis expressed protein 0.0008 0.001 0.0005
Echinococcus multilocularis musashi 0.003 0.0293 0.0289
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0235 0.0403
Echinococcus multilocularis bloom syndrome protein 0.002 0.0156 0.0152
Brugia malayi jmjC domain containing protein 0.006 0.0676 0.1175
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0235 0.0403
Brugia malayi Cytochrome P450 family protein 0.0026 0.0235 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0386 0.0668
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0438 0.0758
Echinococcus multilocularis 0.0016 0.0109 0.0104
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0162 0.1995 0.1991
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0325 0.0369
Toxoplasma gondii cytochrome p450 superfamily protein 0.0016 0.0109 0.0182
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0145 0.0161
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0021 0.0016
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0028 0.0041
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0386 0.0667
Echinococcus granulosus pyruvate kinase 0.0019 0.0151 0.0149
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0104 0.0105
Loa Loa (eye worm) hypothetical protein 0.0016 0.0104 0.0174
Trypanosoma brucei metacaspase MCA2 0.0043 0.0455 0.0788
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0104 0.0105
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0283 0.0282
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0246 0.0278
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0135 0.1648 0.2876
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0283 0.0487
Echinococcus granulosus Smad4 0.0009 0.0022 0.0017
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0016 0.0109 0.0814
Trichomonas vaginalis CMGC family protein kinase 0.0452 0.5718 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0246 0.0423
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0145 0.1097
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0104 0.0101
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0141 0.2337
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0683 0.8688 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0286 0.0493
Loa Loa (eye worm) RecQ helicase 0.002 0.0156 0.0266
Brugia malayi Glycosyl hydrolases family 31 protein 0.0331 0.4168 0.7287
Brugia malayi jmjC domain containing protein 0.0016 0.0104 0.0174
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0293 0.0297
Mycobacterium leprae Conserved hypothetical protein 0.0016 0.0109 0.0637
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0423 0.0429
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0162 0.1995 0.2024
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0016 0.0109 0.0814
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0283 0.0287
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0016 0.0109 0.0814
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0132 0.0223
Brugia malayi Cytochrome P450 family protein 0.0026 0.0235 0.0403
Brugia malayi MH1 domain containing protein 0.0009 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0055 0.0618 0.1073
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.085 0.148
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0104 0.0105
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0257 0.0441
Schistosoma mansoni ferritin 0.0008 0.001 0.001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0132 0.0147
Loa Loa (eye worm) hypothetical protein 0.0027 0.0246 0.0423
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0676 0.0686
Echinococcus multilocularis pyruvate kinase 0.003 0.0284 0.028
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0127 0.0125
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0016 0.0109 0.012
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Plasmodium falciparum metacaspase-like protein 0.0043 0.0455 0.774
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0653 0.0648
Loa Loa (eye worm) hypothetical protein 0.0027 0.0246 0.0423
Brugia malayi jmjC domain containing protein 0.0016 0.0104 0.0174
Brugia malayi nuclear receptor NHR-88 0.0029 0.0283 0.0487
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.085 0.148
Loa Loa (eye worm) hypothetical protein 0.0043 0.0455 0.0788
Onchocerca volvulus 0.0235 0.2927 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0293 0.0289
Loa Loa (eye worm) hypothetical protein 0.0265 0.3316 0.5795
Loa Loa (eye worm) hypothetical protein 0.0029 0.0283 0.0487
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0246 0.0423
Onchocerca volvulus 0.0107 0.1279 0.4361
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0104 0.0174
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0386 0.0667
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0455 0.0461
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0016 0.0109 0.012
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0045 0.007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0283 0.0487
Loa Loa (eye worm) hypothetical protein 0.0027 0.0257 0.0441
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0283 0.0282
Leishmania major cytochrome p450-like protein 0.0016 0.0109 0.0182
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0455 0.0788
Schistosoma mansoni apoferritin-2 0.0008 0.001 0.001
Echinococcus multilocularis ferritin 0.0008 0.001 0.0005
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0283 0.0282
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0109 0.0182
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0586 0.059
Toxoplasma gondii exonuclease III APE 0.0019 0.0145 0.0245
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0132 0.0223
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0331 0.4168 0.7287
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0151 0.0257
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0374 0.0647
Echinococcus granulosus lamin 0.003 0.0293 0.0293
Schistosoma mansoni rotamase 0.0037 0.0386 0.0392
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0009 0.0022 0.0022
Trichomonas vaginalis maltase-glucoamylase, putative 0.0074 0.085 0.148
Loa Loa (eye worm) hypothetical protein 0.0014 0.0083 0.0137
Trypanosoma cruzi metacaspase, putative 0.0043 0.0455 0.0788
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0551 0.0957
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0104 0.0174
Toxoplasma gondii ABC1 family protein 0.0107 0.1279 0.2231
Mycobacterium tuberculosis Conserved protein 0.0107 0.1279 0.1468
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0386 0.0667
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0016 0.0109 0.012
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0283 0.0287
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0141 0.0238
Entamoeba histolytica hypothetical protein 0.004 0.0423 0.495
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0283 0.0487
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0438 0.0758
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.085 0.148
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0016 0.0109 0.0182
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0083 0.0137
Brugia malayi pyruvate kinase 0.0008 0.0006 0.0002
Schistosoma mansoni ferritin 0.0008 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.0107 0.1279 1
Schistosoma mansoni alpha-glucosidase 0.0285 0.3574 0.3625
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.3316 0.3313
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0455 0.0788
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.1279 0.1468
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0037 0.0375 0.0648
Echinococcus granulosus caspase 0.0113 0.136 0.1376
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0374 0.0647
Loa Loa (eye worm) hypothetical protein 0.004 0.0417 0.0722
Schistosoma mansoni hypothetical protein 0.004 0.0423 0.0429
Giardia lamblia Pyruvate kinase 0.0037 0.0386 0.0439
Echinococcus multilocularis lysosomal alpha glucosidase 0.0331 0.4168 0.4165
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0016 0.0109 0.012
Trichomonas vaginalis rotamase, putative 0.0037 0.0386 0.0668
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0145 0.0245
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0132 0.0129
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.1279 0.1293
Loa Loa (eye worm) hypothetical protein 0.0107 0.1279 0.2231
Leishmania major trypanothione reductase 0.0053 0.0586 0.1018
Loa Loa (eye worm) pyruvate kinase 0.0008 0.0006 0.0002
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0676 0.0686
Onchocerca volvulus 0.0055 0.0618 0.2098
Brugia malayi nuclear hormone receptor 0.0029 0.0283 0.0487
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0016 0.0109 0.0814
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0283 0.0278
Onchocerca volvulus 0.003 0.0293 0.0988
Schistosoma mansoni cellular tumor antigen P53 0.0055 0.0618 0.0627
Brugia malayi Cytochrome P450 family protein 0.0016 0.0109 0.0182
Loa Loa (eye worm) transcription factor SMAD2 0.0134 0.1627 0.2839
Leishmania major hypothetical protein, conserved 0.0107 0.1279 0.2231
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0386 0.0667
Leishmania major glycosyl hydrolase-like protein 0.0027 0.0257 0.0441
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0283 0.0487
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0586 0.4564
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0016 0.0109 0.012
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0113 0.0189
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0283 0.0287
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0083 0.0137
Plasmodium falciparum metacaspase 1 0.0043 0.0455 0.774
Brugia malayi conserved hypotetical protein 0.0014 0.0083 0.0137
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0283 0.0287
Schistosoma mansoni pyruvate kinase 0.0037 0.0386 0.0391
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0235 0.1806
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0653 0.0648
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0272
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0016 0.0109 0.0814
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.001 0.0028 0.0182
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0246 0.0423
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0134 0.1634 0.1876
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0037 0.0375 0.4376
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0016 0.0109 0.012
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0016 0.0109 0.012
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0104 0.0101
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0246 0.1483
Loa Loa (eye worm) hypothetical protein 0.002 0.016 0.0272
Mycobacterium leprae putative cytochrome p450 0.0016 0.0109 0.0637
Loa Loa (eye worm) hypothetical protein 0.0107 0.1279 0.2231
Entamoeba histolytica recQ family helicase, putative 0.002 0.0156 0.1794
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0283 0.0282
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0283 0.0278
Schistosoma mansoni pyruvate kinase 0.0019 0.0151 0.0153
Brugia malayi Pre-SET motif family protein 0.003 0.0293 0.0505
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0246 0.2857
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0452 0.5718 1
Plasmodium vivax glutathione reductase, putative 0.0053 0.0586 0.4564
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0016 0.0109 0.0814
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0132 0.0223
Schistosoma mansoni smad1 5 8 and 0.0009 0.0022 0.0022
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0104 0.0174
Giardia lamblia Histone acetyltransferase GCN5 0.0044 0.0468 0.0587
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0083 0.0078
Entamoeba histolytica hypothetical protein 0.004 0.0423 0.495
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.1279 0.2231
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0283 0.0287
Echinococcus multilocularis caspase 2 0.0083 0.0968 0.0964
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0011 0.0051 0.0081
Onchocerca volvulus 0.0027 0.0246 0.0827
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0283 0.0487
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0083 0.0078
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0083 0.0078
Schistosoma mansoni DNA helicase recq1 0.002 0.0156 0.0159
Trypanosoma brucei metacaspase MCA3 0.0043 0.0455 0.0788
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0016 0.0109 0.0182
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0293 0.0289
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0016 0.0109 0.0814
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0452 0.5718 1
Brugia malayi isocitrate dehydrogenase 0.0018 0.0132 0.0223

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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